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Annual Review of Pathology-Mechanisms of Disease最新文献

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Osteoclasts, Master Sculptors of Bone. 破骨细胞，骨骼雕刻大师。
IF 36.2 1区 医学
Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 DOI: 10.1146/annurev-pathmechdis-031521-040919
Deborah J Veis, Charles A O'Brien
{"title":"Osteoclasts, Master Sculptors of Bone.","authors":"Deborah J Veis,&nbsp;Charles A O'Brien","doi":"10.1146/annurev-pathmechdis-031521-040919","DOIUrl":"https://doi.org/10.1146/annurev-pathmechdis-031521-040919","url":null,"abstract":"<p><p>Osteoclasts are multinucleated cells with the unique ability to resorb bone matrix. Excessive production or activation of osteoclasts leads to skeletal pathologies that affect a significant portion of the population. Although therapies that effectively target osteoclasts have been developed, they are associated with sometimes severe side effects, and a fuller understanding of osteoclast biology may lead to more specific treatments. Along those lines, a rich body of work has defined essential signaling pathways required for osteoclast formation, function, and survival. Nonetheless, recent studies have cast new light on long-held views regarding the origin of these cells during development and homeostasis, their life span, and the cellular sources of factors that drive their production and activity during homeostasis and disease. In this review, we discuss these new findings in the context of existing work and highlight areas of ongoing and future investigation.</p>","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":"18 ","pages":"257-281"},"PeriodicalIF":36.2,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10689707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Metabolism and Colorectal Cancer. 代谢与结直肠癌。
IF 36.2 1区 医学
Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 Epub Date: 2022-11-02 DOI: 10.1146/annurev-pathmechdis-031521-041113
Joseph C Sedlak, Ömer H Yilmaz, Jatin Roper
{"title":"Metabolism and Colorectal Cancer.","authors":"Joseph C Sedlak, Ömer H Yilmaz, Jatin Roper","doi":"10.1146/annurev-pathmechdis-031521-041113","DOIUrl":"10.1146/annurev-pathmechdis-031521-041113","url":null,"abstract":"<p><p>Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared toward rapid proliferation, requiring nutrients and the removal of cellular waste in nutrient-poor environments. Intestinal stem cells (ISCs), the primary cell of origin for CRCs, must adapt their metabolism along the adenoma-carcinoma sequence to the unique features of their complex microenvironment that include interactions with intestinal epithelial cells, immune cells, stromal cells, commensal microbes, and dietary components. Emerging evidence implicates modifiable risk factors related to the environment, such as diet, as important in CRC pathogenesis. Here, we focus on describing the metabolism of ISCs, diets that influence CRC initiation, CRC genetics and metabolism, and the tumor microenvironment. The mechanistic links between environmental factors, metabolic adaptations, and the tumor microenvironment in enhancing or supporting CRC tumorigenesis are becoming better understood. Thus, greater knowledge of CRC metabolism holds promise for improved prevention and treatment.</p>","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":"18 ","pages":"467-492"},"PeriodicalIF":36.2,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877174/pdf/nihms-1854966.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9890195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic Resistance. 胰腺癌发病机制和治疗抵抗中的肿瘤微环境
IF 36.2 1区 医学
Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 Epub Date: 2022-09-21 DOI: 10.1146/annurev-pathmechdis-031621-024600
Mara H Sherman, Gregory L Beatty
{"title":"Tumor Microenvironment in Pancreatic Cancer Pathogenesis and Therapeutic Resistance.","authors":"Mara H Sherman, Gregory L Beatty","doi":"10.1146/annurev-pathmechdis-031621-024600","DOIUrl":"10.1146/annurev-pathmechdis-031621-024600","url":null,"abstract":"<p><p>Pancreatic ductal adenocarcinoma (PDAC) features a prominent stromal microenvironment with remarkable cellular and spatial heterogeneity that meaningfully impacts disease biology and treatment resistance. Recent advances in tissue imaging capabilities, single-cell analytics, and disease modeling have shed light on organizing principles that shape the stromal complexity of PDAC tumors. These insights into the functional and spatial dependencies that coordinate cancer cell biology and the relationships that exist between cells and extracellular matrix components present in tumors are expected to unveil therapeutic vulnerabilities. We review recent advances in the field and discuss current understandings of mechanisms by which the tumor microenvironment shapes PDAC pathogenesis and therapy resistance.</p>","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":"18 ","pages":"123-148"},"PeriodicalIF":36.2,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10680880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Pathology of Asthma: What Is Obstructing Our View? 哮喘的病理:是什么阻碍了我们的视线?
IF 36.2 1区 医学
Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 DOI: 10.1146/annurev-pathol-042220-015902
Helena Aegerter, Bart N Lambrecht
{"title":"The Pathology of Asthma: What Is Obstructing Our View?","authors":"Helena Aegerter,&nbsp;Bart N Lambrecht","doi":"10.1146/annurev-pathol-042220-015902","DOIUrl":"https://doi.org/10.1146/annurev-pathol-042220-015902","url":null,"abstract":"<p><p>Despite the advent of sophisticated and efficient new biologics to treat inflammation in asthma, the disease persists. Even following treatment, many patients still experience the well-known symptoms of wheezing, shortness of breath, and coughing. What are we missing? Here we examine the evidence that mucus plugs contribute to a substantial portion of disease, not only by physically obstructing the airways but also by perpetuating inflammation. In this way, mucus plugs may act as an immunogenic stimulus even in the absence of allergen or with the use of current therapeutics. The alterations of several parameters of mucus biology, driven by type 2 inflammation, result in sticky and tenacious sputum, which represents a potent threat, first due to the difficulties in expectoration and second by acting as a platform for viral, bacterial, or fungal colonization that allows exacerbations. Therefore, in this way, mucus plugs are an overlooked but critical feature of asthmatic airway disease.</p>","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":"18 ","pages":"387-409"},"PeriodicalIF":36.2,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10739423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology. 时空代谢肝分区及其病理生理影响。
IF 36.2 1区 医学
Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 DOI: 10.1146/annurev-pathmechdis-031521-024831
Tomaz Martini, Felix Naef, Jan S Tchorz
{"title":"Spatiotemporal Metabolic Liver Zonation and Consequences on Pathophysiology.","authors":"Tomaz Martini,&nbsp;Felix Naef,&nbsp;Jan S Tchorz","doi":"10.1146/annurev-pathmechdis-031521-024831","DOIUrl":"https://doi.org/10.1146/annurev-pathmechdis-031521-024831","url":null,"abstract":"<p><p>Hepatocytes are the main workers in the hepatic factory, managing metabolism of nutrients and xenobiotics, production and recycling of proteins, and glucose and lipid homeostasis. Division of labor between hepatocytes is critical to coordinate complex complementary or opposing multistep processes, similar to distributed tasks at an assembly line. This so-called metabolic zonation has both spatial and temporal components. Spatial distribution of metabolic function in hepatocytes of different lobular zones is necessary to perform complex sequential multistep metabolic processes and to assign metabolic tasks to the right environment. Moreover, temporal control of metabolic processes is critical to align required metabolic processes to the feeding and fasting cycles. Disruption of this complex spatiotemporal hepatic organization impairs key metabolic processes with both local and systemic consequences. Many metabolic diseases, such as nonalcoholic steatohepatitis and diabetes, are associated with impaired metabolic liver zonation. Recent technological advances shed new light on the spatiotemporal gene expression networks controlling liver function and how their deregulation may be involved in a large variety of diseases. We summarize the current knowledge about spatiotemporal metabolic liver zonation and consequences on liver pathobiology.</p>","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":"18 ","pages":"439-466"},"PeriodicalIF":36.2,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9236803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Molecular Monitoring of Lymphomas. 淋巴瘤的分子监测。
IF 36.2 1区 医学
Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 DOI: 10.1146/annurev-pathol-050520-044652
Joseph G Schroers-Martin, Stefan Alig, Andrea Garofalo, Benoit Tessoulin, Takeshi Sugio, Ash A Alizadeh
{"title":"Molecular Monitoring of Lymphomas.","authors":"Joseph G Schroers-Martin,&nbsp;Stefan Alig,&nbsp;Andrea Garofalo,&nbsp;Benoit Tessoulin,&nbsp;Takeshi Sugio,&nbsp;Ash A Alizadeh","doi":"10.1146/annurev-pathol-050520-044652","DOIUrl":"https://doi.org/10.1146/annurev-pathol-050520-044652","url":null,"abstract":"<p><p>Molecular monitoring of tumor-derived alterations has an established role in the surveillance of leukemias, and emerging nucleic acid sequencing technologies are likely to similarly transform the clinical management of lymphomas. Lymphomas are well suited for molecular surveillance due to relatively high cell-free DNA and circulating tumor DNA concentrations, high somatic mutational burden, and the existence of stereotyped variants enabling focused interrogation of recurrently altered regions. Here, we review the clinical scenarios and key technologies applicable for the molecular monitoring of lymphomas, summarizing current evidence in the literature regarding molecular subtyping and classification, evaluation of treatment response, the surveillance of active cellular therapies, and emerging clinical trial strategies.</p>","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":"18 ","pages":"149-180"},"PeriodicalIF":36.2,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10738903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
After the Storm: Regeneration, Repair, and Reestablishment of Homeostasis Between the Alveolar Epithelium and Innate Immune System Following Viral Lung Injury. 风暴过后：病毒性肺损伤后肺泡上皮细胞与先天性免疫系统之间的再生、修复和平衡重建。
IF 36.2 1区 医学
Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 Epub Date: 2022-10-21 DOI: 10.1146/annurev-pathmechdis-031621-024344
Joseph D Planer, Edward E Morrisey
{"title":"After the Storm: Regeneration, Repair, and Reestablishment of Homeostasis Between the Alveolar Epithelium and Innate Immune System Following Viral Lung Injury.","authors":"Joseph D Planer, Edward E Morrisey","doi":"10.1146/annurev-pathmechdis-031621-024344","DOIUrl":"10.1146/annurev-pathmechdis-031621-024344","url":null,"abstract":"<p><p>The mammalian lung has an enormous environmental-epithelial interface that is optimized to accomplish the principal function of the respiratory system, gas exchange. One consequence of evolving such a large surface area is that the lung epithelium is continuously exposed to toxins, irritants, and pathogens. Maintaining homeostasis in this environment requires a delicate balance of cellular signaling between the epithelium and innate immune system. Following injury, the epithelium can be either fully regenerated in form and function or repaired by forming dysplastic scar tissue. In this review, we describe the major mechanisms of damage, regeneration, and repair within the alveolar niche where gas exchange occurs. With a focus on viral infection, we summarize recent work that has established how epithelial proliferation is arrested during infection and how the innate immune system guides its reconstitution during recovery. The consequences of these processes going awry are also considered, with an emphasis on how this will impact postpandemic pulmonary biology and medicine.</p>","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":"18 ","pages":"337-359"},"PeriodicalIF":36.2,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10875627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10739418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroepithelial Interactions in Cancer. 癌症中的神经上皮相互作用。
IF 36.2 1区 医学
Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 DOI: 10.1146/annurev-pathmechdis-031521-023248
Gustavo Ayala
{"title":"Neuroepithelial Interactions in Cancer.","authors":"Gustavo Ayala","doi":"10.1146/annurev-pathmechdis-031521-023248","DOIUrl":"https://doi.org/10.1146/annurev-pathmechdis-031521-023248","url":null,"abstract":"<p><p>Nerves not only regulate the homeostasis and energetic metabolism of normal epithelial cells but also are critical for cancer, as cancer recapitulates the biology of neural regulation of epithelial tissues. Cancer cells rarely develop in denervated organs, and denervation affects tumorigenesis, in vivo and in humans. Axonogenesis occurs to supply the new malignant epithelial growth with nerves. Neurogenesis happens later, first in ganglia around organs or the spinal column and subsequently through recruitment of neuroblasts from the central nervous system. The hallmark of this stage is regulation of homeostasis and energetic metabolism. Perineural invasion is the most efficient interaction between cancer cells and nerves. The hallmark of this stage is increased proliferation and decreased apoptosis. Finally, carcinoma cells transdifferentiate into a neuronal profile in search of neural independence. The latter is the last stage in neuroepithelial interactions. Treatments for cancer must address the biology of neural regulation of cancer.</p>","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":"18 ","pages":"493-514"},"PeriodicalIF":36.2,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10739440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage. 簇状细胞:保守细胞谱系的环境和组织特异性编程。
IF 36.2 1区 医学
Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 DOI: 10.1146/annurev-pathol-042320-112212
Maya E Kotas, Claire E O'Leary, Richard M Locksley
{"title":"Tuft Cells: Context- and Tissue-Specific Programming for a Conserved Cell Lineage.","authors":"Maya E Kotas,&nbsp;Claire E O'Leary,&nbsp;Richard M Locksley","doi":"10.1146/annurev-pathol-042320-112212","DOIUrl":"https://doi.org/10.1146/annurev-pathol-042320-112212","url":null,"abstract":"<p><p>Tuft cells are found in tissues with distinct stem cell compartments, tissue architecture, and luminal exposures but converge on a shared transcriptional program, including expression of taste transduction signaling pathways. Here, we summarize seminal and recent findings on tuft cells, focusing on major categories of function-instigation of type 2 cytokine responses, orchestration of antimicrobial responses, and emerging roles in tissue repair-and describe tuft cell-derived molecules used to affect these functional programs. We review what is known about the development of tuft cells from epithelial progenitors under homeostatic conditions and during disease. Finally, we discuss evidence that immature, or nascent, tuft cells with potential for diverse functions are driven toward dominant effector programs by tissue- or perturbation-specific contextual cues, which may result in heterogeneous mature tuft cell phenotypes both within and between tissues.</p>","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":"18 ","pages":"311-335"},"PeriodicalIF":36.2,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10443898/pdf/nihms-1923264.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10043237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Orchestration of Collective Migration and Metastasis by Tumor Cell Clusters. 肿瘤细胞群集体迁移和转移的协调。
IF 36.2 1区 医学
Annual Review of Pathology-Mechanisms of Disease Pub Date : 2023-01-24 DOI: 10.1146/annurev-pathmechdis-031521-023557
Ami Yamamoto, Andrea E Doak, Kevin J Cheung
{"title":"Orchestration of Collective Migration and Metastasis by Tumor Cell Clusters.","authors":"Ami Yamamoto,&nbsp;Andrea E Doak,&nbsp;Kevin J Cheung","doi":"10.1146/annurev-pathmechdis-031521-023557","DOIUrl":"https://doi.org/10.1146/annurev-pathmechdis-031521-023557","url":null,"abstract":"<p><p>Metastatic dissemination has lethal consequences for cancer patients. Accruing evidence supports the hypothesis that tumor cells can migrate and metastasize as clusters of cells while maintaining contacts with one another. Collective metastasis enables tumor cells to colonize secondary sites more efficiently, resist cell death, and evade the immune system. On the other hand, tumor cell clusters face unique challenges for dissemination particularly during systemic dissemination. Here, we review recent progress toward understanding how tumor cell clusters overcome these disadvantages as well as mechanisms they utilize to gain advantages throughout the metastatic process. We consider useful models for studying collective metastasis and reflect on how the study of collective metastasis suggests new opportunities for eradicating and preventing metastatic disease.</p>","PeriodicalId":50753,"journal":{"name":"Annual Review of Pathology-Mechanisms of Disease","volume":"18 ","pages":"231-256"},"PeriodicalIF":36.2,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10079436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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