Cuaj-Canadian Urological Association Journal最新文献

筛选
英文 中文
Techniques in urology - Tension-relieving microdot vasovasostomies and longitudinal intussuscepted vasoepididymostomy vasectomy reversals A first report. 技术 - 张力松解微点输精管造口术和纵向肠套叠输精管吻合术输精管结扎逆转术:首次报告。
IF 1.9 4区 医学
Cuaj-Canadian Urological Association Journal Pub Date : 2025-03-01 DOI: 10.5489/cuaj.8899
Abdullah Alhamam, Kiera Liblik, Luke Witherspoon, Adam Dorner, Ryan Flannigan
{"title":"Techniques in urology - Tension-relieving microdot vasovasostomies and longitudinal intussuscepted vasoepididymostomy vasectomy reversals A first report.","authors":"Abdullah Alhamam, Kiera Liblik, Luke Witherspoon, Adam Dorner, Ryan Flannigan","doi":"10.5489/cuaj.8899","DOIUrl":"10.5489/cuaj.8899","url":null,"abstract":"<p><strong>Introduction: </strong>Tension and malalignment of vasectomy reversal (VR) anastomoses are hypothesized to contribute to failure. We report VR outcomes using a novel technique introducing a tension-reliving hitch in the multilayer microdot vasovasostomy (VV) and longitudinal intussuscepted vasoepididymostomy (LIVE; VE).</p><p><strong>Methods: </strong>All VR patients between May 2019 and September 2023 from a single surgeon were reviewed. Patients were included if they underwent a VR with at least one semen analysis within six months of surgery and a minimum of six months of followup after the surgery to deem a failure. The primary outcome was patency, which was defined as 1) any sperm in the ejaculate; and 2) functionally as at least two million motile sperm. Late failure was defined as an azoospermic semen analysis result after previously documented presence of sperm.</p><p><strong>Results: </strong>A total of 159 patients were evaluated, of which 136 patients met the inclusion criteria. The patency rate among all VRs was 97.7 %, with an overall functional patency rate of 93.1%. One hundred and one patients underwent bilateral VVs, with a 99% patency rate and 95.5% functional patency rate. Twenty-three patients underwent a mixed VV/VE, with a patency rate of 100% and a functional patency rate of 88.8%. Finally, 12 patients underwent bilateral VE, with a patency rate of 83.3% and a functional patency rate of 77.7%. Among these patients, four VV patients were identified to have a late failure.</p><p><strong>Conclusions: </strong>The combination of tension-relieving stitches for VVs and VEs, along with attention to symmetrical and precise stitch placement, results in high patency rates.</p>","PeriodicalId":50613,"journal":{"name":"Cuaj-Canadian Urological Association Journal","volume":" ","pages":"E114-E118"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142631332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Length of hospital stay and procedure time after partial nephrectomy or percutaneous thermal ablation A systematic review and meta-analysis. 肾部分切除术或经皮热消融术后的住院时间和手术时间:系统回顾和荟萃分析。
IF 1.9 4区 医学
Cuaj-Canadian Urological Association Journal Pub Date : 2025-03-01 DOI: 10.5489/cuaj.8906
Maryam Kandi, Patrick O Richard, Philippe D Violette, Ashwini Sreekanta, Steven Hanna, Rachel Couban, Julian Daza, Russell Leong, Haseeb Faisal, Divyalakshmi Tamilselvan, Jeremy Steen, Wang-Choi Tang, Gordon Guyatt
{"title":"Length of hospital stay and procedure time after partial nephrectomy or percutaneous thermal ablation A systematic review and meta-analysis.","authors":"Maryam Kandi, Patrick O Richard, Philippe D Violette, Ashwini Sreekanta, Steven Hanna, Rachel Couban, Julian Daza, Russell Leong, Haseeb Faisal, Divyalakshmi Tamilselvan, Jeremy Steen, Wang-Choi Tang, Gordon Guyatt","doi":"10.5489/cuaj.8906","DOIUrl":"10.5489/cuaj.8906","url":null,"abstract":"<p><strong>Introduction: </strong>This systematic review addressed the length of hospital stay (LOS) and procedure time in patients with small renal masses (SRM) undergoing open, conventional laparoscopic (OPN), and robot-assisted partial nephrectomy (RAPN), as well as percutaneous thermal ablation (PTA) in different geographic areas.</p><p><strong>Methods: </strong>We conducted a comprehensive search in databases (MEDLINE, EMBASE, CINAHL) until July 2023, and we applied random-effect meta-analysis, with evidence certainty assessed by the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework.</p><p><strong>Results: </strong>We screened 3456 titles and abstracts, ultimately identifying 60 eligible studies. For the length of LOS (days) following OPN, our pooled estimates revealed means of 5.7 in North America, 7.1 in Europe, and 13.4 in Asia; laparoscopic partial nephrectomy means were 3.1, 5.4, and 5.8, respectively; for RAPN, means were 2.7, 3.8, and 7.1, respectively; and for PTA, means were 1.2, 1.6, and 1.6, respectively. Regarding procedure time (minutes) after OPN, means were 187 in North America, 132 in Europe, and 184 in Asia; after laparoscopic partial nephrectomy, means were 198, 127, and 200, respectively; after RAPN, means were 189, 150, and 192, respectively; and for PTA, mean was 144 in North America and no studies addressed procedure time in Europe and Asia.</p><p><strong>Conclusions: </strong>Our study provides the most trustworthy available estimates of LOS and procedure time for patients undergoing invasive procedures for the management of SRM. These findings emphasize the need for context-specific considerations when informing patients and making treatment decisions.</p>","PeriodicalId":50613,"journal":{"name":"Cuaj-Canadian Urological Association Journal","volume":" ","pages":"E104-E113"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of marginalization and PSMA-PET in prostate cancer: An analysis of the Ontario PSMA-PET Registry for Recurrent Prostate Cancer.
IF 1.9 4区 医学
Cuaj-Canadian Urological Association Journal Pub Date : 2025-02-24 DOI: 10.5489/cuaj.9034
Vivian S Tan, Ur Metser, Mohammed Rashid, Deanna L Langer, Pamela MacCrostie, Bo Green, Victor Mak, Girish S Kulkarni, Bobby Shayegan, Stephen Pautler, Luke T Lavallée, Antonio Finelli, Laurence Klotz, Marlon Hagerty, Glenn Bauman
{"title":"Association of marginalization and PSMA-PET in prostate cancer: An analysis of the Ontario PSMA-PET Registry for Recurrent Prostate Cancer.","authors":"Vivian S Tan, Ur Metser, Mohammed Rashid, Deanna L Langer, Pamela MacCrostie, Bo Green, Victor Mak, Girish S Kulkarni, Bobby Shayegan, Stephen Pautler, Luke T Lavallée, Antonio Finelli, Laurence Klotz, Marlon Hagerty, Glenn Bauman","doi":"10.5489/cuaj.9034","DOIUrl":"https://doi.org/10.5489/cuaj.9034","url":null,"abstract":"<p><strong>Introduction: </strong>Prostate-specific membrane antigen positron emission tomography (PSMA PET) is a new standard for the imaging of high-risk or recurrent prostate cancer. While marginalization disparities exist for prostate cancer, less is known in the context of PSMA PET. The objective of the study was to determine if marginalization was associated with access, PET positivity, management change, radiation use, and survival of prostate cancer in a universal healthcare system.</p><p><strong>Methods: </strong>Patients enrolled in the Ontario PSMA PET Registry for Recurrent Prostate Cancer (PREP) between 2018 and 2022 were included. The Ontario Marginalization Index (material resources, racialized/newcomer, age/labor force, household/dwellings) was used. Outcomes included access, PET positivity, management change, radiation use, and survival. Cox proportional hazards and logistic regression models examined the association between marginalization and outcomes. Provincial administrative databases were leveraged to generate a diagnosis and a survivorship cohort of prostate cancer patients who received primary treatment to compare with the PSMA PET cohort.</p><p><strong>Results: </strong>There were 4034 patients in the PSMA PET cohort. Patients at higher material marginalization quintiles were under-represented in the PSMA PET Registry Database. Similar under-representation was noted in the diagnosis (n=123 128) and survival (n=56 753) cohorts. Within the PSMA cohort, marginalization dimensions were not significantly correlated with PET positivity, management change, or radiation use.</p><p><strong>Conclusions: </strong>Marginalization quintiles across PSMA PET access were similar in distribution to prostate cancer diagnoses and survivor cohorts. We found no association of marginalization with PET positivity, management change, or radiation use among those receiving PSMA PET.</p>","PeriodicalId":50613,"journal":{"name":"Cuaj-Canadian Urological Association Journal","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of AI (GPT-4)-generated multiple-choice questions for the examination of surgical subspecialty residents: Report of feasibility and psychometric analysis.
IF 1.9 4区 医学
Cuaj-Canadian Urological Association Journal Pub Date : 2025-02-24 DOI: 10.5489/cuaj.9020
Jin Kyu Kim, Michael Chua, Armando Lorenzo, Mandy Rickard, Laura Andreacchi, Michael Kim, Douglas Cheung, Yonah Krakowsky, Jason Y Lee
{"title":"Use of AI (GPT-4)-generated multiple-choice questions for the examination of surgical subspecialty residents: Report of feasibility and psychometric analysis.","authors":"Jin Kyu Kim, Michael Chua, Armando Lorenzo, Mandy Rickard, Laura Andreacchi, Michael Kim, Douglas Cheung, Yonah Krakowsky, Jason Y Lee","doi":"10.5489/cuaj.9020","DOIUrl":"https://doi.org/10.5489/cuaj.9020","url":null,"abstract":"<p><strong>Introduction: </strong>Multiple-choice questions (MCQs) are essential in medical education and widely used by licensing bodies. They are traditionally created with intensive human effort to ensure validity. Recent advances in AI, particularly large language models (LLMs), offer the potential to streamline this process. This study aimed to develop and test a GPT-4 model with customized instructions for generating MCQs to assess urology residents.</p><p><strong>Methods: </strong>A GPT-4 model was embedded using guidelines from medical licensing bodies and reference materials specific to urology. This model was tasked with generating MCQs designed to mimic the format and content of the 2023 urology examination outlined by the Royal College of Physicians and Surgeons of Canada (RCPSC). Following generation, a selection of MCQs underwent expert review for validity and suitability.</p><p><strong>Results: </strong>From an initial set of 123 generated MCQs, 60 were chosen for inclusion in an exam administered to 15 urology residents at the University of Toronto. The exam results demonstrated a general increasing performance with level of training cohorts, suggesting the MCQs' ability to effectively discriminate knowledge levels among residents. The majority (33/60) of the questions had discriminatory value that appeared acceptable (discriminatory index 0.2-0.4) or excellent (discriminatory index >0.4).</p><p><strong>Conclusions: </strong>This study highlights AI-driven models like GPT-4 as efficient tools to aid with MCQ generation in medical education assessments. By automating MCQ creation while maintaining quality standards, AI can expedite processes. Future research should focus on refining AI applications in education to optimize assessments and enhance medical training and certification outcomes.</p>","PeriodicalId":50613,"journal":{"name":"Cuaj-Canadian Urological Association Journal","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lidocaine solution vs. lidocaine gel instillation for pain management during intravesical botulinum injections.
IF 1.9 4区 医学
Cuaj-Canadian Urological Association Journal Pub Date : 2025-02-24 DOI: 10.5489/cuaj.9011
Cristina Negrean, James Ross, Wenhui Yu, Conrad Maciejewski, Humberto R Vigil, Duane Hickling
{"title":"Lidocaine solution vs. lidocaine gel instillation for pain management during intravesical botulinum injections.","authors":"Cristina Negrean, James Ross, Wenhui Yu, Conrad Maciejewski, Humberto R Vigil, Duane Hickling","doi":"10.5489/cuaj.9011","DOIUrl":"https://doi.org/10.5489/cuaj.9011","url":null,"abstract":"<p><strong>Introduction: </strong>Most Canadian urologists use lidocaine solution prior to botulinium toxin (BoNT) administration; however, this requires additional time. The aim was to compare pain scores in patients undergoing office-based BoNT using lidocaine instillation and lidocaine gel vs lidocaine gel alone.</p><p><strong>Methods: </strong>All patients undergoing office based intradetrusor BoNT between March 1 and September 1, 2022, were included. Group 1 received intravesical lidocaine solution (20 ml 2% lidocaine solution + 30 ml 0.9% normal saline) instillation for 30 minutes and lidocaine gel. Group 2 received lidocaine gel only. The Verbal Numeric Rating Scale (VNRS) was used to measure pain. Patient demographics were compared with t-test for continuous and Chi-squared for categorical variables. The Mann-Whitney U test was used to compare pain scores.</p><p><strong>Results: </strong>A total of 79 patients were included (mean age 61 years, 74.7% female, 58.2% with overactive bladder, and 30.4% received first treatment). Group 1 had 39 patients and group 2 had 40. There was no significant difference in pain scores between groups: group 1 median VNRS 3.0 (interquartile range [IQR] 2.5) vs. group 2 median VNRS 4.0 (IQR 2.0) (p=0.11). No significant differences in pain scores were noted between groups based on sex, indication for treatment, or number of previous BoNT treatments (p>0.05). Post-procedural complications were low. Treatment failure did not occur.</p><p><strong>Conclusions: </strong>Lidocaine gel alone may be an acceptable analgesic alternative while improving availability and efficiency of treatment delivery. Our findings are limited by the retrospective nature of the study and the small sample size.</p>","PeriodicalId":50613,"journal":{"name":"Cuaj-Canadian Urological Association Journal","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the methodologic heterogeneity of Canadian Urological Association guidelines: Adoption of the GRADE approach (2018-2023).
IF 1.9 4区 医学
Cuaj-Canadian Urological Association Journal Pub Date : 2025-02-24 DOI: 10.5489/cuaj.8926
Maylynn Ding, Vardhil Gandhi, Daniel A Gonzalez-Padilla, Philipp Dahm
{"title":"Assessing the methodologic heterogeneity of Canadian Urological Association guidelines: Adoption of the GRADE approach (2018-2023).","authors":"Maylynn Ding, Vardhil Gandhi, Daniel A Gonzalez-Padilla, Philipp Dahm","doi":"10.5489/cuaj.8926","DOIUrl":"https://doi.org/10.5489/cuaj.8926","url":null,"abstract":"<p><strong>Introduction: </strong>The Canadian Urological Association (CUA) has a longstanding tradition of developing evidence-based guidelines. We conducted this study to assess the heterogeneity of the CUA's guideline methodology for developing recommendations from 2018-2023.</p><p><strong>Methods: </strong>We included guidelines from the CUA website from 2018-2023. Two independent reviewers working independently and in duplicate abstracted all data points and categorized the reported methodologic approaches for formulating recommendations and rating the evidence. We performed descriptive statistics only.</p><p><strong>Results: </strong>We included 23 guideline documents with a total of 654 recommendations. The median number of recommendations per guideline was 25 (interquartile range 17; 35). Seven guidelines (187 recommendations) used a modified Oxford Center for Evidence-Based Medicine approach for both the strength of recommendations and the levels of evidence, and eight guidelines (177 recommendations) reported the use of GRADE both for the strength of recommendations and the certainty of evidence. Of the remaining eight guidelines, four (154 recommendations) blended the GRADE approach for the strength of recommendations with modified Oxford levels of evidence, and the remaining four combined the American Urological Association's approach to recommendations with Oxford levels of evidence (n=1), GRADE certainty of evidence (n=2), or used GRADE but made no recommendations (n=1).</p><p><strong>Conclusions: </strong>CUA guidelines have been marked by considerable methodologic heterogeneity that may confuse end users. Continued advancement in the CUA's approach to guideline development will facilitate greater collaboration and resource sharing, thereby supporting the CUA's mission of promoting high-quality, evidence-based care.</p>","PeriodicalId":50613,"journal":{"name":"Cuaj-Canadian Urological Association Journal","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promoting wellness in urology residency programs: Moving beyond tokenism.
IF 1.9 4区 医学
Cuaj-Canadian Urological Association Journal Pub Date : 2025-02-24 DOI: 10.5489/cuaj.9076
Rahim Dhalla, Jason Y Lee, Yonah Krakowsky
{"title":"Promoting wellness in urology residency programs: Moving beyond tokenism.","authors":"Rahim Dhalla, Jason Y Lee, Yonah Krakowsky","doi":"10.5489/cuaj.9076","DOIUrl":"https://doi.org/10.5489/cuaj.9076","url":null,"abstract":"","PeriodicalId":50613,"journal":{"name":"Cuaj-Canadian Urological Association Journal","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using real-world, population-level data to assess the uptake of active surveillance for low-grade prostate cancer before and after the release of clinical guidelines.
IF 1.9 4区 医学
Cuaj-Canadian Urological Association Journal Pub Date : 2025-02-24 DOI: 10.5489/cuaj.9019
Douglas C Cheung, Lisa J Martin, Narhari Timilshina, Maria Komisarenko, Patrick O Richard, Shabbir M H Alibhai, Jonathan Sussman, Nicole Mittmann, Antonio Finelli
{"title":"Using real-world, population-level data to assess the uptake of active surveillance for low-grade prostate cancer before and after the release of clinical guidelines.","authors":"Douglas C Cheung, Lisa J Martin, Narhari Timilshina, Maria Komisarenko, Patrick O Richard, Shabbir M H Alibhai, Jonathan Sussman, Nicole Mittmann, Antonio Finelli","doi":"10.5489/cuaj.9019","DOIUrl":"https://doi.org/10.5489/cuaj.9019","url":null,"abstract":"<p><strong>Introduction: </strong>Clinical guidelines recommend active surveillance (AS) as the preferred strategy for men with localized grade group (GG) 1 prostate cancer (PCa). We determined if the percentage of GG1 PCa patients in Ontario, Canada, managed by AS changed after the introduction of AS clinical guidelines and assessed adherence to the recommended followup protocol.</p><p><strong>Methods: </strong>Using Ontario administrative databases, we conducted time series analysis (autoregressive integrated moving average [ARIMA] models) in a population-based cohort of men diagnosed with GG1 PCa (2010-2018). Men were classified as managed by AS if they had repeat (confirmatory) biopsy within two years. Sensitivity analyses (treatment classification variation) and secondary analyses (low-risk GG1 and GG2 PCa) were conducted.</p><p><strong>Results: </strong>We identified 12 236 eligible GG1 PCa patients, of which 7749 (63.3%) were initially managed by AS. Percentage AS increased from 44% in 2010 to 82% in 2018. Interrupted time series analysis estimated an immediate step change of 6.2 percentage points (95% confidence interval [CI] 3.0, 9.4) and a difference in slope of -2.3 percentage points (95% CI -6.9, 2.3) per year. Findings were robust to sensitivity analyses and similar for low-risk PCa. Adherence to monitoring and AS uptake in GG2 patients were not associated with guideline publication. Limitations include lack of treatment intent information in administrative data.</p><p><strong>Conclusions: </strong>The use of AS for low-grade PCa patients in Ontario increased from almost one in two patients in 2010 to four in five patients in 2017/2018. Adoption appeared to reflect the growing acceptance of AS prior to the guidelines, as well as an increase in response to the guideline introduction.</p>","PeriodicalId":50613,"journal":{"name":"Cuaj-Canadian Urological Association Journal","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of absolute amount of pattern 4 disease on prostate biopsy with oncologic outcomes in intermediate-risk prostate cancer: A systematic review. 前列腺活检第 4 型疾病的绝对数量与中危前列腺癌的肿瘤学预后的关系:系统综述。
IF 1.9 4区 医学
Cuaj-Canadian Urological Association Journal Pub Date : 2025-02-24 DOI: 10.5489/cuaj.8995
Melissa Sam Soon, Scott C Morgan, Luke T Lavallee, Rodney H Breau, Trevor A Flood, Mark T Corkum
{"title":"Association of absolute amount of pattern 4 disease on prostate biopsy with oncologic outcomes in intermediate-risk prostate cancer: A systematic review.","authors":"Melissa Sam Soon, Scott C Morgan, Luke T Lavallee, Rodney H Breau, Trevor A Flood, Mark T Corkum","doi":"10.5489/cuaj.8995","DOIUrl":"https://doi.org/10.5489/cuaj.8995","url":null,"abstract":"<p><strong>Introduction: </strong>Managing intermediate-risk prostate cancer (IRPC) is challenging due to the heterogeneity in patient outcomes within this risk category. Evaluating the absolute amount of Gleason pattern 4 disease (GP4) at biopsy using the total linear length of pattern 4 (GP4-TL) or absolute percentage of pattern 4 (APP4) may enhance risk stratification. This review aimed to determine if these absolute measures predict oncologic outcomes in IRPC and to identify optimal prognostic thresholds.</p><p><strong>Methods: </strong>A systematic review was conducted following PRISMA guidelines. Studies included were those reporting the absolute amount of GP4 on biopsy and related outcomes in IRPC patients undergoing surgery or radiotherapy. Outcomes included biochemical recurrence, androgen deprivation therapy (ADT)-free survival, distant metastasis, prostate cancer-specific mortality, all-cause mortality, and adverse pathology.</p><p><strong>Results: </strong>Seven studies with a total of 2523 patients were included. Analysis revealed that APP4 thresholds were highly predictive of biochemical recurrence, ADT-free survival, and distant metastasis. Both APP4 and GP4-TL were superior to relative %GP4 and Gleason grading (4+3 vs. 3+4) in predicting disease progression and mortality.</p><p><strong>Conclusions: </strong>The absolute amount of GP4 shows consistent associations with important clinical outcomes and offers an accessible and established method to enhance risk stratification. Further research is needed to define optimal thresholds to guide treatment decisions.</p>","PeriodicalId":50613,"journal":{"name":"Cuaj-Canadian Urological Association Journal","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing complications from retroperitoneal lymph node dissection for testicular cancer in North America.
IF 1.9 4区 医学
Cuaj-Canadian Urological Association Journal Pub Date : 2025-02-24 DOI: 10.5489/cuaj.9042
Mithun Kailavasan, Jesus Cendejas, Melissa J Huynh, Brant A Inman, Nicholas Power
{"title":"Assessing complications from retroperitoneal lymph node dissection for testicular cancer in North America.","authors":"Mithun Kailavasan, Jesus Cendejas, Melissa J Huynh, Brant A Inman, Nicholas Power","doi":"10.5489/cuaj.9042","DOIUrl":"https://doi.org/10.5489/cuaj.9042","url":null,"abstract":"<p><strong>Introduction: </strong>Retroperitoneal lymph node dissection (RPLND) is a procedure of significant therapeutic and diagnostic value in the management of testicular cancer. This study aimed to conduct a contemporary review of surgical outcomes following RPLND procedures performed in North America over the last decade.</p><p><strong>Methods: </strong>We queried the National Surgical Quality Improvement Program (NSQIP) database from 2012-2022 (n=9 857 040) to identify patients who underwent RPLND and were diagnosed with testicular cancer. The primary outcome was 30-day morbidity. Secondary outcomes included time-to-complication analysis, rate of additional organ resection, hospital length of stay (LOS), and readmission rates. Binomial logistic regression and a generalized linear model were used to identify risk factors associated with 30-day morbidity and LOS.</p><p><strong>Results: </strong>A total of 513 RPLND procedures met the inclusion criteria. The median age was 30 years (interquartile range [IQR] 24-36.50) with a body mass index of 27.9 kg/m<sup>2</sup> (IQR 24.5- 32.0). There were no deaths within 30 days. The overall 30-day morbidity rate was 17% (n=86). Bleeding/transfusion postoperatively (12%), return to the operating room (3%), and superficial surgical site infection (2%) were the three most common complications. Factors associated with increased 30-day morbidity included: history of smoking (odds ratio [OR] 2.5, 95% confidence interval [CI] 1.35-4.68) and concurrent vascular repair/reconstruction (OR 4.1, 95% CI 1.12-15.46). The median LOS was four days (IQR 3- 6) and the 30-day readmission rate was 7.0%.</p><p><strong>Conclusions: </strong>This study underscores that approximately one in six patients experience complications following RPLND in North America. Identifying the timing of and risk factors for these complications can improve physician-patient communication and overall care.</p>","PeriodicalId":50613,"journal":{"name":"Cuaj-Canadian Urological Association Journal","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信