Computer Aided Surgery最新文献

{"title":"Computerized ellipse method for measuring acetabular version after total hip replacement--a precision study using synthetic and real radiographs.","authors":"Chen-Kun Liaw,&nbsp;Tai-Yin Wu,&nbsp;Sheng-Mou Hou,&nbsp;Rong-Sen Yang,&nbsp;Kao-Shang Shih,&nbsp;Chiou-Shann Fuh","doi":"10.3109/10929088.2013.779749","DOIUrl":"https://doi.org/10.3109/10929088.2013.779749","url":null,"abstract":"<p><strong>Background: </strong>Previous work by our group to address the problem of acetabular positioning based on 2D methods resulted in the development of a measurement method with better precision--Liaw's version. This method may help the early diagnosis of acetabular loosening. In the present study, we hypothesized that our computerized ellipse method could improve the precision of measuring acetabular version.</p><p><strong>Methods: </strong>We developed our Elliversion software to measure acetabular version. Using total hip replacement (THR) Simulator, 96 radiographs were synthesized with random femoral inclination and 5° to 52° version, half with the femoral head included and half without. These synthetic radiographs and 28 real radiographs were measured with both Elliversion and the trigonometric method twice by one of the authors with a one-week interval between measurements. We then calculated the difference in the repeated measurements. Student's t-test was used for statistical analysis of the measuring error and inter-measurement difference.</p><p><strong>Results: </strong>In the precision study, for synthetic radiographs including the femoral head, the ellipse method was significantly better than the trigonometric method (p < 0.01). For synthetic radiographs without the femoral head, there was no significant difference between the ellipse method and the trigonometric method (p = 0.19). As for the repeated measurements, for synthetic radiographs including the femoral head, the ellipse method was significantly better than the trigonometric method (p = 0.001), whereas for synthetic radiographs without the femoral head, there was no significant difference between the two methods (p = 0.17). For real radiographs, there was no significant difference between the two measuring methods (p = 0.12). However, if we excluded the four poor-quality radiographs, there was a significant difference between the two measuring methods (p = 0.04).</p><p><strong>Discussion: </strong>We developed a computerized ellipse method for measuring acetabular version on synthetic radiographs and good-quality real radiographs. This method is characterized by its superior precision as compared to the trigonometric method. With the 2D standardized method (Liaw's version), improving the precision of measurement will help earlier diagnosis of acetabular loosening.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"18 5-6","pages":"195-200"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2013.779749","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31335444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A biomechanical study regarding the effect of tissue harvesting from the thorax on its movement during inspiration.","authors":"Asako Hatano,&nbsp;Tomohisa Nagasao,&nbsp;Yusuke Shimizu,&nbsp;Hongmei Jin,&nbsp;Tsuyoshi Kaneko,&nbsp;Yasunori Cho,&nbsp;Hua Jiang,&nbsp;Kazuo Kishi","doi":"10.3109/10929088.2013.777120","DOIUrl":"https://doi.org/10.3109/10929088.2013.777120","url":null,"abstract":"<p><strong>Objective: </strong>In the practice of plastic surgery, ribs and cartilage are often harvested for use in auto-grafts. This study aimed to elucidate the effect of such harvesting on the inspiration movement of the thorax.</p><p><strong>Materials and methods: </strong>Sixteen three-dimensional computer simulation models were produced by reference to the CT data of 16 patients. To simulate the harvesting of ribs and costal cartilages, parts were removed from these thorax models, thereby producing models with different types of defect. By performing finite element calculation after applying contracture forces on the external intercostal muscles and diaphragm, the movement patterns exhibited by the thoraces during inspiration were analyzed. The relationships between the defect types and the movement patterns were evaluated with reference to the dynamic behavior of the sternum and the increase in thoracic volume.</p><p><strong>Results: </strong>Although the removal of costal cartilage can cause asymmetric movement of the thorax, it did not affect the inspiration movement of the thorax. However, removal of two or more ribs not only caused asymmetric movement of the thorax, but also negatively affected that movement. Removal of two or three ribs impaired the expansion of the hemi-thorax on inspiration by 10% and 40%, respectively.</p><p><strong>Conclusion: </strong>The present study is the first to clarify the quantitative effect of tissue harvesting from the thorax on inspiration. The findings will be useful for surgeons when planning operations requiring harvesting of tissue from the thorax.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"18 5-6","pages":"118-28"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2013.777120","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31298395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of finite element analysis of a Lenke type 5 adolescent idiopathic scoliosis case to assess possible surgical outcomes.","authors":"Hongqi Zhang,&nbsp;Xiheng Hu,&nbsp;Yongfu Wang,&nbsp;Xinhua Yin,&nbsp;Mingxing Tang,&nbsp;Chaofeng Guo,&nbsp;Shaohua Liu,&nbsp;Yuxiang Wang,&nbsp;Ang Deng,&nbsp;Jinyang Liu,&nbsp;Jianhuang Wu","doi":"10.3109/10929088.2012.763185","DOIUrl":"https://doi.org/10.3109/10929088.2012.763185","url":null,"abstract":"<p><strong>Objective: </strong>To use the finite element model of a Lenke 5 adolescent idiopathic scoliosis (AIS) patient to simulate four corrections (including anterior and posterior correction); to investigate the corrective effect of different surgical protocols; and to analyze the biomechanical stress and strain of the scoliotic spines.</p><p><strong>Methods: </strong>Four surgical strategies were designed and simulated with the model of scoliosis. All the main steps of each strategy, including derotation and compression, were simulated. The stress variation of the spine and the corrective effect were compared among the protocols for different surgical approaches and fusion levels.</p><p><strong>Results: </strong>With the four different surgical protocols, the coronary lumbar deformity was corrected to 22°, 23°, 26° and 26°, respectively, and a physiological sagittal configuration was maintained; however, higher stress was observed with solutions A1 (screw model implanted in the convex side of T12-L3) and A2 (screw model implanted in the convex side of T11-L4), while solution B2 (the posterior approach: T10-L5, fusion to SV) lost too many lumbar movement segments. A similar apical rotational correction was recorded (41.68° and 37.79°) for solutions A2 and B1 (the posterior approach: T10-L4, fusion to LEV), which both instrumented the lower end vertebrae.</p><p><strong>Conclusions: </strong>The presented model could be used successfully to simulate correction procedures, including 90° derotation and compression, for the first time. The Lenke 5 AIS in this particular case was more rigid, and solution B1 was considered the ideal choice for treatment of this patient.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"18 3-4","pages":"84-92"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.763185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31307797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive posterior cervical microforaminotomy in the lower cervical spine and C-T junction assisted by O-arm-based navigation.","authors":"David Del Curto,&nbsp;Jin-Sung Kim,&nbsp;Sang-Ho Lee","doi":"10.3109/10929088.2012.760650","DOIUrl":"https://doi.org/10.3109/10929088.2012.760650","url":null,"abstract":"<p><p>Navigated posterior cervical microforaminotomy (PCM) is a promising minimally invasive technique for treating radiculopathy caused by lateral disc herniations and foraminal stenosis. Between December 2009 and October 2010, 14 patients with unilateral foraminal disc herniations or foraminal stenosis at the C6-7 or C7-T1 level underwent PCM assisted by O-arm navigation using the METRx tubular retractor. The main symptoms were radicular arm pain with no significant neck pain. Successful relief of radicular pain was achieved in all 14 patients. Two of the patients were lost during follow-up, and three had to undergo further decompression due to remnant foraminal stenosis being discovered on intraoperative O-arm images. There were no cases of instability or recurrence, and the only complication observed was a dural tear in one patient, which was adequately treated with fibrin glue and bed rest. The duration of symptoms was 4.5 months on average. The mean operation time was 136 minutes, with the additional time required for the image guided surgery assisted by O-arm-based navigation being approximately 28 minutes on average. There were no other complications during the surgical procedure or in the immediate postoperative period. Posterior cervical microforaminotomy assisted by O-arm-based navigation is a safe, effective and minimally invasive procedure for the treatment of lateral disc herniations and foraminal stenosis of the lower cervical spine and C-T junction, offering the possibility of an accurate decompression with a reduced risk of segmental instability. </p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"18 3-4","pages":"76-83"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.760650","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31175925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-operative reliability of ShapeMatch cutting guide placement in total knee arthroplasty.","authors":"Gavin Clark,&nbsp;Anthony Leong,&nbsp;Peter McEwen,&nbsp;Robert Steele,&nbsp;Ton Tran,&nbsp;Adrian Trivett","doi":"10.3109/10929088.2013.774049","DOIUrl":"https://doi.org/10.3109/10929088.2013.774049","url":null,"abstract":"<p><p>Custom cutting guides based on pre-operative imaging have been introduced for total knee arthroplasty (TKA). The aim of this prospective cohort study was to assess the reliability of repeated placement of custom cutting guides by multiple surgeons in a group of patients undergoing TKA. Custom cutting guides (ShapeMatch®, Stryker Orthopaedics) were designed from pre-operative MRI scans. The treating surgeon placed each guide on the femur and tibia of each patient three times without pinning the block. The three-dimensional position and orientation of the guide was measured for each repetition using a computer navigation system. The surgeon was blinded to the navigation system display. Data from 24 patients and 6 surgeons were analyzed. Intraclass correlation coefficients for all measurement parameters were in the range 0.889-0.997 (excellent), and all comparisons were statistically significant (p < 0.001). The range for femoral varus/valgus was 0.0-1.5°, with 96% of patients being within 0.5°. For femoral flexion/extension the range was 0.0-3.5° (92% within 2.5°). On the tibia, varus/valgus had a range of 0.0-1.0° (92% within 0.5°), and for slope the range was 0.0-3.5° (92% within 2.5°). The high degree of agreement indicated that intra-surgeon variation was minimal and that the technique is reliable.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"18 5-6","pages":"159-65"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2013.774049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31282707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Removal of a femoral nail with osseous overgrowth at the end-cap: A navigated and cannulated minimally invasive technique.","authors":"Ivan Marintschev,&nbsp;Sascha Rausch,&nbsp;Albert Fujak,&nbsp;Kajetan Klos,&nbsp;Gunther O Hofmann,&nbsp;Florian Gras","doi":"10.3109/10929088.2012.741623","DOIUrl":"https://doi.org/10.3109/10929088.2012.741623","url":null,"abstract":"<p><p>Intramedullary nail removal can be demanding, especially in cases of implant breakage or bony overgrowth at the end-cap, if the exact insertion depth of the nail is neglected in the index surgery. In the presented case, two challenging nail removals were necessary. The first was performed in a re-nailing procedure due to a pseudarthrosis with implant breakage, and the second was performed during hardware removal after fracture healing in a situation where there was deep intramedullary placement of the exchange nail. For the second implant removal a minimally invasive approach based on instrument placements over a navigated guide-wire was used to reduce the iatrogenic morbidity associated with an extensive open approach to the nail and to decrease the radiation exposure for the patient and the operating team.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"18 1-2","pages":"41-6"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.741623","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31070626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Craniomaxillofacial surgery planning based on 3D models derived from Cone-Beam CT data.","authors":"Nicolai Adolphs,&nbsp;Weichen Liu,&nbsp;Erwin Keeve,&nbsp;Bodo Hoffmeister","doi":"10.3109/10929088.2013.796002","DOIUrl":"https://doi.org/10.3109/10929088.2013.796002","url":null,"abstract":"<p><strong>Introduction: </strong>Individual planning of complex maxillofacial corrections may require 3D models which can be manufactured based on DICOM datasets. The gold standard for image acquisition is still high-resolution multi-slice computed tomography (MSCT). However, appropriate datasets for model fabrication can be acquired by modern Cone-Beam CT (CBCT) devices that have been developed specifically for maxillofacial imaging. The clinical utility of individual models fabricated on the basis of CBCT datasets was assessed.</p><p><strong>Methods: </strong>In five patients affected by different deficiencies of the maxillofacial skeleton, preoperative imaging was performed with ILUMA CBCT. Segmentation of hard tissues was performed manually by thresholding. Corresponding STL datasets were created and exported to an industrial service provider (Alphaform, Munich, Germany) specializing in rapid prototyping, and 3D models were fabricated by the selective laser sintering (SLS) technique. For variance analysis, landmark measurements were performed on both virtual and 3D models. Subsequently, maxillofacial surgery was performed according to the model-based planning.</p><p><strong>Results: </strong>All CBCT-based DICOM datasets could be used for individual model fabrication. Detailed reproduction of individual anatomy was achieved and a topographic survey showed no relevant aberrance between the virtual and real models. The CBCT-based 3D models were therefore used for planning and transfer of different maxillofacial procedures.</p><p><strong>Conclusions: </strong>CBCT-based datasets can be used for the fabrication of surgical 3D models if the correct threshold is set. Preoperative workflow and patient comfort is improved in terms of the fast-track concept by using this \"in-house\" imaging technique.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"18 5-6","pages":"101-8"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2013.796002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31421204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual reconstruction of pelvic tumor defects based on a gender-specific statistical shape model.","authors":"Zdzislaw Krol,&nbsp;Pawel Skadlubowicz,&nbsp;Fritz Hefti,&nbsp;Andreas H Krieg","doi":"10.3109/10929088.2013.777973","DOIUrl":"https://doi.org/10.3109/10929088.2013.777973","url":null,"abstract":"<p><p>Tumors in the pelvic region cause deformation and destruction of bony structures. Because the original pelvic anatomy cannot be adequately assessed at the tumor site, reconstruction with patient-specific implants is required. A widely used strategy for the reconstructive planning is mirroring of the contralateral side. We analyzed the statistical shape model (SSM)-based reconstruction method and compared it with the mirroring approach. Our approach used a gender-specific pelvic SSM (n = 50 for each gender) to generate implant geometries. The main objectives of this study were to analyze and evaluate the virtual anatomical reconstruction of eight tumor-damaged pelvic bones using the SSM approach. We achieved an overall mean deviation distance of 0.89 mm and 1.26 mm for the reconstruction of the equivalent defect in the healthy hemipelvis. Quantitative comparison with the mirroring method showed that the SSM-based reconstruction method reconstructs the defect with the same clinically acceptable accuracy as the mirroring method. The study demonstrates that the presented model can be a valuable tool for the planning of pelvic reconstructive surgery and implant design.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"18 5-6","pages":"142-53"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2013.777973","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31304911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computer assisted planning of autologous fat grafting in breast.","authors":"Paolo Patete,&nbsp;Gino Rigotti,&nbsp;Alessandra Marchi,&nbsp;Guido Baroni","doi":"10.3109/10929088.2012.745169","DOIUrl":"https://doi.org/10.3109/10929088.2012.745169","url":null,"abstract":"<p><p>Autologous fat grafting is an emerging and promising surgical technique in regenerative medicine, and its application is quickly spreading in plastic and reconstructive surgery of the breast. However, despite the advantages of the technique, surgical complications may occur, such as implanted tissue necrosis and resorption and onset of microcalcifications. In view of the hypothesis that the uniformity of the lipoaspirate transplantation is related to graft survival and a lower probability of complications, we developed an interactive lipomodeling planning software application based on a genetic algorithm that allows automatic optimization of the uniformity of fat tissue distribution. The input dataset consists of a 3D model of the patient's thorax, created from MRI scans, on which relevant structures are segmented. The developed software was tested starting from either an automatically generated plan or an initial guess of the optimal surgical plan, and in both cases the application yielded a consistent improvement in the planned fat tissue distribution by optimizing the position of the insertion points and the direction of the insertion pathways. On the basis of the simulations performed, the use of genetic algorithms for optimization of the geometry of autologous fat transfer in the breast proved to be effective. These results will foster further activities focused on the comparison of predicted optimized geometries and those obtained in real surgical cases as a means of obtaining a deeper knowledge of the potential influence of a uniform fat tissue distribution on the quality of the surgical outcome. The presented application is also put forward as representing a noteworthy step towards the clinical application of computer assisted planning tools in breast surgery.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"18 1-2","pages":"10-8"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.745169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31135028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computer-assisted planning and navigation improves cutting accuracy during simulated bone tumor surgery of the pelvis.","authors":"Olivier Cartiaux,&nbsp;Xavier Banse,&nbsp;Laurent Paul,&nbsp;Bernard G Francq,&nbsp;Carl-Éric Aubin,&nbsp;Pierre-Louis Docquier","doi":"10.3109/10929088.2012.744096","DOIUrl":"https://doi.org/10.3109/10929088.2012.744096","url":null,"abstract":"<p><strong>Background: </strong>Resection of bone tumors within the pelvis requires good cutting accuracy to achieve satisfactory safe margins. Manually controlled bone cutting can result in serious errors, especially due to the complex three-dimensional geometry, limited visibility, and restricted working space of the pelvic bone. This experimental study investigated cutting accuracy during navigated and non-navigated simulated bone tumor cutting in the pelvis.</p><p><strong>Methods: </strong>A periacetabular tumor resection was simulated using a pelvic bone model. Twenty-three operators (10 senior and 13 junior surgeons) were asked to perform the tumor cutting, initially according to a freehand procedure and later with the aid of a navigation system. Before cutting, each operator used preoperative planning software to define four target planes around the tumor with a 10-mm desired safe margin. After cutting, the location and flatness of the cut planes were measured, as well as the achieved surgical margins and the time required for each cutting procedure.</p><p><strong>Results: </strong>The location of the cut planes with respect to the target planes was significantly improved by using the navigated cutting procedure, averaging 2.8 mm as compared to 11.2 mm for the freehand cutting procedure (p < 0.001). There was no intralesional tumor cutting when using the navigation system. The maximum difference between the achieved margins and the 10-mm desired safe margin was 6.5 mm with the navigated cutting process (compared to 13 mm with the freehand cutting process).</p><p><strong>Conclusions: </strong>Cutting accuracy during simulated bone cuts of the pelvis can be significantly improved by using a freehand process assisted by a navigation system. When fully validated with complementary in vivo studies, the planning and navigation-guided technologies that have been developed for the present study may improve bone cutting accuracy during pelvic tumor resection by providing clinically acceptable margins.</p>","PeriodicalId":50644,"journal":{"name":"Computer Aided Surgery","volume":"18 1-2","pages":"19-26"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/10929088.2012.744096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31066642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}