Kufa Medical Journal最新文献

{"title":"The Histomorphometric and Histological Evaluation of Renal Cortex in Response to Sleep Disturbance in Adult Male Rat","authors":"Zahraa Aboud Mohsin, Huda Rashid Kamoona","doi":"10.36330/kmj.v20i1.13995","DOIUrl":"https://doi.org/10.36330/kmj.v20i1.13995","url":null,"abstract":"Background: Sleep disturbance affects kidney structure reflected in functional derangement causing renal diseases; this occurs through sympathetic system activation and inflammation. Changes in the renal vascular bed affect the renal corpuscle-related structures such as the glomerular area, and urine space, in addition to the kidney tubular apparatus. Sleep deprivation or sleep interruption differ in their effect on systolic blood pressure causing renal tissue changes that predispose to chronic kidney disease (CKD). Aim of the study: The study aims to evaluate the effect of sleep disturbance on histological changes of renal tissue in control and experiment groups. Patients and methods: An experimental study on a sample of thirty adult male albino Rats, was divided into three groups (10 animals per group). The control group had a normal sleep rhythm which was 12 hours in the dark and 12 hours in light. Group A:  at 12 hours light and 12 hours dark with the production of a flashlight at three-time intervals, every 2 hours, during their sleep period, while Group B includes rats that were exposed to a reduction in sleep time by continuous flashlight stimulation for 7 hours per day, during their sleep period. Then, the kidneys were dissected and prepared for histological evaluation and quantification. The experiment lasted for 14 days for all groups, and the study was performed during the period between the 1st of January 2023 to the 1st of August 2023 in the anatomy department in  Al- Nahrain Medical College. Results: This study showed the effect of sleep disturbance patterns (sleep reduction, and sleep interruption) by light stimulation in adult male rats on cortical renal tubules and cortical vessels. A prominent dilatation in cortical renal tubules with the presence of cortical hemorrhagic areas and cortical necrosis with inflammatory cell infiltration was seen to be associated with sleep deprivation prominently. Histological changes of renal corpuscular areas, glomerular tuft area, and renal space area showed significant variations in sleep disturbance groups, in a p-value ≤ 0.05. Conclusions: Changes in sleep patterns indicate the importance of sleep in maintaining renal cortical tissue structural integrity by its effect on local hemodynamics of cortical vessels that ultimately affect the structure and area of the renal corpuscles. Sleep deprivation represents a powerful factor for renal cortical changes that lead to corpuscular and tubular damage.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"M Multi-Organ Histopathological Changes in SARS COV2 Infection: A Systematic Review and Meta-analysis","authors":"Maream Mohammed Ali Al-Haboobi, Rihab Hameed Al-Mudhafar","doi":"10.36330/kmj.v20i1.15435","DOIUrl":"https://doi.org/10.36330/kmj.v20i1.15435","url":null,"abstract":"Background: The World Health Organization has officially acknowledged the emergence of Coronavirus Disease 2019 (COVID-19), attributed to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, as a rapidly escalating global public health issue and declared it a pandemic. SARS-CoV-2 infection can lead to varied and multiorgan pathologies, with the most notable impacts occurring in the lungs (characterized by phases of diffuse alveolar damage, microthrombi, and bronchopneumonia), heart (involving lymphocytic myocarditis), kidney (resulting in acute tubular injury), and vasculature (involving microthrombi and deep vein thrombi). Objectives: To summarize, resolve contradiction and provide solid evidence on multiorgan histopathological changes caused by SARS-CoV2 infection.   Material and method: Histological data obtained from autopsy and biopsy studies were gathered following the guidelines of the Preferred Reporting Items for Systematic Review (PRISMA). An extensive electronic search was conducted on databases such as PubMed, Science Direct, Scopus, and Google Scholar, covering the period from database inception to March 2022. The collected studies underwent a systematic literature search, and a thorough critical review was performed. Result: After excluding studies that did not meet the eligibility criteria, a total of 58 articles were included in the review. We estimate the histopathological findings of 13 organ. For the pool proportion of exudative, proliferative and fibrotic phase of diffuse alveolar damage of lung is (70.666%, 56.126% and 33.031%) respectively. For liver steotosis is 35.808%. For acute tubular injury of kidney is 74.872%. For adrenal cortical necrosis is 13.113%. For brain gliosis is 13.865%. For heart necrosis is 5.477%. For gastrointestinal tract the pool proportion of inflammatory cells infiltration is 6.171%. For placental infarction is 25.684%. For orchitis is 29.019%. For perivascular inflammation of skin is 35.176%. For lymphocytic depletion of white pulp of spleen is 69.204%. For hemophagiocytosis of lymph node is 7.022%. For bone marrow fibrosis is 8.473%. Conclusion: COVID-19 is characterized as a multiorgan infection closely associated with a hyperinflammatory state, believed to initiate with diffuse alveolar damage and immuno-thrombotic microangiopathy. The extensive activation of the immune system and microvascular damage may contribute to indirect harm to other organs, although the direct impact of the virus on these tissues cannot be ruled out.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"3 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence Of Depressive Symptoms Among Women With Hysterectomy","authors":"Ahmed Saeed, Arafat Hussein Al-Dujaili","doi":"10.36330/kmj.v19i2.13201","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.13201","url":null,"abstract":"Background: Depression is the most common psychological problem suffered by women after hysterectomy and is linked to postoperative complications, negative perceptions about body image, femininity, sexual desire, youth, level of energy, and activity, as well as the inability to have children. Methods:  A descriptive (Cross-Sectional) design is used in the present study to assess the level of depression among women's after hysterectomy. A Non-probability (purposive) sample consists of sixty women's. The current study was conducted at the Obstetrics and Gynecology Consultant Unit at Al-Zahra Teaching Hospital within Al-Najaf Al-Ashraf Health Directorate in Iraq. Results: Most women after hysterectomy have mild levels of depression (47%). Conclusion:The study found that most women after hysterectomy have depression. Recommendations: Enhancing the psychological and emotional condition of women after hysterectomy by nursing professionals Additionally, coordination between the consultant in obstetrics and Gynecology and the hospital's Department of Psychiatry is needed to reduce depression. And providing an effective discharge plan for women with hysterectomy, including a follow-up visit schedule, the required examinations, and referral numbers for each type of expected complaint after hysterectomy, especially psychological complaints.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"308 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Esteem Of Caregivers Of Child With Developmental Dysplasia Of The Hip","authors":"Hanan Baqer, Arafat Hussein","doi":"10.36330/kmj.v19i2.12734","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.12734","url":null,"abstract":"Background: self-esteem could have a negative impact on caregivers and it is important for caregivers to take care of their own mental and physical health to provide the best care for their children.   Aims of the Study: the present study aims to assess the level of self-esteem among caregivers of children with DDH and to find out the relationships between self-esteem among caregivers of child with DDH and different socio-demographic characteristics. Methods: A descriptive cross-sectional research design was used in this study which was conducted in Najaf city hospitals. A non-probability, convenience, technique was used to collect the data. The study subjects included 50 caregivers who have been selected from Najaf Province. The questionnaire is adapted and modified by the researcher to achieve the goals of the study. Results: The results of the study revealed that caregivers of children with DDH have low levels of self-esteem. There is a significant relationship (P<0.05) between self-esteem and the socio-demographic characteristics marital status.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"301 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of ICSI Outcomes and Reactive Oxygen Species Levels in Seminal Plasma between Normozoospermia and Sperm Abnormalities Groups for Infertile Men","authors":"Haider Rafea Chiflawy Alkhafaji, Israa Abdulnabi Al-Nedaw, Sahib Yahiya Hassan","doi":"10.36330/kmj.v19i2.12866","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.12866","url":null,"abstract":"Background: Social life and the healthcare systems are affected by infertility. Infertility could be primary or secondary; secondary infertility is the inability to conceive after one successful pregnancy while primary infertility is the inability to conceive at all. As sperm abnormalities cause male infertility, Intracytoplasmic Sperm Injection (ICSI) is a particular type of in vitro fertilization (IVF) used to treat severe male-factor infertility. Free radical oxygen derivatives are reactive oxygen species (ROS). Reactive oxygen species may cause 30% to 80% of male infertility.  Aims of the study: the present study aims to determine the reactive oxygen species level in seminal plasma and to study the Intracytoplasmic Sperm Injection outcomes for Normospermia group and compare it with Oligozoospermia, Asthenozoospermia and the Teratozoospermia Groups.  Material, and Methods: a cross-sectional study was conducted between January 2023 to June 2023 in Najaf, on a non-random sampling including 50 couples who suffered from a minimum of 12 months of primary fertility with regular unprotected sexual intercourse and who had attended the fertility center in Najaf requesting fertility treatment. A gynecological examination and assessment were done for the female participants while the urologists examined and assessed the male subjects; then, a semen analysis was carried out followed by macroscopic and microscopic examinations. After the preparation of the sample for ICSI and performing ICSI, pregnancy was assessed and the outcomes of the different groups were compared. At the same time, reactive oxygen species levels were assessed by using the Human Reactive Oxygen Species ELISA kit. Then, the SPSS version 26 was used to perform the statistical analysis. Results: Among the twenty-one patients with Normozoospermia, seven with Asthenospermic, seven with Oligozoospermia and fifteen with Teratozoospermia,  there was a significant difference among the four groups regarding sperm concentration, progressive motility, and sperm normal morphology. There was no significant difference among the type of sperm, Normo, Astheno, Tearato, and Oligozoospermia, regarding birth rate and ICSI outcomes. Males with higher progressive motility showed a higher pregnancy rate. In conclusion, despite the presence of reactive oxygen species, Intracytoplasmic Sperm Injection was advantageous and effective for all four groups. reactive oxygen species had no significant effect on Intracytoplasmic Sperm Injection outcomes, however Normozoospermia was associated with greater pregnancy rates. Despite the presence of reactive oxygen species, Intracytoplasmic Sperm Injection was advantageous and effective for all four groups. ROS had no significant effect on Intracytoplasmic Sperm Injection outcomes, however Normozoospermia was associated with greater pregnancy rates.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"221 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Of Adiponectin, Homocysteine, B 12 And Folic Acid In Iraqi Women With Preeclampsia And Its Severity","authors":"Basima Shamkhi Al Ghazali","doi":"10.36330/kmj.v19i2.12522","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.12522","url":null,"abstract":"Background: preeclampsia is a common obstetric disorder that remains a leading cause of maternal and perinatal mortality and morbidity. Maternal serum concentrations of adiponectin, folate, homocysteine, and vitamin B12 have been found to be associated with pre-eclampsia. Nevertheless, reported studies involved still not clear with variable reliably. The aim of the present study is to examine the relationship between these biomarkers and pre-eclampsia and its severity in Iraqi population. Aims: The study aims to evaluate the association between maternal serum adiponectin, homocysteine, B12 and Folic acid and preeclampsia and its severity. Study design and setting: A case control study carried out in Al-Zahraa Maternity and Pediatric Teaching Hospital in Najaf city/ Iraq from the 1st of  December 2019 to the 1st of December 2020. Patient and Methods: The study included 50 pregnant women with preeclampsia and a comparative control group of 50 normotensive pregnant women. Preeclamptic women were further subdivided into 14 women with severe preeclampsia and 36 women with mild preeclampsia. Serum Adiponectin, Homocysteine, B 12, and Folic acid were measured by using special ELIZA (Enzyme linked immunosorbent assay) technique. Results: There was a significant increment in the level of Adiponectin and Homocysteine while vitamin B12 and Folic acid were significantly decreased in preeclamptic pregnant women in comparison to the control group. On the other hand, there was no significant relation between the severity of preeclampsia and the level of Adiponectin, Homocysteine, Vitamin B 12, and Folic acid. Conclusion: Women with preeclampsia had significantly lower vitamin B12 and folic acid and significantly higher concentrations of adiponectin and homocysteine than normotensive pregnant women, but no relation with its severity.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"16 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep Quality And Body Composition Indices Of Obese Female Adolescents Improved Using Indigenous Ampe Exercise Programme","authors":"Daniel Afrifa, Jerry Clifford Quansah, C. Adams, Anthony Asamoah-Mensah, Adocta Vincent Awuuh, Lloyd Chauwa, M. O. Moses","doi":"10.36330/kmj.v19i2.12581","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.12581","url":null,"abstract":"Background: Participation in the ampe exercise programme has been shown to improve the anthropometric and physiological characteristics of children, but its effectiveness on sleep quality and body composition indices of obese female adolescents is yet to be determined. This study confirms that ampe exercise programme improves sleep quality and body composition indices in obese female adolescents. Methods: The study adopted a pretest-posttest experimental design, with fifteen obese female adolescents recruited to participate in a 6-week ampe exercise programme. Before and after intervention, sleep quality, visceral fat, body mass index, and waist to hip ratio were assessed. A paired t-test and bivariate analysis were conducted between the sleep quality and body composition indices of the participants. Results: Body weight (102.33±15.80 < 96.47±15.36, P=0.000), body mass index (33.55±2.56 < 31.61±2.55, P=0.000), visceral fat (10.23±3.03 <8.47± 2.20), (P=0.003), and waist to hip ratio (0.86±0.04 < 0.83±0.05, P=0.000) decreased significantly while sleep quality (P=0.000) improved significantly after ampe exercise programme. The relationship between sleep quality and body composition indices was not significant. Conclusion: Ampe exercise programme potently improved body weight, body mass index, visceral fat, waist to hip ratio, and sleep quality in obese female adolescents.  It is an effective and inexpensive therapeutic exercise programme suggested for individuals with non-communicable diseases and mental health. Further, comprehensive clinical trial studies on cardiovascular disease patients will ascertain the clinical efficacy of ampe exercise programme.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"214 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Intraoperative Placement of Tetracycline, Tetracycline + Gelatin Sponge, and Placebo on Postoperative Dry Socket Incidence After Mandibular Molar Extraction: (A Comparative Prospective Study)","authors":"Mohammad Haykel, Thair A. Lateef","doi":"10.36330/kmj.v19i2.13125","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.13125","url":null,"abstract":"Background:  The aim of the study evaluation 0f tetracycline, tetracycline plus gelatin sponge efficacy in lowering dry socket incidence among patients experienced extraction procedure for mandibular molars compared to control group.. Material and Methods: The sample was divided into three groups each group have 30 patients (34 male and 56 female) :          Group A (patients dealt without intra-socket tetracycline) in which only applying figure of 8 suturing and dressing adhesive material for sockets.          Group B (patients managed with intra-socket tetracycline alone) in which patients managed after extraction with tetracycline solution, figure of 8 suturing and dressing adhesive material.          Group C (patients managed with intra-socket tetracycline plus gelatin sponge complex) in which patients managed after extraction with tetracycline-gelatin sponge vehicle, figure of 8 suturing and adhesive dressing material. Results: Dry socket following extraction was encountered in 4 female patients, with an incidence of 4.4%. Group A reported the highest number. Conclusions: In spite of the limits of this clinical trial, the placement of tetracycline as intra-socket medicament serve in a good choice for treating extracted socket, by reducing bacterial load that will result in lowering the possible chances of infection thus relieving pain, on the other hand the Ora-aid dressing material serve a good way accompanied with suturing in avoiding dry socket occurrence.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"355 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy Rate In Non-Azoospermia With Normal Or Suboptimal Semen Parameter Versus Azoospermic Male Treated By IVF-ICSI Cycle","authors":"Ali A. Abo-Alshaar, Saaduldeen Ghali Al-Esawi, Raghad Hussein Ahmed","doi":"10.36330/kmj.v19i2.12584","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.12584","url":null,"abstract":"Background: Intracytoplasmic sperm injection (ICSI) opens the gate for many cases of male factor infertility to be the biological fathers of their sibling since 1992. Most of cases were non-obstructive azoospermia and different levels of oligoastheno-teratozoospermia. Nowadays many cases of reduced semen parameter or female factor infertility are treated by IVF-ICSI Cycle for better pregnancy rate, biochemical and clinical, and live birth rate. Aim of the study: The study aims to compare biochemical, clinical pregnancy rate and outcome of pregnancies in the group with ejaculated sperm with normal or suboptimal semen parameter and group with non-obstructive azoospermia in whom sperm retrieved by TESE, using ICSI. Method: A retrospective cohort study was conducted between January, 2016 and February, 2023 in the fertility center of Al-Sader Medical City, a total of 372 couple, 90 of the males gave semen sample by masturbation and 282 of the males were non-obstructive azoospermia and their sperms were retrieved by TESE; all are treated by ICSI, all of their female partner were under age of 37 year, the maternal medical condition and obstetric history were not included in this study. Simple random sampling was depended, SPSS version 26 was used to perform the statistical analysis processes. Results: There was a highly significant difference in pregnancy rate by β.HCG between ejaculate group (43.3 %) and azoospermia (26.6 %) with p. value =0.003. A significant difference in clinical pregnancy rate by ultrasound between the ejaculate group (31.1%) and azoospermia (20.9%) with p. value =0.047. There was no statistically significant difference in live birth rate between ejaculate group as (24.4 %) and azoospermia as (17.4 %) with p.value=0.137. Conclusion: Freshly ejaculated sperm with normal or suboptimal semen parameter gave a better biochemical and clinical pregnancy rate than obtained from NOA by TESE, while live birth rate was not largely different in both groups","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"121 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Of IL-6, And IL-10 Gene Snps In Childhood Febrile Seizure","authors":"Merwa A. Raheem, Prof.Dr. Ibrahim A. Altamemi","doi":"10.36330/kmj.v19i2.12921","DOIUrl":"https://doi.org/10.36330/kmj.v19i2.12921","url":null,"abstract":"Background: Febrile seizure are typically defined as convulsions=that-occur in children, between/6 months to 5years, who have a fever of more,,than”38 degrees Celsius, that is not associated with an intracranial’ reason such as an infection, ,head .injury, or epilepsy. It is also known as the immature brain's response to fever, which is age-dependent. As a child’s brain develops, there is an increase in neuronal excitability which puts the child at the risk of febrile seizures. Aims: the aim of the present study is to find out the association of Inflammatory cytokines (IL-6, IL-10) SNP with the onset of childhood febrile seizure. Method- Blood samples from patients with childhood febrile seizure will be collected in a sterile condition, and the association of SNP for both IL-6 (-597) G/A, and IL-10 (-819) C/T with disease susceptibility will be studied by using allele specific PCR. Results: The case-control study of 40 patients with Febrile seizure and 40 control without Febrile seizure has revealed that a substantial difference in the frequency distribution of IL-6 genotypes between the patient group and the control group where (p =0.041). Besides, there was no discernible variation in the frequency distribution of IL-10 genotypes and alleles. (p > 0.05); therefore, none of genotypes or alleles can be regarded as risk factor or protective factor. Conclusion: The present study has concluded that IL-6(-597) G/A, (rs:1800797) single nucleotide polymorphism (SNP) was associated with Febrile seizure susceptibility, and GG, genotype considered as, risk factor, while genotype GA act as protective factor. However, it refers that the IL-10-819C/T (rs:1800871), genes may not represent the  Febrile-seizure-associated genetic risk factor.","PeriodicalId":507092,"journal":{"name":"Kufa Medical Journal","volume":"122 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}