Clinical ImagingPub Date : 2024-10-23DOI: 10.1016/j.clinimag.2024.110328
Syed Muhammad Awais Bukhari , Joshua G. Hunter , Kaustav Bera , Charit Tippareddy , Cody Reid Johnson , Shweta Ravi , Shashwat Chakraborti , Robert Chapman Gilkeson , Amit Gupta
{"title":"Clinical and imaging aspects of pulmonary embolism: a primer for radiologists","authors":"Syed Muhammad Awais Bukhari , Joshua G. Hunter , Kaustav Bera , Charit Tippareddy , Cody Reid Johnson , Shweta Ravi , Shashwat Chakraborti , Robert Chapman Gilkeson , Amit Gupta","doi":"10.1016/j.clinimag.2024.110328","DOIUrl":"10.1016/j.clinimag.2024.110328","url":null,"abstract":"<div><div>Although many advancements have been made in imaging modalities that can be used to diagnose pulmonary embolism (PE), computed tomography pulmonary angiography (CTPA) is still the preferred gold standard for promptly diagnosing pulmonary embolism by looking for filling defects caused by the embolus lodged within the main pulmonary artery or its respective branches. The diagnosis is made by the radiologists in emergency settings where quick detection of a PE on CTPA helps the Pulmonary Embolism Response Team (PERT) in quick management. Thus, utmost care is needed to follow standard image acquisition protocols and optimal contrast administration techniques to achieve a contrast opacification of at least 210 Hounsfield units for the radiologists to easily pinpoint an embolus within the pulmonary arteries. Even following proper CTPA scan acquisition guidelines, a CTPA image is prone to several artifacts that can be mistaken for a PE, resulting in a false positive read. In addition to this, many incidental findings, that can be the etiology of chest pain in a PE-suspected patient, are often overlooked by emergency radiologists who try to be as quick as possible in their read so that timely management of PE can be ensued. Taking this into account, our review paper provides the audience with a comprehensive understanding of the clinical aspects of pulmonary embolism and the imaging modalities used for PE detection. The main focus is on CTPA, its acquisition protocols, and the various incidental findings and artifacts to look for while interpreting a CTPA scan.</div></div><div><h3>Précis</h3><div>Beyond the filling defects, a CTPA scan should also be assessed by the radiologists for any incidental findings while keeping in mind several associated pitfalls and artifacts of CTPA.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"117 ","pages":"Article 110328"},"PeriodicalIF":1.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical ImagingPub Date : 2024-10-23DOI: 10.1016/j.clinimag.2024.110331
Sergey Kochkine , David L. Payne , Katherine Chung , David Chen , Mark P. Bernstein , Alexander B. Baxter , John M. McMenamy
{"title":"Imaging of necrotizing fasciitis","authors":"Sergey Kochkine , David L. Payne , Katherine Chung , David Chen , Mark P. Bernstein , Alexander B. Baxter , John M. McMenamy","doi":"10.1016/j.clinimag.2024.110331","DOIUrl":"10.1016/j.clinimag.2024.110331","url":null,"abstract":"<div><div>Necrotizing Fasciitis (NF) is a rare, but highly lethal, rapidly progressive necrotic infection of the soft-tissue fascia. More common in immunocompromised patients, NF typically affects the extremities, perineal area, genital area (Fournier gangrene), and less commonly the torso. Although classically a clinical diagnosis, imaging is a powerful adjunct to facilitate early diagnosis in equivocal cases. The key features of NF of radiography, ultrasound, CT, and MRI are reviewed, as are the inherent limitations of NF diagnosis for each modality. With a high level of sensitivity, specificity, and soft tissue contrast, MRI remains the gold standard imaging method for evaluation of NF.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"116 ","pages":"Article 110331"},"PeriodicalIF":1.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142578519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical ImagingPub Date : 2024-10-21DOI: 10.1016/j.clinimag.2024.110334
Jacob A. Blythe , Thomas S.C. Ng
{"title":"Ethical principles for practice building in the era of targeted radioligand therapy","authors":"Jacob A. Blythe , Thomas S.C. Ng","doi":"10.1016/j.clinimag.2024.110334","DOIUrl":"10.1016/j.clinimag.2024.110334","url":null,"abstract":"<div><div>Theranostics is emerging as a critical pillar of oncologic management, as exemplified by the success of Lu-177-PSMA-617 for the treatment of castration-resistant prostate cancer. The emergence of such theranostic agents represents an opportunity to reconsider facets of nuclear medicine practice that will enable its engagement in high-volume radioligand delivery. In this article, we aim to explore simple ethical principles that can guide the development of theranostics programs as radiopharmaceutical agents proliferate and the typical nuclear medicine physician transitions from a primarily diagnostic role to a mixed diagnostic and therapeutic role. Such a mixed role will demand all the attendant competencies of direct patient care. We argue that restructuring nuclear medicine practice to meet this challenge involves developing processes for promoting the principle of fairness in patient selection for theranostic agents and for promoting the principle of responsibility during the administration of theranostic agents. We further specify that this responsibility extends to the patient receiving the therapy, the local community of the patient, and the general community exposed to the population of patients receiving theranostic agents.</div></div><div><h3>Précis</h3><div>The expansion of radioligand therapy requires promoting the ethical principle of fairness in patient selection and the ethical principle of responsibility in the delivery of radioligand therapy.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"116 ","pages":"Article 110334"},"PeriodicalIF":1.8,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical ImagingPub Date : 2024-10-20DOI: 10.1016/j.clinimag.2024.110327
Mi Zhou , Hongyun Huang , Deying Bao , Meining Chen
{"title":"Fractional order calculus model-derived histogram metrics for assessing pathological complete response to neoadjuvant chemotherapy in locally advanced rectal cancer","authors":"Mi Zhou , Hongyun Huang , Deying Bao , Meining Chen","doi":"10.1016/j.clinimag.2024.110327","DOIUrl":"10.1016/j.clinimag.2024.110327","url":null,"abstract":"<div><h3>Aim</h3><div>This study evaluates the value of diffusion fractional order calculus (FROC) model for the assessment of pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) for locally advanced rectal cancer (LARC) by using histogram analysis derived from whole-tumor volumes.</div></div><div><h3>Materials and methods</h3><div>Ninety-eight patients were prospectively included. Every patient received MRI scans before and after nCRT using a 3.0-Tesla MRI machine. Parameters of the FROC model, including the anomalous diffusion coefficient (D), intravoxel diffusion heterogeneity (β), spatial parameter (μ), and the standard apparent diffusion coefficient (ADC), were calculated. Changes in median values (ΔX-median) and ratio (rΔX<sub>-median</sub>) were calculated. Receiver operating characteristic (ROC) curves were used for evaluating the diagnostic performance.</div></div><div><h3>Results</h3><div>Pre-treatmentβ<sub>-10th</sub> percentile values were significantly lower in the pCR group compared to the non-pCR group (<em>p</em> < 0.001). The Δβ<sub>-median</sub> showed higher diagnostic accuracy (AUC = 0.870) and sensitivity (76.67 %) for predicting tumor response compared to MRI tumor regression grading (mrTRG) scores (AUC = 0.722; sensitivity = 90.0 %).</div></div><div><h3>Discussion</h3><div>The use of FROC alongside comprehensive tumor histogram analysis was found to be practical and effective in evaluating the tumor response to nCRT in LARC patients.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"116 ","pages":"Article 110327"},"PeriodicalIF":1.8,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical ImagingPub Date : 2024-10-18DOI: 10.1016/j.clinimag.2024.110313
Nina Capiro , Cheryce Fischer , Gelareh Sadigh
{"title":"Reply to “Enhancing breast imaging strategies: The role of ChatGPT in optimizing screening pathways”","authors":"Nina Capiro , Cheryce Fischer , Gelareh Sadigh","doi":"10.1016/j.clinimag.2024.110313","DOIUrl":"10.1016/j.clinimag.2024.110313","url":null,"abstract":"","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"116 ","pages":"Article 110313"},"PeriodicalIF":1.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical ImagingPub Date : 2024-10-18DOI: 10.1016/j.clinimag.2024.110333
Muhammed Shabil , Ganesh Bushi , Sanjit Sah
{"title":"Comment on “Diagnostic performance of dual-energy CT in detecting bone marrow edema in lower limb joint injuries: A meta-analysis”","authors":"Muhammed Shabil , Ganesh Bushi , Sanjit Sah","doi":"10.1016/j.clinimag.2024.110333","DOIUrl":"10.1016/j.clinimag.2024.110333","url":null,"abstract":"","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"116 ","pages":"Article 110333"},"PeriodicalIF":1.8,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical ImagingPub Date : 2024-10-16DOI: 10.1016/j.clinimag.2024.110332
Adam Kinzel , Mark McArthur , Lori Mankowski Gettle , Ely Felker , Maitraya Patel
{"title":"PEComas: A review of imaging and clinical features","authors":"Adam Kinzel , Mark McArthur , Lori Mankowski Gettle , Ely Felker , Maitraya Patel","doi":"10.1016/j.clinimag.2024.110332","DOIUrl":"10.1016/j.clinimag.2024.110332","url":null,"abstract":"<div><div>Perivascular epithelioid cell tumors (PEComas) are a group of rare mesenchymal tumors, which demonstrate varied imaging appearances and treatment options. These tumors may arise de novo or in the setting of systemic disorders, such as tuberous sclerosis. Some PEComas are benign and easily resected while others may represent systemic or metastatic disease with limited therapeutic options. The purpose of this review is to introduce the topic of perivascular epithelioid cell tumors and the most common tumors within the PEComa family as well as discuss the epidemiology, morphology, radiographic appearance, and treatment options of these rare tumors.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"116 ","pages":"Article 110332"},"PeriodicalIF":1.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical ImagingPub Date : 2024-10-16DOI: 10.1016/j.clinimag.2024.110326
Lauren D. Hagenstein , Joseph Jenkins , Colby Adamson , Jourdain Dong , John Moore , Jing Gao
{"title":"Ultrasound normalized local variance to assess metabolic dysfunction-associated steatotic liver disease","authors":"Lauren D. Hagenstein , Joseph Jenkins , Colby Adamson , Jourdain Dong , John Moore , Jing Gao","doi":"10.1016/j.clinimag.2024.110326","DOIUrl":"10.1016/j.clinimag.2024.110326","url":null,"abstract":"<div><h3>Purpose</h3><div>Increased prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) highlights a desire for screening with liver ultrasound normalized local variance (NLV). We aimed to assess variations in NLV values measured at different sampling depths and discuss common technical considerations in measuring liver NLV.</div></div><div><h3>Methods</h3><div>We retrospectively measured liver NLVs at variable depths on ultrasound images pre-recorded in 116 participants who underwent liver magnetic resonance imaging-proton density fat fraction (MRI-PDFF) and ultrasound to screen for MASLD. Liver NLVs were measured and differences at variable depths were tested using one-way analysis of variance (ANOVA) and multiple paired comparisons using post hoc Tukey honestly significant difference (HSD), Scheffé, Bonferroni, and Holm multiple comparisons. Diagnostic performance of NLV values were analyzed by area under the receiver operating characteristic (AUROC) curve.</div></div><div><h3>Results</h3><div>The NLV measured at a depth of 10 cm significantly differed from those measured near the liver capsule and at depths of 6 cm and 8 cm (<em>p</em> < 0.001) from the skin. There was no significant difference in NLV value in other paired groups (<em>p</em> > 0.05). The difference in the area under AUROCs for NLVs measured at variable depths was not significant (<em>p</em> > 0.05).</div></div><div><h3>Conclusions</h3><div>The best diagnostic performance of liver NLV was measured at depth of 8 cm from the skin, although NLV measured at variable depth showed similar diagnostic performance for assessing ≥ mild hepatic steatosis. The study results provide a reference that can be used in the development of standardized scanning protocols and technical considerations in measuring liver NLV.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"116 ","pages":"Article 110326"},"PeriodicalIF":1.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical ImagingPub Date : 2024-10-15DOI: 10.1016/j.clinimag.2024.110330
Laura E. Minton , Jordan Perchik , Cathy Chen , Renu Pandit , Desmin Milner , Rachel Bass , Elainea Smith , Jessica Zarzour
{"title":"Women in Radiology Education (WIRED): An actionable step towards closing the gender gap in radiology","authors":"Laura E. Minton , Jordan Perchik , Cathy Chen , Renu Pandit , Desmin Milner , Rachel Bass , Elainea Smith , Jessica Zarzour","doi":"10.1016/j.clinimag.2024.110330","DOIUrl":"10.1016/j.clinimag.2024.110330","url":null,"abstract":"<div><div>As the representation of women in medicine has grown and reached parity in some specialties over the past two decades, radiology has not only lagged behind, but has remained stagnant. To strengthen the pipeline, the field must institute policies and practices to retain women in radiology and must effectively recruit and mentor women in medical school to enter the field. Women in medical school who are pursuing radiology, however, often struggle to find women mentors, opportunities for research, leadership, and service, and critically, often struggle to find a community that speaks to their experience. WIRED (Women in Radiology Education) is a student-led group dedicated to community building and advancing radiology mentorship, research, and service opportunities for women in medical school. This step-by-step guide to founding a WIRED chapter with examples of successful chapter events can enable radiology programs to provide targeted mentorship to women in medical school, and ultimately, increase the representation of women in radiology.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"116 ","pages":"Article 110330"},"PeriodicalIF":1.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical ImagingPub Date : 2024-10-15DOI: 10.1016/j.clinimag.2024.110329
Muhammad Ansar , Muhammad Arsam Ali , Noraiz Ali , Zeshan Haider , Aruj Latif , Anjum Tazeen , Zareen Fatima , Muhammad Nawaz Anjum
{"title":"Ultrasound shear wave elastography of the placenta: a potential tool for early detection of fetal growth restriction","authors":"Muhammad Ansar , Muhammad Arsam Ali , Noraiz Ali , Zeshan Haider , Aruj Latif , Anjum Tazeen , Zareen Fatima , Muhammad Nawaz Anjum","doi":"10.1016/j.clinimag.2024.110329","DOIUrl":"10.1016/j.clinimag.2024.110329","url":null,"abstract":"<div><h3>Background</h3><div>Sonographic placental elastography has recently been employed as a non-invasive tool to investigate the structural alterations associated with various conditions such as pre-eclampsia, gestational diabetes and fetal growth restriction (FGR). The study was conducted based on the hypothesis that the placental elasticity might differ with varying severity of FGR and with that of appropriate for gestational age (AGA) pregnancies.</div></div><div><h3>Methods</h3><div>This study involved 121 pregnant women, with 54 in the normal group and 67 in the FGR group, which was defined as the fetal weight below the 10th percentile for gestational age. The FGR pregnancies were sub grouped into different stages based on the presence and extent of Doppler abnormalities. Shear-wave elastography was carried out to investigate the placental elasticity values, which were compared using the Kruskal-Wallis test. A <em>P</em> value of ≤0.05 was considered significant.</div></div><div><h3>Results</h3><div>The placental elasticity differed significantly between pregnancies with and without FGR and among the different stages of FGR. There was a significant difference in PE (kPa) and SWV (m/s) among groups, with a p-value of 0.000001. PE and SWV in FGR pregnancies were significantly higher compared to AGA as a whole using <em>t-</em>test with <em>p</em> values of <0.0001. Doppler indices of umbilical, uterine and fetal middle cerebral arteries also correlated significantly with these.</div></div><div><h3>Conclusion</h3><div>The study suggests that placental elasticity values reflect structural alterations associated with FGR and could serve as a valuable tool in the early detection and staging of this condition.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"116 ","pages":"Article 110329"},"PeriodicalIF":1.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142512349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}