{"title":"Comparison of the Outcome of Surgery and Radiotherapy in the Treatment of Early Carcinoma of the Larynx","authors":"Bashudeb Kumar Saha, Md. Ashraful Islam, Shaikh Nurul Fattah Rumi","doi":"10.9734/ajmah/2024/v22i51003","DOIUrl":"https://doi.org/10.9734/ajmah/2024/v22i51003","url":null,"abstract":"Background: The most prevalent disease to afflict the head and neck region is laryngeal cancer. The early stage of this disease, T1T2N0M0, has a higher chance of recovery than the other phases. Radiation therapy and surgery are its therapeutic techniques. \u0000Objective: To Compare the outcome of surgery and radiotherapy in the treatment of early carcinoma of the larynx \u0000Methods: This cross-sectional study was carried out at tertiary hospital Dhaka from January 2022 to January 2023. Where A total of 200 Patients of carcinoma of the larynx are evaluated properly by detailed history taking, clinical examination and relevant investigation. During the study two groups of patients were dealt separately; Group-1: Surgery using LASER, n=100 and Group-2: radiotherapy, n=200. All the patients were followed up after 2 weeks, 1 month and then three monthly for one year. \u0000Results: During the study, supraglottis carcinoma was found in 65% of radiotherapy group and 70% in surgery group, glottic carcinoma was 35% & 30%, respectively in radiotherapy and surgery group. No case found with subglottic carcinoma. Where in surgery group 7% patients had haematoma, 5% patients had seroma & pharyngeal stenosis. In radiotherapy group 2.5% Severe radiation necrosis of skin & 3% had Respiratory distress following radiotherapy. . In the radiotherapy group, 25% cases were scored as normal and 45% as good. For the surgery group, 40% patients had good voice and speech, 35%r had moderate voice and speech, and 5% had poor voice and speech. This difference was statistically significant (p=.001). 14% of the irradiation group had a primary site recurrence compared with 20% in the surgery group at 12th months. There was a significant difference in the pattern of recurrence in the neck between the two treatment groups. Only 5% of those who were treated with irradiation had a recurrence in the neck. 14% of patients in the surgery group had a recurrence in the neck; this difference was statistically significant. \u0000Conclusions: When treating early laryngeal cancer, radiation therapy and surgery are equally successful. However, patients who had radiation therapy had much improved speech and voice quality compared to those who received surgery.","PeriodicalId":505327,"journal":{"name":"Asian Journal of Medicine and Health","volume":"120 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140380189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marliana Nurprilinda, F. Gultom, Devy Serevina, Debora Jenifer
{"title":"Retrospective Analysis of Cancer Cervix at Awal Bros Batam Hospital in 2020-2022","authors":"Marliana Nurprilinda, F. Gultom, Devy Serevina, Debora Jenifer","doi":"10.9734/ajmah/2024/v22i41002","DOIUrl":"https://doi.org/10.9734/ajmah/2024/v22i41002","url":null,"abstract":"Aims: This research aims to determine the characteristics of cervical cancer patients at Awal Bros Hospital, Batam, in 2020-2022. It also aims to create awareness of vaccination. This research used medical records from a sample of 97 people.\u0000Methodology: This research is non-experimental with a retrospective analytical descriptive design using secondary data from medical records of cervical cancer patients at Awal Bros Hospital, Batam, in 2020-2022 in August 2023. The sample in this study was selected from a population that met the inclusion and exclusion criteria, namely 97 people. The research instrument used in this study was medical records of cervical cancer patients at Awal Bros Hospital, Batam, in 2020-2022. Data was processed using the Statistical Product and Service Solution (SPSS) program with univariate tests. The analysis results will be presented as a frequency table and percentage diagram.\u0000Results: From the research results, from the entire patient sample of 97 people aged 25-65 years, it was found that the highest percentage of cancer sufferers were aged 35-50 years, 54 people (55.7%), marital status was 96 people (99%), 51 people had a history of multiparity 3-4 times (52.6%), 49 people (50.5%) had a high school education, 72 people (74.2%) worked as housewives, 52 people had complaints of bleeding (53.6%), and 70 people had a histopathological picture of squamous cell carcinoma. (72.2%), the degree of differentiation was reasonable. As many as 43 people (44.3%)\u0000Conclusion: This study concludes that cervical cancer patients at Awal Bros Batam Hospital in 2020-2022 were mainly aged 36-50 years, with marital status, married, a history of 3-4 times multiparity, had a high school education, and worked as a housewife. They had complaints of bleeding with histopathological features of squamous cell carcinoma and a good differentiation degree.","PeriodicalId":505327,"journal":{"name":"Asian Journal of Medicine and Health","volume":" 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140215540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Outcomes of Surgical Thrombectomy for ILIO-Femoral Deep Vein Thrombosis in Hospitals in Rivers State","authors":"Christian Emeka Amadi, J. Otokwala","doi":"10.9734/ajmah/2024/v22i41001","DOIUrl":"https://doi.org/10.9734/ajmah/2024/v22i41001","url":null,"abstract":"Background: In patients presenting with Deep Vein Thrombosis (DVT) involving the ilio-femoral veins, pulmonary embolism and post-thrombotic syndrome are major concerns. Intervening early by removing the venous thrombus significantly reduces the burden of DVT.\u0000Objective: To assess recanalization, post-procedure development of pulmonary embolism (PE) and or post thrombotic syndrome (PTS) following surgical thrombectomy for ilio-femoral DVT.\u0000Materials and Methods: This is a descriptive cross-sectional study that was conducted at a public and five private healthcare facilities in Port Harcourt with data prospectively collected from March 1, 2018, to February 29, 2024 that evaluated the outcomes of surgical thrombectomy for DVT involving the ilio-femoral veins. Those with strictly below knee (popliteal vein) DVT were excluded from the study, as they were treated mainly by non-surgical means. A pre-designed semi-structured questionnaire was used to obtain variables which included patients’ demography, veins involved, type of DVT, surgical approach, type of anesthesia and outcome. Results are presented as frequencies, tables, and figures. The statistical level of significance was set as p value of ≤ 0.05.\u0000Results: The study involved 19 patients who had surgical thrombectomy during the period under review. There were 12 (63.16%) males and 7 (36.84%) female patients. The age range was 22 to 78years. Of these, 8 (42.10%) patients had femoral or ilio-femoral DVT alone, while 11 (57.90%) patients had calf vein DVT in addition to femoral or ilio-femoral DVT. 16 patients had acute DVT and 3 patients presented with acute-on-chronic DVT. Surgical thrombectomy was done with the aid of fogarty catheters in all cases. All the patients had combined epidural and spinal anesthesia. Recanalization was achieved in all 19 cases, no clinical PE was detected peri-operatively, however, the patients with acute on chronic DVT had significant PTS.\u0000Conclusion: The safety profile and recanalization rate following surgical thrombectomy for iliofemoral DVT is very good especially when done at the acute phase of the DVT. This also significantly prevents the occurrence of post thrombotic syndrome.","PeriodicalId":505327,"journal":{"name":"Asian Journal of Medicine and Health","volume":"58 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140228788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adediran, Morayo Busayo, Ibukunoluwa, Mojirayo Rebecca, Akeju, Adebayo Victor
{"title":"Knowledge, Practices and Attitudes of Traditional Birth Attendants towards Intermittent Preventive Treatment for Malaria Prevention among Pregnant Women within Ondo West Local Government Area of Ondo State, Nigeria","authors":"Adediran, Morayo Busayo, Ibukunoluwa, Mojirayo Rebecca, Akeju, Adebayo Victor","doi":"10.9734/ajmah/2024/v22i41000","DOIUrl":"https://doi.org/10.9734/ajmah/2024/v22i41000","url":null,"abstract":"Intermittent preventive treatment (IPT) for malaria among pregnant women is a recommendation of the World Health Organization (WHO) to combat the various adverse outcomes of malaria in pregnant women. This adverse outcomes includes low birth weight, preterm delivery, severe anemia, maternal morbidity and mortality especially among primigravids. Traditional Birth Attendants (TBAs) has emerged as a significant influence in our society, particularly in the realm of maternal care and childbirth. Several economic, religious and socio-cultural factors have contributed to the preference of some pregnant women for the services of TBAs over medical facilities. Therefore, the study was carried out to assess the knowledge, practices and attitudes of traditional birth attendants within Ondo West Local Government area towards IPT for pregnant women reporting to them for care and delivery. The design employed in the study was descriptive cross-sectional survey. Data were collected by means of an adapted semi-structured interviewer administered-questionnaire. The analysis of the data was done using SPSS version 26.0. Demographic parameters were summarized with simple percentages and non-parametric chi-square test was used to determine the different associations of the variables. P values less than 0.05 were considered statistically significant. The findings indicated that most of the TBAs have good knowledge of the malaria vector and factors promoting the transmission of malaria. Majority (mean=82.9%) also demonstrated excellent understanding of the symptoms associated with malaria in pregnancy however, their knowledge on the risk associated with malaria in a pregnant woman remains comparably low (mean=61.1%) thereby affecting significantly their attitudes and practice to intermittent preventive treatment for malaria prevention. This is because 50% of the TBA have not heard about IPT (P=0.01) and therefore do not administer treatment to asymptomatic pregnant women as recommended by WHO (P=0.00) and report of this study shows that majority (57.40%) of them attend to more than 31 pregnant women in a year. There is need for a government-sponsored partnership between formal health workers and TBAs in this study to ensure they are trained, retrained and equipped. The integration of the TBAs into maternal health care will ensure the sustenance of government policy on the free treatment of all pregnant women intermittently for malaria as recommended by WHO.","PeriodicalId":505327,"journal":{"name":"Asian Journal of Medicine and Health","volume":"55 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140236982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Current Management of Choledocholithiasis-narrative Review Article","authors":"Kumar Hari Rajah","doi":"10.9734/ajmah/2024/v22i4999","DOIUrl":"https://doi.org/10.9734/ajmah/2024/v22i4999","url":null,"abstract":"The most common management of choledocholithiasis involves the two-step method that involves the use of pre-operative endoscopic retrograde cholangiopancreatography (ERCP) followed by laparoscopic cholecystectomy in six weeks’ time. But since the introduction of laparoscopic surgery, laparoscopic common bile duct exploration has been used as a single step method to treat this condition. Another method involves intraoperative endoscopic retrograde cholangiopancreatography (ERCP) and laparoscopic cholecystectomy in the same setting. As there is no consensus on management, we have conducted this review article to look at the various management options for choledocholithiasis.","PeriodicalId":505327,"journal":{"name":"Asian Journal of Medicine and Health","volume":"20 45","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Socio-economic Status as Correlate of Health Status of Undergraduates in Public Universities, Rivers State, Nigeria","authors":"Peter-Kio, O. B., Diri, M.","doi":"10.9734/ajmah/2024/v22i4998","DOIUrl":"https://doi.org/10.9734/ajmah/2024/v22i4998","url":null,"abstract":"This study examined socio-economic status as correlate of health status of undergraduate students in public universities, Rivers State. A descriptive research design was adopted with a population which consisted of 64,691 undergraduates in public universities, Rivers State, Nigeria. A sample size of 1,194 was selected using a multi-stage sampling procedure. The data collection instrument was a structured questionnaire with a reliability coefficient of 0.82. Data analysis was carried out using regression statistics at 0.05 alpha level. The result indicated that a significant positive relationship was found between parent financial status (monthly income) and mental health status (r = 0.13, R2 = 0.019, p<0.05), physical (r = 0.82, R2 = 0.750, p<0.05) and social health status (r = 0.86, R2 = 0.75, p<0.05). Furthermore, a significant positive relationship was found between parent employment status and mental health status (r = 0.94, R2 = 0.883, p<0.05), physical health status (r = 0.93, R2 = 0.866, p<0.05) and social health status (r = 0.91, R2 = 0.825, p<0.05). It was concluded that socio-economic status of parents such as monthly income, and employment status of parents contributed less than 50% to health status of undergraduates in public universities in Rivers State. It was recommended that, the government should establish poverty alleviation programmes for parents/guardians whose children/wards are in university to help any financial stress which may contribute or influence the health status of the students.","PeriodicalId":505327,"journal":{"name":"Asian Journal of Medicine and Health","volume":"14 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140241025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of Habitual Activities on Age of Menarche among Bengali Adolescent School Girls","authors":"Payel Banerjee, Purushottam Pramanik","doi":"10.9734/ajmah/2024/v22i4996","DOIUrl":"https://doi.org/10.9734/ajmah/2024/v22i4996","url":null,"abstract":"Background: Menarche, the first menstrual bleeding is the signal of initiation of reproductive age of girls. There is a secular decline in the average age at menarche. Age at menarche has significant impact on health in adulthood. \u0000Objectives: The present study was an attempt to assess the mean age at menarche and to determine impact of habitual activities on age at onset of menarche. \u0000Methods: A cross sectional questionnaire based study was conducted among school girls having age limit 10-14 years who experienced menarche not more than previous three months. Subjects were divided into two group- experimental and control. Experimental group consisted of subjects those attained menarche below 11.5 years. Subjects of control group attained menarche above 11.5 years. Quantitative data were presented as percentage and/or mean + standard deviation. t-test was done to determine significant of difference between physical characteristics of females early age at menarche and reference age at menarche. Chi square test and logistic regression analysis were done for analysis of our results. \u0000Results: 23% of study population acquired menarche at age below 11.5 years. Anthropometric parameters differed significantly between experimental and reference group. Significant association was observed between age at menarche with habitual activities. Logistic regression analysis suggested that habitual activities might be considered as determinants of early menarche. \u0000Conclusion: Risk of early menarche increases with increasing duration of screen time and decreasing duration of daily physical activities like walking, outdoor playing and bicycle riding. Adolescent girls should encourage for physical activities and minimize including screen time.","PeriodicalId":505327,"journal":{"name":"Asian Journal of Medicine and Health","volume":"138 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140078352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Obstetric Outcome in Patients with Previous Abdominal Myomectomy at a Tertiary Hospital in South-South Nigeria","authors":"T. Kasso, Christian Obinna Ikonwa, Goddy Bassey","doi":"10.9734/ajmah/2024/v22i4995","DOIUrl":"https://doi.org/10.9734/ajmah/2024/v22i4995","url":null,"abstract":"Background: Abdominal myomectomy refers to the surgical removal of fibroids from the uterus through an abdominal incision. It is one of the treatment options for uterine fibroids. Women who had this form of treatment may be faced with increased risks and complications during future pregnancies and deliveries.\u0000Aim: To assess the obstetric risk and delivery outcome of pregnancies achieved after abdominal myomectomy.\u0000Methodology: This was a retrospective study of pregnancy outcome in women who had abdominal myomectomy at University of Port Harcourt Teaching Hospital (UPTH) from 2018 to 2022. The case records of the patients were retrieved, and data on socio-demographic characteristics, mode of delivery, obstetric complications, and foetal outcome was extracted and analysed using SPSS version 25.\u0000Results: There were 7,602 antenatal clinic attendees during the study period, out of which 83 of the women had previous myomectomy and were delivered in UPTH. This accounted for 1.1% of booked patients who attended antenatal care and delivered at the hospital. Seventy-two case notes were retrieved, giving a case retrieval rate of 86.7%. The mean age was 34.89 ± 4.27 years (range from 18 to 47 years). The total Live birth post myomectomy was 56 (77.8%). There were 14 (19.4%) miscarriages and 2 (2.8) stillbirths. Patients that conceived spontaneously were 61 (84.7%), while 11 (15.3%) had in-vitro fertilization (IVF). Caesarean section was used in 67 (93.1%) of deliveries with elective caesarean section accounting for 45 (62.5%) of the deliveries. The commonest indication for caesarean section was previous myomectomy with breached endometrium in 53 (79.1%) cases. Forty-one (56.9%) of the deliveries occurred at 38-40 weeks of gestation.\u0000Conclusion: Obstetric outcome after abdominal myomectomies was good with high live birth rate and no maternal mortality recorded. Women who had abdominal myomectomy should be counselled to attend antenatal care and deliver in adequately equipped centres with skilled personnel to avert adverse pregnancy outcomes.","PeriodicalId":505327,"journal":{"name":"Asian Journal of Medicine and Health","volume":"28 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140263960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Anaemia a Monitoring Tool for Helminth Infection","authors":"Onosakponome Evelyn Orevaoghene, Nyenke, Clement Ugochukwu, Ikpeama, Roseanne Adah, Ezenwaka, Chinonye. Oluchi, Enyinnaya Stella Ogbonnie","doi":"10.9734/ajmah/2024/v22i3993","DOIUrl":"https://doi.org/10.9734/ajmah/2024/v22i3993","url":null,"abstract":"Helminthic infections also known as worm infections affect mostly the gastrointestinal tracts. They are caused by parasites known as helminths. The infection is capable of causing blood loss which often leads to anaemia. However the severity of anaemia is dependent on the intensity of the infection. With an estimated 3.5 billion infected individuals globally, helminth infections are among the most prevalent infections. In tropical and subtropical regions, these infections primarily affect the most impoverished and disadvantaged communities that have limited access to clean water, sanitation, and hygiene. The highest prevalence of these infections has been reported from sub-Saharan Africa, China, and South America. The major helminths that causes anaemia includes Hook worm (Necator americanus and Ancylostoma. duodenale), Ascaris lumbricoides, Trichuris trichiuria (whip worm). Hookworms and whipworms are examples of helminths that cause iron-deficiency anaemia through blood consumption and by causing damage to the intestinal mucosa during feeding. It is estimated that adult hookworms consume 0.05 to 0.2 milliliters of blood per day per worm, with an average daily blood loss of 26.4 milliliters in adult subjects infected with A. Duodenale. There are many risk factors which can lead to acquiring these infections and they include eating raw or undercooked meat and fish, poor hygiene, inadequate availability of clean water, poor sanitation. Some of the symptoms includes blood loss, abdominal pain, vomitting. Helminth infection can be diagnosed through direct wet mount, concentration technique and stool sample is used for this diagnosis. Helminth infections can be treated using antihelminthic drugs. Helminths can be prevented through safe sanitary facilites, maintainance of personal hygiene mass deworming in the affected areas and health education. In conclusion a well developed medical health care system should be put in place to control the devastating effects helminths infections.","PeriodicalId":505327,"journal":{"name":"Asian Journal of Medicine and Health","volume":"47 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140266584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Firmansyah, Veronika Maria Sidharta, Lorettha Wijaya, Sukmawati Tansil Tan
{"title":"Unraveling the Significance of Growth Factors (TGF-β, PDGF, KGF, FGF, Pro Collagen, VEGF) in the Dynamic of Wound Healing","authors":"Y. Firmansyah, Veronika Maria Sidharta, Lorettha Wijaya, Sukmawati Tansil Tan","doi":"10.9734/ajmah/2024/v22i3992","DOIUrl":"https://doi.org/10.9734/ajmah/2024/v22i3992","url":null,"abstract":"The wound healing process is an intricate biological phenomenon that requires various crucial components, including repair cells, proteins, and biological factors. The process of wound healing can be categorized into three interrelated stages: the stage of inflammation, proliferation, and remodeling. Any interruptions during this process can lead to wound healing that deviates from the typical progression. It is crucial to highlight that growth factors have a profoundly influential effect in this particular situation. This study conducts a thorough and analytical literature review to investigate the essential role of growth factors (TGF-β, PDGF, KGF, FGF, Pro Collagen, and VEGF) in wound healing. This study examines the biochemical and molecular mechanisms via which these growth factors impact the wound healing process, including the inflammation, proliferation, and remodeling phases, by analyzing current and authoritative scientific literature. This paper precisely outlines the role of these variables, including the role of the stem cell secretome enriched with growth factors such as TGF-β, PDGF, KGF, FGF, Pro Collagen, VEGF, and exogenous factors, as previously discussed. It explores their impact on tissue regeneration, angiogenesis, and extracellular matrix formation, essential components of the wound healing process. The main objective of this study is to provide a comprehensive summary of the latest research findings, which includes an in-depth analysis of the contributions of stem cell secretomes to wound healing. The findings provide useful insights into potential growth factor-based treatment approaches, highlighting how the components of the stem cell secretome can be leveraged to enhance the wound healing process.","PeriodicalId":505327,"journal":{"name":"Asian Journal of Medicine and Health","volume":"116 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140090720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}