ERJ Open Research最新文献_第9页

Heart Rate Characteristics Predict Risk of Mortality in Preterm Infants in Low and High Target Oxygen Saturation Ranges 心率特征预测低目标氧饱和度范围和高目标氧饱和度范围早产儿的死亡风险

ERJ Open Research Pub Date : 2024-03-14 DOI: 10.1183/23120541.00782-2023

William E. King, U. Sanghvi, N. Ambalavanan, Vivek V Shukla, C. Travers, R. Schelonka, Clyde Wright, Waldemar A. Carlo

{"title":"Heart Rate Characteristics Predict Risk of Mortality in Preterm Infants in Low and High Target Oxygen Saturation Ranges","authors":"William E. King, U. Sanghvi, N. Ambalavanan, Vivek V Shukla, C. Travers, R. Schelonka, Clyde Wright, Waldemar A. Carlo","doi":"10.1183/23120541.00782-2023","DOIUrl":"https://doi.org/10.1183/23120541.00782-2023","url":null,"abstract":"The Neonatal Oxygenation Prospective Meta-analysis found that in infants <28 weeks gestational age, targeting an oxygen saturation (SpO2) range of 85–89%versus91–95% resulted in lower rates of retinopathy of prematurity (ROP) but increased mortality. We aimed to assess the accuracy of the heart rate characteristics index (HRCi) to assess the dynamic risk of mortality among infants managed with low and high target SpO2ranges.The SUPPORT and HRCi datasets from one center where both RCTs overlapped were linked. We examined the maximum daily HRCi (MaxHRCi24) to predict death among patients randomized to the lower and higher SpO2groups by generating predictiveness curves and calculating model performance metrics, including AUROC at prediction windows from 1–60 days. Cox proportional hazards models tested whether MaxHRCi24 was an independent predictor of death. We also conducted a moderation analysis.There were 84 infants in the merged dataset. MaxHRCi24 predicted death in subjects randomized to lower target SpO2, with area under the receiver operating characteristic curve (AUROCs 0.79–0.89) depending upon the prediction window, and higher target SpO2(AUROCs 0.82–0.91). MaxHRCi24 was an important additional predictor of death in multivariable modeling. In moderation analysis, in a model that also included demographic predictor variables, the individual terms and the interaction term between MaxHRCi24 and target SpO2range all predicted death.Associations between HRCi and mortality, at low and high SpO2target ranges, suggest that future research may find HRCi metrics helpful to individually optimize target oxygen saturation ranges for hospitalized preterm infants.","PeriodicalId":504874,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140244383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypercapnia is not excluded by normoxia in neuromuscular disease patients: implications for oximetry 神经肌肉疾病患者的高碳酸血症不能通过正常氧排除：对血氧饱和度的影响

ERJ Open Research Pub Date : 2024-03-07 DOI: 10.1183/23120541.00927-2023

Emma Gray, C. Menadue, Amanda Piper, Keith Wong, Matthew Kiernan, Brendon J. Yee

{"title":"Hypercapnia is not excluded by normoxia in neuromuscular disease patients: implications for oximetry","authors":"Emma Gray, C. Menadue, Amanda Piper, Keith Wong, Matthew Kiernan, Brendon J. Yee","doi":"10.1183/23120541.00927-2023","DOIUrl":"https://doi.org/10.1183/23120541.00927-2023","url":null,"abstract":"Pulse oximetry is widely used in the assessment of chronic respiratory failure (CHRF) in neuromuscular disease (NMD) patients. CHRF is the major cause of morbidity and mortality, necessitating early diagnosis and intervention. Guidelines suggest an arterial blood gas (ABG) is indicated if oxygen saturations (SpO2)≤94% in the absence of lung disease. However, hypercapnia with normoxia (SpO2≥95%) has been observed on ABGs of patients with NMD, in particular those with motor neurone disease (MND).A single-centre retrospective audit of room-air ABGs in stable hypercapnic chronic respiratory failure (CHRF) patients from 1990–2020 was performed. Patients with parenchymal lung disease were excluded. Patients were grouped into three main categories: non-NMD, other-NMD and MND.Two-hundred and ninety-seven ABGs with hypercapnia from 180 patients with extrinsic restrictive lung disease were analysed. No patients with non-NMD, 54% of other-NMD and 36% of MND patients demonstrated hypercapnia with normoxia (χ261.33; p<0.001). The potential mechanism is proposed to be a difference in calculated respiratory quotient (RQ). If the A-a gradient is assumed to be normal, the calculated RQ was significantly higher in MND patients and other-NMD patients compared with non-NMD patients (estimated-marginal-mean 0.99 [95%CI 0.94–1.03]; 0·86 [95%CI 0.76–0.96]; 0·73 [95%CI 0.63—0.83] respectively; p<0.001) by mixed-model analysis.Hypercapnia is not excluded with normal oximetry in NMD patients and may be due to an elevated RQ. This has implications in the diagnosis and monitoring of respiratory insufficiency in NMD patients with oximetry alone.Dr Emma Gray received an NHMRC Postgraduate Scholarship.","PeriodicalId":504874,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140258610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pneumothorax as a complication of dry needling technique 干针技术的并发症--气胸

ERJ Open Research Pub Date : 2024-03-07 DOI: 10.1183/23120541.00156-2024

Jan S.B. Bontinck, Cathelijne Lyphout, Thomas L.A. Malfait

引用次数: 0

Cardiopulmonary exercise testing and body composition 心肺运动测试和身体成分

ERJ Open Research Pub Date : 2024-03-07 DOI: 10.1183/23120541.00970-2023

Per Karlsson, Lars Lind, Karl Michaëlsson, Andrei Malinovschi

{"title":"Cardiopulmonary exercise testing and body composition","authors":"Per Karlsson, Lars Lind, Karl Michaëlsson, Andrei Malinovschi","doi":"10.1183/23120541.00970-2023","DOIUrl":"https://doi.org/10.1183/23120541.00970-2023","url":null,"abstract":"The cardiopulmonary exercise test (CPET) evaluates cardiopulmonary function. In light of the obesity epidemic, it is important to understand how body composition affects interpretation of CPET results.to assess the relationship between CPET measures, others than peak oxygen uptake, and body composition.A total of 330 participants, aged 50 years, performed both a CPET and a Dual-energy x-ray absorptiometry (DXA). From CPET, peak exercise respiratory exchange ratio (RER), ventilatory efficiency (VE/VCO2slope) and work efficiency (ΔVO2/ΔWR) were recorded. Pearson's correlation was used to assess the association between CPET measures and selected body composition measures including body mass index (BMI), waist circumference, fat mass, lean mass, body fat percentage and percentage trunk fat to fat mass. All analyses were done stratified by sex. A p-value<0.05 defined statistical significance.RER was negatively correlated with body composition measures; the strongest correlation was observed with waist circumference in females (r=−0.36). VE/VCO2slope had no significant correlations with any body composition measures.ΔVO2/ΔWR was positively correlated with the body composition measures; the strongest correlation was observed with BMI (r=0.24). The additive role of percentage body fat and percentage trunk fat were studied in a linear regression model using waist circumference and BMI to predict the above-named CPET measures and no additive role was found.RER andΔVO2/ΔWR may be influenced by body composition while VE/VCO2slope is not affected. Adiposity measures from DXA add no additional explanatory value to the CPET measures.","PeriodicalId":504874,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140077975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transition of care from adolescence to early adulthood in severe asthmatic patients treated with omalizumab in real-life 使用奥马珠单抗治疗的重症哮喘患者从青春期到成年早期的护理过渡实况

ERJ Open Research Pub Date : 2024-03-07 DOI: 10.1183/23120541.00976-2023

Camille Taillé, Marc Humbert, Arnaud Bourdin, C. Thonnelier, Audrey Lajoinie, Jules Chassetuillier, Mathieu Molimard, Antoine Deschildre

引用次数: 0

Mortality prevention as the center of COPD management 将预防死亡作为慢性阻塞性肺病管理的核心

ERJ Open Research Pub Date : 2024-03-07 DOI: 10.1183/23120541.00850-2023

A. Papaioannou, G. Hillas, S. Loukides, Theodoros Vassilakopoulos

{"title":"Mortality prevention as the center of COPD management","authors":"A. Papaioannou, G. Hillas, S. Loukides, Theodoros Vassilakopoulos","doi":"10.1183/23120541.00850-2023","DOIUrl":"https://doi.org/10.1183/23120541.00850-2023","url":null,"abstract":"COPD is a major healthcare problem and cause of mortality worldwide. COPD patients at increased mortality risk are those that are more symptomatic, have lower lung function and lower DLCO, have decreased exercise capacity, belong to the emphysematous phenotype and those who have concomitant bronchiectasis. Also mortality risk seems to be greater in patients who experience COPD exacerbations and in those who suffer from concomitant cardiovascular and/or metabolic diseases. To predict the risk of death in COPD patients several composite scores have been created using different parameters. In the previous years, large studies (also called Mega-Trials) have evaluated the efficacy of different therapies on COPD mortality, but until recently only non-pharmaceutical interventions have proven to be effective. However, recent studies on fixed combinations of triple therapy (long-acting beta agonists, long-acting muscarinic antagonists and inhaled corticosteroids) have provided encouraging results, showing for the first time a reduction in mortality compared to dual therapies. The aim of the present review is to summarize available data regarding mortality risk in COPD patients and to describe pharmacologic therapies that have shown effectiveness in reducing mortality.","PeriodicalId":504874,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term associations of PM1vs. PM2.5and PM10with asthma and asthma-related respiratory symptoms in middle-aged and elderly population 中老年人群中 PM1、PM2.5 和 PM10 与哮喘及哮喘相关呼吸道症状的长期关系

ERJ Open Research Pub Date : 2024-03-07 DOI: 10.1183/23120541.00972-2023

Xue-yan Zheng, Shu-jun Guo, Jian-xiong Hu, Rui-lin Meng, Yan-jun Xu, Yun-hong Lv, Ye Wang, N. Xiao, Chuan Li, Xiao-jun Xu, De-jian Zhao, Hong-ye Zhou, Jia-hui He, Xiao-min Tan, Jing Wei, Li-feng Lin, Wei-jie Guan

{"title":"Long-term associations of PM1vs. PM2.5and PM10with asthma and asthma-related respiratory symptoms in middle-aged and elderly population","authors":"Xue-yan Zheng, Shu-jun Guo, Jian-xiong Hu, Rui-lin Meng, Yan-jun Xu, Yun-hong Lv, Ye Wang, N. Xiao, Chuan Li, Xiao-jun Xu, De-jian Zhao, Hong-ye Zhou, Jia-hui He, Xiao-min Tan, Jing Wei, Li-feng Lin, Wei-jie Guan","doi":"10.1183/23120541.00972-2023","DOIUrl":"https://doi.org/10.1183/23120541.00972-2023","url":null,"abstract":"Few studies have compared the associations between long-term exposures to particulate matters (aerodynamic diameter ≤1, 2.5 and 10 µm: PM1, PM2.5and PM10) and asthma and asthma-related respiratory symptoms.To compare the strength of the above-mentioned associations in middle-aged and elderly adults.We calculated the mean 722-day personal exposure estimates of PM1, PM2.5and PM10at 1 km×1 km spatial resolution between 2012 and 2019 at individual levels fromChina High Air Pollutantsdatasets. Using logistic regression model, we presented the associations as odds ratios (ORs) and 95% confidence intervals (95%CIs), for each interquartile range (IQR) increase in PM1/PM2.5/PM10concentration. Asthma denoted a self-reported history of physician-diagnosed asthma, or wheezing in the preceding 12 months.We included 7371 participants inChronic Obstructive Pulmonary Diseases Surveillancefrom Guangdong, China. Each IQR increase in PM1, PM2.5and PM10was associated with a greater odds [OR (95%CI)] of asthma [PM1: 1.22 (1.02, 1.45); PM2.5: 1.24 (1.04, 1.48); PM10: 1.30 (1.07, 1.57)], wheeze [PM1: 1.27 (1.11, 1.44); PM2.5: 1.30 (1.14, 1.48); PM10: 1.34 (1.17, 1.55)], persistent cough [PM1: 1.33 (1.06, 1.66); PM2.5: 1.36 (1.09, 1.71); PM10: 1.31 (1.02, 1.68)] and dyspnea [PM1: 2.10 (1.84, 2.41); PM2.5: 2.17 (1.90, 2.48); PM10: 2.29 (1.96, 2.66)]. Sensitivity analysis results were robust after excluding individuals with a family history of allergy. Associations of PM1, PM2.5and PM10with asthma and asthma-related respiratory symptoms were slightly stronger in males.Long-term exposure to PM is associated with increased risks of asthma and asthma-related respiratory symptoms.","PeriodicalId":504874,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140077655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prematurity-associated lung disease: Is it asthma? 早产相关肺病：是哮喘吗？

ERJ Open Research Pub Date : 2024-03-07 DOI: 10.1183/23120541.00145-2024

Tiffany K. Bradshaw, Elizabeth Smith, R. Urs, D. Evans, N. Hemy, Shannon J. Simpson

引用次数: 0

Motivation and preferences for learning of patients with COPD or asthma and their significant others in pulmonary rehabilitation: a qualitative study 慢性阻塞性肺病或哮喘患者及其重要他人在肺康复中的学习动机和偏好：定性研究

ERJ Open Research Pub Date : 2024-03-07 DOI: 10.1183/23120541.01021-2023

A. Muijsenberg, S. Haesevoets, S. Houben-Wilke, Jan Tatousek, Joyca Lacroix, M. Spruit, D. Janssen

{"title":"Motivation and preferences for learning of patients with COPD or asthma and their significant others in pulmonary rehabilitation: a qualitative study","authors":"A. Muijsenberg, S. Haesevoets, S. Houben-Wilke, Jan Tatousek, Joyca Lacroix, M. Spruit, D. Janssen","doi":"10.1183/23120541.01021-2023","DOIUrl":"https://doi.org/10.1183/23120541.01021-2023","url":null,"abstract":"In depth understanding of educational needs from the perspective of the learners in pulmonary rehabilitation (PR) is lacking. To improve learning in PR, understanding of factors that induce or enhance intrinsic motivation in both patients and their significant others is needed. Therefore, this study aims to gain in-depth understanding of what motivates patients with COPD and asthma referred for PR and their significant others to learn and what their preferences are for education.For this qualitative study, a sample was taken from a previous quantitative study. Data was collected through a one-time face-to-face semi-structured interview. The interviews were transcribed and independently analysed by two researchers using thematic analyses.Twelve patients and four significant others (56% female; age: 63±11 years) have been interviewed. Participants expressed a variety of information needs and learning preferences. Subthemes that emerged within the theme of motivation for learning were: 1) curiosity, such as knowledge gaps and hope for new information; and 2) values and goals, such as own health, caring for loved ones and spending time with family.To enhance intrinsic motivation for learning within PR, autonomy of individuals should be supported by offering several learning topics and education adapted to preferences, while curiosity should be fostered by targeting information needs. Moreover, health education programs should match with the personal values and goals of individuals, such as own health, caring for loved ones and spending time with family.","PeriodicalId":504874,"journal":{"name":"ERJ Open Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140077290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

European Respiratory Society International Congress, Milan, 2023: Highlights from the Assembly 1 – Respiratory clinical care and physiology 欧洲呼吸学会国际大会，米兰，2023 年：大会亮点 1 - 呼吸系统临床护理和生理学

ERJ Open Research Pub Date : 2024-03-07 DOI: 10.1183/23120541.00178-2024

Apolline Gonsard, E. Mekov, Sarah Barron, Giorgio Castellana, Elene Khurtsidze, A. Vontetsianos, Francesca Pennati, P. Sivapalan, Lorna E. Latimer, Mathieu Marillier, C. Hui, G. Kaltsakas, S. Kolekar, Guido Vagheggini, Cláudia Vicente, David Drummond, V. Poberezhets, Sam Bayat, F. Franssen, Ioannis Vogiatzis, Thomas Gille

引用次数: 0