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A novel AIE-NIR-II nano-contrast agent for monitoring and evaluating kidney transplant 用于监测和评估肾移植的新型 AIE-NIR-II 纳米对比剂
National Science Review Pub Date : 2024-02-05 DOI: 10.1093/nsr/nwae048
Yuan-Yuan Zhao, Bokyeong Hwang, Yeju Lee, Juyoung Yoon
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引用次数: 0
A novel AIE-NIR-II nano-contrast agent for monitoring and evaluating kidney transplant 用于监测和评估肾移植的新型 AIE-NIR-II 纳米对比剂
National Science Review Pub Date : 2024-02-05 DOI: 10.1093/nsr/nwae048
Yuan-Yuan Zhao, Bokyeong Hwang, Yeju Lee, Juyoung Yoon
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引用次数: 0
Stereoselective recognition of morphine enantiomers by μ-opioid receptor μ-阿片受体对吗啡对映体的立体选择性识别
National Science Review Pub Date : 2024-01-22 DOI: 10.1093/nsr/nwae029
Yibo Wang, A. Van Ngo, Xiaohui Wang
{"title":"Stereoselective recognition of morphine enantiomers by μ-opioid receptor","authors":"Yibo Wang, A. Van Ngo, Xiaohui Wang","doi":"10.1093/nsr/nwae029","DOIUrl":"https://doi.org/10.1093/nsr/nwae029","url":null,"abstract":"\u0000 Stereospecific recognition of chiral molecules plays a crucial role in biological systems. The μ-opioid receptor (MOR) exhibits binding affinity towards (-)-morphine, a well-established gold standard in pain management, while it shows minimal binding affinity for the (+)-morphine enantiomer, resulting in a lack of analgesic activity. Understanding how MOR stereo-selectively recognizes morphine enantiomers has remained a puzzle in neuroscience and pharmacology for over half a century due to the lack of direct observation techniques. To unravel this mystery, we constructed the binding and unbinding processes of morphine enantiomers with MOR via molecular dynamics simulations to investigate the thermodynamics and kinetics governing MOR’s stereoselective recognition of morphine enantiomers. Our findings reveal that the binding of (-)-morphine stabilizes MOR in its activated state, exhibiting a deep energy well and a prolonged residence time. In contrast, (+)-morphine fails to sustain the activation state of MOR. Furthermore, the results suggest that specific residues, namely D1142.50 and D1473.32, are deprotonated in the active state of MOR bound to (-)-morphine. This work highlights that the selectivity in molecular recognition goes beyond binding affinities, extending into the realm of residence time.","PeriodicalId":507754,"journal":{"name":"National Science Review","volume":"39 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139523277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ten years of NSR—Progress and perspectives 国家科学研究十年--进展与展望
National Science Review Pub Date : 2024-01-11 DOI: 10.1093/nsr/nwae002
Chun-li Bai, M. Poo
{"title":"Ten years of NSR—Progress and perspectives","authors":"Chun-li Bai, M. Poo","doi":"10.1093/nsr/nwae002","DOIUrl":"https://doi.org/10.1093/nsr/nwae002","url":null,"abstract":"","PeriodicalId":507754,"journal":{"name":"National Science Review","volume":"37 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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