Kufa Medical Journal最新文献

{"title":"Association of Interleukin-17 and ACCP levels with Rheumatoid arthritis patients and Control Groups","authors":"Haneen Jassim, T. Al-Turaihi","doi":"10.36330/kmj.v19i2.13050","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.13050","url":null,"abstract":"Background: Rheumatoid arthritis (RA) represents the prevailing form of chronic inflammatory polyarthritis, characterized by an autoimmune response directed against citrullinated antigens and subsequent synovial joint destruction. The susceptibility to RA appears to be influenced by a complex interplay between a specific immune response to various environmental factors and a favorable genetic predisposition. IL-17 Association with Diseases found to be elevated in various chronic inflammatory conditions including  RA especially in cases resistant to anti-TNF therapy. Aim : To investigate the value of IL-17 and ACCP levels with study groups as well as the association of chronic periodontal disease as an environmental risk factor of RA. Methods : This case-control study involved a total of 140 participants were enrolled, with 70 individuals meeting specific criteria and serological testing confirming their RA diagnosis, while the remaining 70 served as healthy controls.The study involved the collection of blood samples from the participants. Various measurements and tests were conducted, including the assessment of disease activity using the Disease Activity Score (DAS28-ESR) and erythrocyte sedimentation rate (ESR), detection of RF through latex agglutination, quantification of anti-cyclic citrullinated peptide (ACCP) and interleukin-17 (IL-17) levels via enzyme-linked immunosorbent assay (ELISA). Results : RA patients exhibited substantially higher values  for ESR, RF, ACCP compared to the control group. Also IL-17 substantially higher values  for RA patients  Notably, the p-values for ESR, ACCP, and IL-17 were 0.0001, 0.02, and 0.0001, respectively, indicating strong statistical significance. patients who had gum problems were 43(61.4 %) while the control group was 9 (12.5%) had a gum problem Statistically, parameter had significant differences (p.value=0.0001).","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"44 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xanthogranulomatous Osteomyelitis: Two Rare Cases Report","authors":"Alaa Salah Jumaah, Asaad Al- Janabi, Raad Jawad Kadhim","doi":"10.36330/kmj.v19i2.12914","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.12914","url":null,"abstract":"INTRODUCTION: Xanthogranulomatous osteomyelitis (XO) is a rare chronic inflammatory lesion that is histologically characterized by the presence of foamy histiocytes and plasma cells (1-8). Radiologic and gross examinations can mimic malignancy (9), so carful workup and definitive diagnosis should be made by histopathologic evaluation. Case Report:  There are two rare cases being reported here; the first one is a 21-year-old male who presented with chronic pain and swelling of upper leg for one year. He has history of healed traumatic fracture of fibula 7 years ago. Radiological examination revealed highly suspicious radio opaque lesions of upper fibula. The second case is a 30 years old female, presented with pain and swelling of wrist for six months with clinical suspicion of Ewing sarcoma. Radiological examination revealed highly suspicious radio opaque, lytic lesions of lower radius. Biopsy of both lesions were done. Microscopic examination showed marked chronic inflammatory cells infiltration mainly foamy histiocytes and lymphoid cells with many foreign body giant cells. No evidence of tuberculosis or malignancy. Conclusion: As these lesions were clinically highly suspicious of malignancy or associated with other diseases, so proper diagnostic roles in xanthogranulomatous osteomyelitis should include histopathological examination in order to rule out any malignant conditions of the bone.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"58 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity Among Adult Patients Aged 18 Years Old And Above Attending Main Primary Health Care Centers In Babil Governorate, Iraq 2015: Prevalence And Some Possible Risk Factors","authors":"Hayder Fadhil Obaid Al-Bayati, Ali Mousah Easah Albadri, Salam Jasim Mohammed","doi":"10.36330/kmj.v19i2.13473","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.13473","url":null,"abstract":"Background: A cross-sectional survey was conducted at the period from 1st of January to 31st of March 2015 in Babil governorate-Iraq. A systematic random sampling technique was used to collect 420 patients from 8 main primary health care centers chosen randomly. They consented to interview directly by the researcher using questionnaire  Of the 420 patients, 168 (40%) were obese. The body mass index classes had a statistical significant association with ; age, occupation, residence (P=0.000). Eating: sweet, chocolate (P=0.000); fruit (P= 0.001); skipping breakfast (P=0.027); TV watching time (P=0.004);  moderate activity frequency and time consumed (P=0.000), sleep duration, family history of obesity (P=0.000). Logistic regression analysis predicted some factors that increased the odds of obesity; age (OR=1.159), no job or retired(OR=10), business (OR=12.6), skipping breakfast (OR=1.46), eating sweet and chocolate (OR=2.709), time of TV watching (OR=3.319), and family history (OR=3.746), whereas some factors decreased the odds like; farmer (OR=0.013), laborer (OR=0.042), rural residence (OR=0.136), eating fruit (OR=0.502), moderate physical activity (OR=0.26) . Conclusions and recommendations: Obesity prevalence was 40%, and associated with socio-demographic features, eating habits, physical activity , sleep duration, and family history. The study recommended adoption of health education programs about obesity by Ministry of Health regarding healthy diet, decrease sedentary lifestyle, encouraging of physical activity at  all ages for proper prevention of obesity.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"225 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Manifestations Of Otolaryngology In COVID-19","authors":"Firas Mowaffak Hassan Alkhamaisi","doi":"10.36330/kmj.v19i2.14041","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.14041","url":null,"abstract":"Background: In late 2019, a new coronavirus known as SARS-CoV-2 emerged, causing an acute respiratory disease called COVID-19. The outbreak originated in China and quickly gained a global attention. COVID-19 can cause various upper respiratory tract symptoms such as sore throat, nasal obstruction, and loss of smell function. Patients and Methods: this is a cross-sectional descriptive study done during the COVID-19 pandemic from June 1st, 2020 to August 31st, 2020. The study was carried out in some isolation hospitals located in Baghdad and Najaf cities. The collected data are from laboratory-confirmed COVID-19 positive patients by using a pre-designed questionnaire which included demographic information such as age, gender, occupation, and place of residence. All participants were specifically asked about their symptoms related to the ear, nose, and throat (ENT) system. Results: A Total number of 408 confirmed Covid-19 cases had been included in the current study. Age range of participants was from 12 to 86 years with average of 51.42 years. The study has  revealed that sore throat is the predominant ENT symptom in COVID-19 cases, while ear symptoms are uncommon. The most common nasal manifestations observed in COVID-19 patients were anosmia/ hyposmia and nasal obstruction. Discussion: This study demonstrated the different ENT manifestations occurred  COVID-19 patients. These manifestations involved both lower and upper respiratory tract symptoms. Looking to these different manifestations with more interest can help in the early diagnosis and treatment of COVID-19 cases.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"406 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect Of Maternal Body Mass Index On Duration Of Induced Labor","authors":"Basima Shamkhi Al Ghazali","doi":"10.36330/kmj.v19i2.13270","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.13270","url":null,"abstract":"Background: Induction is the stimulation of uterine contractions to aid childbirth. Meanwhile, the prevalence of obesity is predicted to grow by 33% worldwide by the year 2030. Genetic, environmental, behavioral, and social elements all have a role in the development of obesity. The prevalence of obesity is highly associated with both ancestry and ethnicity. Numerous illnesses and malignancies are only a few of the many that can be exacerbated by obesity. Menstrual irregularities, infertility, and premature birth are just a few of the ways that obesity negatively affects a woman's ability to have healthy, natural children. Longer labors and more cesarean sections are directly related to the rising prevalence of maternal obesity, which also correlates with an increase in the use of labor induction. The present study aims to evaluate the effect of maternal body mass index on the duration of induction of labor. Methods: A prospective cohort study was conducted at AL-Zahraa Teaching Hospital from December 2022 to June 2023. It included 100 pregnant women divided into overweight/obese and non-obese groups. Prim and multi gravida term pregnant women with unfavorable cervix and not in labor were included. The collected data included demographical, menstrual, medical, and surgical history, and assessment of labor duration and success. Labor was induced by using PGE1 and oxytocin. Failed induction was defined as cervical dilatation >4 cm not achieved after 12 ± 3 h of labor or ending with a cesarean section. Results: The study examined 100 women undergoing labor induction, finding a success rate of 80% for vaginal delivery and 20% ending in caesarean sections. Notably, failed inductions were associated with larger gestational age and higher Body Mass Index (BMI). In fact, 90% of those who had a failed induction of labor were obese (BMI >30 kg/m²). Despite these findings, there were no significant variations in maternal age, gravidity, parity, and miscarriage rates between the successful and failed induction groups. Conclusion: Higher BMI increases the likelihood of failed labor induction but its impact on the duration of induction is not clearly established from the current data which may need further study with increasing sample size.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"40 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression Of Cyclooxygenase-2 And Interlukin-6 Mrnas In Iraqi Patients With Breast Cancer","authors":"Marwa Hussien","doi":"10.36330/kmj.v19i2.13259","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.13259","url":null,"abstract":"Background: Breast cancer is one of the most common malignant tumors that endanger women's health internationally, relatively uncommon in men, accounting for only 1% of all cancer cases. Location, way of life, age at marriage, and obesity are a few environmental variables that increase the risk of breast cancer. Aim of study: the study aims to explain how the pro-inflammatory cytokines (IL-6) induce the inflammatory events in patients with breast cancer and to describe whether cyclooxygenase-2 promotes tumor growth in breast cancer or not. Materials and methods: The current case-control cross-sectional study included 45 patients with a history of breast cancer, and it was done in multiple places in Hilla, Babylon Province, between November 2022 and March 2023.Interlukin-6 and Cyclooxygenase-2 by QPCR. Results: The results have shown a significant increase of IL-6 (P < 0.05) in patients compared with control.  Also, the results have shown a significant increase (P < 0.05) of COX2 in patients compared with control. Conclusion: There is a significant increase in the means of Interlukin-6 and Cyclooxygenase-2 in the patients with breast cancer.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"37 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum levels of Interleukin-6 in patients with Idiopathic Carpal Tunnel Syndrome: A case control study in Najaf Province","authors":"Shahad mohammed Al-shareefi, Fouad Shareef","doi":"10.36330/kmj.v19i2.12706","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.12706","url":null,"abstract":"Background: Carpal Tunnel Syndrome (CTS) is a disease caused by a compression of the median nerve at the wrist within carpal canal that lead to multiple symptoms as paraesthesia, numbness and pain sensation in the median distribution fingers. If untreated, it leads to sensation loss, thenar muscle weakness and atrophy. It is most frequent peripheral neuropathy of upper limbs and is most predominant in female gender. The pathogenesis of CTS is yet unknown, and the majority of conditions are idiopathic. Interleukin 6 is a cytokine that has multiple functions including pro-inflammatory and anti-inflammatory or regenerative actions. The impact of serum inflammatory cytokines on incidence and severity of CTS is still unclear. Aim of the study: this study aims to correlate the clinical severity of CTS and the serum interleukin 6 concentrations. Patients and methods: This is a case control study which involved 140 participants who were categorized into 70 patients with CTS and 70 healthy persons according to clinical assessment and nerve conduction study results. After that, the participants were divided to normal, mild, moderate and severe groups according to Boston carpal tunnel questionnaire (BCTQ). Then, a blood sample was taken from each participant to assess serum interleukin 6 levels. A statistical analysis by SPSS was done for the collected data. Results: The study has shown that there was no significant correlation between serum interleukin 6 levels and the clinical severity score of CTS (P value >0.05). Conclusion: It has been concluded that serum interleukin 6 levels did not have an impact on incidence and clinical severity of CTS and that its role in CTS is yet unclear.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"73 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment Of Healthcare Workers’ Knowledge About Vaccines In Al-Najaf Primary Health Care Centers","authors":"Mustafa Alghanemi, Alaa K. Jasim, Abdulkareem A.Mahmood","doi":"10.36330/kmj.v19i2.12364","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.12364","url":null,"abstract":"Background: Immunization performed an important role in enhancing global health through decreased transmission of infectious diseases. Numerous aspects within healthcare facilities including supervision, cold-chain management, immunization session procedure, and reporting, must be thoroughly examined to ensure the effective delivery of immunization service. The study aims to evaluate the knowledge of healthcare workers working in the immunization unit in randomly selected primary healthcare centers at Najaf Province. For subjects and method, a cross-sectional research descriptive study took place at 26 healthcare facilities at six districts of Najaf, by using simple random sampling. The study involved a total of 143 healthcare personnel, including 122 healthcare workers working in the immunization units and 21 doctors. A questionnaire was used to evaluate the vaccine knowledge of healthcare workers. Data collecting began on December 2nd, 2022, and ended on March 2nd, 2023. The statistical program Statistical Package for Social Sciences/version 26 was used to examine and achieve the desired findings. Analytic statistics of Chi-square test (X2) was used to establish the statistically significant relationship between variables. Results: The study's findings revealed that healthcare workers have moderate degrees of overall vaccine knowledge (mean of score =2.23). Furthermore, a statistically significant link was discovered between the place of residence of healthcare workers and their knowledge (P=0.007), indicating that those live-in urban regions had greater knowledge levels than those living in rural areas. Conclusion: Healthcare workers possess good knowledge regarding vaccine types, doses, and schedules, moderate knowledge about contraindications and causes of postponement, and their knowledge was substantially associated with their place of residence.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"429 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}