Annual Review of Pathology-Mechanisms of Disease最新文献_第4页

Comparative Pathogenesis of Severe Acute Respiratory Syndrome Coronaviruses. 严重急性呼吸系统综合征冠状病毒发病机制的比较。

IF 36.2 1区医学

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2024-01-24 Epub Date: 2023-10-13 DOI: 10.1146/annurev-pathol-052620-121224

Jingshu Zhang, Melanie Rissmann, Thijs Kuiken, Bart L Haagmans

{"title":"Comparative Pathogenesis of Severe Acute Respiratory Syndrome Coronaviruses.","authors":"Jingshu Zhang, Melanie Rissmann, Thijs Kuiken, Bart L Haagmans","doi":"10.1146/annurev-pathol-052620-121224","DOIUrl":"10.1146/annurev-pathol-052620-121224","url":null,"abstract":"Over the last two decades the world has witnessed the global spread of two genetically related highly pathogenic coronaviruses, severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2. However, the impact of these outbreaks differed significantly with respect to the hospitalizations and fatalities seen worldwide. While many studies have been performed recently on SARS-CoV-2, a comparative pathogenesis analysis with SARS-CoV may further provide critical insights into the mechanisms of disease that drive coronavirus-induced respiratory disease. In this review, we comprehensively describe clinical and experimental observations related to transmission and pathogenesis of SARS-CoV-2 in comparison with SARS-CoV, focusing on human, animal, and in vitro studies. By deciphering the similarities and disparities of SARS-CoV and SARS-CoV-2, in terms of transmission and pathogenesis mechanisms, we offer insights into the divergent characteristics of these two viruses. This information may also be relevant to assessing potential novel introductions of genetically related highly pathogenic coronaviruses.","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":" ","pages":"423-451"},"PeriodicalIF":36.2,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41219353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurodegenerative Disease Tauopathies. 神经退行性疾病Taopathies。

IF 36.2 1区医学

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2024-01-24 Epub Date: 2023-10-13 DOI: 10.1146/annurev-pathmechdis-051222-120750

Benjamin C Creekmore, Ryohei Watanabe, Edward B Lee

引用次数: 0

Haploinsufficient Transcription Factors in Myeloid Neoplasms. 髓系肿瘤中的单倍体转录因子。

IF 36.2 1区医学

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2024-01-24 Epub Date: 2023-10-31 DOI: 10.1146/annurev-pathmechdis-051222-013421

Tanner C Martinez, Megan E McNerney

引用次数: 0

The Immunobiology and Pathogenesis of Celiac Disease. 乳糜泻的免疫生物学及其发病机制。

IF 36.2 1区医学

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 DOI: 10.1146/annurev-pathmechdis-031521-032634

Rasmus Iversen, Ludvig M Sollid

引用次数: 15

My Journey. 我的旅程

IF 36.2 1区医学

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 DOI: 10.1146/annurev-pathmechdis-031621-025854

Lucy Balian Rorke-Adams

引用次数: 0

New Insights into the Pathogenesis of Mastocytosis: Emerging Concepts in Diagnosis and Therapy. 肥大细胞增多症发病机制的新认识:诊断和治疗的新概念。

IF 36.2 1区医学

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 DOI: 10.1146/annurev-pathmechdis-031521-042618

Peter Valent, Cem Akin, Wolfgang R Sperr, Hans-Peter Horny, Michel Arock, Dean D Metcalfe, Stephen J Galli

{"title":"New Insights into the Pathogenesis of Mastocytosis: Emerging Concepts in Diagnosis and Therapy.","authors":"Peter Valent, Cem Akin, Wolfgang R Sperr, Hans-Peter Horny, Michel Arock, Dean D Metcalfe, Stephen J Galli","doi":"10.1146/annurev-pathmechdis-031521-042618","DOIUrl":"https://doi.org/10.1146/annurev-pathmechdis-031521-042618","url":null,"abstract":"Mastocytosis is a heterogeneous group of neoplasms defined by a numerical increase and accumulation of clonal mast cells (MCs) in various organ systems. The disease may present as cutaneous mastocytosis or systemic mastocytosis (SM). On the basis of histopathological and molecular features, clinical variables, and organ involvement, SM is divided into indolent SM, smoldering SM, SM with an associated hematologic neoplasm, aggressive SM, and MC leukemia. Each variant is defined by unique diagnostic criteria and a unique spectrum of clinical presentations. A key driver of MC expansion and disease evolution is the oncogenic machinery triggered by mutant forms of KIT. The genetic background, additional somatic mutations, and comorbidities also contribute to the course and prognosis. Patients with SM may also suffer from mediator-related symptoms or even an MC activation syndrome. This article provides an update of concepts on the genetics, etiology, and pathology of mastocytosis, with emphasis on diagnostic criteria and new treatment concepts.","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":"18 ","pages":"361-386"},"PeriodicalIF":36.2,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10739420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Tumor-Derived Extracellular Vesicles: Multifunctional Entities in the Tumor Microenvironment. 肿瘤来源的细胞外囊泡:肿瘤微环境中的多功能实体。

IF 36.2 1区医学

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 DOI: 10.1146/annurev-pathmechdis-031521-022116

James W Clancy, Crislyn D'Souza-Schorey

{"title":"Tumor-Derived Extracellular Vesicles: Multifunctional Entities in the Tumor Microenvironment.","authors":"James W Clancy, Crislyn D'Souza-Schorey","doi":"10.1146/annurev-pathmechdis-031521-022116","DOIUrl":"https://doi.org/10.1146/annurev-pathmechdis-031521-022116","url":null,"abstract":"Tumor cells release extracellular vesicles (EVs) that can function as mediators of intercellular communication in the tumor microenvironment. EVs contain a host of bioactive cargo, including membrane, cytosolic, and nuclear proteins, in addition to noncoding RNAs, other RNA types, and double-stranded DNA fragments. These shed vesicles may deposit paracrine information and can also be taken up by stromal cells, causing the recipient cells to undergo phenotypic changes that profoundly impact diverse facets of cancer progression. For example, this unique form of cellular cross talk helps condition the premetastatic niche, facilitates evasion of the immune response, and promotes invasive and metastatic activity. These findings, coupled with those demonstrating that the number and content of EVs produced by tumors can vary depending on their tumor of origin, disease stage, or response to therapy, have raised the exciting possibility that EVs can be used for risk stratification, diagnostic, and even prognostic purposes. We summarize recent developments and the current knowledge of EV cargoes, their impact on disease progression, and implementation of EV-based liquid biopsies as tumor biomarkers.","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":"18 ","pages":"205-229"},"PeriodicalIF":36.2,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10333918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Adipose Tissue Remodeling in Pathophysiology. 病理生理学中的脂肪组织重塑。

IF 36.2 1区医学

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 DOI: 10.1146/annurev-pathol-042220-023633

Christopher Auger, Shingo Kajimura

引用次数: 16

Oropharyngeal Carcinoma with a Special Focus on HPV-Related Squamous Cell Carcinoma. 口咽癌，特别关注与 HPV 相关的鳞状细胞癌。

IF 28.4 1区医学

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 DOI: 10.1146/annurev-pathmechdis-031521-041424

Robert L Ferris, William Westra

{"title":"Oropharyngeal Carcinoma with a Special Focus on HPV-Related Squamous Cell Carcinoma.","authors":"Robert L Ferris, William Westra","doi":"10.1146/annurev-pathmechdis-031521-041424","DOIUrl":"10.1146/annurev-pathmechdis-031521-041424","url":null,"abstract":"Human papillomavirus-positive oropharyngeal squamous cell carcinoma (HPV-OPSCC) has one of the most rapidly increasing incidences of any cancer in high-income countries. The most recent (8th) edition of the Union for International Cancer Control/American Joint Committee on Cancer staging system separates HPV-OPSCC from its HPV-negative counterpart to account for the improved prognosis seen in the former. Indeed, owing to its improved prognosis and greater prevalence in younger individuals, numerous ongoing trials are examining the potential for treatment deintensification as a means to improve quality of life while maintaining acceptable survival outcomes. Owing to the distinct biology of HPV-OPSCCs, targeted therapies and immunotherapies have become an area of particular interest. Importantly, OPSCC is often detected at an advanced stage, highlighting the need for diagnostic biomarkers to aid in earlier detection. In this review, we highlight important advances in the epidemiology, pathology, diagnosis, and clinical management of HPV-OPSCC and underscore the need for a progressive understanding of the molecular basis of this disease toward early detection and precision care.","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":"18 ","pages":"515-535"},"PeriodicalIF":28.4,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11227657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10741017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Pathogenesis of African Trypanosomiasis. 非洲锥虫病的发病机制。

IF 36.2 1区医学

Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 DOI: 10.1146/annurev-pathmechdis-031621-025153

Etienne Pays, Magdalena Radwanska, Stefan Magez

{"title":"The Pathogenesis of African Trypanosomiasis.","authors":"Etienne Pays, Magdalena Radwanska, Stefan Magez","doi":"10.1146/annurev-pathmechdis-031621-025153","DOIUrl":"https://doi.org/10.1146/annurev-pathmechdis-031621-025153","url":null,"abstract":"African trypanosomes are bloodstream protozoan parasites that infect mammals including humans, where they cause sleeping sickness. Long-lasting infection is required to favor parasite transmission between hosts. Therefore, trypanosomes have developed strategies to continuously escape innate and adaptive responses of the immune system, while also preventing premature death of the host. The pathology linked to infection mainly results from inflammation and includes anemia and brain dysfunction in addition to loss of specificity and memory of the antibody response. The serum of humans contains an efficient trypanolytic factor, the membrane pore-forming protein apolipoprotein L1 (APOL1). In the two human-infective trypanosomes, specific parasite resistance factors inhibit APOL1 activity. In turn, many African individuals express APOL1 variants that counteract these resistance factors, enabling them to avoid sleeping sickness. However, these variants are associated with chronic kidney disease, particularly in the context of virus-induced inflammation such as coronavirus disease 2019. Vaccination perspectives are discussed.","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":"18 ","pages":"19-45"},"PeriodicalIF":36.2,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10671618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9