Frontiers in Musculoskeletal Disorders最新文献

{"title":"Assessment of fitting methods and variability of IVIM parameters in muscles of the lumbar spine at rest","authors":"Erin K. Englund, David B. Berry, John J. Behun, Lawrence R. Frank, Samuel R. Ward, Bahar Shahidi","doi":"10.3389/fmscd.2024.1386276","DOIUrl":"https://doi.org/10.3389/fmscd.2024.1386276","url":null,"abstract":"Intravoxel incoherent motion (IVIM) MRI provides insight into tissue diffusion and perfusion. Here, estimates of perfusion fraction (f), pseudo-diffusion coefficient (D*), and diffusion coefficient (D) obtained via different fitting methods are compared to ascertain (1) the optimal analysis strategy for muscles of the lumbar spine and (2) repeatability of IVIM parameters in skeletal muscle at rest. Diffusion-weighted images were acquired in the lumbar spine at rest in 15 healthy participants. Data were fit to the bi-exponential IVIM model to estimate f, D* and D using three variably segmented approaches based on non-linear least squares fitting, and a Bayesian fitting method. Assuming that perfusion and diffusion are temporally stable in skeletal muscle at rest, and spatially uniform within a spinal segment, the optimal analysis strategy was determined as the approach with the lowest temporal or spatial variation and smallest residual between measured and fit data. Inter-session repeatability of IVIM parameters was evaluated in a subset of 11 people. Finally, simulated IVIM signal at varying signal to noise ratio were evaluated to understand precision and bias. Experimental results showed that IVIM parameter values differed depending on the fitting method. A three-step non-linear least squares fitting approach, where D, f, and D* were estimated sequentially, generally yielded the lowest spatial and temporal variation. Solving all parameters simultaneously yielded the lowest residual between measured and fit data, however there was substantial spatial and temporal variability. Results obtained by Bayesian fitting had high spatial and temporal variability in addition to a large residual between measured and fit data. Simulations showed that all fitting methods can fit the IVIM data at signal to noise ratios >35, and that D* was the most challenging to accurately obtain. Overall, this study motivates use of a three-step non-linear least squares fitting strategy to quantify IVIM parameters in skeletal muscle.","PeriodicalId":507589,"journal":{"name":"Frontiers in Musculoskeletal Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140714250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tendon evaluation with ultrashort echo time (UTE) MRI: a systematic review","authors":"B. Malhi, H. Jang, M. Malhi, David B. Berry, S. Jerban","doi":"10.3389/fmscd.2024.1324050","DOIUrl":"https://doi.org/10.3389/fmscd.2024.1324050","url":null,"abstract":"Tendon disease ranks among the leading reasons patients consult their general practitioners, comprising approximately one-third of musculoskeletal appointments. Magnetic resonance imaging (MRI) is regarded as the gold standard for assessing tendons. Due to their short transverse relaxation time (T2), Tendons show up as a signal void in conventional MRI scans, which employ sequences with echo times (TEs) around several milliseconds. Ultrashort echo time (UTE) sequences utilize TEs that are 100–1,000 times shorter than those used in conventional sequences. This enables the direct visualization of tendons and assessment of their relaxation times, which is the basis for quantitative MRI. A systematic review was conducted on publications after 1990 in Google Scholar and PubMed databases. The search terms “ultrashort echo time,” “tendon,” and “UTE” were used to identify studies related to this investigation. This review discussed the current knowledge in quantitative UTE-MRI imaging of tendons. Quantitative UTE-T1, UTE-T2*, UTE-MT, and UTE-T1ρ techniques were described, and their reported applications in the literature were summarized in this review. We also discussed the advantages and challenges of these techniques and how these quantitative biomarkers may change in response to tendon pathology.","PeriodicalId":507589,"journal":{"name":"Frontiers in Musculoskeletal Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elastic modulus of cadaveric acetabular labrum correlates with ultrashort echo time (UTE) apparent spin-spin (T2*) and spin-lattice (T1) relaxation times","authors":"Dina Moazamian, T. Hananouchi, Hamidreza Shaterian Mohammadi, Alireza Tayarani, Erik W. Dorthé, Darryl D'Lima, Saeed Jerban","doi":"10.3389/fmscd.2024.1359296","DOIUrl":"https://doi.org/10.3389/fmscd.2024.1359296","url":null,"abstract":"The acetabulum labrum plays a critical role in hip function. Medical imaging techniques for measuring changes in labral properties due to its degeneration may help improve our knowledge of its role in hip osteoarthritis (OA). This study aimed to explore the correlation between the mechanical properties of the acetabulum labrum and ultrashort echo time (UTE) MRI properties.Acetabular labrum specimens were dissected from 12 fresh-frozen human cadaveric hip joints (64.6 ± 11.6 years old at the time of death, 7 female). UTE Cones sequences were used to measure apparent spin-spin (T2*) and spin-lattice (T1) relaxation times using a knee coil at 3 T in a clinical MR scanner. The stiffness and the elastic modulus (E) of the specimens were measured before MRI scans using uniaxial tensile tests. Spearman's rank correlation coefficients of Tendons' UTE-T2* and -T1 with their mechanical properties were calculated.The human labrum specimen elastic modulus showed a significant inverse correlation with UTE-T2* (R = −0.66, P < 0.01) and with UTE-T1 (R = −0.56, P = 0.05). The stiffness of the specimens showed significant inverse correlations with UTE-T2* (R = −0.53, P = 0.01) and UTE-T1 (R = −0.63, P = 0.02).This study highlighted the potential of UTE-MRI techniques for the mechanical assessment of the acetabular labrum. UTE-MRI may improve labrum degeneration detection and monitoring, which requires further investigations.","PeriodicalId":507589,"journal":{"name":"Frontiers in Musculoskeletal Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140087557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of neuromuscular electrical stimulation therapy using the StimaWELL 120MTRS system on erector spinae morphology in patients with chronic low back pain","authors":"Loïck Balthazard, Daniel Wolfe, Maryse Fortin","doi":"10.3389/fmscd.2023.1240331","DOIUrl":"https://doi.org/10.3389/fmscd.2023.1240331","url":null,"abstract":"Chronic low-back pain (CLBP) is the leading cause of disability globally. CLBP is associated with a decrease in cross-sectional area (CSA) and an increase in fat infiltration (FI) of the lumbar paraspinal muscles, such as erector spinae (ES). Neuromuscular electrical stimulation (NMES) therapy showed promising outcomes in the treatment of CLBP, but its impact on ES morphology is unknown. Therefore, this study aimed to compare the effect of two NMES protocols on ES CSA and FI in a cohort of patients with CLBP.Twenty participants with CLBP (aged 18–60 years old) were randomized into the phasic (n = 11) or the combined (n = 9) protocol groups. They completed a 10-week (20 sessions) NMES therapy using the StimaWELL 120MTRS device. Magnetic resonance imaging (MRI) examinations were acquired at baseline and post-intervention to assess ES CSA and FI at all spinal levels (e.g., L1–L2 to L5–S1). Statistical analyses were conducted to assess the effect of the intervention on ES morphology irrespective of groups, and between groups.Irrespective of groups, participants showed a decrease in left ES CSA (p = 0.005) at L2–L3 and left ES FI at L5–S1 (p = 0.040). We also observed a greater decrease in ES FI in the combined protocol compared to the phasic protocol on the right side at L3–L4 (p = 0.029) and L4–L5 (p = 0.015). No other changes in ES CSA or FI were observed (p > 0.05).NMES therapy demonstrated minimal effect on ES morphology in patients with CLBP. Further research is needed to extend and confirm our findings.","PeriodicalId":507589,"journal":{"name":"Frontiers in Musculoskeletal Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139181125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening practices, efficacy, safety and adherence to biologic therapies in a South African tertiary hospital","authors":"Mohammed Awad Eltoum Ahmed, Christiaan Scott, A. Gcelu, Jonel Steffen, Thuraya Isaacs, Bridget Hodkinson","doi":"10.3389/fmscd.2023.1281548","DOIUrl":"https://doi.org/10.3389/fmscd.2023.1281548","url":null,"abstract":"The high cost and concern of adverse events, particularly infections, limit the use of biologic therapies. We undertook this retrospective study to document their use for immune-mediated diseases, and explore the screening practices, efficacy, safety, and adherence to bDMARDs in a tertiary hospital.A folder review of all adult and paediatric patients treated for IMDs with bDMARDs. Changes in disease activity were measured by disease-specific tools at 6, 12, 24-months and at the last available visit, and patient adherence to bDMARDs was explored by folder and pharmacy record review.We studied 120 folders; 145 bDMARDs were prescribed (23 patients switched bDMARD). BDMARDs prescribed included tumour necrosis factor inhibitors (TNFi) (76), rituximab (54), tocilizumab (9), anakinra (3), abatacept (1), ustekinumab (1) and tofacitinib (1). The vast majority of patients had an excellent response and achieved low disease activity or remission at their last available visit. Adverse events included severe infection (9) including two cases of tuberculosis (TB), mild skin reaction (6) and severe infusion reactions (4). Therapy was discontinued in 13 patients, most commonly due to infection (5), lack of response (4), or poor adherence (3). Poor adherence was noted in 8/120 (6.7%). Complete latent TB infection screening was performed in only 35 patients (29.2%). Screening for Hepatitis B, C and HIV was performed in 28 (23.3%), 62 (51.7%) and 61 (50.8%) patients, respectively. Only 20.8% and 20.0% received the influenza and pneumococcal vaccination.Biologic therapy was effective, and the most important serious adverse effect was infection, which was significantly associated with TNFi therapy. Vaccination and screening for TB, viral hepatitis and HIV was suboptimal. Of concern, poor adherence to bDMARDs was frequently encountered.","PeriodicalId":507589,"journal":{"name":"Frontiers in Musculoskeletal Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139181171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lumbar multifidus characteristics and body composition in university level athletes","authors":"Meagan Anstruther, Amanda Rizk, S. Frenette, Maryse Fortin","doi":"10.3389/fmscd.2023.1235114","DOIUrl":"https://doi.org/10.3389/fmscd.2023.1235114","url":null,"abstract":"Body composition is well known to affect sport performance and previous studies suggested that structural and functional lumbar multifidus (LM) impairments in athletes were associated with low back pain and lower leg injuries. However few studies have examined the relationship between LM characteristics and body composition in athletic populations.This cross-sectional study included a total of 134 university varsity athletes (hockey, soccer, rugby, and football players). Ultrasound imaging was used to examined LM characteristics at the L5 bilaterally [e.g., size, thickness at rest, thickness during contraction, echo-intensity (EI) and % thickness change from rest to contraction] and body composition parameters (dual-energy x-ray absorptiometry). Pearson correlations were used to assess the relationship between LM characteristics and body composition parameters. One-way ANOVA assessed differences in LM characteristics and body composition between sports. All analyses were performed separately by sex.LM size and thickness were positively correlated with weight, height, lean body mass and total bone mass (male: r = 0.23–0.55, p < 0.01–0.05; female: r = 0.30–0.39, p < 0.01–0.05). LM EI was strongly correlated with % body fat (male: r = 0.62, female: r = 0.71, p < 0.01). LM thickness at rest (r = 0.42, p < 0.01) and contracted (r = 0.27, p < 0.05) were positively correlated and % thickness change was negatively correlated with % body fat in male athletes (r = −0.43, p < 0.01).The significant differences in body composition and LM characteristics between sports may be attributed to sport specific demands. Understanding connections between body composition and LM may aid in preseason screening for athletes at risk of low back pain or lower leg injuries during the season.","PeriodicalId":507589,"journal":{"name":"Frontiers in Musculoskeletal Disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139198420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}