SusMat Pub Date : 2024-08-17 DOI: 10.1002/sus2.235

Anxiong Liu, Lu Chen, Luhe Qi, Jing Huang, Yongkang Zou, Zhiwen Hu, Le Yu, Zibiao Zhong, Qifa Ye, Chaoji Chen

{"title":"Biosafe, rapid, and ultrahigh‐capacity endotoxin purification in blood by a sustainable and recyclable MOF‐functionalized chitin microsphere adsorbent","authors":"Anxiong Liu, Lu Chen, Luhe Qi, Jing Huang, Yongkang Zou, Zhiwen Hu, Le Yu, Zibiao Zhong, Qifa Ye, Chaoji Chen","doi":"10.1002/sus2.235","DOIUrl":"https://doi.org/10.1002/sus2.235","url":null,"abstract":"Abstract Sepsis is responsible for approximately 5.3 million deaths globally each year. Here, we constructed hierarchical chitin microspheres loaded with MOF‐919 (Ch/metal–organic frameworks [MOFs]) for the rapid and efficient removal of lipopolysaccharide (LPS) in complex blood environments. Furthermore, abundant active sites on MOF‐919(Sc) also enable a record‐high adsorption capacity of 9.56 mg/g in biomass‐based adsorbents due to the coordination interactions between endotoxin and MOF‐919(Sc). The LPS level of sepsis rabbits was less than 2 EU/mL (clearance rate >95%) after 90‐min hemoperfusion, showing no adverse effect on the rabbit organs. Additionally, compared to the commonly used LPS scrubber Toraymyxin (polymethyl methacrylate), the chitin adsorbent is significantly more cost‐effective and environmentally friendly. The preparation strategy for hierarchical porous microspheres offers notable advantages in designability, recyclability, and renewability, providing a new approach to sepsis treatment and promising prospects for the biomedical application of sustainable biomass materials.","PeriodicalId":506315,"journal":{"name":"SusMat","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sus2.235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Inhibited superoxide‐induced halide oxidation with a bioactive factor for stabilized inorganic perovskite solar cells 稳定无机钙钛矿太阳能电池用生物活性因子抑制超氧化物诱导的卤化物氧化

SusMat Pub Date : 2024-07-29 DOI: 10.1002/sus2.233

Xingxing Duan, Jialong Duan, Naimin Liu, Jiabao Li, Jie Dou, Xinyu Zhang, Qiyao Guo, Yingli Wang, Zhen Wang, Yuanyuan Zhao, Chi Jiang, Jinze Li, Qunwei Tang

{"title":"Inhibited superoxide‐induced halide oxidation with a bioactive factor for stabilized inorganic perovskite solar cells","authors":"Xingxing Duan, Jialong Duan, Naimin Liu, Jiabao Li, Jie Dou, Xinyu Zhang, Qiyao Guo, Yingli Wang, Zhen Wang, Yuanyuan Zhao, Chi Jiang, Jinze Li, Qunwei Tang","doi":"10.1002/sus2.233","DOIUrl":"https://doi.org/10.1002/sus2.233","url":null,"abstract":"Abstract Active oxygen highly affects the efficiency and stability of perovskite solar cells (PSCs) owing to the capacity to either passivate defects or decompose perovskite lattice. To better understand the in‐depth interaction, we demonstrate for the first time that photooxidation mechanism in all‐inorganic perovskite film dominates the phase deterioration kinetics by forming superoxide species in the presence of light and oxygen, which is significantly different from that in organic‒inorganic hybrid and even tin‐based perovskites. In all‐inorganic perovskites, the superoxide species prefer to oxidize longer and weaker Pb‒I bond to PbO and I 2 , leaving the much stable CsPbBr 3 phase. From this chemical proof‐of‐concept, we employ an organic bioactive factor, Tanshinone IIA, as a superoxide sweeper to enhance the environmental tolerance of inorganic perovskite, serving as a “skincare” agent for anti‐aging organisms. Combined with another key point on healing defective lattice, the best carbon‐based all‐inorganic CsPbI 2 Br solar cell delivers an efficiency as high as 15.12% and superior stability against oxygen, light, humidity, and heat attacks. This method is also applicable to enhance the efficiency of p‒i‒n inverted (Cs 0.05 MA 0.05 FA 0.9 )Pb(I 0.93 Br 0.07 ) 3 cell to 23.46%. These findings not only help us understand the perovskite decomposition mechanisms in depth but also provide a potential strategy for advanced PSC platforms.","PeriodicalId":506315,"journal":{"name":"SusMat","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/sus2.233","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147915509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

Nanocarbon catalysts with co‐active S−P−C sites enhance metal‐free direct oxidation of alcohols 具有共活 S-P-C 位点的纳米碳催化剂可增强醇的无金属直接氧化作用

SusMat Pub Date : 2024-07-15 DOI: 10.1002/sus2.221

Juan Meng, Huidong Liu, Jianing Xu, Yu-Jiao Lou, Haixin Sun, Bo Jiang, Yongzhuang Liu, Hengfei Qin, Shuo Dou, Haipeng Yu

{"title":"Nanocarbon catalysts with co‐active S−P−C sites enhance metal‐free direct oxidation of alcohols","authors":"Juan Meng, Huidong Liu, Jianing Xu, Yu-Jiao Lou, Haixin Sun, Bo Jiang, Yongzhuang Liu, Hengfei Qin, Shuo Dou, Haipeng Yu","doi":"10.1002/sus2.221","DOIUrl":"https://doi.org/10.1002/sus2.221","url":null,"abstract":"In this study, a sulfur–phosphorus co‐doped nanocarbon (SPC) catalyst was synthesized using a straightforward one‐step colloidal carbonization method and demonstrated high performance in the metal‐free direct oxidation of alcohols to aldehydes. This metal‐free SPC catalyst showed exceptional efficiency, achieving a conversion rate of 90% for benzyl alcohol and a selectivity of 94% toward benzaldehyde within only 1 h at 130°C. Moreover, it displays exceptional cycle stability and a high turnover frequency (17.1 × 10−3 mol g−1 h−1). Theoretical analysis suggested that the catalyst's superior performance is attributed to the presence of unsaturated edge defects and S−P− moieties, which increase the density of states at the Fermi level, lower the band gap energy, and promote electron localization. Additionally, the doping introduces cooperative co‐active S−P−C sites, facilitating a synergistic multisite catalytic effect that lowers the energy barriers. These findings represent a significant advancement in the field of metal‐free direct alcohol oxidation.","PeriodicalId":506315,"journal":{"name":"SusMat","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible mica films coated by magnetron sputtered insulating layers for high‐temperature capacitive energy storage 用于高温电容式储能的磁控溅射绝缘层涂层柔性云母薄膜

SusMat Pub Date : 2024-07-11 DOI: 10.1002/sus2.228

Chao Yin, Tiandong Zhang, Changhai Zhang, Yue Zhang, Chang Kyu Jeong, Geon‐Tae Hwang, Q. Chi

{"title":"Flexible mica films coated by magnetron sputtered insulating layers for high‐temperature capacitive energy storage","authors":"Chao Yin, Tiandong Zhang, Changhai Zhang, Yue Zhang, Chang Kyu Jeong, Geon‐Tae Hwang, Q. Chi","doi":"10.1002/sus2.228","DOIUrl":"https://doi.org/10.1002/sus2.228","url":null,"abstract":"High‐temperature energy storage performance of dielectric capacitors is crucial for the next generation of power electronic devices. However, conduction losses rise sharply at elevated temperature, limiting the application of energy storage capacitors. Here, the mica films magnetron sputtered by different insulating layers are specifically investigated, which exhibit the excellent high‐temperature energy storage performance. The experimental results revealed that the PbZrO3/Al2O3/PbZrO3 (PZO/AO/PZO) interface insulating layers can effectively reduce the high‐temperature leakage current and conduction loss of the composite films. Consequently, the ultrahigh energy storage density (Wrec) and charge‒discharge efficiency (η) can be achieved simultaneously in the flexible mica‐based composite films. Especially, PZO/AO/PZO/mica/PZO/AO/PZO (PAPMPAP) films possess excellent Wrec of 27.5 J/cm3 and η of 87.8% at 200°C, which are significantly better than currently reported high‐temperature capacitive energy storage dielectric materials. Together with outstanding power density and electrical cycling stability, the flexible films in this work have great application potential in high‐temperature energy storage capacitors. Moreover, the magnetron sputtering technology can deposit large‐area nanoscale insulating layers on the surface of capacitor films, which can provide technical support for the industrial production of capacitors.","PeriodicalId":506315,"journal":{"name":"SusMat","volume":"45 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141655545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

V2O3/VN electrocatalysts with coherent heterogeneous interfaces for selecting low‐energy nitrogen reduction pathways 具有相干异质界面的 V2O3/VN 电催化剂，用于选择低能氮还原途径

SusMat Pub Date : 2024-07-11 DOI: 10.1002/sus2.226

Taehee An, Chengkai Xia, Minyeong Je, Hyunjung Lee, Seulgi Ji, Min‐Cheol Kim, S. Surendran, Mi-Kyung Han, Jaehyoung Lim, Dong‐Kyu Lee, Joonyoung Kim, Tae-Hoon Kim, Heechae Choi, Jung Kyu Kim, U. Sim

{"title":"V2O3/VN electrocatalysts with coherent heterogeneous interfaces for selecting low‐energy nitrogen reduction pathways","authors":"Taehee An, Chengkai Xia, Minyeong Je, Hyunjung Lee, Seulgi Ji, Min‐Cheol Kim, S. Surendran, Mi-Kyung Han, Jaehyoung Lim, Dong‐Kyu Lee, Joonyoung Kim, Tae-Hoon Kim, Heechae Choi, Jung Kyu Kim, U. Sim","doi":"10.1002/sus2.226","DOIUrl":"https://doi.org/10.1002/sus2.226","url":null,"abstract":"Electrochemical nitrogen reduction reaction (NRR) is a sustainable alternative to the Haber‒Bosch process for ammonia (NH3) production. However, the significant uphill energy in the multistep NRR pathway is a bottleneck for favorable serial reactions. To overcome this challenge, we designed a vanadium oxide/nitride (V2O3/VN) hybrid electrocatalyst in which V2O3 and VN coexist coherently at the heterogeneous interface. Since single‐phase V2O3 and VN exhibit different surface catalytic kinetics for NRR, the V2O3/VN hybrid electrocatalyst can provide alternating reaction pathways, selecting a lower energy pathway for each material in the serial NRR pathway. As a result, the ammonia yield of the V2O3/VN hybrid electrocatalyst was 219.6 µg h−1 cm−2, and the Faradaic efficiency was 18.9%, which is much higher than that of single‐phase VN, V2O3, and VNxOy solid solution catalysts without heterointerfaces. Density functional theory calculations confirmed that the composition of these hybrid electrocatalysts allows NRR to proceed from a multistep reduction reaction to a low‐energy reaction pathway through the migration and adsorption of intermediate species. Therefore, the design of metal oxide/nitride hybrids with coherent heterointerfaces provides a novel strategy for synthesizing highly efficient electrochemical catalysts that induce steps favorable for the efficient low‐energy progression of NRR.","PeriodicalId":506315,"journal":{"name":"SusMat","volume":"118 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141656788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking barriers: Sunlight‐activated self‐healing polymers with unprecedented photoaging resistance 打破障碍：阳光激活的自修复聚合物具有前所未有的抗光老化性能

SusMat Pub Date : 2024-07-11 DOI: 10.1002/sus2.227

Yan Mei Li, Z. Zhang, M. Rong, Ming Qiu Zhang

{"title":"Breaking barriers: Sunlight‐activated self‐healing polymers with unprecedented photoaging resistance","authors":"Yan Mei Li, Z. Zhang, M. Rong, Ming Qiu Zhang","doi":"10.1002/sus2.227","DOIUrl":"https://doi.org/10.1002/sus2.227","url":null,"abstract":"Sunlight‐triggered self‐healing of polymers has attractive advantages, but the same illumination inevitably causes photoaging. The resulting properties deterioration and shortened lifespan run counter to the desire for self‐healing. Herein, the authors propose an innovative solution by introducing carbazolyl‐based dithiocarbamate units. The proof‐of‐concept crosslinked poly(carbazolyl dithiocarbamates‐urethane) shows that the multitasking reactivities of the dynamic bonds stimulated by the sun's ultraviolet rays concurrently implement self‐healing and improve the photoaging resistance. As reflected by the xenon weatherometer measurements, it retains 73.5% of the original strength after 576 h owing to the effects of hydroperoxide intermediates elimination and fluorescence emission. The anti‐photoaging ability is far superior to the control filled with commercial stabilizer. Meantime, networks rearrangement via dynamic exchange reactions among the sunlight‐sensitive dithiocarbamates and long‐range free radicals transfer are allowed in surface layer and the interior, so that the cracks up to 8.5 mm deep are repaired. The work provides a feasible way to break the bottleneck in application of photochemical self‐healing polymers.","PeriodicalId":506315,"journal":{"name":"SusMat","volume":"81 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141657951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing weakly and strongly solvating polymer electrolytes: Systematically boosting high‐voltage lithium metal batteries 设计弱溶解和强溶解聚合物电解质：系统提升高压锂金属电池的性能

SusMat Pub Date : 2024-07-10 DOI: 10.1002/sus2.219

Tianyi Wang, Yimeng Zhang, Xueyan Huang, Peifeng Su, M. Xiao, Shuanjin Wang, Sheng Huang, Dongmei Han, Yuezhong Meng

{"title":"Designing weakly and strongly solvating polymer electrolytes: Systematically boosting high‐voltage lithium metal batteries","authors":"Tianyi Wang, Yimeng Zhang, Xueyan Huang, Peifeng Su, M. Xiao, Shuanjin Wang, Sheng Huang, Dongmei Han, Yuezhong Meng","doi":"10.1002/sus2.219","DOIUrl":"https://doi.org/10.1002/sus2.219","url":null,"abstract":"Practical high‐voltage lithium metal batteries hold promise for high energy density applications, but face stability challenges in electrolytes for both 4 V‐class cathodes and lithium anode. To address this, we delve into the positive impacts of two crucial moieties in electrolyte chemistry: fluorine atom (‐F) and cyano group (‐CN) on the electrochemical performance of polyether electrolytes and lithium metal batteries. Cyano‐bearing polyether electrolytes possess strong solvation, accelerating Li+ desolvation with minimal SEI impact. Fluorinated polyether electrolytes possess weak solvation, and stabilize the lithium anode via preferential decomposition of F‐segment, exhibiting nearly 6000‐h stable cycling of lithium symmetric cell. Furthermore, the electron‐withdrawing properties of ‐F and ‐CN groups significantly bolster the high‐voltage tolerance of copolymer electrolyte, extending its operational range up to 5 V. This advancement enables the development of 4 V‐class lithium metal batteries compatible with various cathodes, including 4.45 V LiCoO2, 4.5 V LiNi0.8Co0.1Mn0.1O2, and 4.2 V LiNi0.5Co0.2Mn0.3O2. These findings provide insights into design principles centered around polymer components for high‐performance polymer electrolytes.","PeriodicalId":506315,"journal":{"name":"SusMat","volume":"11 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly stretchable double‐network gel electrolytes integrated with textile electrodes for wearable thermo‐electrochemical cells 用于可穿戴热电化学电池的集成纺织电极的高伸缩性双网凝胶电解质

SusMat Pub Date : 2024-07-10 DOI: 10.1002/sus2.225

Yuetong Zhou, Ding Zhang, Shuai Zhang, Yuqing Liu, Rujun Ma, Gordon Wallace, Jun Chen

{"title":"Highly stretchable double‐network gel electrolytes integrated with textile electrodes for wearable thermo‐electrochemical cells","authors":"Yuetong Zhou, Ding Zhang, Shuai Zhang, Yuqing Liu, Rujun Ma, Gordon Wallace, Jun Chen","doi":"10.1002/sus2.225","DOIUrl":"https://doi.org/10.1002/sus2.225","url":null,"abstract":"Thermo‐electrochemical cells (TECs) provide a new potential for self‐powered devices by converting heat energy into electricity. However, challenges still remain in the fabrication of flexible and tough gel electrolytes and their compatibility with redox actives; otherwise, contact problems exist between electrolytes and electrodes during stretching or twisting. Here, a novel robust and neutral hydrogel with outstanding stretchability was developed via double‐network of crosslinked carboxymethyl chitosan and polyacrylamide, which accommodated both n‐type (Fe2+/Fe3+) and p‐type ([Fe(CN)6]3−/[Fe(CN)6]4−) redox couples and maintained stretchability (>300%) and recoverability (95% compression). Moreover, poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) textile electrodes with porous structure are integrated into gel electrolytes that avoid contact issues and effectively boost the Pmax of n‐ and p‐type thermocell by 76% and 26%, respectively. The optimized thermocell exhibits a quick current density response and is continually fully operational under deformations, which satisfies the working conditions of wearable devices. Multiple thermocells (four pairs) are effectively connected in alternating single n‐ and p‐type cells in series and outputted nearly 74.3 mV at ΔT = 10°C. The wearable device is manufactured into a soft‐pack thermocells to successfully harvest human body heat and illuminate an LED, demonstrating the potential of the actual application of the thermocell devices.","PeriodicalId":506315,"journal":{"name":"SusMat","volume":"2 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141662079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Air‐stable Li3.12P0.94Bi0.06S3.91I0.18 solid‐state electrolyte with high ionic conductivity and lithium anode compatibility toward high‐performance all‐solid‐state lithium metal batteries 具有高离子电导率和锂负极兼容性的空气稳定 Li3.12P0.94Bi0.06S3.91I0.18 固态电解质，可用于制造高性能全固态锂金属电池

SusMat Pub Date : 2024-07-08 DOI: 10.1002/sus2.218

Daokuan Jin, Haodong Shi, Yuxin Ma, Yangyang Liu, Yang Wang, Yanfeng Dong, Mingbo Wu, Zhong‐Shuai Wu

{"title":"Air‐stable Li3.12P0.94Bi0.06S3.91I0.18 solid‐state electrolyte with high ionic conductivity and lithium anode compatibility toward high‐performance all‐solid‐state lithium metal batteries","authors":"Daokuan Jin, Haodong Shi, Yuxin Ma, Yangyang Liu, Yang Wang, Yanfeng Dong, Mingbo Wu, Zhong‐Shuai Wu","doi":"10.1002/sus2.218","DOIUrl":"https://doi.org/10.1002/sus2.218","url":null,"abstract":"Sulfide solid‐state electrolytes (SSEs) with superior ionic conductivity and processability are highly promising candidates for constructing all‐solid‐state lithium metal batteries (ASSLMBs). However, their practical applications are limited by their intrinsic air instability and serious interfacial incompatibility. Herein, a novel glass‐ceramic electrolyte Li3.12P0.94Bi0.06S3.91I0.18 was synthesized by co‐doping Li3PS4 with Bi and I for high‐performance ASSLMBs. Owing to the strong Bi‒S bonds that are thermodynamically stable to water, increased unit cell volume and Li+ concentration caused by P5+ substitution with Bi3+, and the in situ formed robust solid electrolyte interphase layer LiI at lithium surface, the as‐prepared Li3.12P0.94Bi0.06S3.91I0.18 SSE achieved excellent air stability with a H2S concentration of only 0.205 cm3 g−1 (after 300 min of air exposure), outperforming Li3PS4 (0.632 cm3 g−1) and the most reported sulfide SSEs, together with high ionic conductivity of 4.05 mS cm−1. Furthermore, the Li3.12P0.94Bi0.06S3.91I0.18 effectively improved lithium metal stability. With this SSE, an ultralong cyclability of 700 h at 0.1 mA cm−2 was realized in a lithium symmetrical cell. Moreover, the Li3.12P0.94Bi0.06S3.91I0.18‐based ASSLMBs with LiNi0.8Mn0.1Co0.1O2 cathode achieved ultrastable capacity retention rate of 95.8% after 300 cycles at 0.1 C. This work provides reliable strategy for designing advanced sulfide SSEs for commercial applications in ASSLMBs.","PeriodicalId":506315,"journal":{"name":"SusMat","volume":"3 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of an intranasal drug delivery system with hypothalamus‐targeting nanoparticles 利用下丘脑靶向纳米颗粒构建鼻内给药系统

SusMat Pub Date : 2024-07-02 DOI: 10.1002/sus2.222

Qianru Rao, Yujie Xu, Xiaorong Wang, Hang Luo, Haoqi Li, Jingyuan Xiong, Huile Gao, G. Cheng

{"title":"Construction of an intranasal drug delivery system with hypothalamus‐targeting nanoparticles","authors":"Qianru Rao, Yujie Xu, Xiaorong Wang, Hang Luo, Haoqi Li, Jingyuan Xiong, Huile Gao, G. Cheng","doi":"10.1002/sus2.222","DOIUrl":"https://doi.org/10.1002/sus2.222","url":null,"abstract":"Dysfunction of the hypothalamus is associated with endocrine imbalances, growth abnormalities, and reproductive disorders. However, there is a lack of targeted treatment strategies focused on the hypothalamus. In this study, we constructed a multifunctional nanocarrier system (S@ANP) to directly target the hypothalamic neurokinin receptor 3 (NK3R) via an intranasal delivery strategy. This system could overcome the primary obstacles in drug delivery for hypothalamus‐related diseases. Under the guidance of a modified (Trp7, β‐Ala8)‐neurokinin A (4‐10) peptide with cysteine, nanoparticles encapsulated with SB222200, an NK3R inhibitor, were found to readily penetrate hypothalamic cells with substantial loading capacity, encapsulation efficiency, and sustained release in vitro. Moreover, intranasal delivery represents an optimal delivery strategy that allows for a significant reduction in oral dosage and enables nanoparticles to bypass the blood‒brain barrier and target relevant parts of the brain. The mucolytic agent N‐acetyl‐L‐cysteine (NAC) was loaded into the nanoparticles (S@ANP + NAC) to increase mucosal solubility and intranasal delivery efficiency. In vivo evaluations showed that S@ANP + NAC could effectively target the hypothalamus and modulate NK3R‐regulated hypothalamic functions in mice. Due to its high hypothalamic targeting efficiency and low toxicity, this intranasal nanoparticle drug delivery system may serve as a potential strategy for precision therapy of hypothalamic disorders.","PeriodicalId":506315,"journal":{"name":"SusMat","volume":"66 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141687014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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