Medical Journal of Indonesia最新文献

Obesity in urban Indonesia: evidence from the 2007 and 2018 Basic Health Research 印度尼西亚城市中的肥胖症：来自 2007 年和 2018 年基础健康研究的证据

Medical Journal of Indonesia Pub Date : 2024-07-24 DOI: 10.13181/mji.oa.247183

A. Ferdina, P. P. Arfines, N. Aryastami

{"title":"Obesity in urban Indonesia: evidence from the 2007 and 2018 Basic Health Research","authors":"A. Ferdina, P. P. Arfines, N. Aryastami","doi":"10.13181/mji.oa.247183","DOIUrl":"https://doi.org/10.13181/mji.oa.247183","url":null,"abstract":"BACKGROUND The prevalence of obesity in urbanizing Indonesia is rising, where the double burden of malnutrition poses a significant challenge. This study aimed to examine the prevalence and increment of obesity-related noncommunicable diseases (NCDs) of diabetes and hypertension. \u0000METHODS Secondary data from the latest 2018 Basic Health Research (RISKESDAS) were used to analyze the obesity rate and its associations with lifestyle, sociodemographics, and certain comorbidities among urban Indonesians. This study included non-pregnant adults aged ≥18 years who lived in the urban area and whose blood pressure and glucose levels were measured in the survey. Results were compared to a similar study using data from 2007. \u0000RESULTS The proportion of obesity among Indonesia’s urban population was more than doubled from 23.0% in 2007 to 50.1% in 2018 for obesity and 28.0% to 57.2% for central obesity. Additionally, females, individuals with higher socioeconomic status, and higher education levels exhibited a higher obesity prevalence. \u0000CONCLUSIONS Urban Indonesia has witnessed a dramatic rise in obesity prevalence. Our findings highlighted the urgent need for policymakers to consider the escalating prevalence of NCDs associated with obesity. Strengthening and concretizing health promotion and prevention policies at the community level are crucial to combat this alarming public health challenge.","PeriodicalId":506124,"journal":{"name":"Medical Journal of Indonesia","volume":"35 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141809981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Diabetic foot score: a predictive model for leg amputation in patients with diabetic foot disease 糖尿病足评分：糖尿病足病患者截肢的预测模型

Medical Journal of Indonesia Pub Date : 2024-07-24 DOI: 10.13181/mji.oa.247427

Agustinus Vincent, S. Soelistijo, Deasy Ardiany, Agung Pranoto, Michael Lusida, Lukita Pradhevi, Rendra Prasetya Saefudin

{"title":"Diabetic foot score: a predictive model for leg amputation in patients with diabetic foot disease","authors":"Agustinus Vincent, S. Soelistijo, Deasy Ardiany, Agung Pranoto, Michael Lusida, Lukita Pradhevi, Rendra Prasetya Saefudin","doi":"10.13181/mji.oa.247427","DOIUrl":"https://doi.org/10.13181/mji.oa.247427","url":null,"abstract":"BACKGROUND Patients with diabetes mellitus are at a higher risk for peripheral artery disease (PAD) and diabetic foot disease (DFD), which can ultimately result in leg amputation. This study aimed to develop a novel scoring system to predict the risk of leg amputation using widely available modalities, including demographic characteristics and various laboratory data. \u0000METHODS This study was conducted at Dr. Soetomo General Hospital and analyzed risk factors for leg amputation in 99 patients with DFD who underwent leg amputation compared with 80 control patients. This study presented a predictive model for leg amputation in patients with DFD, using odds ratio (OR) analysis and logistic regression approach with confidence intervals (CIs) set at 95%. The data analysis was conducted using SPSS software version 25.0. \u0000RESULTS PAD (OR 6.52, 95% CI = 2.19–19.37, p = 0.001), high low-density lipoprotein cholesterol (OR 5.97, 95% CI = 2.31–15.43, p<0.001), type of DFD (OR 4.58, 95% CI = 2.14–9.79, p<0.001), poor glycemic control (OR 4.48, 95% CI = 1.78–11.28, p = 0.001), and neutrophil-to-lymphocyte ratio level (OR 1.04, 95% CI = 1.00–1.07, p = 0.025) were the independent predictors for leg amputation. The predictive model, developed using multivariate analysis with an area under the curve of 89%, optimum threshold of 0.5 (score 6), sensitivity of 84.8%, and specificity of 78.8%, indicating a promising approach for predicting leg amputation outcomes. \u0000CONCLUSIONS The newly developed diabetic foot score may assist in making decisions regarding therapeutic options for patients with DFD.","PeriodicalId":506124,"journal":{"name":"Medical Journal of Indonesia","volume":"19 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141806297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutting-edge technology application for prostate disease management in Indonesia: implementation of Healthcare 5.0 towards Indonesia’s Golden Vision 2045 印尼前列腺疾病管理的尖端技术应用：实施医疗保健 5.0，实现印尼 2045 年黄金愿景

Medical Journal of Indonesia Pub Date : 2024-07-24 DOI: 10.13181/mji.com.247688

Agus Rizal Ardy Hariandy Hamid

引用次数: 0

Flaps or flat: a case report of double free flap survival after a prolonged cardiac arrest 皮瓣或扁平：长期心脏骤停后双游离皮瓣存活的病例报告

Medical Journal of Indonesia Pub Date : 2024-07-24 DOI: 10.13181/mji.cr.247422

P. Atmodiwirjo, M. R. Ramadan, Michael Djohan, N. F. Amanda

{"title":"Flaps or flat: a case report of double free flap survival after a prolonged cardiac arrest","authors":"P. Atmodiwirjo, M. R. Ramadan, Michael Djohan, N. F. Amanda","doi":"10.13181/mji.cr.247422","DOIUrl":"https://doi.org/10.13181/mji.cr.247422","url":null,"abstract":"This case addressed patient and free flap survival after cardiac arrest with the contentious use of vasopressors amid concerns about potential vasoconstrictive effects on flap vitality. A 59-year-old male with mucoepidermoid carcinoma underwent post-total maxillectomy and double free flap reconstruction (free fibular flap and anterolateral thigh free flap). Intraoperatively, he experienced cardiac arrest after anastomosis due to hypovolemia or hypoxia, requiring external cardiac massage and vasopressor administration. Despite the initial restoration of circulation, subsequent cardiac arrest ensued, necessitating further resuscitation. Postoperatively, vasopressors were also administered due to hemodynamic instability. Contrary to concerns, both flaps demonstrated sustained vitality, challenging prevailing apprehensions about vasopressor-induced vasoconstriction compromising flap viability. This observation suggests that vasopressors may not significantly threaten flap viability, prompting reconsideration of hesitations and encouraging further investigation. The study advocates for a judicious evaluation of vasopressor administration in free flap procedures, enriching clinical considerations for optimal patient care.","PeriodicalId":506124,"journal":{"name":"Medical Journal of Indonesia","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141807756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kegel exercises with a guidebook for stress urinary incontinence treatment 凯格尔运动与压力性尿失禁治疗指南

Medical Journal of Indonesia Pub Date : 2024-07-24 DOI: 10.13181/mji.oa.247142

S. Hakim, Budi Iman Santoso, H. Rahardjo, Siti Setiati, W. Kusumaningsih, J. Prihartono, Nurhadi Ibrahim, Wresti Indriatmi, Erwinanto

{"title":"Kegel exercises with a guidebook for stress urinary incontinence treatment","authors":"S. Hakim, Budi Iman Santoso, H. Rahardjo, Siti Setiati, W. Kusumaningsih, J. Prihartono, Nurhadi Ibrahim, Wresti Indriatmi, Erwinanto","doi":"10.13181/mji.oa.247142","DOIUrl":"https://doi.org/10.13181/mji.oa.247142","url":null,"abstract":"BACKGROUND Stress urinary incontinence (SUI) is uncontrollable urine leakage when intra-abdominal pressure increases. Behavioral therapy with Kegel exercise is currently the best conservative management recommendation for treating SUI patients. This study aimed to investigate the success of supervised Kegel exercises using the Kegel exercises guidebook in women with SUI. \u0000METHODS This quasi-experimental study involved both groups being taught the same regiment of Kegel exercises, but the intervention group was given the Kegel exercises guidebook. After 12 weeks, the compliance, subjective, and objective success rates were evaluated through the patient’s notes, Urinary Distress Inventory-6, Incontinence Impact Questionnaire-7, perineometer, and pad test. \u0000RESULTS Patients with a higher level of education had lower compliance to Kegel exercises (p = 0.01; odds ratio [OR] 0.38; 0.18–0.79). No significant difference was observed in the subjective symptom improvement between the two groups. The intervention group had a significantly higher success rate based on objective success by analyzing the 1-hour pad test results. The intervention group was also more adherent (p<0.001; OR 4.78; 2.51–9.0). \u0000CONCLUSIONS Patients who received the Kegel exercises guidebook were more compliant and more objectively successful than those who did not receive the manuals.","PeriodicalId":506124,"journal":{"name":"Medical Journal of Indonesia","volume":"41 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141807881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Syndecan-4 levels in bronchoalveolar lavage fluid and serum in non-small cell lung cancer 非小细胞肺癌支气管肺泡灌洗液和血清中的 Syndecan-4 水平

Medical Journal of Indonesia Pub Date : 2024-07-24 DOI: 10.13181/mji.oa.247264

Asrul Abdul Azis, Arif Santoso, I. Djaharuddin, Harun Iskandar, Muhammad Ilyas, Nurjannah Lihawa

{"title":"Syndecan-4 levels in bronchoalveolar lavage fluid and serum in non-small cell lung cancer","authors":"Asrul Abdul Azis, Arif Santoso, I. Djaharuddin, Harun Iskandar, Muhammad Ilyas, Nurjannah Lihawa","doi":"10.13181/mji.oa.247264","DOIUrl":"https://doi.org/10.13181/mji.oa.247264","url":null,"abstract":"BACKGROUND Lung cancer has the highest cancer-related mortality rate worldwide. Research has been conducted to improve early detection and markers of predictive value but only focused on the expression of syndecan-4 (SDC4) in serum. Studies in bronchoalveolar lavage (BAL) fluids of non-small cell lung cancer (NSCLC) patients are still limited. This study aimed to evaluate the clinical value of SDC4 in serum and BAL in NSCLC patients. \u0000METHODS Blood serum and BAL fluids were obtained from 44 patients with NSCLC and 41 non-cancer patients as the control. The level of SDC4 was measured. The relationships between SDC4 and clinicopathologic factors were also analyzed. \u0000RESULTS Serum SDC4 levels in NSCLC patients were significantly lower than the control group (p = 0.002). Furthermore, the disease stages and serum SDC4 levels had a negative correlation, which was lower in the advanced stage (IIIb/IV) than in the initial stage (I/II/IIIa) (p = 0.517). The same results were obtained from BAL fluids SDC4 levels, which were significantly lower in the advanced stage (IIIb/IV) than in the early stage (I/II/IIIa) (p = 0.007). \u0000CONCLUSIONS Serum SDC4 levels in NSCLC patients were lower than those of non-cancer patients. They also performed different results in disease stages. SDC4 could be a helpful biomarker in NSCLC.","PeriodicalId":506124,"journal":{"name":"Medical Journal of Indonesia","volume":"59 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141809174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of selective androgen receptor modulator RAD140 on prostate and testosterone levels in Wistar strain rats with bilateral orchidectomy 选择性雄激素受体调节剂 RAD140 对双侧睾丸切除 Wistar 株大鼠前列腺和睾酮水平的影响

Medical Journal of Indonesia Pub Date : 2024-07-24 DOI: 10.13181/mji.oa.247289

Taufiq Nur Budaya, Pradana Nurhadi, Kenty W. Anita, Prasetyo Nugroho, Fauzan Kurniawan Dhani

{"title":"Effect of selective androgen receptor modulator RAD140 on prostate and testosterone levels in Wistar strain rats with bilateral orchidectomy","authors":"Taufiq Nur Budaya, Pradana Nurhadi, Kenty W. Anita, Prasetyo Nugroho, Fauzan Kurniawan Dhani","doi":"10.13181/mji.oa.247289","DOIUrl":"https://doi.org/10.13181/mji.oa.247289","url":null,"abstract":"BACKGROUND Selective androgen receptor modulators (SARMs) have been investigated as a potential treatment for hypogonadism, a condition characterized by low testosterone levels in men. The idea is to provide therapeutic benefits similar to traditional testosterone replacement therapy. However, research in this area is still in its early stages, and more extensive studies are needed to establish the efficacy of SARM. This study aimed to determine the impact of SARM RAD140 on testosterone levels, fibromuscular stroma, and prostate mass in rats undergoing bilateral orchidectomy. \u0000METHODS This was an in vivo study using posttest-only control group design in rats (Rattus norvegicus). The positive and negative control groups consisted of rats with and without bilateral orchidectomy, respectively. The treatment groups were rats given SARM RAD140 with and without orchidectomy. Testosterone levels, histopathology, and prostate mass were examined at the end of week 6, and the quantitative data were analyzed using one-way ANOVA. \u0000RESULTS This study found no difference in prostate mass (0.598 [0.05] g versus 0.590 [0.07] g, p = 0.984), fibromuscular stroma ratio (0.483 [0.094] versus 0.463 [0.057], p = 0.984), and testosterone level (0.006 [0.005] ng/dl versus 0.014 [0.004] ng/dl, p = 0.098) compared to positive control with orchidectomy and SARM RAD140 administration 6 weeks after treatment. \u0000CONCLUSIONS There were no differences in testosterone levels, prostate mass, or the ratio of fibromuscular stroma to epithelium area in rats undergoing bilateral orchidectomy and placebo surgery with the administration of SARM RAD140.","PeriodicalId":506124,"journal":{"name":"Medical Journal of Indonesia","volume":"23 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141808771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tackling obesity in Indonesia: current problems and future directions 解决印度尼西亚的肥胖问题：当前问题和未来方向

Medical Journal of Indonesia Pub Date : 2024-07-24 DOI: 10.13181/mji.ed.247691

D. Tahapary

引用次数: 0

Association between immune system parameter and clinical characteristics among patients with solid cancer 实体癌患者的免疫系统参数与临床特征之间的关系

Medical Journal of Indonesia Pub Date : 2024-07-24 DOI: 10.13181/mji.oa.247272

R. Cahyanur, Alvina Widhani, Nico Iswanto Pantoro, Annisa Tsana Madadika

{"title":"Association between immune system parameter and clinical characteristics among patients with solid cancer","authors":"R. Cahyanur, Alvina Widhani, Nico Iswanto Pantoro, Annisa Tsana Madadika","doi":"10.13181/mji.oa.247272","DOIUrl":"https://doi.org/10.13181/mji.oa.247272","url":null,"abstract":"BACKGROUND Lymphopenia has been reported to be a major predictor of chemotherapy-related toxicity. This study aimed to investigate the correlation between neutrophils, lymphocytes, CD4, and CD8 in solid cancer patients and cancer clinical characteristics. \u0000METHODS This was a cross-sectional study of patients who will undergo chemotherapy at the Hematology and Medical Oncology Clinic, Cipto Mangunkusumo Hospital, from June to September 2023. Clinical characteristics, CD4 and CD8 levels, and neutrophil and lymphocyte counts were assessed at the first visit. A comparative test was carried out on the patients’ average CD4, CD8, neutrophil, and lymphocyte counts. \u0000RESULTS Types of cancer were associated with CD4 levels. Patients with head and neck cancer had lower CD4 levels (411.3 [119.3–1,427.5] cells/mm³) compared with colorectal (514.7 [129.2–861.3] cells/mm³), breast and gynecological (567.5 [180.1–939 cells/mm³), and other cancers (681.4 [175.1–2,056.9] cells/mm³), with p = 0.009. Patients aged ≥40 years had higher CD8 levels than those aged <40 years (376.4 [142.8–1,293.1] cells/mm³ versus 565.3 [185.9–1,944] cells/mm³, p = 0.01). Additionally, lymphocyte count was associated with cancer type, with the lowest number in head and neck cancer (1,380 [280–2,660] μl, p = 0.044). \u0000CONCLUSIONS CD4 levels and lymphocyte counts were associated with the cancer type, whereas CD8 levels were influenced by age.","PeriodicalId":506124,"journal":{"name":"Medical Journal of Indonesia","volume":"40 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141809803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of cilostazol in promoting the maturation of newly created arteriovenous fistula in patients with end-stage renal disease: a systematic review and meta-analysis 西洛他唑促进终末期肾病患者新建动静脉瘘成熟的疗效：系统综述和荟萃分析

Medical Journal of Indonesia Pub Date : 2024-04-16 DOI: 10.13181/mji.oa.247252

Herick Alvenus, Willim, Erica Sugandi, Alvin Ariyanto Sani, Hengky Khouw, H. A. Willim

{"title":"Efficacy of cilostazol in promoting the maturation of newly created arteriovenous fistula in patients with end-stage renal disease: a systematic review and meta-analysis","authors":"Herick Alvenus, Willim, Erica Sugandi, Alvin Ariyanto Sani, Hengky Khouw, H. A. Willim","doi":"10.13181/mji.oa.247252","DOIUrl":"https://doi.org/10.13181/mji.oa.247252","url":null,"abstract":"BACKGROUND Arteriovenous fistula (AVF) is considered the gold standard for vascular access in hemodialysis. However, achieving the successful maturation of AVF remains a challenge. Cilostazol, a phosphodiesterase-3 inhibitor, has shown promise in enhancing AVF maturation. This study aimed to assess the clinical efficacy of cilostazol in promoting AVF maturation. \u0000METHODS This meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive systematic literature search was performed using PubMed, ScienceDirect, Cochrane Library, ProQuest, and Google Scholar to identify studies investigating the efficacy of cilostazol on the maturation of newly created AVF in patients with end-stage renal disease and published up to August 2023. The intervention group received perioperative cilostazol therapy, while the control group did not receive cilostazol. The outcomes were the maturation rate of AVF and AVF-related complications. Meta-analysis was conducted using Review Manager software version 5.3. \u0000RESULTS 5 studies involving 549 patients were included. The intervention group comprised 228 patients, while the control group comprised 321 patients. In the pooled analysis, patients in the intervention group had a significantly higher rate of AVF maturation (odds ratio [OR] = 2.18, 95% confidence interval [CI]: 1.29–3.68, p = 0.003, I2 = 47%) and a lower rate of AVF-related complications (OR = 0.46, 95% CI: 0.28–0.77, p = 0.003, I2 = 27%) compared to the control. \u0000CONCLUSIONS Cilostazol was associated with a higher rate of AVF maturation and a lower rate of AVF-related complications.","PeriodicalId":506124,"journal":{"name":"Medical Journal of Indonesia","volume":"90 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140695695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0