Colombia Medica最新文献

{"title":"Abdominal actinomycosis by <i>Actinomyces shaaliae georgiae</i> mimicking neoplasia.","authors":"Mateo Londoño Barrientos, Carlos Alberto Lopez Zapata, Laura Álvarez Herrera, Marco Frusteri, Carlos Andres Delgado Lopez","doi":"10.25100/cm.v56i2.6672","DOIUrl":"10.25100/cm.v56i2.6672","url":null,"abstract":"<p><strong>Case description: </strong>We report the case of a 77-year-old male who presented with a three-week history of constitutional symptoms, accompanied by an indurated epigastric mass measuring 10 × 7 cm with a 4 cm phlyctenae, exhibiting local and systemic inflammatory responses.</p><p><strong>Clinical findings: </strong>Abdominal computed tomography demonstrated focal thickening of the transverse colon with a poorly defined inflammatory lesion extending to the abdominal wall and a collection suggestive of colo-cutaneous fistula. The clinical and imaging findings raised a strong suspicion of malignancy. Microbiological culture from drainage material isolated <i>Actinomyces shaaliae georgiae</i>, further reinforcing the suspicion of neoplastic disease due to the tumor-like presentation.</p><p><strong>Treatment and outcomes: </strong>Initial management included antimicrobial therapy and percutaneous drainage. Surgical exploration revealed a stony hard mass without cleavage planes, adherent to adjacent organs. Histopathological examination excluded malignancy, confirming an infectious process caused by <i>A. shaaliae georgiae</i>. The patient received prolonged antibiotic therapy, resulting in a favorable clinical outcome.</p><p><strong>Clinical relevance: </strong>To our knowledge, this represents the first reported case of abdominal actinomycosis caused by <i>A. shaaliae georgiae</i> with this unique presentation. Actinomycotic lesions form purulent foci surrounded by extensive fibrosis, creating tumor-like masses that clinically and radiologically mimic neoplastic processes. This case expands the clinical spectrum and microbiological repertoire of <i>A. shaaliae georgiae</i>, emphasizing the critical importance of maintaining high clinical suspicion, implementing multidisciplinary diagnostic approaches, and ensuring appropriate antimicrobial management in abdominal actinomycosis to avoid unnecessary surgical interventions and improve patient outcomes.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"56 2","pages":"e5006672"},"PeriodicalIF":1.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12633640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145589536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum interleukin-36γ levels in children with allergic rhinitis: a cross-sectional study.","authors":"Dogukan Aydenizoz, Omer Tarik Selcuk, Hulya Eyigor, Hamit Yasar Ellidag, Serkan Filiz, Sennur Keles","doi":"10.25100/cm.v56i2.6690","DOIUrl":"10.25100/cm.v56i2.6690","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate whether serum Interleukin 36 gamma (IL-36γ) levels in pediatric allergic rhinitis patients correlate with disease severity (mild, moderate, severe) and duration (intermittent, persistent). Additionally, we assessed the potential of IL-36γ as a biomarker and its role in disease pathogenesis to inform future treatment strategies.</p><p><strong>Methods: </strong>In this cross-sectional observational study, pediatric allergic rhinitis patients from outpatient clinics were compared with healthy controls. Serum IL-36γ levels were measured from blood samples and analyzed across subgroups based on disease severity and duration.</p><p><strong>Results: </strong>Fifty patients with allergic rhinitis and forty controls were included. IL-36γ levels were higher in the patient group with borderline significance (<i>p</i>= 0.050). Female patients had significantly higher IL-36γ levels than male controls (<i>p</i>= 0.044).</p><p><strong>Conclusions: </strong>This is the first study to evaluate IL-36γ levels in pediatric allergic rhinitis. Although the difference between groups showed borderline significance, larger studies may confirm these findings. The observed gender-related difference suggests IL-36γ could be a potential biomarker. Additionally, a significant negative correlation with total IgE and a nonsignificant negative correlation with eosinophil counts were noted.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"56 2","pages":"e2016690"},"PeriodicalIF":1.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12574362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence with hormonal therapy in women with breast cancer: a cross-sectional study in Medellin, Colombia.","authors":"Katerin Puerta Alzate, Camila Lema Calidonio, Mauricio Lema Medina, Paula Villa García","doi":"10.25100/cm.v56i2.6613","DOIUrl":"10.25100/cm.v56i2.6613","url":null,"abstract":"<p><strong>Background: </strong>Although hormone therapy is a cornerstone in the treatment of breast cancer, low therapeutic adherence is commonly reported, and there is limited evidence on the predictors that contributes to improving adherence in this population.</p><p><strong>Objective: </strong>To identify factors associated with adherence to hormone therapy in women with breast cancer, in an oncology clinic in Medellín-Colombia (2019- 2023).</p><p><strong>Methods: </strong>Cross-sectional analytical study. Women >18 years old with hormone receptor-positive breast cancer who were undergoing hormone therapy were included. The MMAS-8 scale was used to measure and classify therapeutic adherence into three levels: low, medium, and high. Data was analyzed by multinomial logistic regression.</p><p><strong>Results: </strong>One hundred seventy-eight patients with a median age of 64.0 years were included. 50.0% were treated with tamoxifen. The prevalence of non-adherence was 48.9%. 70.2% had adverse effects of hormone therapy, and forgetfulness was the main reason for discontinuation (76.19%). Age was associated with therapeutic adherence, with older women being the most adherent (83.5%). Women with adverse effects, stage III-IV, low socioeconomic and educational level, and a lack of support network had lower therapeutic adherence.</p><p><strong>Conclusions: </strong>A high prevalence of moderate and low therapeutic adherence is demonstrated in younger women from lower socioeconomic and educational backgrounds. Preventive strategies are needed to mitigate factors that negatively influence therapeutic adherence.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"56 2","pages":"e2006613"},"PeriodicalIF":1.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12560826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145402767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induction of labor with dinoprostone in hypertensive disorders of pregnancy: comparative analysis with normotensive pregnant women.","authors":"Laura Camila Molina-Barrera, María Sady Bustamante-De la Ossa, John Jairo Zuleta-Tobón","doi":"10.25100/cm.v56i1.6719","DOIUrl":"10.25100/cm.v56i1.6719","url":null,"abstract":"<p><strong>Objective: </strong>To describe obstetric outcomes associated with the use of dinoprostone and its effectiveness in cervical ripening in pregnant women with hypertensive disorders of pregnancy compared to normotensive pregnant women.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted at a tertiary-level hospital in Medellín, Colombia (March 2020 - October 2024). The study included pregnant women with singleton pregnancies, beyond 30 weeks of gestation, with a live fetus in cephalic presentation, and undergoing cervical ripening with dinoprostone vaginal insert. Women were excluded if they had used other ripening methods, had a favorable cervix at admission, or had an unclassified hypertensive disorder. Primary outcomes included successful cervical ripening, vaginal delivery, time to favorable Bishop score and to delivery, and indications for cesarean section. Adverse events considered were placental abruption, non-reassuring fetal status, tachysystole, and worsening of hypertensive condition.</p><p><strong>Results: </strong>A total of 400 patients were included (200 with hypertensive disorders, of whom 100 had severe preeclampsia). The success rate of cervical ripening was similar between patients with hypertensive disorders and healthy women (crude RR: 0.95, 95% CI: 0.88-1.03; adjusted RR for gestational age, maternal age, and parity 0.96, 95% CI: 0.88-1.04). The vaginal delivery rate was also similar (44% vs. 55%, <i>p</i>= 0.16). The median time to favorable Bishop score and to delivery was comparable between normotensive and hypertensive groups, even in severe cases. Cesarean delivery was mainly due to failed ripening and medical decision. Adverse events, except for tachysystole, were more frequent in the hypertensive group but did not reach statistical significance.</p><p><strong>Conclusion: </strong>Dinoprostone is effective in hypertensive pregnant women, including those receiving magnesium sulfate, with no significant differences compared to normotensive women.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"56 1","pages":"e2016719"},"PeriodicalIF":0.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12203923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic surgical alternative in the treatment of ruptured cornual heterotopic pregnancy.","authors":"Enrique Herrera Castañeda, Gustavo Luna, Jessica Sejnaui Sayegh, Luisa M Vacca Orrego, Juan Manuel Tobar Parra","doi":"10.25100/cm.v56i1.5576","DOIUrl":"10.25100/cm.v56i1.5576","url":null,"abstract":"<p><strong>Case description: </strong>A 35-year-old woman with a history of intrauterine device use for family planning presented with a spontaneously conceived heterotopic pregnancy.</p><p><strong>Clinical findings: </strong>The patient developed a ruptured cornual ectopic pregnancy, leading to hemodynamic instability and an acute abdomen, while concurrently carrying a viable intrauterine pregnancy.</p><p><strong>Treatment and outcome: </strong>A laparoscopic intervention was performed to manage the ruptured ectopic pregnancy. The surgical technique employed minimized the impact on maternal blood volume, ensuring patient stabilization and favorable progression of the intrauterine pregnancy.</p><p><strong>Clinical relevance: </strong>Heterotopic pregnancy is the coexistence of gestation in two different implantation sites, both intrauterine and extrauterine. This condition is associated with significant maternal morbidity and mortality. Management remains a challenge due to the lack of consensus and limited clinical experience. The primary goal is maternal stabilization while preserving the intrauterine pregnancy whenever possible. This case highlights the importance of modern surgical strategies tailored to optimize maternal and fetal outcomes.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"56 1","pages":"e5005576"},"PeriodicalIF":0.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What does Colombia require to earn a Nobel Prize in Medicine?","authors":"Mauricio Palacios Gómez, Derlin Yinery Porras Zapata","doi":"10.25100/cm.v56i1.6989","DOIUrl":"10.25100/cm.v56i1.6989","url":null,"abstract":"","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"56 1","pages":"e1006989"},"PeriodicalIF":1.3,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12440147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-minute sit-to-stand test reference values in people living at high altitudes.","authors":"Mauricio Morales-Satan, Sofía Dávila-Oña, Rodrigo Torres-Castro, Cristhel Hidrovo-Moreno, Matías Otto-Yáñez, Wilmer Esparza, Camila Madera, Carlos Moreta Nuñez, Pamela Serón, Lilian Solis-Navarro","doi":"10.25100/cm.v56i1.6674","DOIUrl":"10.25100/cm.v56i1.6674","url":null,"abstract":"<p><strong>Introduction: </strong>The one-minute sit-to-stand test (1min-STST) is a practical assessment tool for measuring functional ability. Reference values are currently unavailable for populations residing at high altitudes.</p><p><strong>Aims: </strong>This study to establish reference values for the 1min-STST in people living at high altitudes by sex and age range. Additionally, we correlate the variables analyzed with the number of repetitions obtained in the tests.</p><p><strong>Methods: </strong>Multicenter cross-sectional research was conducted, collecting data from two cities at high altitudes. Healthy adults between 18 and 80 years old were recruited. Anthropometric measurements, physical activity levels, smoking habits, and the number of repetitions during the 1min-STST were recorded. A multiple linear regression was performed to determine the predictive equations by sex. The stepwise method was used to generate the predictive model.</p><p><strong>Results: </strong>As many as 400 healthy subjects (58% women) were included. Participants had a median (P25-P75) height of 1.62 (1.56-1.68) cm, a weight of 63.0 (57.8-70.1) kg, and a BMI of 24.2 (22.5-26.0) kg/m². The predictive equations were: 1minSTST_Men=19.833 - (age* 0.168) + (height * 0.204) - (weight * 0.122); 1minSTST_Women= 27.845 - (age * 0.198) + (height * 0.145) - (weight* 0.094).</p><p><strong>Conclusion: </strong>The reference values for 1min-STST were determined for the healthy population aged 18-80 years living at high altitudes.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"56 1","pages":"e2006674"},"PeriodicalIF":0.7,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144530835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical practice guideline for the evaluation, treatment, and follow-up of children in contact with patients with pulmonary tuberculosis in Colombia.","authors":"Dione Benjumea-Bedoya, Jaime Alberto Robledo-Restrepo, Maria Patricia Arbelaez-Montoya, Andres Felipe Estupiñán-Bohorquez, Vanessa Sofia Sabella-Jimenez, Andrea Victoria Restrepo-Gouzy, Claudia Patricia Beltran-Arroyave, Jairo Bedoya-Giraldo, Jurg Niederbacher-Velasquez, Isabel Cristina Hurtado-Palacios, Lina Marcela Cadavid-Álvarez, Dora Elena Vanegas-Rojas, Maribel Murillo Tenorio, Lizeth Paniagua-Saldarriaga, Anibal Vicente Arteaga-Noriega, Javier M Sierra, Claudia Marcela Vélez, Jorge Humberto Botero-Garcés, Fernando Nicolas Montes-Zuluaga, Esteban Villegas-Arbelaez, David Castaño-Osorio, Victor Hugo Andrade-Agudelo, Lina Maria Pedraza-Moreno, Oscar Andrés Cruz-Martínez, Claudia Llerena-Polo, Andrea Juliana Gómez, Monica Gil-Artunduaga, María Lucia Cataño, Ivan D Florez","doi":"10.25100/cm.v56i1.5918","DOIUrl":"10.25100/cm.v56i1.5918","url":null,"abstract":"<p><strong>Introduction: </strong>The available clinical practice guidelines on tuberculosis infection are not exclusive to the pediatric population.</p><p><strong>Objective: </strong>To formulate evidence-based recommendations for the evaluation, treatment, and follow-up of children in contact with patients with pulmonary tuberculosis in Colombia.</p><p><strong>Methods: </strong>A multidisciplinary development panel (composed by clinical and field experts, researchers, and methodologists who declared conflicts of interests), including patient representatives, and decision-makers formulated 10 questions and prioritized outcomes related to diagnosis (clinical evaluation, chest X-ray, and interferon-gamma release assays-IGRA), treatment (efficacy of regimens in different clinical scenarios), and follow-up (monitoring and strategies to increase adherence) for children exposed to tuberculosis. We conducted systematic literature reviews to identify guidelines, systematic reviews, and primary studies. We assessed these sources' quality and risk of bias with specific tools. We synthesized the evidence narratively and, in some cases, performed de novo meta-analyses (diagnostic and network meta-analyses). We evaluated the certainty of evidence using the GRADE system. We used the GRADE evidence-to-recommendation framework to formulate the recommendations.</p><p><strong>Results: </strong>We recommend 1) the use of IGRA tests to identify tuberculosis infection and chest X-rays to screen for active tuberculosis in children exposed to tuberculosis, 2) short instead of extended regimens for children with and without immunosuppression, 3) levofloxacin or susceptibility-guided regimens in cases of contact with drug-resistant tuberculosis, 4) monthly clinical follow-up during the treatment, 5) the implementation of comprehensive approaches to identify barriers to encourage treatment adherence.</p><p><strong>Conclusions: </strong>The guideline panel provides context-specific, evidence-based recommendations for assessing and treating children exposed to tuberculosis in Colombia.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"56 1","pages":"e6005918"},"PeriodicalIF":1.3,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12180750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144477728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological autopsy study of suicide risk factors in the Colombian Coffee Region, 2017-2019.","authors":"Carolina González Zapata, Oscar Mauricio Castaño Ramírez, Jairo Franco Londoño, Juan Carlos Medina Osorio, Jennifer Nessim Salazar, Germán Moreno-Gómez, Leonardo Beltrán, María Catalina Echeverri-Londoño, Luz Damaris Rojas, Andrés Fandiño-Losada","doi":"10.25100/cm.v56i1.5175","DOIUrl":"10.25100/cm.v56i1.5175","url":null,"abstract":"<p><strong>Objective: </strong>To identify demographic, psychosocial, and life cycle risk factors for suicides in the Colombian Coffee zone between second half of 2017 and the end of 2019.</p><p><strong>Methods: </strong>A matched case-control design. A sample of 176 individuals, of which 101 were suicides (cases) and 75 were deaths by road traffic accidents (controls); psychological autopsies were used for research purposes. Penalized maximum likelihood logistic regression analyzes were conducted, indicating odds ratio of suicide, adjusting for sex, age group, province of legal autopsy and source of data. Logistic regressions were applied in three blocks: mental health issues, psychoactive substance use, and adversities during the life course. Statistical analysis was done with Stata®.</p><p><strong>Results: </strong>78.2% of cases and 84.0% of controls were male. The mean age of cases was 39 years, and of controls, 43 years. The key risk factors for suicide, at <i>p</i> <0.05, were forced labor during adolescence (OR: 32.41), financial dependence (OR: 4.3), verbal or physical abuse from the partner (OR: 10.28), any mental disorder (OR: 26.14), previous suicide attempt (OR: 11.64; <i>p</i>= 0.061), and record of major depressive disorder (OR: 24.86). A protective factor was death of a close relative at some point in life (OR: 0.34; <i>p</i>= 0.073).</p><p><strong>Conclusions: </strong>Forced labor in adolescence, verbal and physical abuse from the partner, financial dependence on others, any mental disorder, major depressive disorder, and previous suicide attempts were risk factors of suicide; the death of any close relative at some point in life was a protective factor of suicide.</p>","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"56 1","pages":"e2025175"},"PeriodicalIF":1.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12503112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychiatric medicalization in university life.","authors":"María Adelaida Arboleda-Trujillo","doi":"10.25100/cm.v55i4.6757","DOIUrl":"https://doi.org/10.25100/cm.v55i4.6757","url":null,"abstract":"","PeriodicalId":50667,"journal":{"name":"Colombia Medica","volume":"55 4","pages":"e1006757"},"PeriodicalIF":0.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}