Clinical Journal of Pain最新文献

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Preoperative Bilateral External Oblique Intercostal Plus Rectus Sheath Block for Postoperative Pain Management Following Laparoscopic Cholecystectomy: A Noninferior Double-Blind Placebo-Controlled Trial. 用于腹腔镜胆囊切除术后疼痛控制的术前双侧肋间外斜肌加直肠鞘阻滞:一项非劣效性双盲安慰剂对照试验。
IF 2.6 3区 医学
Clinical Journal of Pain Pub Date : 2024-10-01 DOI: 10.1097/AJP.0000000000001235
Ke Mo, Weirong Kong, Jiaxin Chen, Shuhua Zhao, Qianqian Zhu
{"title":"Preoperative Bilateral External Oblique Intercostal Plus Rectus Sheath Block for Postoperative Pain Management Following Laparoscopic Cholecystectomy: A Noninferior Double-Blind Placebo-Controlled Trial.","authors":"Ke Mo, Weirong Kong, Jiaxin Chen, Shuhua Zhao, Qianqian Zhu","doi":"10.1097/AJP.0000000000001235","DOIUrl":"10.1097/AJP.0000000000001235","url":null,"abstract":"<p><strong>Objectives: </strong>The transversus abdominis plane (TAP) block has proven efficacy and is an important component of multimodal analgesia in laparoscopic cholecystectomy (LC). The external oblique intercostal (EOI) block can provide a dermatomal sensory blockade of T6 to T10 using an anterior axillary line injection. The bilateral rectus sheath (RS) block can significantly reduce early postoperative pain caused by umbilical or periumbilical incisions. The current study aimed to compare the analgesic efficacies of ultrasound-guided subcostal TAP (UG-TAP) combined with the RS block and ultrasound-guided EOI (UG-EOI) combined with the RS block for LC.</p><p><strong>Methods: </strong>Patients were randomly assigned to TAP or EOI group. Patients in TAP group received UG-TAP combined with an RS block. Patients in EOI group received UG-EOI combined with an RS block. The primary outcome was postoperative 24-hour sufentanil consumption.</p><p><strong>Results: </strong>A total of 49 patients were included in the final analysis. The postoperative 24-hour sufentanil consumption in the EOI group was significantly lower than that in the TAP group (9.79±10.22 vs. 18.67±12.58 µg; P [noninferiority] <0.01; noninferiority confirmed). Fewer patients in the EOI versus TAP group had a numerical rating score of >3 during motion. Furthermore, the mean postoperative 48-hour sufentanil consumption was lower in the EOI versus TAP group (11.54±11.70 vs. 23.04±17.10 µg; P =0.01). The mean postoperative 24-hour Quality of Recovery-15 score was higher in the EOI versus TAP group (135.21±4.40 vs. 131.91±5.11; P =0.02).</p><p><strong>Discussion: </strong>These findings suggest that UG-EOI combined with an RS block was superior to UG-TAP combined with an RS block for postoperative pain management in patients undergoing LC.</p>","PeriodicalId":50678,"journal":{"name":"Clinical Journal of Pain","volume":" ","pages":"601-606"},"PeriodicalIF":2.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to "Competing Narratives: Moving the Field Forward on Spinal Cord Stimulation". 对 "相互竞争的叙述:推动脊髓刺激领域的发展"。
IF 2.6 3区 医学
Clinical Journal of Pain Pub Date : 2024-09-01 DOI: 10.1097/AJP.0000000000001232
Sam Eldabe, Sarah Nevitt, Anthony Bentley, Nagy A Mekhail, Christopher Gilligan, Bart Billet, Peter S Staats, Michelle Maden, Nicole Soliday, Angela Leitner, Rui V Duarte
{"title":"Response to \"Competing Narratives: Moving the Field Forward on Spinal Cord Stimulation\".","authors":"Sam Eldabe, Sarah Nevitt, Anthony Bentley, Nagy A Mekhail, Christopher Gilligan, Bart Billet, Peter S Staats, Michelle Maden, Nicole Soliday, Angela Leitner, Rui V Duarte","doi":"10.1097/AJP.0000000000001232","DOIUrl":"10.1097/AJP.0000000000001232","url":null,"abstract":"","PeriodicalId":50678,"journal":{"name":"Clinical Journal of Pain","volume":" ","pages":"557-560"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141635589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitigating Persistent Symptoms Following Rehabilitation in Musculoskeletal Disorders: A Scoping Review on After-discharge Strategies. 缓解肌肉骨骼疾病康复后的持续症状:出院后策略范围综述》。
IF 2.6 3区 医学
Clinical Journal of Pain Pub Date : 2024-09-01 DOI: 10.1097/AJP.0000000000001230
Frédérique Dupuis, Jean-Sébastien Roy, Anthony Lachance, Arielle Tougas, Martine Gagnon, Pascale Marier-Deschênes, Anne Marie Pinard, Hugo Massé-Alarie
{"title":"Mitigating Persistent Symptoms Following Rehabilitation in Musculoskeletal Disorders: A Scoping Review on After-discharge Strategies.","authors":"Frédérique Dupuis, Jean-Sébastien Roy, Anthony Lachance, Arielle Tougas, Martine Gagnon, Pascale Marier-Deschênes, Anne Marie Pinard, Hugo Massé-Alarie","doi":"10.1097/AJP.0000000000001230","DOIUrl":"10.1097/AJP.0000000000001230","url":null,"abstract":"<p><strong>Background: </strong>The majority of patients with musculoskeletal pain (62% to 64%) achieve their treatment goals upon completing rehabilitation. However, a high re-consultation rate after discharge is frequently reported. Numerous authors have recognized the necessity of secondary prevention programs (after-discharge strategy) to ensure that the gains are maintained or further pursued after the completion of a rehabilitation program. Little is known about the different strategies currently in use, and a detailed review of the existing strategies is needed for future integration into the healthcare systems.</p><p><strong>Objective: </strong>This review systematically scopes and synthesizes the after-discharge strategies reported in the literature following rehabilitation for individuals experiencing musculoskeletal pain.</p><p><strong>Methods: </strong>Four databases (OVID MEDLINE, EMBASE, Web of Sciences, and OVID PsycInfo) were screened from their inception until May 4, 2023. Literature search, screening, and extraction were performed according to the PRISMA extension for scoping review guidelines.</p><p><strong>Results: </strong>Different after-discharge strategies were identified and grouped into 2 main categories: (1) in-person and (2) remote strategies. In-person strategies included (1.1) in-person booster sessions and (1.2) the use of existing community programs after discharge. Remote strategies included remote strategies that (2.1) involve a health care professional service or (2.2) strategies that do not involve any health care professional service.</p><p><strong>Discussion: </strong>We identified various after-discharge strategies designed to sustain gains and improve patients' self-management skills following the completion of a rehabilitation program. The existence of numerous promising strategies suggests their potential suitability for various contexts.</p>","PeriodicalId":50678,"journal":{"name":"Clinical Journal of Pain","volume":" ","pages":"542-556"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141447435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the Evidence for Erector Spinae Plane Block in Spine Surgery. 回复:评估脊柱手术中脊柱前凸平面阻滞的证据。
IF 2.6 3区 医学
Clinical Journal of Pain Pub Date : 2024-09-01 DOI: 10.1097/AJP.0000000000001228
Qing Peng, Liang Zhang
{"title":"Assessing the Evidence for Erector Spinae Plane Block in Spine Surgery.","authors":"Qing Peng, Liang Zhang","doi":"10.1097/AJP.0000000000001228","DOIUrl":"10.1097/AJP.0000000000001228","url":null,"abstract":"","PeriodicalId":50678,"journal":{"name":"Clinical Journal of Pain","volume":" ","pages":"560-561"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Competing Narratives: Moving the Field Forward on Spinal Cord Stimulation. 竞相叙述:推动脊髓刺激领域的发展。
IF 2.6 3区 医学
Clinical Journal of Pain Pub Date : 2024-09-01 DOI: 10.1097/AJP.0000000000001229
Adrian Traeger
{"title":"Competing Narratives: Moving the Field Forward on Spinal Cord Stimulation.","authors":"Adrian Traeger","doi":"10.1097/AJP.0000000000001229","DOIUrl":"10.1097/AJP.0000000000001229","url":null,"abstract":"","PeriodicalId":50678,"journal":{"name":"Clinical Journal of Pain","volume":" ","pages":"518-519"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network Meta-analysis and Economic Evaluation of Neurostimulation Interventions for Chronic Nonsurgical Refractory Back Pain. 神经刺激干预治疗慢性非手术难治性背痛的网络荟萃分析和经济评估
IF 2.6 3区 医学
Clinical Journal of Pain Pub Date : 2024-09-01 DOI: 10.1097/AJP.0000000000001223
Sam Eldabe, Sarah Nevitt, Anthony Bentley, Nagy A Mekhail, Christopher Gilligan, Bart Billet, Peter S Staats, Michelle Maden, Nicole Soliday, Angela Leitner, Rui V Duarte
{"title":"Network Meta-analysis and Economic Evaluation of Neurostimulation Interventions for Chronic Nonsurgical Refractory Back Pain.","authors":"Sam Eldabe, Sarah Nevitt, Anthony Bentley, Nagy A Mekhail, Christopher Gilligan, Bart Billet, Peter S Staats, Michelle Maden, Nicole Soliday, Angela Leitner, Rui V Duarte","doi":"10.1097/AJP.0000000000001223","DOIUrl":"10.1097/AJP.0000000000001223","url":null,"abstract":"<p><strong>Objectives: </strong>Different types of spinal cord stimulation (SCS) have been evaluated for the management of chronic nonsurgical refractory back pain (NSRBP). A direct comparison between the different types of SCS or between closed-loop SCS with conventional medical management (CMM) for patients with NSRBP has not been previously conducted, and therefore, their relative effectiveness and cost-effectiveness remain unknown. The aim of this study was to perform a systematic review, network meta-analysis (NMA) and economic evaluation of closed-loop SCS compared with fixed-output SCS and CMM for patients with NSRBP.</p><p><strong>Methods: </strong>Databases were searched to September 8, 2023. Randomized controlled trials of SCS for NSRBP were included. The results of the studies were combined using fixed-effect NMA models. A cost-utility analysis was performed from the perspective of the UK National Health Service with results reported as incremental cost per quality-adjusted life-year (QALY).</p><p><strong>Results: </strong>Closed-loop SCS resulted in statistically and clinically significant reductions in pain intensity (mean difference [MD] 32.72 [95% CrI 15.69-49.78]) and improvements in secondary outcomes (Oswestry Disability Index [ODI] and health-related quality of life [HRQoL]) compared with fixed-output SCS at 6-month follow-up. Compared with CMM, both closed-loop and fixed-output SCS resulted in statistically and clinically significant reductions in pain intensity (closed-loop SCS vs. CMM MD 101.58 [95% CrI 83.73-119.48]; fixed-output SCS versus CMM MD 68.86 [95% CrI 63.43-74.31]) and improvements in secondary outcomes (ODI and HRQoL). Cost-utility analysis showed that closed-loop SCS dominates fixed-output SCS and CMM, and fixed-output SCS also dominates CMM.</p><p><strong>Discussion: </strong>Current evidence showed that closed-loop and fixed-output SCS provide more benefits and cost-savings compared with CMM for patients with NSRBP.</p>","PeriodicalId":50678,"journal":{"name":"Clinical Journal of Pain","volume":" ","pages":"507-517"},"PeriodicalIF":2.6,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intranasal Tapentadol Versus Intravenous Paracetamol for Postoperative Analgesia in Lower Limb Orthopaedic Surgeries Under Spinal Anaesthesia: A Single Blind RCT. 椎管内麻醉下下肢矫形手术术后镇痛的鼻内注射他喷他多与静脉注射扑热息痛:单盲 RCT。
IF 2.6 3区 医学
Clinical Journal of Pain Pub Date : 2024-08-01 DOI: 10.1097/AJP.0000000000001225
Priyanka Suresh, Ravish V Ningegowda, Anu Ramu
{"title":"Intranasal Tapentadol Versus Intravenous Paracetamol for Postoperative Analgesia in Lower Limb Orthopaedic Surgeries Under Spinal Anaesthesia: A Single Blind RCT.","authors":"Priyanka Suresh, Ravish V Ningegowda, Anu Ramu","doi":"10.1097/AJP.0000000000001225","DOIUrl":"10.1097/AJP.0000000000001225","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to compare the analgesic effectiveness of intranasal tapentadol nasal spray 44.5 mg and intravenous (IV) paracetamol 1 gm during the postoperative period in patients undergoing lower limb orthopedic surgeries under spinal anesthesia.</p><p><strong>Methods: </strong>This prospective, randomized, single-blind clinical trial was carried out in a tertiary care teaching hospital. Patients aged between 18 and 60 years of physical status ASA grade 1-3 were included in the study. Postoperative pain scores were measured using the visual analog scale (VAS) in centimeters (cm) every 12 hours in 37 patients per group. The patients were administered either intranasal tapentadol or IV paracetamol every 6 hours for 72 hours, beginning 3 hours after surgery.</p><p><strong>Results: </strong>There was a significant group by intervention effect favoring intranasal tapentadol, suggesting a greater reduction in VAS pain scores after the intervention at 72 hours (estimate: -1.58 cm; SE:0.2; P<0.001). Group by time effect for all the measured time frames, except for 36 hours, favored intranasal tapentadol with estimated values for greater reduction in VAS pain scores ranging from -0.8 cm to -1.6 cm.</p><p><strong>Discussion: </strong>The results of the present study suggests that intranasal tapentadol results in a greater reduction of postoperative pain compared with IV paracetamol in lower limb orthopedic surgeries. The ease of administration of tapentadol may make it a preferred option over IV paracetamol in such surgeries.</p>","PeriodicalId":50678,"journal":{"name":"Clinical Journal of Pain","volume":" ","pages":"463-468"},"PeriodicalIF":2.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computed Tomography-Guided Dorsal Root Ganglion Ozone Injection Combined With Pulsed Radiofrequency for Acute Herpes Zoster Neuralgia Treatment of Middle-aged and Elderly People: A Randomized, Double-blinded, Controlled Trial. CT引导下背根神经节臭氧注射联合脉冲射频治疗中老年人急性带状疱疹神经痛:一项随机、双盲、对照试验。
IF 2.6 3区 医学
Clinical Journal of Pain Pub Date : 2024-08-01 DOI: 10.1097/AJP.0000000000001226
Ruxiang Wang, Zhangtian Xia, Ying Ma, Bing Huang, Ming Yao, Ling Ma
{"title":"Computed Tomography-Guided Dorsal Root Ganglion Ozone Injection Combined With Pulsed Radiofrequency for Acute Herpes Zoster Neuralgia Treatment of Middle-aged and Elderly People: A Randomized, Double-blinded, Controlled Trial.","authors":"Ruxiang Wang, Zhangtian Xia, Ying Ma, Bing Huang, Ming Yao, Ling Ma","doi":"10.1097/AJP.0000000000001226","DOIUrl":"10.1097/AJP.0000000000001226","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the efficacy and safety of pulsed radiofrequency of the dorsal root ganglion combined with ozone injection for treating acute herpes zoster (HZ) neuralgia in middle-aged and elderly adults.</p><p><strong>Methods: </strong>A total of 164 middle-aged and elderly patients with acute HZ were randomly assigned to 2 groups: the pulsed radiofrequency combined with ozone injection group (group A) and the pulsed radiofrequency group (group B). The therapeutic effects were evaluated using Numeric Rating Scale (NRS) scores and the average doses of gabapentin (mg/d) preoperatively and 1 day, 2 weeks, 4 weeks, 12 weeks, and 24 weeks postoperatively. The incidence of clinically significant postherpetic neuralgia (PHN) and complications in the 2 groups were recorded.</p><p><strong>Results: </strong>The data showed that the NRS scores and the doses of gabapentin after treatment were significantly lower when compared with the baseline values in both groups. Compared with group B, the NRS scores and the doses of postoperative gabapentin were significantly lower in group A. The incidence of PHN was significantly lower at weeks 4, 12, and 24 in group A than in group B. No adverse reactions occurred in either of the 2 groups post-treatment.</p><p><strong>Conclusions: </strong>The results indicated that ozone injection in the dorsal root ganglion combined with pulsed radiofrequency therapy was more effective in treating acute HZ neuralgia in middle-aged and elderly adults. It provides patients with longer-lasting pain relief, decreased incidence of PHN and the doses of medication, and improved quality of life than with Pulsed Radiofrequency treatment.</p>","PeriodicalId":50678,"journal":{"name":"Clinical Journal of Pain","volume":" ","pages":"469-477"},"PeriodicalIF":2.6,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determining Postoperative Analgesic Efficacy of Dexamethasone Plus Bupivacaine for Regional Block. 确定地塞米松加布比卡因用于区域阻滞的术后镇痛效果。
IF 2.6 3区 医学
Clinical Journal of Pain Pub Date : 2024-07-01 DOI: 10.1097/AJP.0000000000001213
Nong He, Fu-Shan Xue, Cheng-Wen Li
{"title":"Determining Postoperative Analgesic Efficacy of Dexamethasone Plus Bupivacaine for Regional Block.","authors":"Nong He, Fu-Shan Xue, Cheng-Wen Li","doi":"10.1097/AJP.0000000000001213","DOIUrl":"10.1097/AJP.0000000000001213","url":null,"abstract":"","PeriodicalId":50678,"journal":{"name":"Clinical Journal of Pain","volume":" ","pages":"458"},"PeriodicalIF":2.6,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140332197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Preoperative Aripiprazole on Postoperative Analgesia in Laparoscopic Hysterectomy: A Randomized Double-blind Placebo-controlled Trial. 腹腔镜子宫切除术中术前阿立哌唑对术后镇痛的影响:随机双盲安慰剂对照试验》。
IF 2.9 3区 医学
Clinical Journal of Pain Pub Date : 2024-06-01 DOI: 10.1097/AJP.0000000000001210
Amin Mohamed Alansary, Marwa Ahmed Khairy Elbeialy
{"title":"Impact of Preoperative Aripiprazole on Postoperative Analgesia in Laparoscopic Hysterectomy: A Randomized Double-blind Placebo-controlled Trial.","authors":"Amin Mohamed Alansary, Marwa Ahmed Khairy Elbeialy","doi":"10.1097/AJP.0000000000001210","DOIUrl":"10.1097/AJP.0000000000001210","url":null,"abstract":"<p><strong>Objectives: </strong>Aripiprazole is a second-generation atypical antipsychotic with worldwide clinical approval. Nevertheless, its perioperative antinociceptive application has not been studied. As a result, the purpose of this study was to investigate the analgesic effects of perioperative aripiprazole on reducing postoperative pain, as well as the possible adverse effects.</p><p><strong>Patients and methods: </strong>This randomized controlled study enrolled 80 female patients scheduled for laparoscopic hysterectomy who were assigned randomly into 2 equal groups in 1:1; aripiprazole group (n = 40), patients received an aripiprazole 30 mg tablet orally 3 hours before surgery and placebo group (n = 40), patients received a placebo tablet 3 hours before surgery. The 24-hour morphine consumption postoperatively was the primary outcome, and the time to the first analgesic request, sedation scores, and the incidence of perioperative adverse events were the secondary outcomes.</p><p><strong>Results: </strong>The mean 24-hour morphine consumption was significantly lower with aripiprazole (2.5 ± 0.5 mg) than with placebo (23.7 ± 1.6 mg; mean ± SE -21.2 ± 0.3, 95% CI: -21.7 to -20.6, P < 0.001). In addition, the mean time to the first analgesic request was significantly longer with aripiprazole (212.2 ± 14.7 min) than with placebo (27.0 ± 2.0 min; mean ± SE 185.2 ± 2.3, 95% CI: 180.5 to 189.8, P < 0.001). Furthermore, the aripiprazole group reported higher sedation scores ( P < 0.001). Bradycardia and hypotension were reported more frequently among patients in the aripiprazole group ( P < 0.05).</p><p><strong>Conclusion: </strong>Aripiprazole was effective in reducing pain after laparoscopic hysterectomy. Although self-limited, side effects should be taken into consideration when using the medication perioperatively.</p>","PeriodicalId":50678,"journal":{"name":"Clinical Journal of Pain","volume":" ","pages":"341-348"},"PeriodicalIF":2.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140050928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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