Theoretical and Natural Science最新文献_第3页

Research progress and future development direction of Alzheimer's therapy 阿尔茨海默病治疗的研究进展和未来发展方向

Theoretical and Natural Science Pub Date : 2024-03-08 DOI: 10.54254/2753-8818/33/20240896

Dingjiayi Zhai

引用次数: 0

Proposed total synthesis of the potential antidiabetic compound 5,7-dihydroxy-6-(3-methybut-2-enyl)-isobenzofuran-(13H)-one 潜在抗糖尿病化合物 5,7-二羟基-6-(3-甲基丁-2-烯基)-异苯并呋喃-(13H)-酮的全合成建议

Theoretical and Natural Science Pub Date : 2024-03-08 DOI: 10.54254/2753-8818/33/20240589

Kexin Li

引用次数: 0

Transfer learning-enabled classification of drugs for Alzheimers Disease 通过迁移学习对治疗阿尔茨海默病的药物进行分类

Theoretical and Natural Science Pub Date : 2024-03-08 DOI: 10.54254/2753-8818/33/20240821

Ruoning Gu

引用次数: 0

Biochemical characterization of the NTPDases family and thrombosis NTPDases 家族的生化特征与血栓形成

Theoretical and Natural Science Pub Date : 2024-03-08 DOI: 10.54254/2753-8818/33/20240957

Yuchen Jiang

{"title":"Biochemical characterization of the NTPDases family and thrombosis","authors":"Yuchen Jiang","doi":"10.54254/2753-8818/33/20240957","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240957","url":null,"abstract":"This paper provides insight into the key role of the Nucleoside Triphosphate Diphosphohydrolase (NTPDase) family in thrombosis and its therapeutic potential. Thrombosis is an important mechanism to prevent bleeding, but its abnormal formation can lead to serious health problems such as myocardial infarction and stroke. This paper employs the method of literature analysis, obtaining materials through the investigation of previous literature, thereby conducting a literature review on the biochemical characteristics of some members of the NTPDase family. This paper begins with a description of the basic mechanisms of thrombosis and the biochemical characterization of the NTPDase family, including the structure, function, and specific substrate specificity of its members. The NTPDase enzymes regulate platelet activation by hydrolyzing extracellular Adenosine Triphosphate (ATP) and Adenosine Diphosphate (ADP), thereby preventing excessive thrombosis. The article describes in detail the catalytic roles of the NTPDase family members, their relationship to platelets and thrombosis, and discusses their role in regulating platelet function and blood coagulation. Finally, the article identifies NTPDase family members as promising targets for the treatment of thrombosis and explores the possibility of utilizing these enzymes in the clinical prevention and treatment of thrombosis-related diseases, highlighting their therapeutic potential in the control of inflammatory vascular diseases.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"44 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140076959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of COVID-19 on the health sector COVID-19 对卫生部门的影响

Theoretical and Natural Science Pub Date : 2024-03-08 DOI: 10.54254/2753-8818/33/20240789

Junxi Li

{"title":"The influence of COVID-19 on the health sector","authors":"Junxi Li","doi":"10.54254/2753-8818/33/20240789","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240789","url":null,"abstract":"Healthcare, as a fundamental component of human well-being, plays a pivotal role in shaping overall quality of life. This research investigates the extensive ramifications of the COVID-19 epidemic on the healthcare sector, encompassing the challenges and opportunities that have emerged in its wake. This study investigates the implications for hospital infrastructure through a comprehensive analysis of pertinent literature. The findings reveal significant deficiencies in essential resources such as ventilators and personal protective equipment (PPE). The evident manifestation of the psychological burden experienced by healthcare personnel highlights the imperative of allocating additional resources to support them. The advent of the pandemic has given rise to telemedicine and other digital alternatives, leading to a significant transformation in the field of healthcare delivery. Lockdowns, mask mandates, and other public health interventions are crucial in mitigating the transmission of the pathogen. Despite facing significant challenges, the ongoing pandemic has accelerated advancements in the field of medicine. This study contributes to the existing body of knowledge regarding effective strategies for addressing future pandemics and underscores the imperative of establishing a healthcare system that is adaptable and responsive. In the era following the COVID-19 pandemic, it is imperative to proactively tackle challenges and explore untapped opportunities in the healthcare sector by continuous research and assertive endeavors.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"99 S99","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140256949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein oxidation in dairy products and effects on intestinal health 乳制品中的蛋白质氧化及其对肠道健康的影响

Theoretical and Natural Science Pub Date : 2024-03-08 DOI: 10.54254/2753-8818/33/20240915

Jiayi Han

{"title":"Protein oxidation in dairy products and effects on intestinal health","authors":"Jiayi Han","doi":"10.54254/2753-8818/33/20240915","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240915","url":null,"abstract":"Lipid oxidation and microbial action have long been attributed to reduced food quality, but the effect on quality has only been gradually noticed in recent years. In food systems, protein oxidation can occur naturally and can also be triggered by processing. Therefore, the oxidation phenomenon is very common in the processing process of protein food. It is very important to study the detailed oxidation mechanism of protein. The new problem is the intake of oxidized protein impacts the health of the human body and intestinal microorganisms in its role, microorganisms in the human body intake of oxidized protein's detailed role is not clear. However, it is undeniable that the gut microbiota plays a vital role in human gut health, and it is very important to study the detailed function of the human gut microbiota after ingestion of oxidized proteins. This study conducted a detailed analysis of food processing to create a protein oxidation environment, protein oxidation mechanism, protein oxidation modification on human intestinal health, and digestion characteristics. Besides, the study also analyzes the role of microorganisms and puts forward the insufficiency. The paper also provides references and help for protein oxidation research.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"47 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140257732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An overview of remedial treatment for sudden hearing loss 突发性听力损失补救治疗概述

Theoretical and Natural Science Pub Date : 2024-03-08 DOI: 10.54254/2753-8818/33/20240823

Wenchen Ling, Zheng Wei, Suwei Jie, Zhao Xinyu, Zhihui Xu, Huang Pin

引用次数: 0

Review of the theoretical basis of the heart-brain correlation 回顾心脑关联的理论基础

Theoretical and Natural Science Pub Date : 2024-03-08 DOI: 10.54254/2753-8818/33/20240843

Yunqiu Gongye, Ling Feng

引用次数: 0

Theoretical and Natural Science Pub Date : 2024-03-08 DOI: 10.54254/2753-8818/33/20240882

Jiaxuan Liao

{"title":"GBA-related diseases and the application in Tourette syndrome treatment","authors":"Jiaxuan Liao","doi":"10.54254/2753-8818/33/20240882","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240882","url":null,"abstract":"This paper discusses the gut-brain axis (GBA) and how it takes part in various neurological diseases, including Alzheimers disease (AD), Attention-deficit hyperactivity disorder (ADHD), and Tourette syndrome. The gut microbiota, inducing vital communications with the brain through the GBA, is not to be neglected in maintaining physiological balance, with the potential to become a source of new therapeutic opportunities for treating these diseases. Current studies show that methods such as personalized diets, oral bacteriotherapy, and multi-strain probiotics like SLAB51 and DEX have promising results in treating AD and ADHD through manipulation of the biotas. Based on the analysis of previous research, this paper finds how changes in gut microbiota amount in feces between healthy and TS mice, in particular the decrease in Firmicutes and Actinobacteria, and the increase in Bacteroidetes and Proteobacteria. However, future studies and experiments are required to evaluate potential side effects of microbiome alterations in humans, and potential treatments for Tourettes syndrome based on gut microbiota analysis. The GBA is a promising area for developing new therapeutic approaches for neurological diseases, and future research in this field holds great potential for advancements in the treatment of these disorders currently with no verified cures.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"51 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140077112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of genetically modified technology in food 转基因技术在食品中的应用

Theoretical and Natural Science Pub Date : 2024-03-08 DOI: 10.54254/2753-8818/33/20240928

Kaichen Yan

{"title":"Application of genetically modified technology in food","authors":"Kaichen Yan","doi":"10.54254/2753-8818/33/20240928","DOIUrl":"https://doi.org/10.54254/2753-8818/33/20240928","url":null,"abstract":"At present, the arable land area in China is continuously decreasing, but the population is steadily increasing, and the demand for food quality among people is also increasing. Genetically modified food, with its high yield, disease and insect resistance, high survival rate, and excellent quality, will be rapidly developed, and the development prospects of genetically modified food are bright. Compared with non-genetically modified foods, genetically modified foods have similar nutrition, equal safety, and excellent quality. It will bring greater economic benefits. With the development of the times, science and technology are constantly changing, and genetically modified engineering is gradually entering our lives, affecting our lives. Food is one aspect of it. The application of genetically modified technology in food is increasingly attracting people's attention. The research method used in this article is a literature review, which studies the benefits and disadvantages of genetically modified technology on food, as well as the advantages and disadvantages of genetically modified technology on food, and our measures. Advantages: Increase crop yield and quality, and improve nutritional value. Disadvantages have an impact on human health or the management and use of genetically modified foods, the following targeted measures can be taken: strict safety assessment and supervision, strengthening research and development, etc. The conclusion of this study is to continue to refine genetically modified technology and comprehensively strengthen the regulation of genetically modified foods, to benefit humanity better. The study provides suggestions about public health security, food safety, and supply, accumulation of scientific knowledge","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"95 S89","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140256951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0