European Journal of Internal Medicine最新文献_第7页

Post-extubation high-flow nasal cannula (HFNC) therapy with a ROX index-based strategy: A real step forward in weaning? 基于ROX指数的拔管后高流量鼻插管（HFNC）治疗：在脱机方面迈出了真正的一步？

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2025-09-08 DOI: 10.1016/j.ejim.2025.106498

Lara Pisani, Roberto Dongilli

引用次数: 0

Sodium-glucose cotransporter 2 inhibitors may increase iron availability with beneficial effects on erythropoiesis and cardiovascular mortality in patients with type 2 diabetes mellitus. 钠-葡萄糖共转运蛋白2抑制剂可能增加铁的可用性，对2型糖尿病患者的红细胞生成和心血管死亡率有有益影响。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2025-09-06 DOI: 10.1016/j.ejim.2025.106496

Philip Murphy

引用次数: 0

T follicular helper cells (T_FH): From physiological to pathological aging. T滤泡辅助细胞（TFH）：从生理性衰老到病理性衰老。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2025-09-06 DOI: 10.1016/j.ejim.2025.106505

Laura de Lisio, Remo Poto, Laura Andreea Ceparano, Grazia Daniela Femminella, Antonietta Liotti, Veronica De Rosa, Gilda Varricchi, Giuseppe Rengo

{"title":"T follicular helper cells (T<sub>FH</sub>): From physiological to pathological aging.","authors":"Laura de Lisio, Remo Poto, Laura Andreea Ceparano, Grazia Daniela Femminella, Antonietta Liotti, Veronica De Rosa, Gilda Varricchi, Giuseppe Rengo","doi":"10.1016/j.ejim.2025.106505","DOIUrl":"https://doi.org/10.1016/j.ejim.2025.106505","url":null,"abstract":"<p><p>The fraction that the elderly represent in the world's population is growing rapidly; numerous alterations that impact all organs and systems, including the immune system, are related to aging. A complex process common in the elderly, known as immunosenescence, is characterized by a decreased ability to respond to vaccination as well as an increased risk of bacterial and viral infections, autoimmune, cardiovascular and neurodegenerative diseases. These processes are associated with alterations in the innate and adaptive immune system and lead to a condition of chronic low-grade inflammation, referred to as inflammaging. However, the mechanisms underlying these processes are still unclear. Several types of immune cells are involved in this condition, including CD4<sup>+</sup>T cells subsets. T follicular helper (T<sub>FH</sub>) cells and T follicular regulatory cells (T<sub>FR</sub>) can be found in peripheral blood and lymphoid organs and are involved in maintaining immune homeostasis by regulating antibody production by B cells. Age-related changes in T<sub>FH</sub> cells phenotype and function have been observed in both aging humans and mouse models. Cardiovascular and neurodegenerative diseases, prevalent in elderly subjects, are associated with dysfunctional T<sub>FH</sub> cells and an altered T<sub>FH</sub>/T<sub>FR</sub> ratio. This review discusses the cellular and molecular alterations in T<sub>FH</sub> cells and in their ratio to T<sub>FR</sub> cells that occur with age, along with recent findings suggesting a possible link between T<sub>FH</sub> cells and/or their subsets and cardiovascular and neurodegenerative diseases.</p>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106505"},"PeriodicalIF":6.1,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aetiology of inflammatory abdominal aortic aneurysms influences prognosis. 炎症性腹主动脉瘤的病因影响预后。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2025-09-05 DOI: 10.1016/j.ejim.2025.106502

Océane Rieux, Marie Morard, Antoine Benichou, Loubna Dari, Olivier Espitia

引用次数: 0

Bolus or continuous for AHF? lessons from DIUR-AHF. AHF是单药还是连续药？DIUR-AHF的经验教训。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2025-09-05 DOI: 10.1016/j.ejim.2025.106497

Yuxiao Zhai, Yinghan Sun

引用次数: 0

Navigating the pitfalls of pulmonary function testing in chronic lung allograft dysfunction and chronic pulmonary graft-versus-host disease. 慢性同种异体肺移植功能障碍和慢性肺移植物抗宿主病肺功能检测的缺陷

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2025-09-04 DOI: 10.1016/j.ejim.2025.106500

Libor Fila, Andrea Zajacova

引用次数: 0

Drug-induced hyponatremia in clinical care 药物性低钠血症的临床护理。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2025-09-01 DOI: 10.1016/j.ejim.2025.05.024

Chaker Ben Salem, Dhouha Sahnoun

引用次数: 0

Blood pressure values in healthy normal weight children and adolescents in eight European countries: auscultatory and oscillometric measurements 八个欧洲国家健康正常体重儿童和青少年的血压值：听诊和振荡测量。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2025-09-01 DOI: 10.1016/j.ejim.2025.06.011

Lurbe E , Regueiro-Ons C , Mancia G , Düzova A , Erdine S , Herceg-Cavrak V , Kulaga Z , Litwin M , Pall D , Petricevic N , Seeman T , Simão C , Stabouli S , Redon J , González López-Valcarcel B

{"title":"Blood pressure values in healthy normal weight children and adolescents in eight European countries: auscultatory and oscillometric measurements","authors":"Lurbe E , Regueiro-Ons C , Mancia G , Düzova A , Erdine S , Herceg-Cavrak V , Kulaga Z , Litwin M , Pall D , Petricevic N , Seeman T , Simão C , Stabouli S , Redon J , González López-Valcarcel B","doi":"10.1016/j.ejim.2025.06.011","DOIUrl":"10.1016/j.ejim.2025.06.011","url":null,"abstract":"<div><div><em><strong>Aim:</strong></em> The aim of the study is to provide BP values adjusted for sex, age and height in a large sample of healthy and normal weight children and adolescents 3–17 years in eight European countries, using standardized BP measurement by oscillometric and auscultatory methods.</div></div><div><h3>Subjects and Methods</h3><div>In 38.374 children (20.189 girls) BP values were measured following the European Society of Hypertension guidelines. To derive BP percentiles the estimated influences of age and height simultaneously on BP levels were estimated.</div></div><div><h3>Results</h3><div>The estimated BP values corresponding to 90th, 95th, and 99th systolic and diastolic percentiles according to height percentiles, age and sex were calculated. In both methods, the 90th and 95th percentiles of systolic blood pressure, tended to increase with both age and height, higher in boys than in girls without differences in diastolic blood pressure. The study illustrates the differences in 95th Blood Pressure percentile obtained by oscillometric and auscultatory methods in both sexes at the 50th height percentile. The threshold corresponding to 95th percentile at age 13 is close to 130/80 mmHg in both sexes and measurement methods at median height and at age 17 it is around 140/90 mmHg for boys.</div></div><div><h3>Conclusions</h3><div>The progressive increment of blood pressure in children across age is largely influenced by height. In boys blood pressure values still increase after 13 years old, while in girls the BP increment after this age was lower. Differences in systolic blood pressure and diastolic blood pressure among the two used methods are minimal except in the oldest age group.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"139 ","pages":"Article 106382"},"PeriodicalIF":6.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are ACE2 rs2285666 and TMPRSS2 rs12329760 polymorphisms a risk factor for the development of Post-COVID-19 condition? ACE2 rs2285666和TMPRSS2 rs12329760多态性是covid -19后病情发展的危险因素吗？

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2025-09-01 DOI: 10.1016/j.ejim.2025.06.030

César Fernández-de-las-Peñas , Lars Arendt-Nielsen , Antonio Gil-Crujera , Stella M. Gómez-Sánchez , Gema Díaz-Gil

引用次数: 0

Drug-induced hyponatremia in clinical care. Authors' reply 药物性低钠血症的临床护理。作者的回答。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2025-09-01 DOI: 10.1016/j.ejim.2025.07.002

B. Mannheimer , J.D. Lindh , H. Falhammar , J. Skov

引用次数: 0