OSMANGAZİ JOURNAL OF MEDICINE最新文献

Evaluation of Clinical and Epidemiologic Characteristics, Risk Factors and Treatment Regimens of Invasive Candida Infections in Children 评估儿童侵袭性念珠菌感染的临床和流行病学特征、风险因素和治疗方案

OSMANGAZİ JOURNAL OF MEDICINE Pub Date : 2024-07-16 DOI: 10.20515/otd.1422739

Yalçın Kara, Mahmut Can Kızıl, Merve İşeri Nepesov, E. Kaçmaz, Eylem Kıral, Gürkan Bozan, Yasemin Öz, Ömer Kılıç, Ener Çağrı Dinleyici

{"title":"Evaluation of Clinical and Epidemiologic Characteristics, Risk Factors and Treatment Regimens of Invasive Candida Infections in Children","authors":"Yalçın Kara, Mahmut Can Kızıl, Merve İşeri Nepesov, E. Kaçmaz, Eylem Kıral, Gürkan Bozan, Yasemin Öz, Ömer Kılıç, Ener Çağrı Dinleyici","doi":"10.20515/otd.1422739","DOIUrl":"https://doi.org/10.20515/otd.1422739","url":null,"abstract":"Invasive candida infections are one of the most common healthcare-associated infections. In this study, we have aimed both to determine the risk factors for invasive fungal infections and to evaluate clinical and epidemiologic characteristics of the cases. Pediatric cases who were followed up due to invasive fungal infection in Eskisehir Osmangazi University Hospital Pediatrics Clinic between January 2015 and March 2023 were included in the study. The study included 41 pediatric cases consisting of 23 (56%) males with an overall average age of 38 months. The most common candida species were Candida albicans (54%), Candida parapsilosis (27%), and Candida glabrata. The most common risk factors were prior antibiotherapy (100%), hospitalization (100%), intensive care unit stay (88%), central catheterization (88%), and total parenteral nutrition (TPN). C.albicans strains were resistant to fluconazole in 5%, caspofungin, and micafungin in 10% of the cases. C. parapicillosis strains were resistant to fluconazole in 37%, caspofungin in 45% micafungin in 55%, and amphotericin-B in only 9% of the cases. TPN use and mortality rates were higher in the C. albicans-infected group, negative blood culture persisted for a longer period in the non-albicans candida group.Invasive fungal infections are among the most important healthcare-associated infectious agents and the most important risk factors include the use of broad-spectrum antibiotics, prolonged hospital and intensive care unit stays, central catheterization, mechanical ventilation, TPN use, increased prophylactic antifungal and steroid use. Although C. albicans is still the most common candida species, C parapsilosis is being identified at an increasing rate.","PeriodicalId":506575,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141831801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Omalizumab for the Treatment of Bullous Pemphigoid: A Single Center Experience 奥马珠单抗治疗大疱性类天疱疮：单中心经验

OSMANGAZİ JOURNAL OF MEDICINE Pub Date : 2024-07-11 DOI: 10.20515/otd.1474691

E. Ağaoğlu, Hilal Kaya Erdoğan, Ersoy Acer, Halil İbrahim Yanık, Z. N. Saraçoğlu

{"title":"Omalizumab for the Treatment of Bullous Pemphigoid: A Single Center Experience","authors":"E. Ağaoğlu, Hilal Kaya Erdoğan, Ersoy Acer, Halil İbrahim Yanık, Z. N. Saraçoğlu","doi":"10.20515/otd.1474691","DOIUrl":"https://doi.org/10.20515/otd.1474691","url":null,"abstract":"Bullous pemphigoid is the most common bullous dermatosis seen in elderly population and accompanied by many comorbidities. Since immunoglobuline-E (Ig-E) antibodies play an important role in the pathogenesis of the disease, omalizumab targeting Ig-E proposes an effective and safe profile. In this study, we aimed to evaluate the efficacy and safety of omalizumab in bullous pemphigoid patients. Nineteen patients who received omalizumab treatment for at least 3 months with the diagnosis of bullous pemphigoid were included in the study. All patients had at least 1 comorbid condition, the most common being hypertension (79.0%) and type 2 diabetes mellitus (68.4%). The mean number of omalizumab treatments was 7.0±2.9. With omalizumab treatment, complete response was achieved in 11 (57.9%) of the patients and partial response was achieved in 8 (42.1%). The initial systemic steroid dose could be reduced in all patients with a complete response. All patients tolerated omalizumab without side‐effects. In conclusion, omalizumab is an effective and safe treatment option that reduces the need for systemic corticosteroids in patients with older age and multiple comorbidities. Further large-scale and prospective studies are needed to evaluate the efficacy of omalizumab in the treatment of bullous pemphigoid.","PeriodicalId":506575,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"108 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141657409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Features and Relapse/Refractory Disease Risk Factors of Patients with Acquired Thrombotic Thrombocytopenic Purpura in the Western Mediterranean Region of Turkey 土耳其西地中海地区获得性血小板减少性紫癜患者的特征和复发/难治性疾病风险因素

OSMANGAZİ JOURNAL OF MEDICINE Pub Date : 2024-07-09 DOI: 10.20515/otd.1478471

Ü. Ataş, Sevgi Gülşen, Lütfullah Zahit Koç, Orhan Kemal Yücel, U. Iltar, O. Salim, E. Kurtoğlu, L. Ündar, V. Karakuş

{"title":"Features and Relapse/Refractory Disease Risk Factors of Patients with Acquired Thrombotic Thrombocytopenic Purpura in the Western Mediterranean Region of Turkey","authors":"Ü. Ataş, Sevgi Gülşen, Lütfullah Zahit Koç, Orhan Kemal Yücel, U. Iltar, O. Salim, E. Kurtoğlu, L. Ündar, V. Karakuş","doi":"10.20515/otd.1478471","DOIUrl":"https://doi.org/10.20515/otd.1478471","url":null,"abstract":"The importance of parameters that predict and prevent relapse has increased in thrombotic thrombocytopenic purpura (TTP), where response and overall survival rates exceed 90% with current approaches. In this respect, we examined the clinical presentations, laboratory findings, treatments, treatment responses, states of relapsed/refractory disease and overall survival rates of immune-mediated TTP (iTTP) patients in the western Mediterranean region. 35 adult patients who were diagnosed with iTTP in the last 10 years were included in the study. The median follow-up period of the patients was 46 (2-118) months, and 32 patients (91.4%) survived. While clinical remission was achieved in 20 (57.1%) patients in the first-line treatment group, clinical remission was achieved in 20 of 21 patients who received second-line treatment due to relapsed/refractory disease. Rituximab, which was used as the first-line treatment in only 4 patients, was given to 14 patients as the second-line treatment. Due to relapse, 5 patients received third-line treatment, and 2 patients received fourth-line treatment. There was no relationship between age, sex, clinical presentation, laboratory findings, the number of plasmapheresis treatments, and either ADAMTS13 inhibitor levels or relapsed/refractory disease. Although several parameters, such as age, low ADAMTS13 activation, and high lactate dehydrogenase, have been reported to be prognostic in the past, we believe that these findings should be reconsidered with current treatment approaches that provide a greater than 90% response and overall survival. In our study, we did not detect either a predictive factor for relapsed/refractory disease or a clinical indicator influenced by ADAMTS13 inhibitor levels.","PeriodicalId":506575,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"40 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141663613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship Between Disaster Literacy and the Factors Affecting it and the State-Trait Anxiety in the Elderly of West Turkey 土耳其西部老年人的灾害知识及其影响因素与状态-特质焦虑之间的关系

OSMANGAZİ JOURNAL OF MEDICINE Pub Date : 2024-07-08 DOI: 10.20515/otd.1456174

Halide Karakaş, Mustafa Tözün

{"title":"Relationship Between Disaster Literacy and the Factors Affecting it and the State-Trait Anxiety in the Elderly of West Turkey","authors":"Halide Karakaş, Mustafa Tözün","doi":"10.20515/otd.1456174","DOIUrl":"https://doi.org/10.20515/otd.1456174","url":null,"abstract":"The aim of this study is to measure the effect of anxiety levels and some sociodemographic characteristics of elderly individuals, who are a vulnerable group in disasters, on their disaster literacy. This study is a cross-sectional type study. March May 7 – 2, 2022 residents of the nursing home, located in Izmir Metropolitan Municipality Social Life Campus in Buca district of Izmir province, are the Decedents of the study. As a working group, 210 people were reached. In the questionnaire form created in the study, some sociodemographic characteristics of the participants and their knowledge about disasters were questioned, the State-Continuous Anxiety Scale, Disaster Literacy Scale (DLS) were used. Multinominal Logistic Regression Analysis model was established with categorized of DLS's total score. The mean score of the DLS was insufficient with a score of 27.9±9.41. According to the results of multinomial regression analysis, high trait anxiety state (OR: 1,058 (95% CI: 1,010-1,111)) were found to be risk factors for \"insufficient\" disaster literacy level (p<0.05). Disaster literacy is a very important concept in protecting against the risks and dangers of disasters. In order to achieve a successful disaster management, all vulnerabilities in the society should be identified and the level of literacy should be increased.","PeriodicalId":506575,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"105 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Travmatik Kemik Çıkığı Olgularının Adli Tıbbi Değerlendirilmesi 创伤性骨脱位病例的法医评估

OSMANGAZİ JOURNAL OF MEDICINE Pub Date : 2024-07-08 DOI: 10.20515/otd.1490838

Ümit Şimşek, E. Atalay, Aytek Hüseyin Çeliksöz, Kenan Karbeyaz

{"title":"Travmatik Kemik Çıkığı Olgularının Adli Tıbbi Değerlendirilmesi","authors":"Ümit Şimşek, E. Atalay, Aytek Hüseyin Çeliksöz, Kenan Karbeyaz","doi":"10.20515/otd.1490838","DOIUrl":"https://doi.org/10.20515/otd.1490838","url":null,"abstract":"Türk Ceza Kanunu’nda, yaralanma nedeni ile kemik çıkığı oluşması halinde cezanın artırılacağı belirtilmiştir. Bu çalışmada, Adli Tıp Anabilim Dalı’na yansıyan travmatik çıkık olgularının değerlendirilmesi, olay türlerinin, olgulara ait demografik verilerin ve adli rapor içeriklerinin literatürle paylaşılması amaçlanmıştır. Çalışmamızda 1 Ocak 2014 ile 1 Ocak 2024 tarihleri arasındaki 10 yıllık dönemde Adli Tıp Anabilim Dalı’na başvuran tüm travmatik çıkık olguları retrospektif olarak değerlendirilmiştir. Olguların, yaş, yaş grubu, cinsiyet, olay türü, olay orijini, çıkığın lokalizasyonu, eşlik eden diğer bulgular, tedavi türü, tedavi olduğu bölüm, hastanede yatma süresi, adli rapor içerikleri incelenmiştir. 10 yıllık dönemde Anabilim dalımıza 138 travmatik kemik çıkığı olgusu başvurmuştur. 138 olgunun 97’sinin (% 70,3) erkek olduğu, yaş ortalamasının 29,5±7,2 olduğu belirlenmiştir. Yaralanmaların 76’sının (% 55,1) kaza, 62’sinin (% 44,9) etkili eylem nedeniyle meydana geldiği saptanmıştır. En sık travmatik omuz çıkığı olgusuna rastlanılmıştır (n=31, % 22,5). Sunulan çalışmada elde edilen bulgular, adli travmatolojiyi ilgilendiren literatürle genel olarak uyumlu bulunmuştur. Kemik çıkığı olgularında, radyolojik bulgular, ortopedi başta olmak üzere ilgili bölümlerin muayene bulguları ve tedavi süreçleri adli rapora esas teşkil etmektedir. Travmatik çıkık olgularında ilgili bölümlerle iş birliği içinde çalışılmalıdır.","PeriodicalId":506575,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"101 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ruh Sağlığı Alanında Yapay Zeka Araştırmaları: Bibliyometrik Bir Değerlendirme 心理健康领域的人工智能研究：文献计量学评估

OSMANGAZİ JOURNAL OF MEDICINE Pub Date : 2024-07-08 DOI: 10.20515/otd.1435157

Esra Uslu, Emrah Atılgan

{"title":"Ruh Sağlığı Alanında Yapay Zeka Araştırmaları: Bibliyometrik Bir Değerlendirme","authors":"Esra Uslu, Emrah Atılgan","doi":"10.20515/otd.1435157","DOIUrl":"https://doi.org/10.20515/otd.1435157","url":null,"abstract":"Bu çalışmada ruh sağlığı alanındaki yapay zeka yayınlarının bibliyometrik olarak incelenmesi amaçlanmıştır. Çalışmada 1984 ile 2024 yılları arasında Web of Science veri tabanında İngilizce \"mental health and artificial intelligence- ruh sağlığı ve yapay zeka\" anahtar kelimeleri ile belirlenen 2773 makale incelenmiştir. Veri analizi ve grafiksel sunumlar, R yazılımındaki Bibliometrix Paketi kullanılarak yapılmıştır. Çalışmaların ortalama yayın yaşı 2,7 ve yıllık artış oranı %18,36 olarak belirlenmiştir. En aktif ülke Amerika Birleşik Devletleri ve Çin olup, en fazla yayın yapan dergi Frontiers in Psychiatry'dir. Makine öğrenimi konusu, alanın hem en sık kullanılanı hem de öncü temasıdır. Benzer şekilde, Chatbot, alanı şekillendiren temalar arasında yer almaktadır. Alzheimer Hastalığı ve bipolar bozukluk, ortaya çıkan veya kaybolan temalar (emerging or declining themes) arasındadır. Derin öğrenme, şizofreni ve demans konuları, alanı şekillendiren temaların gelişmeye devam etmekte, gelişmiş ancak izole kalmış, ortaya çıkan veya kaybolmaya başlayanların kesişim noktasında bulunmaktadır. Bu çalışma ile bibliyometrik verileriler kullanarak ruh sağlığı alanındaki YZ çalışmalarının performansı ve kapsamı analiz edilmiştir. Sonuçlar, konuya ilgi duyan bilgi teknolojileri ve ruh sağlığı profesyonellerine çalışmalarında rehberlik edebilir.","PeriodicalId":506575,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":" 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141670092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stem Cell Studies of Professor Doctor Sureyya Tahsin Aygun Sureyya Tahsin Aygun 教授的干细胞研究

OSMANGAZİ JOURNAL OF MEDICINE Pub Date : 2024-07-04 DOI: 10.20515/otd.1495919

Hakan Ay, Abdullah Ortadeveci, Burak Küçük, Hilmi Özden

{"title":"Stem Cell Studies of Professor Doctor Sureyya Tahsin Aygun","authors":"Hakan Ay, Abdullah Ortadeveci, Burak Küçük, Hilmi Özden","doi":"10.20515/otd.1495919","DOIUrl":"https://doi.org/10.20515/otd.1495919","url":null,"abstract":"Stem cells are unspecialized cells in the human body. They can differentiate into any cell of the organism and have the ability to renew themselves. Thus, they contribute to the formation of all mature cells in the body and form the basis of every cell, tissue and organ. A stem cell can ensure both self-renewal and differentiation. \u0000Süreyya Tahsin Aygün received his Ph.D. from the Berlin School of Veterinary Medicine in 1926. He focused on cell culture and conducted studies on cardiac stem cells. He observed the regenerative and proliferative capacity of cardiac stem cells. Aygün concluded that young, immature, homogeneous human cells have an unexpected medical effect because animal cells are suitable for animal organism and human cells are suitable for human organism. Aygün's treatment with human cell cultures can be used for many diseases such as heart, kidney, liver and circulatory diseases, stroke, tumors, schizophrenia and multiple sclerosis. Even prolongation of physiological age and life expectancy combined with visible rejuvenation has come into the realm of possibility as pathophysiologically aging cells regress and are replaced by young, viable human cultured cells. \u0000Süreyya Tahsin Aygün is the first Turkish scientist to work on stem cells. Süreyya Tahsin Aygün's studies in Germany and Turkey demonstrate his contribution to stem cell and regenerative medicine. Looking at Aygün's other studies, one better understands the importance of joint research between veterinary medicine and medicine. Ord. prof. Aygün's work \"Die Human-Zellkultur-Therapie, Neue erfolgreiche Möglichkeiten zur Therapie des Mongolismus und anderer Krankheiten\" and other works should be reissued in view of their contribution to today's medical developments.","PeriodicalId":506575,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tıp Fakültesi Öğrencilerinde Gece Yeme Sendromu ve Kronik Kas İskelet Sistemi Ağrıları Arasındaki İlişki 医学生夜食综合征与慢性肌肉骨骼疼痛之间的关系

OSMANGAZİ JOURNAL OF MEDICINE Pub Date : 2024-07-02 DOI: 10.20515/otd.1481787

Fulya Bakılan, Barış Akzorba, Elif Amet, Harun Doğantürk, Tarık Özdemir, Türkan Hüseynli, Zenfira Babazade

{"title":"Tıp Fakültesi Öğrencilerinde Gece Yeme Sendromu ve Kronik Kas İskelet Sistemi Ağrıları Arasındaki İlişki","authors":"Fulya Bakılan, Barış Akzorba, Elif Amet, Harun Doğantürk, Tarık Özdemir, Türkan Hüseynli, Zenfira Babazade","doi":"10.20515/otd.1481787","DOIUrl":"https://doi.org/10.20515/otd.1481787","url":null,"abstract":"Giriş: Literatürde gece yeme sendromu olan bireylerde kronik kas iskelet sistemi ağrısının daha fazla görülüp görülmediğini araştıran bir çalışmaya rastlamamıştır. Bu çalışmanın amacı, tıp fakültesi birinci sınıf öğrencilerinde gece yeme sendromu ve kas iskelet sisteminde kronik ağrı sıklığı belirlemek ve gece yeme sendromu olanlarda, olmayanlara kıyasla kronik kas iskelet sistemi ağrısının daha sık görülüp görülmediğini araştırmaktır. \u0000Gereç ve yöntem: Bu çalışma Tıp Fakültesi 1. Sınıftaki 177 öğrenci ile gerçekleştirilmiştir. Demografik özellikler sorgulanmıştır. Kas iskelet sisteminde en az 3 aydır kronik ağrı varlığı, ağrılı bölge sayısı, ağrılı bölgelerin yeri sorgulanmış, ağrı şiddeti ise Vizüel Analog Skala ile değerlendirilmiştir. Gece yeme sendromu tanısı ile Allison ve arkadaşlarının geliştirdiği tanı ölçütleri ile konulmuştur. \u0000Sonuç: Gece yeme sendromu sıklığı %20,3, kronik kas iskelet sistemi ağrısı sıklığı %25,4 olarak saptanmıştır. Öğrenciler gece yeme sendromu olan ve olmayan olarak iki gruba ayrılmıştır. Demografik özellikler, Vizüel Analog Skala, ağrılı bölgelerin dağılımı açısından her 2 grup arasında istatistiksel olarak anlamlı bir fark saptanmamıştır. Gece yeme sendromu olan öğrencilerin %36’sında kas iskelet sisteminin herhangi bir yerinde kronik ağrı saptanırken, gece yeme sendromu olmayan öğrencilerde bu oran daha düşük, %22 olarak saptanmıştır. Ancak bu farklılık istatistiğe yansımamıştır. İstatistiksel olarak anlamlı tek farklılık gece yeme sendromu olan öğrencilerin yüksek olan ağrılı bölge sayısında idi. \u0000Tartışma: Öğrencilere gece yeme sendromunun yol alabileceği durumlar ve doğru beslenme alışkanlıkları ile ilgili eğitimler planlanmalıdır.","PeriodicalId":506575,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"23 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141685507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erişkin Bağışıklamada Kaçan Fırsatlar 错失成人免疫机会

OSMANGAZİ JOURNAL OF MEDICINE Pub Date : 2024-07-02 DOI: 10.20515/otd.1491532

Hasip Kahraman

{"title":"Erişkin Bağışıklamada Kaçan Fırsatlar","authors":"Hasip Kahraman","doi":"10.20515/otd.1491532","DOIUrl":"https://doi.org/10.20515/otd.1491532","url":null,"abstract":"Çocukluk dönemi aşı programlarının yaygın kullanımı ile çok sayıda bulaşıcı hastalığın morbidite ve mortalitesi önemli ölçüde azaltılabilmiştir ancak erişkin yaş grubunda aşı ile önlenebilir hastalıklar halen önemli bir halk sağlığı sorunu olmaya devam etmektedir. Bu çalışmada, aşılama endikasyonu bulunan erişkin yaş grubundaki kişilerin altta yatan risk faktörlerine göre aşılanma oranlarının değerlendirilmesi amaçlanmıştır. Bu çalışmada 01.04.2024-30.04.2024 tarihleri arasında enfeksiyon hastalıkları polikliniğine başvuran 18 yaş ve üzeri olgular retrospektif olarak değerlendirilmiştir. Olguların yaş grupları veya altta yatan risk faktörlerine (diyabet, malignite, kronik akciğer, renal veya kardiyak hastalık, sağlık çalışanı vb.) göre aşılama endikasyonları ve aşılama oranları değerlendirildi. Polikliniğimizde değerlendirilen 495 olgunun %56'sını kadın hastalar oluştururken, yaş ortalaması 46,1 ± 18,1 yıl idi. Olguların %19,6'sı 65 yaş ve üzerindeydi ve %15,2'sinin aşılanmaya engel bir durumu bulunmaktaydı. Polikliniğe başvuran 177 kişide kronik hastalık saptanmazken, 201 olguda bir, 117 olguda ise iki veya daha fazla kronik hastalık mevcuttu. Kronik hastalıklar arasında en yaygın olanlar diyabet, hipertansiyon, HIV, otoimmün hastalıklar ve malignitelerdi. Olguların son 10 yıl içindeki aşılama durumlarına göre en yaygın uygulanan aşılar Covid-19, difteri/tetanoz ve pnömokok aşılarıydı. Aşılama endikasyonları benzer olmasına rağmen, tüm hasta gruplarında influenza aşısının pnömokok aşısına kıyasla daha düşük seviyelerde uygulandığı görüldü. Sağlık hizmeti sunucularının erişkin aşılaması konusunda farkındalıklarını artırmak, erişkin bağışıklama polikliniklerinde danışmanlık hizmetlerinin güçlendirilmesi, aşıya erişim kolaylığının sağlanması ve toplum bilincinin artırılması aşılamada kaçan fırsatların önüne geçilmesinde önemli bir katkı sağlayacaktır.","PeriodicalId":506575,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"360 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141686386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene Expression Patterns and Phenotypic Associations in Chondrogenesis: Insights into Skeletal Dysplasia Nosology 软骨形成过程中的基因表达模式和表型关联：骨骼发育不良命名的启示

OSMANGAZİ JOURNAL OF MEDICINE Pub Date : 2024-07-01 DOI: 10.20515/otd.1493433

B. Karaosmanoğlu, M. S. Ozisin, Gozde Imren, E. Taşkıran

{"title":"Gene Expression Patterns and Phenotypic Associations in Chondrogenesis: Insights into Skeletal Dysplasia Nosology","authors":"B. Karaosmanoğlu, M. S. Ozisin, Gozde Imren, E. Taşkıran","doi":"10.20515/otd.1493433","DOIUrl":"https://doi.org/10.20515/otd.1493433","url":null,"abstract":"The differentiation of mesenchymal stem cells (MSCs) into chondrocytes, known as chondrogenesis, is a complex process that plays a fundamental role in cartilage formation and skeletal development. This study elucidates the transcriptional dynamics and phenotypic correlations at various stages of chondrogenesis (early, mid, and late) using RNA-seq data. We focused on the differential expression of transcription factors (TFs) and RNA-binding proteins (RBPs). We identified critical genes during their highest expression periods and generated heatmaps to visualize these temporal patterns. Additionally, we conducted a comprehensive analysis of skeletal dysplasia nosology genes, determining their highest expression periods and phenotypic implications using the DisGeNET database. Our findings reveal that early-stage (D1) gene expression is linked to craniofacial development and limb formation anomalies, primarily involving genes responsible for extracellular matrix (ECM) organization and signal transduction. Mid-stage (D7) genes are associated with cartilage matrix composition and skeletal growth, highlighting roles in chondrocyte proliferation and matrix deposition. Late-stage (D21) genes are implicated in bone mineral density, cartilage integrity, and joint formation, ensuring the maturation and functionality of cartilage tissue. This study provides a detailed analysis of gene expression regulators and their phenotypic correlations during chondrogenesis, offering insights into the molecular mechanisms driving cartilage development and skeletal dysplasias. Understanding these temporal gene expression patterns enhances our knowledge of chondrogenesis and aids in developing targeted therapies for cartilage-related diseases. These findings underscore the significance of time-point analyses in capturing the dynamic regulation of gene expression throughout the differentiation process.","PeriodicalId":506575,"journal":{"name":"OSMANGAZİ JOURNAL OF MEDICINE","volume":"106 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141695462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0