Development Genes and Evolution最新文献_第5页

Implications of a cheliceral axial duplication in Tetragnatha versicolor (Araneae: Tetragnathidae) for arachnid deuterocerebral appendage development. 彩色四角蛛(蜘蛛目:四角蛛科)化学轴向复制对蛛形动物后脑附属物发育的影响。

IF 2.4 3区生物学

Development Genes and Evolution Pub Date : 2021-12-01 Epub Date: 2021-06-14 DOI: 10.1007/s00427-021-00678-9

Darko D Cotoras, Pedro de S Castanheira, Prashant P Sharma

{"title":"Implications of a cheliceral axial duplication in Tetragnatha versicolor (Araneae: Tetragnathidae) for arachnid deuterocerebral appendage development.","authors":"Darko D Cotoras, Pedro de S Castanheira, Prashant P Sharma","doi":"10.1007/s00427-021-00678-9","DOIUrl":"https://doi.org/10.1007/s00427-021-00678-9","url":null,"abstract":"The homology of the arachnid chelicera with respect to other head appendages in Panarthropoda has long been debated. Gene expression data and the re-interpretation of early transitional fossils have supported the homology of the deutocerebrum and its associated appendages, implying a homology between primary antennae (mandibulates), chelicerae (euchelicerates), and chelifores (sea spiders). Nevertheless, comparatively little is known about the mechanistic basis of proximo-distal (PD) axis induction in chelicerates, much less the basis for cheliceral fate specification. Here, we describe a new cheliceral teratology in the spider Tetragnatha versicolor Walckenaer, 1841, which consists on a duplication of the PD axis of the left chelicera associated with a terminal secondary schistomely on the fang of the lower axis. This duplication offers clues as to potential shared mechanisms of PD axis formation in the chelicera. We review the state of knowledge on PD axis induction mechanisms in arthropods and identify elements of gene regulatory networks that are key for future functional experiments of appendage development in non-insect model systems. Such investigations would allow a better understanding of PD axis induction of modified and poorly studied arthropod limbs (e.g., chelicerae, chelifores, and ovigers).","PeriodicalId":50588,"journal":{"name":"Development Genes and Evolution","volume":"231 5-6","pages":"131-139"},"PeriodicalIF":2.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00427-021-00678-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39012251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Potential stress tolerance roles of barley germins and GLPs. 大麦发芽和glp的潜在抗逆性作用。

IF 2.4 3区生物学

Development Genes and Evolution Pub Date : 2021-12-01 Epub Date: 2021-08-07 DOI: 10.1007/s00427-021-00680-1

Elif Karlik

{"title":"Potential stress tolerance roles of barley germins and GLPs.","authors":"Elif Karlik","doi":"10.1007/s00427-021-00680-1","DOIUrl":"https://doi.org/10.1007/s00427-021-00680-1","url":null,"abstract":"Germins and germin-like proteins (GLPs) known as germination markers are encoded by multigene families in several plant species, including barley. To date, functional analysis has revealed germins and GLPs are involved in diverse processes such as embryonic development and stress responses. The aim of this study was the analysis of barley germins and GLPs. In this study, 80 putative germins and GLPs have been identified in barley by using known 17 germins and GLP sequences. Analysis of germins and GLPs showed all germins and GLPs are distributed on all seven chromosomes that most of them spread through chromosome 3, 4 and 7 with 16, 18 and 12 proteins on each, respectively. The protein sizes varied between 185 and 335 amino acids, with an average length of 225 aa. Twelve conserved motifs were found. While germin motifs 1 and 3 were detected in all germins and GLPs, some motifs were found to be related to signalization. Interestingly, protein-protein interaction analysis demonstrated some GLPs are associated with RAB6-interacting golgin, oligopeptide transmembrane transporter activity, beta-glucuronidase activity, protein N-linked glycosylation, multi-pass membrane protein, and proteins containing zinc finger (Znf) domain and RING (really interesting new gene)-type zinc finger domains. Our findings suggest that barley germins and GLPs may have diverse functions that make them important candidates for crop improvement.","PeriodicalId":50588,"journal":{"name":"Development Genes and Evolution","volume":"231 5-6","pages":"109-118"},"PeriodicalIF":2.4,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39287510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The color pattern inducing gene wingless is expressed in specific cell types of campaniform sensilla of a polka-dotted fruit fly, Drosophila guttifera. 色纹诱导基因无翼在斑点果蝇钟形感受器的特定细胞类型中表达。

IF 2.4 3区生物学

Development Genes and Evolution Pub Date : 2021-07-01 Epub Date: 2021-03-27 DOI: 10.1007/s00427-021-00674-z

Masato Koseki, Nobuaki K Tanaka, Shigeyuki Koshikawa

{"title":"The color pattern inducing gene wingless is expressed in specific cell types of campaniform sensilla of a polka-dotted fruit fly, Drosophila guttifera.","authors":"Masato Koseki, Nobuaki K Tanaka, Shigeyuki Koshikawa","doi":"10.1007/s00427-021-00674-z","DOIUrl":"https://doi.org/10.1007/s00427-021-00674-z","url":null,"abstract":"A polka-dotted fruit fly, Drosophila guttifera, has a unique pigmentation pattern on its wings and is used as a model for evo-devo studies exploring the mechanism of evolutionary gain of novel traits. In this species, a morphogen-encoding gene, wingless, is expressed in species-specific positions and induces a unique pigmentation pattern. To produce some of the pigmentation spots on wing veins, wingless is thought to be expressed in developing campaniform sensillum cells, but it was unknown which of the four cell types there express(es) wingless. Here we show that two of the cell types, dome cells and socket cells, express wingless, as indicated by in situ hybridization together with immunohistochemistry. This is a unique case in which non-neuronal SOP (sensory organ precursor) progeny cells produce Wingless as an inducer of pigmentation pattern formation. Our finding opens a path to clarifying the mechanism of evolutionary gain of a unique wingless expression pattern by analyzing gene regulation in dome cells and socket cells.","PeriodicalId":50588,"journal":{"name":"Development Genes and Evolution","volume":"231 3-4","pages":"85-93"},"PeriodicalIF":2.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00427-021-00674-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25522725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Expression patterns of signalling molecules and transcription factors in the early rabbit embryo and their significance for modelling amniote axis formation. 兔早期胚胎中信号分子和转录因子的表达模式及其对羊膜轴形成的模拟意义。

IF 2.4 3区生物学

Development Genes and Evolution Pub Date : 2021-07-01 Epub Date: 2021-06-07 DOI: 10.1007/s00427-021-00677-w

Ruben Plöger, Christoph Viebahn

{"title":"Expression patterns of signalling molecules and transcription factors in the early rabbit embryo and their significance for modelling amniote axis formation.","authors":"Ruben Plöger, Christoph Viebahn","doi":"10.1007/s00427-021-00677-w","DOIUrl":"10.1007/s00427-021-00677-w","url":null,"abstract":"The anterior-posterior axis is a central element of the body plan and, during amniote gastrulation, forms through several transient domains with specific morphogenetic activities. In the chick, experimentally proven activity of signalling molecules and transcription factors lead to the concept of a 'global positioning system' for initial axis formation whereas in the (mammotypical) rabbit embryo, a series of morphological or molecular domains are part of a putative 'three-anchor-point model'. Because circular expression patterns of genes involved in axis formation exist in both amniote groups prior to, and during, gastrulation and may thus be suited to reconcile these models, the expression patterns of selected genes known in the chick, namely the ones coding for the transcription factors eomes and tbx6, the signalling molecule wnt3 and the wnt inhibitor pkdcc, were analysed in the rabbit embryonic disc using in situ hybridisation and placing emphasis on their germ layer location. Peripheral wnt3 and eomes expression in all layers is found initially to be complementary to central pkdcc expression in the hypoblast during early axis formation. Pkdcc then appears - together with a posterior-anterior gradient in wnt3 and eomes domains - in the epiblast posteriorly before the emerging primitive streak is marked by pkdcc and tbx6 at its anterior and posterior extremities, respectively. Conserved circular expression patterns deduced from some of this data may point to shared mechanisms in amniote axis formation while the reshaping of localised gene expression patterns is discussed as part of the 'three-anchor-point model' for establishing the mammalian body plan.","PeriodicalId":50588,"journal":{"name":"Development Genes and Evolution","volume":"231 3-4","pages":"73-83"},"PeriodicalIF":2.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00427-021-00677-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39004244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological changes during the post-embryonic ontogeny of mesothelan spiders and aspects of character evolution in early spiders. 中皮纲蜘蛛胚胎后个体发育过程中的形态变化及早期蜘蛛的特征演化。

IF 2.4 3区生物学

Development Genes and Evolution Pub Date : 2021-07-01 Epub Date: 2021-04-18 DOI: 10.1007/s00427-021-00675-y

Thomas Huber, Carolin Haug

{"title":"Morphological changes during the post-embryonic ontogeny of mesothelan spiders and aspects of character evolution in early spiders.","authors":"Thomas Huber, Carolin Haug","doi":"10.1007/s00427-021-00675-y","DOIUrl":"https://doi.org/10.1007/s00427-021-00675-y","url":null,"abstract":"Most morphological studies focus on adult specimens, or if developmental studies are pursued, especially in Euarthropoda, they focus on embryonic development. Araneae (spiders) is one of these groups, in consequence with understudied post-embryonic development. Here we present aspects of the post-embryonic stages of different species of Mesothelae, sister group to the remaining spiders (when fossil species are not taken into account). We used different imaging methods and measured different external morphological structures to detect possible ontogenetic changes. One structure exhibiting post-embryonic changes is the chelicera. Here the significant change occurs between the last immature stage and the adult, yet only in males. For the spinnerets, we could not detect ontogenetic changes, but instead a high variability in length and width, probably due to their lack of pivot joints between the elements. The strongest morphological change during ontogeny occurred on the sternum, which begins with a rather roundish shape in the first stage and changes to being fairly elongate in shape in the last immature stages and the adult. This specific sternum shape only occurs in adults of mesothelan spiders, while opisthothelan spiders have a broader sternum also in the adult. We discuss our results in an evolutionary context, also taking into account recent finds of fossil spiders.","PeriodicalId":50588,"journal":{"name":"Development Genes and Evolution","volume":"231 3-4","pages":"47-56"},"PeriodicalIF":2.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00427-021-00675-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38882717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Evolutionary divergence of a Hoxa2b hindbrain enhancer in syngnathids mimics results of functional assays. 合颌动物Hoxa2b后脑增强子的进化分化模拟了功能分析的结果。

IF 2.4 3区生物学

Development Genes and Evolution Pub Date : 2021-07-01 Epub Date: 2021-05-18 DOI: 10.1007/s00427-021-00676-x

Allison M Fuiten, William A Cresko

{"title":"Evolutionary divergence of a Hoxa2b hindbrain enhancer in syngnathids mimics results of functional assays.","authors":"Allison M Fuiten, William A Cresko","doi":"10.1007/s00427-021-00676-x","DOIUrl":"https://doi.org/10.1007/s00427-021-00676-x","url":null,"abstract":"Hoxa2 genes provide critical patterning signals during development, and their regulation and function have been extensively studied. We report a previously uncharacterized significant sequence divergence of a highly conserved hindbrain hoxa2b enhancer element in the family syngnathidae (pipefishes, seahorses, pipehorses, seadragons). We compared the hox cis-regulatory element variation in the Gulf pipefish and two species of seahorse against eight other species of fish, as well as human and mouse. We annotated the hoxa2b enhancer element binding sites across three species of seahorse, four species of pipefish, and one species of ghost pipefish. Finally, we performed in situ hybridization analysis of hoxa2b expression in Gulf pipefish embryos. We found that all syngnathid fish examined share a modified rhombomere 4 hoxa2b enhancer element, despite the fact that this element has been found to be highly conserved across all vertebrates examined previously. Binding element sequence motifs and spacing between binding elements have been modified for the hoxa2b enhancer in several species of pipefish and seahorse, and that the loss of the Prep/Meis binding site and further space shortening happened after ghost pipefish split from the rest of the syngnathid clade. We showed that expression of this gene in rhombomere 4 is lower relative to the surrounding rhombomeres in developing Gulf pipefish embryos, reflecting previously published functional tests for this enhancer. Our findings highlight the benefits of studying highly derived, diverse taxa for understanding of gene regulatory evolution and support the hypothesis that natural mutations can occur in deeply conserved pathways in ways potentially related to phenotypic diversity.","PeriodicalId":50588,"journal":{"name":"Development Genes and Evolution","volume":"231 3-4","pages":"57-71"},"PeriodicalIF":2.4,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00427-021-00676-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38994384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bicaudal C is required for the function of the follicular epithelium during oogenesis in Rhodnius prolixus. 在繁殖过程中，双头C是卵泡上皮功能所必需的。

IF 2.4 3区生物学

Development Genes and Evolution Pub Date : 2021-03-01 Epub Date: 2021-03-11 DOI: 10.1007/s00427-021-00673-0

Agustina Pascual, Emiliano S Vilardo, Catalina Taibo, Julia Sabio Y García, Rolando Rivera Pomar

{"title":"Bicaudal C is required for the function of the follicular epithelium during oogenesis in Rhodnius prolixus.","authors":"Agustina Pascual, Emiliano S Vilardo, Catalina Taibo, Julia Sabio Y García, Rolando Rivera Pomar","doi":"10.1007/s00427-021-00673-0","DOIUrl":"https://doi.org/10.1007/s00427-021-00673-0","url":null,"abstract":"The morphology and physiology of the oogenesis have been well studied in the vector of Chagas disease Rhodnius prolixus. However, the molecular interactions that regulate the process of egg formation, key for the reproductive cycle of the vector, is still largely unknown. In order to understand the molecular and cellular basis of the oogenesis, we examined the function of the gene Bicaudal C (BicC) during oogenesis and early development of R. prolixus. We show that R. prolixus BicC (Rp-BicC) gene is expressed in the germarium, with cytoplasmic distribution, as well as in the follicular epithelium of the developing oocytes. RNAi silencing of Rp-BicC resulted in sterile females that lay few, small, non-viable eggs. The ovaries are reduced in size and show a disarray of the follicular epithelium. This indicates that Rp-BicC has a central role in the regulation of oogenesis. Although the follicular cells are able to form the chorion, the uptake of vitelline by the oocytes is compromised. We show evidence that the polarity of the follicular epithelium and the endocytic pathway, which are crucial for the proper yolk deposition, are affected. This study provides insights into the molecular mechanisms underlying oocyte development and show that Rp-BicC is important for de developmental of the egg and, therefore, a key player in the reproduction of this insect.","PeriodicalId":50588,"journal":{"name":"Development Genes and Evolution","volume":"231 1-2","pages":"33-45"},"PeriodicalIF":2.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00427-021-00673-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25475826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Analysis of codon usage bias and evolution in the chloroplast genome of Mesona chinensis Benth. 中国泥鳅叶绿体基因组密码子使用偏向性及进化分析。

IF 2.4 3区生物学

Development Genes and Evolution Pub Date : 2021-03-01 Epub Date: 2020-11-12 DOI: 10.1007/s00427-020-00670-9

Danfeng Tang, Fan Wei, Zhongquan Cai, Yanyan Wei, Aziz Khan, Jianhua Miao, Kunhua Wei

{"title":"Analysis of codon usage bias and evolution in the chloroplast genome of Mesona chinensis Benth.","authors":"Danfeng Tang, Fan Wei, Zhongquan Cai, Yanyan Wei, Aziz Khan, Jianhua Miao, Kunhua Wei","doi":"10.1007/s00427-020-00670-9","DOIUrl":"https://doi.org/10.1007/s00427-020-00670-9","url":null,"abstract":"Mesona chinensis Benth (MCB) is one of the main economic crops in tropical and subtropical areas. To understand the codon usage bias (CUB) in M. chinensis Benth, chloroplast genome is essential to study its genetic law, molecular phylogenetic relationships, and exogenous gene expression. Results showed that the GC content of 53 CDS sequences was 37.95%, and GC1, GC2, and GC3 content were 46.02%, 38.26%, and 29.85%, respectively. The general GC content order was GC1>GC2>GC3. Moreover, the majority of genes had an effective number of codon (ENC) value greater than 40, except ndhE, rps8, and rps18. Correlation analysis results revealed that the GC content was significantly correlated with GC1, GC2, GC3, and ENC. Neutrality plot analysis, ENC-plot analysis, and PR2-plot analysis presented that the CUB of M. chinensis Benth chloroplast genome was mainly affected by mutation and selection. In addition, GGG, GCA, and TCC were found to be the optimal codons. Furthermore, results of cluster analysis and evolutionary tree showed that M. chinensis Benth was closely related to Ocimum basilicum, indicating that there was a certain correlation between the CUB of the chloroplast gene and the genetic relationship of plant species. Overall, the study on the CUB of chloroplast genome laid a basis for genetic modification and phylogenetic research of M. chinensis Benth chloroplast genome.","PeriodicalId":50588,"journal":{"name":"Development Genes and Evolution","volume":"231 1-2","pages":"1-9"},"PeriodicalIF":2.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00427-020-00670-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38594874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Identification of a novel germ cell marker MnTdrd from the oriental river prawn Macrobrachium nipponense. 日本沼虾生殖细胞新标记MnTdrd的鉴定。

IF 2.4 3区生物学

Development Genes and Evolution Pub Date : 2021-03-01 Epub Date: 2020-11-26 DOI: 10.1007/s00427-020-00671-8

Yao-Ting Dong, Hai-Yang Feng, Xiao-Qing Tian, Qi-Liang Wang, Shu-Fang Zhang, Ke-Yi Ma, Gao-Feng Qiu

{"title":"Identification of a novel germ cell marker MnTdrd from the oriental river prawn Macrobrachium nipponense.","authors":"Yao-Ting Dong, Hai-Yang Feng, Xiao-Qing Tian, Qi-Liang Wang, Shu-Fang Zhang, Ke-Yi Ma, Gao-Feng Qiu","doi":"10.1007/s00427-020-00671-8","DOIUrl":"https://doi.org/10.1007/s00427-020-00671-8","url":null,"abstract":"Germ cell-specific genes play an important role in establishing the reproductive system in sexual organisms and have been used as valuable markers for studying gametogenesis and sex differentiation. Previously, we isolated a vasa transcript as a germ cell marker to trace the origin and migration of germ cells in the oriental river prawn Macrobrachium nipponense. Here, we identified a new germ cell-specific marker MnTdrd RNA and assessed its temporal and spatial expression during oogenesis and embryogenesis. MnTdrd transcripts were expressed in high abundance in unfertilized eggs and embryos at cleavage stage and then dropped significantly during late embryogenesis, suggesting that MnTdrd mRNA is maternally inherited. In situ hybridization of ovarian tissue showed that MnTdrd mRNA was initially present in the cytoplasm of previtellogenic oocyte and localized to the perinuclear region as the accumulation of yolk in vitellogenic oocyte. Whole-mount in situ hybridization of embryos showed that MnTdrd-positive signals were only localized in one blastomere until 16-cell stage. In the blastula, there were approximately 16 MnTdrd-positive blastomeres. During embryonized-zoea stage, the MnTdrd-positive cells aggregated as a cluster and migrated to the genital rudiment which would develop into primordial germ cells (PGCs). The localized expression pattern of MnTdrd transcripts resembled that of the previously identified germ cell marker vasa, supporting the preformation mode of germ cell specification. Therefore, we concluded that MnTdrd, together with vasa, is a component of the germ plasm and might have critical roles in germ cell formation and differentiation in the prawn. Thus, MnTdrd can be used as a novel germ cell marker to trace the origin and migration of germ cells.","PeriodicalId":50588,"journal":{"name":"Development Genes and Evolution","volume":"231 1-2","pages":"11-19"},"PeriodicalIF":2.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00427-020-00671-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38647872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Molecular signatures of selection on the human GLI3 associated central nervous system specific enhancers. 人类GLI3相关中枢神经系统特异性增强子选择的分子特征。

IF 2.4 3区生物学

Development Genes and Evolution Pub Date : 2021-03-01 Epub Date: 2021-03-02 DOI: 10.1007/s00427-021-00672-1

Irfan Hussain, Rabail Zehra Raza, Shahid Ali, Muhammad Abrar, Amir Ali Abbasi

{"title":"Molecular signatures of selection on the human GLI3 associated central nervous system specific enhancers.","authors":"Irfan Hussain, Rabail Zehra Raza, Shahid Ali, Muhammad Abrar, Amir Ali Abbasi","doi":"10.1007/s00427-021-00672-1","DOIUrl":"https://doi.org/10.1007/s00427-021-00672-1","url":null,"abstract":"The zinc finger-containing transcription factor Gli3 is a key mediator of Hedgehog (Hh) signaling pathway. In vertebrates, Gli3 has widespread expression pattern during early embryonic development. Along the anteroposterior axes of the central nervous system (CNS), dorsoventral neural pattern elaboration is achieved through Hh mediated spatio-temporal deployment of Gli3 transcripts. Previously, we and others uncovered a set of enhancers that mediate many of the known aspects of Gli3 expression during neurogenesis. However, the potential role of Gli3 associated enhancers in trait evolution has not yet received any significant attention. Here, we investigate the evolutionary patterns of Gli3 associated CNS-specific enhancers that have been reported so far. A subset of these enhancers has undergone an accelerated rate of molecular evolution in the human lineage in comparison to other primates/mammals. These fast-evolving enhancers have acquired human-specific changes in transcription factor binding sites (TFBSs). These human-unique changes within subset of Gli3 associated CNS-specific enhancers were further validated as single nucleotide polymorphisms through 1000 Genome Project Phase 3 data. This work not only infers the molecular evolutionary patterns of Gli3 associated enhancers but also provides clues for putative genetic basis of the population-specificity of gene expression regulation.","PeriodicalId":50588,"journal":{"name":"Development Genes and Evolution","volume":"231 1-2","pages":"21-32"},"PeriodicalIF":2.4,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00427-021-00672-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25431802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2