M. J. Muñoz-Dávila, M. T. Cabezas Fernández, M. R. Maresca, Miguel J. Martínez-Lirola
{"title":"Usefulness of Xpert MTB/RIF Ultra in Respiratory Specimens With Doubtful Auramine Staining Result and Comparison With Predecessor Test","authors":"M. J. Muñoz-Dávila, M. T. Cabezas Fernández, M. R. Maresca, Miguel J. Martínez-Lirola","doi":"10.1097/ipc.0000000000001355","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001355","url":null,"abstract":"","PeriodicalId":505905,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":"57 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Skin Involvement","authors":"Pulido-Pérez Ana, Bergón-Sendín Marta, Suárez-Fernández Ricardo, Á. Rosell-Díaz, Barchino-Ortiz Lucía, Nieto-Benito Lula, Muñoz Patricia, Bouza Emilio","doi":"10.1097/ipc.0000000000001351","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001351","url":null,"abstract":"\u0000 Skin involvement can occur at the beginning of a septic episode (primary skin and soft tissue infections) or during its progression (secondary or metastatic skin lesions), making skin a useful accessible tissue in the study of septic patients. The objective of this study was to determine the overall prevalence of sepsis-related skin findings and evaluate their possible prognostic value. A retrospective, single-center study of septic patients with documented bloodstream infections admitted in a tertiary hospital in 2019 was carried out. Unselected samples of 320 episodes of sepsis from 265 patients were included. Skin lesions were documented in 83 septic episodes from 69 patients (25.9%). Skin involvement was more frequently associated with bloodstream infections caused by Staphylococcus aureus (P = 0.0001), coagulase-negative staphylococci (P = 0.036), and Pseudomonas aeruginosa (P = 0.005). Mean hospital stay (37.58 vs 27.82 days, P = 0.023) and sepsis-related mortality (18.1% vs 11.0%, P = 0.024) were higher in patients with skin lesions than in individuals without them. Our results suggest that skin involvement (primary and/or secondary) is an unfavorable indicator in the evolution of septic patients with bloodstream infections. Thorough examination of the skin is recommended in the routine evaluation of septic patients, whether or not the origin of the infection is known.","PeriodicalId":505905,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":"28 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140743941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Central Retinal Vein Occlusion in COVID-19","authors":"Arunava Saha, George M. Abraham","doi":"10.1097/ipc.0000000000001354","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001354","url":null,"abstract":"\u0000 Central retinal vein occlusion (CRVO) secondary to severe acute respiratory syndrome coronavirus 2–induced coagulation abnormalities is rare. A 32-year-old man presented with bilateral CRVO. He had a history of retinal migraine with occasional floaters and received 2 primary and a booster dose of the BNT162b2 vaccine 7 months prior. Four months before presentation, he developed acute blurring of vision in the left eye and was diagnosed with a nonischemic CRVO with dot-blot hemorrhages. He was managed conservatively with aspirin. Three weeks later, he contracted COVID-19 and received 5 days of nirmatrelvir/ritonavir. Four weeks after his COVID infection, repeat fundoscopic evaluation demonstrated resolving hemorrhages in the left eye but a new CRVO in the right eye. Antivascular endothelial growth factor injections were deferred because of normal visual acuity. He had a normal magnetic resonance imaging of the brain and a normal bilateral carotid duplex and was planned for close follow-up with ophthalmology. COVID-19 patients presenting with visual symptoms should be screened for CRVO.","PeriodicalId":505905,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140746341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Changing Paradigms in Epidemiology, Microbiology, and Outcomes of Infective Endocarditis","authors":"Nancy Khardori","doi":"10.1097/ipc.0000000000001357","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001357","url":null,"abstract":"","PeriodicalId":505905,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":"250 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140282053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adrienne Yun, Virginia Zacharias, Susan M Szpunar, Louis Saravolatz
{"title":"A Comparison of Non–COVID-19 Hospital Mortality Rates During COVID-19 Surges Compared With Prepandemic Periods","authors":"Adrienne Yun, Virginia Zacharias, Susan M Szpunar, Louis Saravolatz","doi":"10.1097/ipc.0000000000001340","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001340","url":null,"abstract":"\u0000 A retrospective chart review comparing non–COVID-19–related diseases during the pandemic and prepandemic periods found no difference in the hospital mortality rate during the initial COVID-19 surge compared with pre–COVID-19 baseline. This difference from the literature may be because of assigning more physicians to the hospital during the COVID-19 surge.","PeriodicalId":505905,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":"90 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139855582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ji Hyun Yang, Liliana Tavares, Soo Jin Moon, Tae Kyung Yoo, Leonardo Wagner, Felipe Barbosa, George Kinzfogl, Lucas Chen, Thomas Treadwell
{"title":"Endocarditis in a Community Teaching Hospital","authors":"Ji Hyun Yang, Liliana Tavares, Soo Jin Moon, Tae Kyung Yoo, Leonardo Wagner, Felipe Barbosa, George Kinzfogl, Lucas Chen, Thomas Treadwell","doi":"10.1097/ipc.0000000000001342","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001342","url":null,"abstract":"\u0000 \u0000 Endocarditis is a life-threatening condition with protean manifestations. The clinical syndrome continues to evolve with an aging population, the opioid epidemic, and changing microbiological profiles. Much of the clinical data for endocarditis comes from tertiary care centers with on-site cardiac surgery. Previous community cohorts do not reflect the current patient populations or current microbiology and predate the current opioid epidemic. We retrospectively reviewed the baseline clinical characteristics, microbiologic spectrum, surgical indication, tertiary referral, and outcomes for patients presenting to a community hospital with infective endocarditis (IE).\u0000 \u0000 \u0000 \u0000 We retrospectively reviewed all adult medical patient admitted over a 5-year period with a clinical diagnosis of IE, from February 2016 to September 2021, to a single suburban safety net community hospital without on-site cardiac surgery.\u0000 \u0000 \u0000 \u0000 We identified 99 patients with a clinical diagnosis of IE. We observed a bimodal age distribution, with more comorbidities and predisposing cardiac conditions in the older patients and more intravenous drug use in the younger patients. Surgical indications were present in 44% of patients. Staphylococcus aureus was the most common pathogen. Overall survival was associated with fewer comorbidities and the absence of methicillin-resistant S. aureus infection. There was no difference in survival between patients with and without surgical indications.\u0000 \u0000 \u0000 \u0000 IE continues to primarily affect older patients with comorbidities and results in a high 1-year mortality of 33%. A simple score including age, Charlson comorbidity index of 6.5, and methicillin-resistant S. aureus infection was predictive for in-patient, 30-day, and 1-year mortality.\u0000","PeriodicalId":505905,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":"6 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139795495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adrienne Yun, Virginia Zacharias, Susan M Szpunar, Louis Saravolatz
{"title":"A Comparison of Non–COVID-19 Hospital Mortality Rates During COVID-19 Surges Compared With Prepandemic Periods","authors":"Adrienne Yun, Virginia Zacharias, Susan M Szpunar, Louis Saravolatz","doi":"10.1097/ipc.0000000000001340","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001340","url":null,"abstract":"\u0000 A retrospective chart review comparing non–COVID-19–related diseases during the pandemic and prepandemic periods found no difference in the hospital mortality rate during the initial COVID-19 surge compared with pre–COVID-19 baseline. This difference from the literature may be because of assigning more physicians to the hospital during the COVID-19 surge.","PeriodicalId":505905,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":"26 44","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139795743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ji Hyun Yang, Liliana Tavares, Soo Jin Moon, Tae Kyung Yoo, Leonardo Wagner, Felipe Barbosa, George Kinzfogl, Lucas Chen, Thomas Treadwell
{"title":"Endocarditis in a Community Teaching Hospital","authors":"Ji Hyun Yang, Liliana Tavares, Soo Jin Moon, Tae Kyung Yoo, Leonardo Wagner, Felipe Barbosa, George Kinzfogl, Lucas Chen, Thomas Treadwell","doi":"10.1097/ipc.0000000000001342","DOIUrl":"https://doi.org/10.1097/ipc.0000000000001342","url":null,"abstract":"\u0000 \u0000 Endocarditis is a life-threatening condition with protean manifestations. The clinical syndrome continues to evolve with an aging population, the opioid epidemic, and changing microbiological profiles. Much of the clinical data for endocarditis comes from tertiary care centers with on-site cardiac surgery. Previous community cohorts do not reflect the current patient populations or current microbiology and predate the current opioid epidemic. We retrospectively reviewed the baseline clinical characteristics, microbiologic spectrum, surgical indication, tertiary referral, and outcomes for patients presenting to a community hospital with infective endocarditis (IE).\u0000 \u0000 \u0000 \u0000 We retrospectively reviewed all adult medical patient admitted over a 5-year period with a clinical diagnosis of IE, from February 2016 to September 2021, to a single suburban safety net community hospital without on-site cardiac surgery.\u0000 \u0000 \u0000 \u0000 We identified 99 patients with a clinical diagnosis of IE. We observed a bimodal age distribution, with more comorbidities and predisposing cardiac conditions in the older patients and more intravenous drug use in the younger patients. Surgical indications were present in 44% of patients. Staphylococcus aureus was the most common pathogen. Overall survival was associated with fewer comorbidities and the absence of methicillin-resistant S. aureus infection. There was no difference in survival between patients with and without surgical indications.\u0000 \u0000 \u0000 \u0000 IE continues to primarily affect older patients with comorbidities and results in a high 1-year mortality of 33%. A simple score including age, Charlson comorbidity index of 6.5, and methicillin-resistant S. aureus infection was predictive for in-patient, 30-day, and 1-year mortality.\u0000","PeriodicalId":505905,"journal":{"name":"Infectious Diseases in Clinical Practice","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139855560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}