Ateroscleroz最新文献

{"title":"Polymorphisms of the ATP-binding cassette sterol efflux transporter genes g5 and g8 in cardiovascular diseases and type 2 diabetes mellitus","authors":"I. N. Grigor’eva, T. Notova, T. Suvorova, D. Nepomnyashchikh","doi":"10.52727/2078-256x-2024-20-1-6-15","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-1-6-15","url":null,"abstract":"Mutations with a decrease in the expression and function of the of the ATP-binding cassette genes proteins ABCG5 and ABCG8, as the main sterol efflux transporters, lead to the accumulation of xenosterols in plasma associated with changes in the lipid profile, hyperglycemia and the risk of cardiovascular diseases (CVD) and type 2 diabetes mellitus (DM2). The review presents studies of the role of ABCG5/G8 polymorphisms in CVD and DM2. In several studies, including large–scale ones, the influence of ABCG5/G8 variants (rs4245791, rs41360247 rs4299376, rs11887534, rs7598542, rs78451356, etc.) on the risk of coronary heart disease (CHD) was proved, in others – when confirming the association of the risk of CHD with ABCG5 polymorphism, this status for ABCG8 was denied. Since sterol metabolism disorders observed in individuals with DM2 are probably associated with low insulin sensitivity, many authors confirmed the association of variants rs4299376, rs4148211, rs140231607 and rs6720173 of the ABCG5/G8 with the risk of DM2, but some authors did not find such a connection with DM2 for variants rs4299376, rs11887534 and rs4148217 of the ABCG8. A decrease in ABCG5/G8 mRNA expression was observed in DM2 in experimental animals and in humans; on the contrary, overexpression of ABCG5/G8 in db/db mice restored the sensitivity of the liver to insulin, which led to a decrease in fasting glucose, lipids and improved glucose tolerance. The inconsistency of data on the association of ABCG5/G8 gene polymorphism with the risk of CVD and DM2 may probably be due to inter-population differences, which necessitates further study of the contribution of ABCG5/G8 variants to the risk of these diseases.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possibilities of non-drug treatment methods in the correction of dyslipidemia and manifestations of individual components of the metabolic syndrome","authors":"V. Drobyshev, L. A. Shpagina, I. I. Logvinenko, L. Agasarov, S. Abramovich, E. A. Zaikina, N. P. Kareva","doi":"10.52727/2078-256x-2024-20-1-24-34","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-1-24-34","url":null,"abstract":"Aim of the study was to identify the place of low-intensity electro-pulse therapy with biofeedback when it is included in the rehabilitation complex of patients with abdominal obesity to correct the quality of life and individual components of the metabolic syndrome.Material and methods. In the conditions of the outpatient diagnostic center of City Clinical Hospital No. 2 of Novosibirsk, 60 men and women with abdominal obesity, arterial hypertension and insulin resistance were examined, divided into 3 groups: 1st (main group, n = 25) in addition for standard therapy received a 15-day course of dynamic electroneurostimulation (DENS) from the Neurodance-PCM device; the 2nd (comparison group 1, n = 20), in addition to the basic complex, received DENS procedures from a placebo device, the 3rd (comparison group 2, n = 15) was treated with the use of only a basic therapeutic complex. The control group included 17 men and women without clinical manifestations from the endocrine and cardiovascular systems. The examination included examinations by an endocrinologist, a nutritionist, anthropometry and bioimpedance, assessment of quality of life parameters.Results. In group 1 patients, 1 month after the start of rehabilitation, there was a greater tendency than in the comparison groups to decrease the body mass index by 9.0 %, a correction of the percentage content in the body structure of fat mass by 1.4 times (p = 0.029) occurred, preprandial glycemia decreased by 1.4 times (p = 0.043) and the level of triglycerides in the blood serum – by 1.4 times (p = 0.044), the increased concentration of free leptin and resistin decreased (1.2 times, p = 0.039), the content of adiponectin in the blood serum increased by 1.2 times (p = 0.041), the quality of life improved 1 month after the start of rehabilitation according to the components of physical and psychological health, which is not observed in the placebo and standard treatment groups.Conclusions. The inclusion   of DENS from the Neurodance-PCM device   in the comprehensive rehabilitation of patients with abdominal obesity can contribute to the correction of anthropometry, bioimpedance, carbohydrate and adipokine metabolism indicators. This makes it possible to recommend the inclusion of low-intensity electro-pulse therapy in complex rehabilitation for the correction of quality of life indicators and individual components of the metabolic syndrome.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution of new coronavirus infection to the development of cardiovascular diseases (systematic review)","authors":"N. E. Apartseva, A. D. Khudiakova","doi":"10.52727/2078-256x-2024-20-1-42-54","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-1-42-54","url":null,"abstract":"In 2020, the National Institute for Health and Care Excellence in the UK   proposed   the concept of post-Covid syndrome. One of the main manifestations of the post-COVID syndrome are cardiovascular diseases (CVD) and dyslipidemia. However, the pathogenetic patterns of CVD development in COVID-19 convalescents remain unclear. The purpose of the systematic review was to analyze research data on the contribution of past new coronavirus infection to the development of dyslipidemia and atherosclerosis-associated diseases (AAD) in the post-COVID period. 106 publications were selected for analysis. After excluding clinical cases, drug studies, literature reviews and publications devoted to the acute period of COVID-19, a total of 19 articles were selected from Russian and international search engines. Analysis of studies has led to the conclusion that COVID-19 infection makes a significant contribution to the development of new AADs and worsening existing. One of the most likely mechanisms for occurrence of this phenomenon seems to be the development of endotheliitis against the background of the course of COVID-19, however, there are not enough works devoted to this problem.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the association of the rs12329760 polymorphism of the TMPRSS2 gene with acute coronary syndrome in patients with new coronavirus infection","authors":"V. A. Kozik, L. A. Shpagina, I. Shpagin, S. V. Maksimova, N. G. Lozhkina, V. N. Maksimov","doi":"10.52727/2078-256x-2024-20-1-35-41","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-1-35-41","url":null,"abstract":"Introduction. Cardiovascular diseases (СVD) rank first in terms of morbidity and mortality not only in the Russian Federation but throughout the world. Since the end of 2019 a pandemic of Severe Acute Respiratory Syndrome (SARS) or new coronavirus infection (NCI) has spread throughout the world, which contributed to the development and course of CVD. Therefore, genetic markers began to be considered as factors potentially influencing CVD, its development and severity. Objective: To evaluate the association of the nucleotide sequence variant rs12329760 of the TMPRSS2 gene with acute coronary syndrome in patients who have had a new coronavirus infection.Material and methods. The study included 100 patients (women – 50, men – 50) with ACS and previous NCI, who were selected on the basis of a positive PCR test for the presence of SARS-CoV-2 in the anamnesis, hospitalized at the regional vascular center No. 7 of the City Clinical Hospital No. 2 of the city of Novosibirsk. Women age was 59.5 ± 7.2 years, men age was 53.5 ± 9.3 years. The diagnosis of ACS was established according to a set of criteria proposed and established by the Russian Society of Cardiology and in accordance with the updated clinical recommendations of the Ministry of Health of the Russian Federation of 2020. Patients underwent clinical and instrumental examination, coronary angiography with possible stenting, as provided for in the standards of medical care and clinical guidelines. The nucleotide sequence variant rs12329760 of the TMPSS2 gene was determined in patients using PCR with further analysis of restriction fragment length polymorphism. The comparison group consisted of 200 patients with ACS without previous NCI (no positive PCR test, no positive antibodies).Results. Carriage of CC, СТ, TT, genotype variants of the nucleotide sequence rs12329760 of the TMPSS2 gene are not associated with an increased risk of developing ACS in patients with previous NCI. When comparing the frequencies of the rs12329760 genotypes of the TMPSS2 gene in groups with ACS with NCI and ACS without NCI, no statistically significant differences were obtained. In the group with ACS with NCI, carriage of the homozygous genotype was more common (p = 0.011).Conclusions. Variants of the nucleotide sequence rs12329760 of the TMPSS2 gene are  not associated with  ACS with previous  NCI.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of pro-atherogenic risk factors with thyroid-stimulating hormone level in women 25–44 years old","authors":"V. I. Alferova, S. Mustafina, O. Rymar, L. V. Shcherbakova, S. M. Voevoda, E. Stakhneva, D. Denisova","doi":"10.52727/2078-256x-2024-20-1-16-23","DOIUrl":"https://doi.org/10.52727/2078-256x-2024-20-1-16-23","url":null,"abstract":"Thyroid hormones play an important role in regulating metabolism. A large body of literature suggests an increased risk of developing metabolic syndrome (MS) in individuals with hypothyroidism, but little data exists on the effects of high-normal levels of thyroid-stimulating hormone (TSH) on metabolism.Material and methods. The study was conducted on a representative sample of people aged 25–44 years (n = 1513, of which 840 were women). The analysis included the results of 343 women. A questionnaire, anthropometric and biochemical study were carried out. Biochemical parameters were analyzed in quartiles of TSH content. Determination of MS was carried out using the criteria of NCEP ATP III (2001), IDF (2005), VNOK (2009).Results. TSH content in the examined sample was 1.5 [1.0; 2.2] mU/l (median [lower quartile; upper quartile]). Among women 25–44 years old, women with highly normal TSH level (3.1 [2.7, 3.8] mU/l) have less favorable metabolic parameters. MS was detected in 31 % cases, with a predominant increase in the frequency of abdominal obesity – in 51 %, with increased triglyceride levels in 18 %. Women with hypertriglyceridemia had higher TSH content than those with normal triglyceride levels (2.4 ± 1.6 vs. 1.8 ± 1.3 mU/L, respectively, p = 0.007).Conclusions. In women 25–44 years of age, high-normal TSH content is more often associated with metabolic unhealth.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of “hidden” forms of chronic heart failure","authors":"E. A. Medvedeva, N. G. Lozhkina, Z. K. Zhilokov","doi":"10.52727/2078-256x-2023-19-4-457-468","DOIUrl":"https://doi.org/10.52727/2078-256x-2023-19-4-457-468","url":null,"abstract":"The article discusses the prevalence of chronic heart failure and the possibility of its detection at an early, asymptomatic stage, when timely treatment can slow the progression of the disease. The data on the widely used and recognized biomarkers and their informative value for diagnostics of the “hidden: forms are presented, and also on the search of new markers. We used information on the topic from publications based on PubMed and Google Scholar databases, 5 years in depth.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Klotho protein level and blood lipid parameters with carotid atherosclerosis in men","authors":"O. V. Timoshchenko, Yu. V. Shchepina, Yulia I. Ragino, E. Stakhneva, V. S. Shramko, A. N. Ryabikov","doi":"10.52727/2078-256x-2023-19-4-426-433","DOIUrl":"https://doi.org/10.52727/2078-256x-2023-19-4-426-433","url":null,"abstract":"Aim of the study was to investigate the association of serum Klotho protein content and lipid parameters with atherosclerosis of the brachiocephalic arteries (BCA) in men.Material and methods. A cross-sectional comparative study that included men aged 50–65 years (n = 63, age 54 [53; 60] years (median [lower quartile; upper quartile])) underwent ultrasound examination of BCA at the outpatient department of the Institute of Internal and Preventive Medicine. Biochemical parameters were determined by standard enzymatic methods. Serum concentration of Klotho protein was measured by enzyme immunoassay.Results. A trend towards content of Klotho protein in serum was found in the group of persons with BCA atherosclerosis compared to the group without BCA atherosclerosis (705 [463; 1255] and 447 [282; 881] pg/ml, respectively, p = 0.061). Also, in men of this group, higher level of triglycerides (TG) (1.7 [1.1; 2.2] and 1.4 [0.9; 1.8] mmol/l, p = 0.046) and lower high-density lipoprotein cholesterol (HDL-C) content (1.1 [0.8; 1.3] m 1.4 [0.9; 1.6] mmol/l, p = 0.016) has been found. Correlation analysis in the group of men with BCA atherosclerosis revealed a direct relationship of Klotho protein with TG level (0.290; p = 0.031) and a negative relationship with HDL-C content (–0.361; p = 0.046). The results of logistic regression analysis showed that the probability of atherosclerotic plaques presence in BCA increased by 1.2 times (95 % confidence interval (95 % CI) 1.0–1.4, p = 0.038) with increasing age and by 9.2 times (95 % CI 2, 3–36.5, p = 0.002) in the presence of hypertension.Conclusions. In a clinical sample of men aged 50–65 years, the relative risk of carotid atherosclerosis is directly associated with age and the presence of hypertension and is not associated with the level of Klotho serum protein.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherogenic features of the fatty acid profile of erythrocyte membranes of patients with fatty liver disease of mixed genesis","authors":"M. Kruchinina, A. V. Belkovets, M. V. Parulikova, A. Gromov","doi":"10.52727/2078-256x-2023-19-4-350-368","DOIUrl":"https://doi.org/10.52727/2078-256x-2023-19-4-350-368","url":null,"abstract":"Aim of the study was to investigate the features of the fatty acid (FA) profile of erythrocyte membranes of patients with fatty liver disease (FLD) of mixed genesis (metabolic + alcoholic) from the point of view of atherogenic changes.Material and methods. 31 men (50.6 ± 9.9 years old) with FLD of mixed genesis, the degree of liver fibrosis corresponded to 0-1 (FibroScan ® 502 Echosens, France), and 28 persons of the comparison group, comparable in age, were examined. The study of the composition of FAs of erythrocyte membranes was carried out using gas chromatography/mass spectrometry – a system based on three quadrupoles Agilent 7000B (USA).Results. Patients with FLD of mixed genesis had higher level of palmitoleic (p = 0.03), pentadecanoic (p = 0.05), omega-6 to omega-3 polyunsaturated fatter acids (PUFA) ratio (p = 0.03) and, conversely, lower level of docosahexaenoic (p = 0.0002), total content of eicosapentaenoic and docosahexaenoic FA (p = 0.0007), of all omega-3 PUFA (p = 0.001) in the membranes of erythrocytes compared to healthy persons. There are trends towards a decrease in the content of omega-3 eicosapentaenoic acid and an increase in the ratio of SFA/PUFA in patients with fibroids of mixed genesis in contrast to healthy individuals. The level of individual FA provided high diagnostic accuracy in differentiating patients with FLD of mixed genesis from healthy individuals: palmitoleic (9-C16:1) (area under ROC (AUC) 0.702, sensitivity 66.7 %, specificity 69.6 %), docosahexaenoic (C22:6n-3) (AUC 0.795, sensitivity 77.3 %, specificity 78.3 %), as well as the total content of eicosapentaenoic and docosegexaenoic FA (C20:5n-3 + C22:6n-3) (AUC 0.777, sensitivity 70.1 %, specificity 82.6 %).Conclusions. The revealed features of the profile of erythrocyte membrane FA in FLD of mixed genesis – increase of saturated, monounsaturated, omega-6 PUFA content and reduce of omega-3 PUFA concentration are atherogenic. The continuation of research in terms of the use of FAs as biomarkers of this pathology and targets for therapeutic effects should be considered promising.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in adherence to treatment in patients with myocardial infarction","authors":"D. Sedykh, O. Barbarash","doi":"10.52727/2078-256x-2023-19-4-414-425","DOIUrl":"https://doi.org/10.52727/2078-256x-2023-19-4-414-425","url":null,"abstract":"The aim of the study is to identify factors affecting adherence to treatment in men and women with myocardial infarction (MI).Material and methods. The study included 150 patients diagnosed with MI (47 women and 103 men). Treatment readiness was assessed according to the S.V. Davydov method and with the calculation of the integral indicator of adherence to treatment (IIAT).Results. During 6-month follow-up, men and women with MI were comparable in mortality rates, however, men were more frequently hospitalized for cardiovascular complications. Adherence to treatment was high in both genders. Treatment readiness at the time of MI indicated higher satisfaction with the results of treatment in women, and higher willingness to pay for treatment, higher confidence in the treatment strategy and a higher IIAT in men. Both women and men with MI reported a comparable number of outpatient visits within 6 months (not exceeding 56 %). Only small number of patients reached the target heart rate (HR) and low-density lipoprotein (LDL) content within 6 months. Patients of both genders who reached and not reached the target LDL level and HR did not differ in mortality rates, hospitalizations and adherence to treatment within 6 months. At the same time, patients who reached the target HR, regardless of gender, were more likely to make outpatient postMI visits compared with those who did not reach the targets; men with MI who did not achieve the target HR were less likely to visit a doctor, whereas women with MI who achieved the target HR and LDL were more likely to have a high IIAT during in-patient care and were more willing to pay for further treatment (an exclusive characteristic of women who reached target HR). Moreover, we have identified predictors of IIAT and achievement of HR and LDL in women and men with MI.Conclusions. Patients with MI present with sex-specific factors that are affecting treatment adherence, which should be accounted for in the development of measures for secondary prevention of disease.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139178426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Origin and formation of early changes in the retina under the influence of atherosclerosis factors","authors":"A. Y. Lazutkina","doi":"10.52727/2078-256x-2023-19-4-385-403","DOIUrl":"https://doi.org/10.52727/2078-256x-2023-19-4-385-403","url":null,"abstract":"Lesions of the microcirculatory bed of the retina are an urgent problem due to their prevalence, severity of irreversible changes and their association with an unfavorable cardiovascular prognosis. Their pathogenesis is associated with endothelial dysfunction. Determining the processes of the formation and progression of retinopathy (RP) will bring closer the solution of problematic issues in ophthalmology and cardiology, and reduce cardiovascular morbidity and mortality.Aim. To study the processes of formation and progression of retinopathy in the initial stages of mixed origin (hypertensive, diabetic, unspecified etiology).Material and methods. The origin and progression of I–II degree RP under the influence of predictors of this symptom has been revealed through statistical analysis using the data of the 2008–2013 prospective follow-up of 22 clinical indicators of a natural group of initially healthy 7.959 male workers of locomotive crews of the Trans-Baikal Railway aged 18–66 years. Multivariate stepwise analysis, a 2 × 2 confusion matrix, Cox and Kaplan-Meier proportional hazard models were used, and a relative risk was assessed.Results. Such predictors of grade I–II RP as arterial hypertension, I–III degree obesity, smoking, dyslipidemia, left ventricular hypertrophy, family history of early cardiovascular disease, hyperglycemia, aortic atherosclerosis, creatininemia, atherosclerotic plaque / intima-media complex thickening, microalbuminuria, type 2 diabetes mellitus and age showed statistical heterogeneity in mathematical models. The distinctive feature was the different mutually exclusive assessment of the predictors’ significance in the models used. Thus, the predictors of I–II degree RP showed their specific identification characteristics, defined in qualitative and quantitative dimensions, by which they could be found and studied in the cell as well as their damaging effect.Conclusions. The course of endothelial dysfunction varies significantly when influenced by RP predictors. Its manifestations are determined by the influence of a specific factor, a set of factors or by all predictors taken together and involved simultaneously. This shows the need to determine the qualitative and quantitative ultrastructural and biochemical specific markers of endothelial dysfunction of the microvasculature of the eye appearing under the influence of RP predictors during the formation and progression of this pathological symptom in order to restore the normal function of the endothelial cell and the affected organ as a whole, as long as there is still room for therapeutic efforts.","PeriodicalId":504796,"journal":{"name":"Ateroscleroz","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}