Computer Aided Surgery最新文献

{"title":"Accuracy of navigation in hip resurfacing with different surgeons and varying anatomy.","authors":"Iris Schleicher,&nbsp;Matthias Haselbacher,&nbsp;Eckart Mayr,&nbsp;Peter M Kaiser,&nbsp;Florian W Lenze,&nbsp;Alexander Keiler,&nbsp;Michael Nogler","doi":"10.3109/10929088.2011.652674","DOIUrl":"https://doi.org/10.3109/10929088.2011.652674","url":null,"abstract":"<p><p>The accuracy of a commercial imageless navigation system for hip resurfacing and its reproducibility among different surgeons and for varying femoral anatomy was tested by comparing conventional and navigated implantation of the femoral component on different sawbones in a hip simulator. The position of the component was measured on postoperative radiographs. Variance for varus/valgus alignment and anteversion was higher for conventional implantation. Among the three surgeons, operation time, chosen implant size and anteversion were significantly different for conventional implantation but not for the navigated method. Using navigation, no difference was found for normal and abnormal anatomy. Values obtained with the navigation system were consistent with those measured on radiographs. Navigation appeared to be accurate and helped to reduce outliers. This was true for the three different surgeons and in varying anatomical situations.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 2","pages":"77-85"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2011.652674","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30471937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometric analysis of anatomical implant forms for minimally invasive acetabular fracture osteosynthesis.","authors":"Dirk Maier,&nbsp;Lukas Kamer,&nbsp;Hansrudi Noser,&nbsp;Zoran Stankovic,&nbsp;Andreas Guth,&nbsp;Peter Bäurle,&nbsp;Norbert P Südkamp,&nbsp;Wolfgang Köstler","doi":"10.3109/10929088.2012.709278","DOIUrl":"https://doi.org/10.3109/10929088.2012.709278","url":null,"abstract":"<p><strong>Introduction: </strong>Anatomical implants enable minimally invasive osteosynthesis (MIO) and represent ideal complements of computer-assisted surgical workflows. This 3D morphometric study analyzes anatomical implant forms (AIF) for acetabular fracture osteosynthesis (AFO).</p><p><strong>Materials and methods: </strong>Three-dimensional pelvis models were created from clinical CT data of 99 European-Caucasian patients (50 females, 49 males). The mean age of the patients was 60.1 years (range: 20-89; SD 10.8). Definition of a referential region of interest (ROI) corresponding to an AIF for AFO was followed by automated ROI computation for each of the 198 hemipelvises. Three-dimensional statistical modeling and analysis of the resulting 198 homologous ROIs consisted of thin-plate spline transformation, generalized Procrustes fit, and principal component analysis.</p><p><strong>Results: </strong>The mean ROI length was 18.2 cm (range: 16.1-20.1 cm; SD 0.76). The first principal component (PC1) mainly modeled the ROI length, which correlated well with body height (r = 0.325; p < 0.001). PC1 comprised 47.4% of the overall ROI form variation. PC2 primarily influenced the ROI curvature in the anterior-posterior (inlet) view. Curvatures were more pronounced in female patients compared to males (p < 0.001). There was no gender-specific ROI size variation. PC1-4 contained 80.2% of the total ROI form variation. Left and right ROI forms displayed symmetry.</p><p><strong>Conclusion: </strong>This 3D morphometric study demonstrates the feasibility of anatomical implants for minimally invasive acetabular fracture osteosynthesis. Implant size/length is by far the most important variable of form variation. The necessity of gender-specific implant forms requires further investigation. The non-fractured, contralateral hemipelvis can be used for preoperative surgical planning. Ultimately, the plate design will depend on prospective implant fit tests based on the required fit as defined by the clinician.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 5","pages":"240-8"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.709278","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30791511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the femoral anteversion measurement method used in imageless navigation.","authors":"Glen A Turley,&nbsp;Shahbaz M Y Ahmed,&nbsp;Mark A Williams,&nbsp;Damian R Griffin","doi":"10.3109/10929088.2012.690230","DOIUrl":"https://doi.org/10.3109/10929088.2012.690230","url":null,"abstract":"<p><p>Total hip arthroplasty restores lost mobility to patients suffering from osteoarthritis and acute trauma. In recent years, navigated surgery has been used to control prosthetic component placement. Furthermore, there has been increasing research on what constitutes correct placement. This has resulted in the definition of a safe-zone for acetabular cup orientation. However, there is less definition with regard to femoral anteversion and how it should be measured. This study assesses the validity of the femoral anteversion measurement method used in imageless navigation, with particular attention to how the neutral rotation of the femur is defined. CT and gait analysis methodologies are used to validate the reference which defines this neutral rotation, i.e., the ankle epicondyle piriformis (AEP) plane. The findings of this study indicate that the posterior condylar axis is a reliable reference for defining the neutral rotation of the femur. In imageless navigation, when these landmarks are not accessible, the AEP plane provides a useful surrogate to the condylar axis, providing a reliable baseline for femoral anteversion measurement.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 4","pages":"187-97"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.690230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30676369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of robot-assisted and conventional total knee arthroplasty: a controlled cadaver study using multiparameter quantitative three-dimensional CT assessment of alignment.","authors":"Young-Wan Moon,&nbsp;Chul-Won Ha,&nbsp;Kwan-Hong Do,&nbsp;Chang-Young Kim,&nbsp;Jeong-Hoon Han,&nbsp;Sang-Eun Na,&nbsp;Choong-Hee Lee,&nbsp;Jae-Gyoon Kim,&nbsp;Youn-Soo Park","doi":"10.3109/10929088.2012.654408","DOIUrl":"https://doi.org/10.3109/10929088.2012.654408","url":null,"abstract":"<p><strong>Introduction: </strong>A functional total knee replacement has to be well aligned, which implies that it should lie along the mechanical axis and in the correct axial and rotational planes. Incorrect alignment will lead to abnormal wear, early mechanical loosening, and patellofemoral problems. There has been increased interest of late in total knee arthroplasty with robotic assistance. This study was conducted to determine whether robot-assisted total knee arthroplasty is superior to the conventional surgical method with regard to the precision of implant positioning.</p><p><strong>Materials and methods: </strong>Twenty knee replacements, comprising ten robot-assisted procedures and ten conventional operations, were performed on ten cadavers. Two experienced surgeons performed the surgeries. Both procedures on each cadaver were performed by the same surgeon. The choice of which procedure was to be performed first was randomized. Following implantation of the prosthesis, the mechanical axis deviation, femoral coronal angle, tibial coronal angle, femoral sagittal angle, tibial sagittal angle, and femoral rotational alignment were measured via 3D CT scanning. These variables were then compared with the preoperatively planned values.</p><p><strong>Results: </strong>In the knees that underwent robot-assisted surgery, the mechanical axis deviation ranged from -1.94° to 2.13° (mean: -0.21°), the femoral coronal angle from 88.08° to 90.99° (mean: 89.81°), the tibial coronal angle from 89.01° to 92.36° (mean: 90.42°), the tibial sagittal angle from 81.72° to 86.24° (mean: 83.20°), and the femoral rotational alignment from 0.02° to 1.15° (mean: 0.52°) in relation to the transepicondylar axis. In the knees that underwent conventional surgery, the mechanical axis deviation ranged from -3.19° to 3.84° (mean: -0.48°), the femoral coronal angle from 88.36° to 92.29° (mean: 90.50°), the tibial coronal angle from 88.15° to 91.51° (mean: 89.83°), the tibial sagittal angle from 80.06° to 87.34° (mean: 84.50°), and the femoral rotational alignment from 0.32° to 4.13° (mean: 2.76°) in relation to the transepicondylar axis. In the conventional knee replacement group, there were two instances of outliers outside the range of 3° varus/valgus for the mechanical axis deviation. The robot-assisted knee replacements showed significantly superior femoral rotational alignment results compared with conventional surgery (p = 0.006). There was no statistically significant difference between robot-assisted and conventional total knee arthroplasty with regard to the other variables. All the measurements showed high intra-observer and inter-observer reliability.</p><p><strong>Conclusion: </strong>Robot-assisted total knee arthroplasty showed excellent precision in the sagittal and coronal planes of the 3D CT scan. In particular, the robot-assisted technique showed better accuracy in femoral rotational alignment compared to the conventional surgery, despite the fact that ","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 2","pages":"86-95"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.654408","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30471938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgically oriented measurements for three-dimensional characterization of tunnel placement in anterior cruciate ligament reconstruction.","authors":"Austin J Ramme,&nbsp;Brian R Wolf,&nbsp;Bryan A Warme,&nbsp;Kiran H Shivanna,&nbsp;Michael C Willey,&nbsp;Carla L Britton,&nbsp;Vincent A Magnotta,&nbsp;Nicole M Grosland","doi":"10.3109/10929088.2012.707230","DOIUrl":"https://doi.org/10.3109/10929088.2012.707230","url":null,"abstract":"<p><strong>Objective: </strong>To develop and evaluate the feasibility and reliability of an alternative three-dimensional (3D) measurement system capable of characterizing tunnel position and orientation in ACL reconstructed knees.</p><p><strong>Methods: </strong>We developed a surgically oriented 3D measurement system for characterizing femoral and tibial drill tunnels from ACL reconstructions. This is accomplished by simulating the positioning of the drill bit originally used to create the tunnels within the bone, which allows for angular and spatial descriptions along defined axes that are established with respect to previously described anatomic landmarks and radiographic views. Computer-generated digital phantoms composed of simplified geometries were used to verify proper calculation of angular and spatial measurements. We also evaluated the inter-observer reliability of the measurements using 10 surfaces generated from cadaveric knees in which ACL tunnels were drilled. The reliability of the measurements was evaluated by intraclass correlation coefficients.</p><p><strong>Results: </strong>The digital phantom evaluation verified the measurement methods by computing angular and spatial values that matched the known values in all cases. The intraclass correlation coefficient was calculated for four users and was found to range from 0.95 to 0.99 for the femoral and tibial measurements, demonstrating near-perfect agreement.</p><p><strong>Conclusions: </strong>The characterization of ACL tunnels has historically concentrated on two-dimensional (2D) measurements; however, it can be difficult to define ACL tunnel placement using 2D methods. We have presented novel techniques for defining graft tunnel placement from 3D surface representations of the ACL reconstructed knee. These measurements provide exact tunnel location spatially and along axes that offer the potential to comparatively analyze ACL reconstructions post-operatively using advanced imaging. These methods are reliable, and have been demonstrated to be applicable to multiple single-bundle techniques for ACL reconstruction.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 5","pages":"221-31"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.707230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30838198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomical relationships of human pelvises and their application to registration techniques.","authors":"Martin Haimerl,&nbsp;Mario Schubert,&nbsp;Melanie Wegner,&nbsp;Sabine Kling","doi":"10.3109/10929088.2012.711368","DOIUrl":"https://doi.org/10.3109/10929088.2012.711368","url":null,"abstract":"<p><p>Knowledge of consistent anatomical relationships is an important criterion for establishing registration procedures for orthopedic navigation systems. Based on an analysis of 420 CT data sets, we investigated whether a robust registration of the pelvis in a lateral decubitus position could be achieved based on anatomical relationships. For this purpose, we assessed basic statistics and variation in anatomical parameters. It was found that inter-teardrop and inter-fossa distances exhibit a high degree of consistency in pelvises of the same gender. Additionally, stable relationships were found between the anterior pelvic plane (APP) and other reference planes that rely on acetabular points instead of pubic points. Based on these results, a registration procedure for the pelvis was developed which uses only landmarks that are accessible intra-operatively from the ipsilateral side. The deviation between a standard APP registration and this new registration method was assessed. For a standard cup position (40° inclination, 15° anteversion), the resulting deviations were found to be 0.15 ± 2.86° for inclination and 0.27 ± 3.46° for anteversion. Of the registrations, 99% had cup positions within the Lewinnek safe zone. This shows that accurate lateral pelvis registration based on anatomical relationships is achievable.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 5","pages":"232-9"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.711368","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30838199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of a patient-specific CAD/CAM surgical jig in extremity bone tumor resection and custom prosthetic reconstruction.","authors":"K C Wong,&nbsp;S M Kumta,&nbsp;K Y Sze,&nbsp;C M Wong","doi":"10.3109/10929088.2012.725771","DOIUrl":"https://doi.org/10.3109/10929088.2012.725771","url":null,"abstract":"<p><p>Computer navigation has recently been introduced for bone tumor surgery in the orthopedic field, with the aim of achieving increased accuracy and precision in tumor resection and in custom prosthetic reconstruction. However, the technique requires bulky navigation facilities, the presence of a system operator in the operating room, and surgeons with prior experience in navigated surgery. We describe a new and simple method of using a patient-specific computer-aided design/computer-aided modeling (CAD/CAM) surgical jig to realize the preoperative planning in the surgical field. The accuracy of the proposed method was first tested in a cadaver trial. It took one minute to set the location of the jig prior to the bone resection and three minutes to perform the bone resections via the cutting slits of the jig. The dimensional difference between the achieved and planned bone resection was <1 mm on validation with the help of a junctional plate and a navigation system. The technique was then applied successfully to a patient with a low-grade osteosarcoma of the femur. An intercalated tumor resection was performed using a patient-specific surgical jig, and a custom CAD prosthesis reconstruction matched accurately to the skeletal defect. Further assessment in a larger population is necessary to determine the clinical efficacy of the technique.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 6","pages":"284-93"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.725771","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30949898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinematics and laxity of a linked total elbow arthroplasty following computer navigated implant positioning.","authors":"James R Brownhill,&nbsp;Colin P McDonald,&nbsp;Louis M Ferreira,&nbsp;J W Pollock,&nbsp;James A Johnson,&nbsp;Graham J W King","doi":"10.3109/10929088.2012.706644","DOIUrl":"https://doi.org/10.3109/10929088.2012.706644","url":null,"abstract":"<p><p>Aseptic loosening in total elbow arthroplasty (TEA) remains the most common cause of long-term failure. While several different mechanisms of implant loosening have been suggested, it is likely that one important underlying cause is implant malpositioning, resulting in changes in joint kinematics and loading. Although use of computer navigation has been shown to improve component positioning in other joints, no such system currently exists for the elbow. This study used real-time computer feedback for humeral, ulnar, and radial component positioning in 11 cadaveric extremities. An elbow motion simulator evaluated joint kinematics. Endosteal abutment of the stems of the humeral and ulnar components precluded optimal positioning in 5 and 6 specimens, respectively. Loss of the normal valgus angulation following elbow arthroplasty (p < 0.05) suggests that errors in humeral component positioning translate directly into changes in joint kinematics during active motion. These findings suggest that although computer navigation can reproduce normal joint kinematics, optimal implant positioning may require a TEA system which allows for some modularity to accommodate the normal variations in osseous morphology of the elbow.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 5","pages":"249-58"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.706644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30790682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy assessment of an imaging technique to examine ulnohumeral joint congruency during elbow flexion.","authors":"Emily A Lalone,&nbsp;Terry M Peters,&nbsp;Graham W King,&nbsp;James A Johnson","doi":"10.3109/10929088.2012.673638","DOIUrl":"https://doi.org/10.3109/10929088.2012.673638","url":null,"abstract":"<p><p>A CT-based imaging technique to investigate ulnohumeral joint congruency of elbows undergoing physiologic flexion is introduced. This technique, which employed landmark registration and a previously developed inter-bone distance algorithm, was validated experimentally. Results obtained with this imaging technique were validated in a single specimen by comparing the resulting joint congruency maps to results obtained with experimental casting in a static position. Additionally, the accuracy of the registration technique was assessed in four specimens using fiducial and target registration error to evaluate the positional and angular accuracy. Preliminary data from an intact cadaveric elbow was shown to demonstrate the utility of this technique. The overall accuracy of the registration was better than 1 mm, and the congruency maps showed excellent correspondence with the casting, validating the use of a CT-based imaging technique to examine the congruency of joints undergoing quasi-static flexion.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 3","pages":"142-52"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.673638","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30563679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of measurements of herniary area and volume and abdominal cavity volume in the treatment of incisional hernia: application of CT 3D reconstruction in 17 cases.","authors":"Sheng Yao,&nbsp;Ji-ye Li,&nbsp;Fei-de Liu,&nbsp;Li-juan Pei","doi":"10.3109/10929088.2011.636453","DOIUrl":"https://doi.org/10.3109/10929088.2011.636453","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the value of CT 3D reconstruction in the diagnosis and treatment of incisional hernia and the related factor of abdominal cavity volume.</p><p><strong>Methods: </strong>Abdominal wall defect and herniary volume were measured using 3D reconstruction based on plain CT scans in 17 patients with incisional hernias.</p><p><strong>Results: </strong>The herniary diameter, area and volume could be measured in the 17 patients and the abdominal cavity volume was also measured in 10 patients using the 3D reconstruction technique. The correlation indices of the abdominal cavity volume with the patient's height, weight and body mass index (BMI) were all less than 0.01.</p><p><strong>Conclusion: </strong>Herniary area and volume and abdominal cavity volume can be accurately calculated through CT 3D reconstruction. The patch area should be more than 5 times as large as the defect area; combined with the perioperative overlap margin measurement method, this results in more scientific surgical management. The ratio of the herniary volume to the abdominal cavity volume may be conducive to preoperative assessment of the risk of abdominal compartment syndrome (ACS); however, the ratio that may lead to postoperative ACS remains to be determined. There are correlations of abdominal cavity volume with patient height, weight and BMI, especially with weight. We therefore propose that the abdominal cavity volume should be evaluated with internationally accepted indices.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"17 1","pages":"40-5"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2011.636453","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30305510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}