Central European Journal of Medicine最新文献

{"title":"Physicochemical and Microbiological Characteristics of Thermal Healing Spring Waters in the Districts of Varna and Burgas, Black Sea Region, Bulgaria","authors":"","doi":"10.13187/ejm.2019.2.120","DOIUrl":"https://doi.org/10.13187/ejm.2019.2.120","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79284175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug Interactions of Dihydropyridine Calcium Channel Blockers (CCBs) involving CYP3A4 Enzymes","authors":"","doi":"10.13187/ejm.2019.2.106","DOIUrl":"https://doi.org/10.13187/ejm.2019.2.106","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"307 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73610123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Electromagnetic Fields over DNA Hydrogen Bonds of Hamsters with Implanted Graffi Tumor","authors":"","doi":"10.13187/ejm.2019.2.92","DOIUrl":"https://doi.org/10.13187/ejm.2019.2.92","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88828972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal ultrasound for diagnosing abdominal tuberculosis or disseminated tuberculosis with abdominal involvement in HIV-positive individuals.","authors":"Daniel J Van Hoving, Rulan Griesel, Graeme Meintjes, Yemisi Takwoingi, Gary Maartens, Eleanor A Ochodo","doi":"10.1002/14651858.CD012777.pub2","DOIUrl":"10.1002/14651858.CD012777.pub2","url":null,"abstract":"<p><strong>Background: </strong>Accurate diagnosis of tuberculosis in people living with HIV is difficult. HIV-positive individuals have higher rates of extrapulmonary tuberculosis and the diagnosis of tuberculosis is often limited to imaging results. Ultrasound is such an imaging test that is widely used as a diagnostic tool (including point-of-care) in people suspected of having abdominal tuberculosis or disseminated tuberculosis with abdominal involvement.</p><p><strong>Objectives: </strong>To determine the diagnostic accuracy of abdominal ultrasound for detecting abdominal tuberculosis or disseminated tuberculosis with abdominal involvement in HIV-positive individuals.To investigate potential sources of heterogeneity in test accuracy, including clinical setting, ultrasound training level, and type of reference standard.</p><p><strong>Search methods: </strong>We searched for publications in any language up to 4 April 2019 in the following databases: MEDLINE, Embase, BIOSIS, Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Conference Proceedings Citation Index- Science (CPCI-S), and also ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform to identify ongoing trials.</p><p><strong>Selection criteria: </strong>We included cross-sectional, cohort, and diagnostic case-control studies (prospective and retrospective) that compared the result of the index test (abdominal ultrasound) with one of the reference standards. We only included studies that allowed for extraction of numbers of true positives (TPs), true negatives (TNs), false positives (FPs), and false negatives (FNs). Participants were HIV-positive individuals aged 15 years and older. A higher-quality reference standard was the bacteriological confirmation of Mycobacterium tuberculosis from any clinical specimen, and a lower-quality reference standard was a clinical diagnosis of tuberculosis without microbiological confirmation. We excluded genitourinary tuberculosis.</p><p><strong>Data collection and analysis: </strong>For each study, two review authors independently extracted data using a standardized form. We assessed the quality of studies using a tailored Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. We used the bivariate model to estimate pooled sensitivity and specificity. When studies were few we simplified the bivariate model to separate univariate random-effects logistic regression models for sensitivity and specificity. We explored the influence of the type of reference standard on the accuracy estimates by conducting separate analyses for each type of reference standard. We assessed the certainty of the evidence using the GRADE approach.</p><p><strong>Main results: </strong>We included 11 studies. The risks of bias and concern about applicability were often high or unclear in all domains. We included six studies in the main analyses of any abnormal finding on abdominal ultrasound; five studies ","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"2 1","pages":"CD012777"},"PeriodicalIF":8.4,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90818524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Catholyte Water on the Development of Experimental Graffi Tumor on Hamsters","authors":"I. Ignatov, Christos Drossinakis, R. Toshkova, E. Zvetkova","doi":"10.13187/ejm.2019.1.45","DOIUrl":"https://doi.org/10.13187/ejm.2019.1.45","url":null,"abstract":"The paper describes the results of a pilot study aimed at the investigation of the influence of catholyte (electrolyzed\u0000alkaline water) on the development of tumors. In the experiments solid Graffi tumor was transplanted subcutaneously in\u0000the back of the experimental group of Golden Syrian hamsters. Tumor appearance and growth were registered every day.\u0000Blood parameters were measured on the 10th and 25th day after transplantation and blood smears were prepared.\u0000Hamsters treated with catholyte developed tumor with some delay compared to untreated (drinking tap water) ones.\u0000Also, the tumor growth was slow and the survival rate was increased. The analysis of blood parameters and cell\u0000morphology has shown significant differences in the value of some hematometric parameters and morphological changes\u0000of some blood cells. The obtained results suggest about the beneficial influence of catholyte and the possible use of it as a\u0000supporting non-invasive therapy of cancer diseases.\u0000Keywords: ORP: Oxidation Reduction Potential; AST: Average Survival Time; WBCs/LR: White Blood Cells to\u0000Lymphocyte Ratio; NLR: Neutrophil to Lymphocyte Ratio; TILs: Tumor-Infiltration Cells","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75541862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug Interactions of Acetaminophen (Paracetamol) involving CYP and UGT Enzymes","authors":"","doi":"10.13187/ejm.2019.1.30","DOIUrl":"https://doi.org/10.13187/ejm.2019.1.30","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84920753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Herbal Therapy for Some Cardiovascular Diseases in Bulgaria","authors":"","doi":"10.13187/ejm.2019.1.57","DOIUrl":"https://doi.org/10.13187/ejm.2019.1.57","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81839281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Observational Study on Assessment of Adverse Drug Reactions in Patients taking First Line Antitubercular Drugs at Tertiary Care Teaching Hospital, Nellore","authors":"","doi":"10.13187/ejm.2019.1.35","DOIUrl":"https://doi.org/10.13187/ejm.2019.1.35","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74153587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods for Research of Effects of Device ABIEM. Applications","authors":"","doi":"10.13187/ejm.2019.1.3","DOIUrl":"https://doi.org/10.13187/ejm.2019.1.3","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87582699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Roots and Mechanisms of Oncology","authors":"","doi":"10.13187/ejm.2019.1.21","DOIUrl":"https://doi.org/10.13187/ejm.2019.1.21","url":null,"abstract":"","PeriodicalId":50709,"journal":{"name":"Central European Journal of Medicine","volume":"133 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73774672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}