Annals Academy of Medicine Singapore最新文献_第7页

Case studies of fetal mosaicisms detected by non-invasive prenatal testing. 通过无创产前检测检测胎儿嵌合体的病例研究。

IF 5.2 4区医学

Annals Academy of Medicine Singapore Pub Date : 2023-01-01 DOI: 10.47102/annals-acadmedsg.2022409

Arun S. Gosavi, Nora Izzati Hj Ali Mashod, Jocelyn Ziqi Quek, Sarah Aung, Stephie Siew Fong Chin, Biswas Arijit, S. Ho

引用次数: 0

Early COVID-19 booster is beneficial in cancer patients. 早期新冠肺炎加强针对癌症患者有益。

IF 5.2 4区医学

Annals Academy of Medicine Singapore Pub Date : 2023-01-01 DOI: 10.47102/annals-acadmedsg.2022458

J. Samol

引用次数: 0

Association between self-care and chronic kidney disease in patients with type 2 diabetes mellitus. 2型糖尿病患者自我保健与慢性肾脏疾病的关系

IF 5.2 4区医学

Annals Academy of Medicine Singapore Pub Date : 2023-01-01

Gwyneth Joy Lim, Serena Low, Allen Yan Lun Liu, Yi Ming Shao, Tavintharan Subramaniam, Chee Fang Sum, Su Chi Lim

引用次数: 0

Clinical efficacy and long-term immunogenicity of an early triple dose regimen of SARS-CoV-2 mRNA vaccination in cancer patients. 早期三剂量方案的SARS-CoV-2 mRNA疫苗在癌症患者中的临床疗效和长期免疫原性。

IF 5.2 4区医学

Annals Academy of Medicine Singapore Pub Date : 2023-01-01 DOI: 10.47102/annals-acadmedsg.2022302

Matilda Lee, Siyu Peng, A. Lee, S. Wong, R. Tay, Jiaqi Li, A. Tariq, C. Goh, Y. Tan, Benjamin Kye Jyn Tan, C. B. Teo, E. Chan, M. Ooi, W. Chng, C. Chee, C. L. Ho, R. Walsh, M. Wong, Yan Su, Lezhava Alexander, S. Sethi, Shaun S Tan, Y. Chan, K. B. Tan, Soo-Chin Lee, L. Chai, R. Sundar

{"title":"Clinical efficacy and long-term immunogenicity of an early triple dose regimen of SARS-CoV-2 mRNA vaccination in cancer patients.","authors":"Matilda Lee, Siyu Peng, A. Lee, S. Wong, R. Tay, Jiaqi Li, A. Tariq, C. Goh, Y. Tan, Benjamin Kye Jyn Tan, C. B. Teo, E. Chan, M. Ooi, W. Chng, C. Chee, C. L. Ho, R. Walsh, M. Wong, Yan Su, Lezhava Alexander, S. Sethi, Shaun S Tan, Y. Chan, K. B. Tan, Soo-Chin Lee, L. Chai, R. Sundar","doi":"10.47102/annals-acadmedsg.2022302","DOIUrl":"https://doi.org/10.47102/annals-acadmedsg.2022302","url":null,"abstract":"INTRODUCTION\u0000Three doses of SARS-CoV-2 mRNA vaccines have been recommended for cancer patients to reduce the risk of severe disease. Anti-neoplastic treatment, such as chemotherapy, may affect long-term vaccine immunogenicity.\u0000\u0000\u0000METHOD\u0000Patients with solid or haematological cancer were recruited from 2 hospitals between July 2021 and March 2022. Humoral response was evaluated using GenScript cPASS surrogate virus neutralisation assays. Clinical outcomes were obtained from medical records and national mandatory-reporting databases.\u0000\u0000\u0000RESULTS\u0000A total of 273 patients were recruited, with 40 having haematological malignancies and the rest solid tumours. Among the participants, 204 (74.7%) were receiving active cancer therapy, including 98 (35.9%) undergoing systemic chemotherapy and the rest targeted therapy or immunotherapy. All patients were seronegative at baseline. Seroconversion rates after receiving 1, 2 and 3 doses of SARS-CoV-2 mRNA vaccination were 35.2%, 79.4% and 92.4%, respectively. After 3 doses, patients on active treatment for haematological malignancies had lower antibodies (57.3%±46.2) when compared to patients on immunotherapy (94.1%±9.56, P<0.05) and chemotherapy (92.8%±18.1, P<0.05). SARS-CoV-2 infection was reported in 77 (28.2%) patients, of which 18 were severe. No patient receiving a third dose within 90 days of the second dose experienced severe infection.\u0000\u0000\u0000CONCLUSION\u0000This study demonstrates the benefit of early administration of the third dose among cancer patients.","PeriodicalId":50774,"journal":{"name":"Annals Academy of Medicine Singapore","volume":"52 1 1","pages":"8-16"},"PeriodicalIF":5.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45873476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Surgical margins assessment reduces re-excision rates in breast-conserving surgery. 手术边缘评估可降低保乳手术的再切除率。

IF 5.2 4区医学

Annals Academy of Medicine Singapore Pub Date : 2023-01-01 DOI: 10.47102/annals-acadmedsg.2021454

Chang Yi Woon, S. Goh, Lin Seong Soh, Chloe Fu Cui Yeo, Marc Weijie Ong, Benjamin Wong, Joelle Hoi Ting Leong, J. T. T. Goo, C. Chia

引用次数: 2

Ablation therapies for paroxysmal atrial fibrillation: A systematic review and patient-level network meta-analysis. 阵发性心房颤动的消融治疗:一项系统综述和患者水平网络荟萃分析。

IF 5.2 4区医学

Annals Academy of Medicine Singapore Pub Date : 2023-01-01

Khi Yung Fong, Joseph J Zhao, Yiong Huak Chan, Yue Wang, Colin Yeo, Vern Hsen Tan

{"title":"Ablation therapies for paroxysmal atrial fibrillation: A systematic review and patient-level network meta-analysis.","authors":"Khi Yung Fong, Joseph J Zhao, Yiong Huak Chan, Yue Wang, Colin Yeo, Vern Hsen Tan","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Despite promising trials, catheter ablation is still regarded as an adjunct to antiarrhythmic drugs (AADs) in the treatment of paroxysmal atrial fibrillation (PAF). This study aimed to compare the effectiveness of various ablation therapies and AADs.Method: Randomised controlled trials or propensity score-matched studies comparing atrial tachyarrhythmia recurrence among any combination of ablation modalities or AAD were retrieved. Kaplan-Meier curves and risk tables for this outcome were graphically reconstructed to extract patient-level data. Frequentist network meta-analysis (NMA) using derived hazard ratios (HRs), as well as 2 restricted mean survival time (RMST) NMAs, were conducted. Treatment strategies were ranked using P-scores.Results: Across 24 studies comparing 6 ablation therapies (5,132 patients), Frequentist NMA-derived HRs of atrial fibrillation recurrence compared to AAD were 0.35 (95% confidence interval [CI]=0.25-0.48) for cryoballoon ablation (CBA), 0.34 (95% CI=0.25-0.47) for radiofrequency ablation (RFA), 0.14 (95% CI=0.07-0.30) for combined CBA and RFA, 0.20 (95% CI=0.10-0.41) for hot-balloon ablation, 0.43 (95% CI=0.15-1.26) for laser-balloon ablation (LBA), and 0.33 (95% CI=0.18-0.62) for pulmonary vein ablation catheter. RMST-based NMAs similarly showed significant benefit of all ablation therapies over AAD. The combination of CBA + RFA showed promising long-term superiority over CBA and RFA, while LBA showed favourable short-term efficacy.Conclusion: The advantage of ablation therapies over AAD in preventing atrial tachyarrhythmia recurrence suggests that ablation should be considered as the first-line treatment for PAF in patients fit for the procedure. The promising nature of several specific therapies warrants further trials to elicit their long-term efficacy and perform a cost-benefit analysis.","PeriodicalId":50774,"journal":{"name":"Annals Academy of Medicine Singapore","volume":"52 1","pages":"27-40"},"PeriodicalIF":5.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9228187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case studies of fetal mosaicisms detected by non-invasive prenatal testing. 通过无创产前检测检测胎儿嵌合体的病例研究。

IF 5.2 4区医学

Annals Academy of Medicine Singapore Pub Date : 2023-01-01

Arundhati Gosavi, Nora Izzati Hj Ali Mashod, Jocelyn Ziqi Quek, Sarah Aung, Stephie Siew Fong Chin, Biswas Arijit, Sherry Sze Yee Ho

引用次数: 0

Vaccination and surveillance: Two basic tools for a final poliomyelitis eradication. 疫苗接种和监测:最终消灭脊髓灰质炎的两个基本工具。

IF 5.2 4区医学

Annals Academy of Medicine Singapore Pub Date : 2023-01-01

Ricardo Walter Rüttimann

引用次数: 0

Catheter ablation as first-line treatment for paroxysmal atrial fibrillation. 导管消融作为阵发性心房颤动的一线治疗。

IF 5.2 4区医学

Annals Academy of Medicine Singapore Pub Date : 2023-01-01 DOI: 10.47102/annals-acadmedsg.2022466

Xuanming Pung, C. Ching

引用次数: 1

Combating a resurgence of poliomyelitis through public health surveillance and vaccination. 通过公共卫生监测和疫苗接种，防止小儿麻痹症死灰复燃。

IF 5.2 4区医学

Annals Academy of Medicine Singapore Pub Date : 2023-01-01

Chia Yin Chong, Kai Qian Kam, Chee Fu Yung

{"title":"Combating a resurgence of poliomyelitis through public health surveillance and vaccination.","authors":"Chia Yin Chong, Kai Qian Kam, Chee Fu Yung","doi":"","DOIUrl":"","url":null,"abstract":"Poliomyelitis, or polio, is a highly infectious disease and can result in permanent flaccid paralysis of the limbs. Singapore was certified polio-free by the World Health Organization (WHO) on 29 October 2000, together with 36 other countries in the Western Pacific Region. The last imported case of polio in Singapore was in 2006. Fortunately, polio is vaccine-preventable-the world saw the global eradication of wild poliovirus types 2 and 3 achieved in 2015 and 2019, respectively. However, in late 2022, a resurgence of paralytic polio cases from vaccine-derived poliovirus (VDPV) was detected in countries like Israel and the US (specifically, New York); VDPV was also detected during routine sewage water surveillance with no paralysis cases in London, UK. Without global eradication, there is a risk of re-infection from importation and spread of wild poliovirus or VDPV, or new emergence and circulation of VDPV. During the COVID-19 pandemic, worldwide routine childhood vaccination coverage fell by 5% to 81% in 2020-2021. Fortunately, Singapore has maintained a constantly high vaccination coverage of 96% among 1-year-old children as recorded in 2021. All countries must ensure high poliovirus vaccination coverage in their population to eradicate poliovirus globally, and appropriate interventions must be taken to rectify this if the coverage falters. In 2020, WHO approved the emergency use listing of a novel oral polio vaccine type 2 for countries experiencing circulating VDPV type 2 outbreaks. Environmental and wastewater surveillance should be implemented to allow early detection of \"silent\" poliovirus transmission in the population, instead of relying on clinical surveillance of acute flaccid paralysis based on case definition alone.","PeriodicalId":50774,"journal":{"name":"Annals Academy of Medicine Singapore","volume":"52 1","pages":"17-26"},"PeriodicalIF":5.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9255486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0