Cerebellum最新文献_第3页

Effects of Baclofen on Central Paroxysmal Positional Downbeat Nystagmus. 巴氯芬对中枢阵发性位置性眼球震颤的影响

IF 2.7 3区医学

Cerebellum Pub Date : 2024-10-01 Epub Date: 2024-03-18 DOI: 10.1007/s12311-024-01684-z

So-Yeon Yun, Jong-Hee Lee, Hyo-Jung Kim, Jeong-Yoon Choi, Ji-Soo Kim

{"title":"Effects of Baclofen on Central Paroxysmal Positional Downbeat Nystagmus.","authors":"So-Yeon Yun, Jong-Hee Lee, Hyo-Jung Kim, Jeong-Yoon Choi, Ji-Soo Kim","doi":"10.1007/s12311-024-01684-z","DOIUrl":"10.1007/s12311-024-01684-z","url":null,"abstract":"Paroxysmal positional nystagmus frequently occurs in lesions involving the cerebellum, and has been ascribed to disinhibition and enhanced canal signals during positioning due to cerebellar dysfunction. This study aims to elucidate the mechanism of central positional nystagmus (CPN) by determining the effects of baclofen on the intensity of paroxysmal positional downbeat nystagmus due to central lesions. Fifteen patients with paroxysmal downbeat CPN were subjected to manual straight head-hanging before administration of baclofen, while taking baclofen 30 mg per day for at least one week, and two weeks after discontinuation of baclofen. The maximum slow phase velocity (SPV) and time constant (TC) of the induced paroxysmal downbeat CPN were analyzed. The positional vertigo was evaluated using an 11-point numerical rating scale (0 to 10) in 9 patients. After treatment with baclofen, the median of the maximum SPV of paroxysmal downbeat CPN decreased from 30.1°/s [interquartile range (IQR) = 19.6-39.0°/s] to 15.2°/s (IQR = 11.2-22.0°/s, Wilcoxon signed rank test, p < 0.001) with the median decrement ratio at 40.2% (IQR = 28.2-50.6%). After discontinuation of baclofen, the maximum SPV re-increased to 24.6°/s (IQR = 13.1-34.4°/s, Wilcoxon signed rank test, p = 0.001) with the median increment ratio at 23.5% (IQR = 5.2-87.9%). In contrast, the TCs of paroxysmal downbeat CPN remained unchanged at approximately 3.0 s throughout the evaluation. The positional vertigo also decreased with the medication (Wilcoxon signed rank test, p = 0.020), and remained unchanged even after discontinuation of medication (Wilcoxon signed rank test, p = 0.737). The results of this study support the prior presumption that paroxysmal CPN is caused by enhanced responses of the semicircular canals during positioning due to cerebellar disinhibition. Baclofen may be tried in symptomatic patients with paroxysmal CPN.","PeriodicalId":50706,"journal":{"name":"Cerebellum","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11489365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140159465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification of Solid Embryonic Cerebellar Graft Volume in a Degenerative Ataxia Model. 变性共济失调模型中实体胚胎小脑移植体积的定量分析

IF 2.7 3区医学

Cerebellum Pub Date : 2024-10-01 Epub Date: 2024-03-02 DOI: 10.1007/s12311-024-01676-z

Zdenka Purkartova, Kristyna Krakorova, Vaclav Babuska, Jan Tuma, Zbyněk Houdek, Nilpawan Roy Choudhury, Stepan Kapl, Yaroslav Kolinko, Martina Sucha, Elena Porras-Garcia, Milena Kralickova, Jan Cendelin

{"title":"Quantification of Solid Embryonic Cerebellar Graft Volume in a Degenerative Ataxia Model.","authors":"Zdenka Purkartova, Kristyna Krakorova, Vaclav Babuska, Jan Tuma, Zbyněk Houdek, Nilpawan Roy Choudhury, Stepan Kapl, Yaroslav Kolinko, Martina Sucha, Elena Porras-Garcia, Milena Kralickova, Jan Cendelin","doi":"10.1007/s12311-024-01676-z","DOIUrl":"10.1007/s12311-024-01676-z","url":null,"abstract":"Substitution of lost neurons by neurotransplantation would be a possible management of advanced degenerative cerebellar ataxias in which insufficient cerebellar reserve remains. In this study, we examined the volume and structure of solid embryonic cerebellar grafts in adult Lurcher mice, a model of olivocerebellar degeneration, and their healthy littermates. Grafts taken from enhanced green fluorescent protein (EGFP)-positive embryos were injected into the cerebellum of host mice. Two or six months later, the brains were examined histologically. The grafts were identified according to the EGFP fluorescence in frozen sections and their volumes were estimated using the Cavalieri principle. For gross histological evaluation, graft-containing slices were processed using Nissl and hematoxylin-eosin staining. Adjustment of the volume estimation approach suggested that it is reasonable to use all sections without sampling, but that calculation of values for up to 20% of lost section using linear interpolation does not constitute substantial error. Mean graft volume was smaller in Lurchers than in healthy mice when examined 6 months after the transplantation. We observed almost no signs of graft destruction. In some cases, compact grafts disorganized the structure of the host's cerebellar cortex. In Lurchers, the grafts had a limited contact with the host's cerebellum. Also, graft size was of greater variability in Lurchers than in healthy mice. The results are in compliance with our previous findings that Lurcher phenotype-associated factors have a negative effect on graft development. These factors can hypothetically include cerebellar morphology, local tissue milieu, or systemic factors such as immune system abnormalities.","PeriodicalId":50706,"journal":{"name":"Cerebellum","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemporal Gait Analysis of Patients with Spinocerebellar Ataxia Types 3 and 10 Using Inertial Measurement Units: A Comparative Study. 使用惯性测量单元对脊髓小脑共济失调 3 型和 10 型患者进行时空步态分析：比较研究。

IF 2.7 3区医学

Cerebellum Pub Date : 2024-10-01 Epub Date: 2024-06-13 DOI: 10.1007/s12311-024-01709-7

Igor Barcellos, Clint Hansen, Giovanna Klüppel Strobel, Johanna Geritz, Renato P Munhoz, Mariana Moscovich, Walter Maetzler, Hélio Afonso Ghizoni Teive

{"title":"Spatiotemporal Gait Analysis of Patients with Spinocerebellar Ataxia Types 3 and 10 Using Inertial Measurement Units: A Comparative Study.","authors":"Igor Barcellos, Clint Hansen, Giovanna Klüppel Strobel, Johanna Geritz, Renato P Munhoz, Mariana Moscovich, Walter Maetzler, Hélio Afonso Ghizoni Teive","doi":"10.1007/s12311-024-01709-7","DOIUrl":"10.1007/s12311-024-01709-7","url":null,"abstract":"Given the high morbidity related to the progression of gait deficits in spinocerebellar ataxias (SCA), there is a growing interest in identifying biomarkers that can guide early diagnosis and rehabilitation. Spatiotemporal parameter (STP) gait analysis using inertial measurement units (IMUs) has been increasingly studied in this context. This study evaluated STP profiles in SCA types 3 and 10, compared them to controls, and correlated them with clinical scales. IMU portable sensors were used to measure STPs under four gait conditions: self-selected pace (SSP), fast pace (FP), fast pace checking-boxes (FPCB), and fast pace with serial seven subtractions (FPS7). Compared to healthy subjects, both SCA groups had higher values for step time, variability, and swing time, with lower values for gait speed, cadence, and step length. We also found a reduction in speed gain capacity in both SCA groups compared to controls and an increase in speed dual-task cost in the SCA10 group. However, there were no significant differences between the SCA groups. Swing time, mean speed, and step length were correlated with disease severity, risk of falling and functionality in both clinical groups. In the SCA3 group, fear of falling was correlated with cadence. In the SCA10 group, results of the Montreal cognitive assessment test were correlated with step time, mean speed, and step length. These results show that individuals with SCA3 and SCA10 present a highly variable, short-stepped, slow gait pattern compared to healthy subjects, and their gait quality worsened with a fast pace and dual-task involvement.","PeriodicalId":50706,"journal":{"name":"Cerebellum","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141312158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebello-Hippocampal Interactions in the Human Brain: A New Pathway for Insights Into Aging. 人脑中的大脑-海马相互作用：洞察衰老的新途径

IF 2.7 3区医学

Cerebellum Pub Date : 2024-10-01 Epub Date: 2024-03-04 DOI: 10.1007/s12311-024-01670-5

Jessica A Bernard

{"title":"Cerebello-Hippocampal Interactions in the Human Brain: A New Pathway for Insights Into Aging.","authors":"Jessica A Bernard","doi":"10.1007/s12311-024-01670-5","DOIUrl":"10.1007/s12311-024-01670-5","url":null,"abstract":"The cerebellum is recognized as being important for optimal behavioral performance across task domains, including motor function, cognition, and affect. Decades of work have highlighted cerebello-thalamo-cortical circuits, from both structural and functional perspectives. However, these circuits of interest have been primarily (though not exclusively) focused on targets in the cerebral cortex. In addition to these cortical connections, the circuit linking the cerebellum and hippocampus is of particular interest. Recently, there has been an increased interest in this circuit, thanks in large part to novel findings in the animal literature demonstrating that neuronal firing in the cerebellum impacts that in the hippocampus. Work in the human brain has provided evidence for interactions between the cerebellum and hippocampus, though primarily this has been in the context of spatial navigation. Given the role of both regions in cognition and aging, and emerging evidence indicating that the cerebellum is impacted in age-related neurodegenerative disease such as Alzheimer's, I propose that further attention to this circuit is warranted. Here, I provide an overview of cerebello-hippocampal interactions in animal models and from human imaging and outline the possible utility of further investigations to improve our understanding of aging and age-related cognitive decline.","PeriodicalId":50706,"journal":{"name":"Cerebellum","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Cerebellum and Basal Ganglia Functional Connectivity in Altered Voluntary Movement Execution in Essential Tremor. 小脑和基底节功能连接在本质性震颤患者自主运动执行能力改变中的作用

IF 2.7 3区医学

Cerebellum Pub Date : 2024-10-01 Epub Date: 2024-05-18 DOI: 10.1007/s12311-024-01699-6

Massimiliano Passaretti, Claudia Piervincenzi, Viola Baione, Gabriele Pasqua, Donato Colella, Sara Pietracupa, Nikolaos Petsas, Luca Angelini, Antonio Cannavacciuolo, Giulia Paparella, Alfredo Berardelli, Patrizia Pantano, Matteo Bologna

{"title":"The Role of Cerebellum and Basal Ganglia Functional Connectivity in Altered Voluntary Movement Execution in Essential Tremor.","authors":"Massimiliano Passaretti, Claudia Piervincenzi, Viola Baione, Gabriele Pasqua, Donato Colella, Sara Pietracupa, Nikolaos Petsas, Luca Angelini, Antonio Cannavacciuolo, Giulia Paparella, Alfredo Berardelli, Patrizia Pantano, Matteo Bologna","doi":"10.1007/s12311-024-01699-6","DOIUrl":"10.1007/s12311-024-01699-6","url":null,"abstract":"Substantial evidence highlights the role of the cerebellum in the pathophysiology of tremor in essential tremor (ET), although its potential involvement in altered movement execution in this condition remains unclear. This study aims to explore potential correlations between the cerebellum and basal ganglia functional connectivity and voluntary movement execution abnormalities in ET, objectively assessed with kinematic techniques. A total of 20 patients diagnosed with ET and 18 healthy subjects were enrolled in this study. Tremor and repetitive finger tapping were recorded using an optoelectronic kinematic system. All participants underwent comprehensive 3T-MRI examinations, including 3D-T1 and blood-oxygen-level dependent (BOLD) sequences during resting state. Morphometric analysis was conducted on the 3D-T1 images, while a seed-based analysis was performed to investigate the resting-state functional connectivity (rsFC) of dorsal and ventral portions of the dentate nucleus and the external and internal segments of the globus pallidus. Finally, potential correlations between rsFC alterations in patients and clinical as well as kinematic scores were assessed. Finger tapping movements were slower in ET than in healthy subjects. Compared to healthy subjects, patients with ET exhibited altered FC of both dentate and globus pallidus with cerebellar, basal ganglia, and cortical areas. Interestingly, both dentate and pallidal FC exhibited positive correlations with movement velocity in patients, differently from that we observed in healthy subjects, indicating the higher the FC, the faster the finger tapping. The findings of this study indicate the possible role of both cerebellum and basal ganglia in the pathophysiology of altered voluntary movement execution in patients with ET.","PeriodicalId":50706,"journal":{"name":"Cerebellum","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11489212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140959950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Regional Brain Activity Following Repeat Transcranial Magnetic Stimulation in SCA3: A Secondary Analysis of a Randomized Clinical Trial. 重复经颅磁刺激对 SCA3 患者大脑区域活动的影响：一项随机临床试验的二次分析。

IF 2.7 3区医学

Cerebellum Pub Date : 2024-10-01 Epub Date: 2024-04-01 DOI: 10.1007/s12311-024-01689-8

Xia Liu, Lin Zhang, Hao-Lin Xu, Xia-Hua Liu, Arif Sikandar, Meng-Cheng Li, Xiao-Yue Xia, Zi-Qiang Huang, Na-Ping Chen, Yu-Qing Tu, Jian-Ping Hu, Shi-Rui Gan, Qun-Lin Chen, Xin-Yuan Chen, Shi-Zhong Wang

{"title":"Effect of Regional Brain Activity Following Repeat Transcranial Magnetic Stimulation in SCA3: A Secondary Analysis of a Randomized Clinical Trial.","authors":"Xia Liu, Lin Zhang, Hao-Lin Xu, Xia-Hua Liu, Arif Sikandar, Meng-Cheng Li, Xiao-Yue Xia, Zi-Qiang Huang, Na-Ping Chen, Yu-Qing Tu, Jian-Ping Hu, Shi-Rui Gan, Qun-Lin Chen, Xin-Yuan Chen, Shi-Zhong Wang","doi":"10.1007/s12311-024-01689-8","DOIUrl":"10.1007/s12311-024-01689-8","url":null,"abstract":"Repetitive transcranial magnetic stimulation (rTMS), a noninvasive neuroregulatory technique used to treat neurodegenerative diseases, holds promise for spinocerebellar ataxia type 3 (SCA3) treatment, although its efficacy and mechanisms remain unclear. This study aims to observe the short-term impact of cerebellar rTMS on motor function in SCA3 patients and utilize resting-state functional magnetic resonance imaging (RS-fMRI) to assess potential therapeutic mechanisms. Twenty-two SCA3 patients were randomly assigned to receive actual rTMS (AC group, n = 11, three men and eight women; age 32-55 years) or sham rTMS (SH group, n = 11, three men and eight women; age 26-58 years). Both groups underwent cerebellar rTMS or sham rTMS daily for 15 days. The primary outcome measured was the ICARS scores and parameters for regional brain activity. Compared to baseline, ICARS scores decreased more significantly in the AC group than in the SH group after the 15-day intervention. Imaging indicators revealed increased Amplitude of Low Frequency Fluctuation (ALFF) values in the posterior cerebellar lobe and cerebellar tonsil following AC stimulation. This study suggests that rTMS enhances motor functions in SCA3 patients by modulating the excitability of specific brain regions and associated pathways, reinforcing the potential clinical utility of rTMS in SCA3 treatment. The Chinese Clinical Trial Registry identifier is ChiCTR1800020133.","PeriodicalId":50706,"journal":{"name":"Cerebellum","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140337594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Converging and Diverging Cerebellar Pathways for Motor and Social Behaviors in Mice. 小鼠运动和社交行为的小脑通路的汇聚与发散

IF 2.7 3区医学

Cerebellum Pub Date : 2024-10-01 Epub Date: 2024-05-23 DOI: 10.1007/s12311-024-01706-w

Meike E van der Heijden

引用次数: 0

Mitochondrial Dysfunction due to Novel COQ8A Variation with Poor Response to CoQ10 Treatment: A Comprehensive Study and Review of Literatures. 新型 COQ8A 变异导致的线粒体功能障碍与辅酶 Q10 治疗反应不良：一项综合研究和文献综述。

IF 2.7 3区医学

Cerebellum Pub Date : 2024-10-01 Epub Date: 2024-03-02 DOI: 10.1007/s12311-024-01671-4

Jiayin Wang, Yan Lin, Zhihong Xu, Chuanzhu Yan, Yuying Zhao, Kunqian Ji

{"title":"Mitochondrial Dysfunction due to Novel COQ8A Variation with Poor Response to CoQ10 Treatment: A Comprehensive Study and Review of Literatures.","authors":"Jiayin Wang, Yan Lin, Zhihong Xu, Chuanzhu Yan, Yuying Zhao, Kunqian Ji","doi":"10.1007/s12311-024-01671-4","DOIUrl":"10.1007/s12311-024-01671-4","url":null,"abstract":"COQ8A plays an important role in the biosynthesis of coenzyme Q10 (CoQ10), and variations in COQ8A gene are associated with primary CoQ10 deficiency-4 (COQ10D4), also known as COQ8A-ataxia. The current understanding of the association between the specific variant type, the severity of CoQ10 deficiency, and the degree of oxidative stress in individuals with primary CoQ10 deficiencies remains uncertain. Here we provide a comprehensive analysis of the clinical and genetic characteristics of an 18-year-old patient with COQ8A-ataxia, who exhibited novel compound heterozygous variants (c.1904_1906del and c.637C > T) in the COQ8A gene. These variants reduced the expression levels of COQ8A and mitochondrial proteins in the patient's muscle and skin fibroblast samples, contributed to mitochondrial respiration deficiency, increased ROS production and altered mitochondrial membrane potential. It is worth noting that the optimal treatment for COQ8A-ataxia remains uncertain. Presently, therapy consists of CoQ10 supplementation, however, it did not yield significant improvement in our patient's symptoms. Additionally, we reviewed the response of CoQ10 supplementation and evolution of patients in previous literatures in detail. We found that only half of patients could got notable improvement in ataxia. This research aims to expand the genotype-phenotype spectrum of COQ10D4, address discrepancies in previous reviews regarding the effectiveness of CoQ10 in these disorders, and help to establish a standardized treatment protocol for COQ8A-ataxia.","PeriodicalId":50706,"journal":{"name":"Cerebellum","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Communication in Ataxia: A Multifaceted Approach to Alternative and Augmentative Communication (AAC). 优化共济失调患者的交流：替代性和辅助性交流 (AAC) 的多元方法。

IF 2.7 3区医学

Cerebellum Pub Date : 2024-10-01 Epub Date: 2024-03-07 DOI: 10.1007/s12311-024-01675-0

Adam P Vogel, Caroline Spencer, Katie Burke, Daniella de Bruyn, Peter Gibilisco, Scott Blackman, Jennifer M Vojtech, Thayabaran Kathiresan

{"title":"Optimizing Communication in Ataxia: A Multifaceted Approach to Alternative and Augmentative Communication (AAC).","authors":"Adam P Vogel, Caroline Spencer, Katie Burke, Daniella de Bruyn, Peter Gibilisco, Scott Blackman, Jennifer M Vojtech, Thayabaran Kathiresan","doi":"10.1007/s12311-024-01675-0","DOIUrl":"10.1007/s12311-024-01675-0","url":null,"abstract":"The progression of multisystem neurodegenerative diseases such as ataxia significantly impacts speech and communication, necessitating adaptive clinical care strategies. With the deterioration of speech, Alternative and Augmentative Communication (AAC) can play an ever increasing role in daily life for individuals with ataxia. This review describes the spectrum of AAC resources available, ranging from unaided gestures and sign language to high-tech solutions like speech-generating devices (SGDs) and eye-tracking technology. Despite the availability of various AAC tools, their efficacy is often compromised by the physical limitations inherent in ataxia, including upper limb ataxia and visual disturbances. Traditional speech-to-text algorithms and eye gaze technology face challenges in accuracy and efficiency due to the atypical speech and movement patterns associated with the disease.In addressing these challenges, maintaining existing speech abilities through rehabilitation is prioritized, complemented by advances in digital therapeutics to provide home-based treatments. Simultaneously, projects incorporating AI driven solutions aim to enhance the intelligibility of dysarthric speech through improved speech-to-text accuracy.This review discusses the complex needs assessment for AAC in ataxia, emphasizing the dynamic nature of the disease and the importance of regular reassessment to tailor communication strategies to the changing abilities of the individual. It also highlights the necessity of multidisciplinary involvement for effective AAC assessment and intervention. The future of AAC looks promising with developments in brain-computer interfaces and the potential of voice banking, although their application in ataxia requires further exploration.","PeriodicalId":50706,"journal":{"name":"Cerebellum","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11489254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disrupted Rotational Perception During Simultaneous Stimulation of Rotation and Inertia. 同时刺激旋转和惯性时的旋转感知中断。

IF 2.7 3区医学

Cerebellum Pub Date : 2024-10-01 Epub Date: 2024-05-03 DOI: 10.1007/s12311-024-01698-7

Ju-Young Lee, So-Yeon Yun, Yu-Jin Koo, Jung-Mi Song, Hyo-Jung Kim, Jeong-Yoon Choi, Ji-Soo Kim

{"title":"Disrupted Rotational Perception During Simultaneous Stimulation of Rotation and Inertia.","authors":"Ju-Young Lee, So-Yeon Yun, Yu-Jin Koo, Jung-Mi Song, Hyo-Jung Kim, Jeong-Yoon Choi, Ji-Soo Kim","doi":"10.1007/s12311-024-01698-7","DOIUrl":"10.1007/s12311-024-01698-7","url":null,"abstract":"Two vestibular signals, rotational and inertial cues, converge for the perception of complex motion. However, how vestibular perception is built on neuronal behaviors and decision-making processes, especially during the simultaneous presentation of rotational and inertial cues, has yet to be elucidated in humans. In this study, we analyzed the perceptual responses of 20 participants after pairwise rotational experiments, comprised of four control and four test sessions. In both control and test sessions, participants underwent clockwise and counterclockwise rotations in head-down and head-up positions. The difference between the control and test sessions was the head re-orientation relative to gravity after rotations, thereby providing only rotational cues in the control sessions and both rotational and inertial cues in the test sessions. The accuracy of perceptual responses was calculated by comparing the direction of rotational and inertial cues acquired from participants with that predicted by the velocity-storage model. The results showed that the accuracy of rotational perception ranged from 80 to 95% in the four control sessions but significantly decreased to 35 to 75% in the four test sessions. The accuracy of inertial perception in the test sessions ranged from 50 to 70%. The accuracy of rotational perception improved with repetitive exposure to the simultaneous presentation of both rotational and inertial cues, while the accuracy of inertial perception remained steady. The results suggested a significant interaction between rotational and inertial perception and implied that vestibular perception acquired in patients with vestibular disorders are potentially inaccurate.","PeriodicalId":50706,"journal":{"name":"Cerebellum","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0