{"title":"Capacity planning in a decentralized autologous cell therapy manufacturing network for low-cost resilience.","authors":"Junxuan Li, Chelsea C White","doi":"10.1007/s10696-022-09475-6","DOIUrl":"10.1007/s10696-022-09475-6","url":null,"abstract":"<p><p>The goals for increased patient access and fast fulfillment have motivated considerable interest in autologous cell therapy manufacturing networks having multiple and geographically distributed manufacturing facilities. However, the cost of safety manufacturing capacity to mitigate supplier disruption risk-a significant risk in the emerging cell manufacturing industry-would be lower if manufacturing is centralized. In this paper, we analyze a decentralized network that has as its objective to minimize the cost of network resilience for mitigating supplier disruption by making use of the fact that bioreactors for autologous therapy manufacturing are small enough to be relocatable. We model this problem as a Markov decision process and develop efficient algorithms that are based on real-time demand data to minimize safety manufacturing capacity and determine how relocatable capacity should be distributed while satisfying resilience constraints. In case studies, based in part on data collected from a Chimeric antigen receptor T cell therapy manufacturing facility at the University of Pennsylvania, we compare decentralized network models with different heuristic algorithms. Results indicate that transshipment in a decentralized network can result in a significant reduction of required safety capacity, reducing the cost of network resilience.</p>","PeriodicalId":50441,"journal":{"name":"Flexible Services and Manufacturing Journal","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9930658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ismail M. Ali, H. Turan, R. Chakrabortty, S. Elsawah
{"title":"Multi-objective-based differential evolution for balancing production cost, diversity and aggregated performance attributes in product family design","authors":"Ismail M. Ali, H. Turan, R. Chakrabortty, S. Elsawah","doi":"10.1007/s10696-022-09480-9","DOIUrl":"https://doi.org/10.1007/s10696-022-09480-9","url":null,"abstract":"","PeriodicalId":50441,"journal":{"name":"Flexible Services and Manufacturing Journal","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46940848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Energy-efficient on/off control in serial production lines with Bernoulli machines","authors":"Xiaohan Wang, Yaping Dai, Zhiyang Jia","doi":"10.1007/s10696-022-09481-8","DOIUrl":"https://doi.org/10.1007/s10696-022-09481-8","url":null,"abstract":"","PeriodicalId":50441,"journal":{"name":"Flexible Services and Manufacturing Journal","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49490782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vincent Augusto, N. Lahrichi, Ettore Lanzarone, Taesik Lee, Jie Song
{"title":"Analytics and Optimization in Healthcare Management","authors":"Vincent Augusto, N. Lahrichi, Ettore Lanzarone, Taesik Lee, Jie Song","doi":"10.1007/s10696-022-09478-3","DOIUrl":"https://doi.org/10.1007/s10696-022-09478-3","url":null,"abstract":"","PeriodicalId":50441,"journal":{"name":"Flexible Services and Manufacturing Journal","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41511417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dominic Breuer, Khedidja Seridi, N. Lahrichi, Mohit Shukla, J. Benneyan
{"title":"Correction to: Robust multi-period capacity, location, and access of rural cardiovascular services under uncertainty","authors":"Dominic Breuer, Khedidja Seridi, N. Lahrichi, Mohit Shukla, J. Benneyan","doi":"10.1007/s10696-022-09451-0","DOIUrl":"https://doi.org/10.1007/s10696-022-09451-0","url":null,"abstract":"","PeriodicalId":50441,"journal":{"name":"Flexible Services and Manufacturing Journal","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45109234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Balancing and sequencing of mixed-model assembly line considering preventive maintenance scenarios: mathematical model and a migrating birds optimization algorithm","authors":"Kai Meng, Qiuhua Tang, Zikai Zhang","doi":"10.1007/s10696-022-09477-4","DOIUrl":"https://doi.org/10.1007/s10696-022-09477-4","url":null,"abstract":"","PeriodicalId":50441,"journal":{"name":"Flexible Services and Manufacturing Journal","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2022-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46952740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Koppiahraj Karuppiah, Bathrinath Sankaranarayanan, S. Ali, R. Bhalaji
{"title":"Decision modeling of the challenges to human–robot collaboration in industrial environment: a real world example of an emerging economy","authors":"Koppiahraj Karuppiah, Bathrinath Sankaranarayanan, S. Ali, R. Bhalaji","doi":"10.1007/s10696-022-09474-7","DOIUrl":"https://doi.org/10.1007/s10696-022-09474-7","url":null,"abstract":"","PeriodicalId":50441,"journal":{"name":"Flexible Services and Manufacturing Journal","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46039739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Maritime inventory routing with transshipment: the case of Yamal LNG","authors":"Mingyu Li, K. Fagerholt, P. Schütz","doi":"10.1007/s10696-022-09476-5","DOIUrl":"https://doi.org/10.1007/s10696-022-09476-5","url":null,"abstract":"","PeriodicalId":50441,"journal":{"name":"Flexible Services and Manufacturing Journal","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42290524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jaap-Jan van der Steeg, Menno Oudshoorn, N. Yorke-Smith
{"title":"Berth planning and real-time disruption recovery: a simulation study for a tidal port","authors":"Jaap-Jan van der Steeg, Menno Oudshoorn, N. Yorke-Smith","doi":"10.1007/s10696-022-09473-8","DOIUrl":"https://doi.org/10.1007/s10696-022-09473-8","url":null,"abstract":"","PeriodicalId":50441,"journal":{"name":"Flexible Services and Manufacturing Journal","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46598488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}