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Tumor Cell-Derived Complement Component C1r Acts as a Prognostic Biomarker and Promotes Esophageal Squamous Cell Carcinoma Progression 肿瘤细胞衍生的补体成分 C1r 可作为预后生物标记物并促进食管鳞状细胞癌的进展
IF 3.1 4区 生物学
Frontiers in Bioscience-Landmark Pub Date : 2024-04-02 DOI: 10.31083/j.fbl2904138
Maolin Tang, Shisheng Zhao, Ling Ren, Qianqian Li, Li Li, Chaoli Wang, Chunmei Meng, Yuling Chen, Weimin Hu
{"title":"Tumor Cell-Derived Complement Component C1r Acts as a Prognostic Biomarker and Promotes Esophageal Squamous Cell Carcinoma Progression","authors":"Maolin Tang, Shisheng Zhao, Ling Ren, Qianqian Li, Li Li, Chaoli Wang, Chunmei Meng, Yuling Chen, Weimin Hu","doi":"10.31083/j.fbl2904138","DOIUrl":"https://doi.org/10.31083/j.fbl2904138","url":null,"abstract":"Background : Mounting evidence indicates that complement components play a crucial role in cancer progression. Recent findings indicate that certain complement components display a significant rise in expression within esophageal squamous cell carcinoma (ESCC). However, the specific tumorigenic functions of these components remain unclear. This study focuses on investigating the expression pattern of C1r, elucidating a role for C1r in ESCC, as well as exploring underlying mechanisms controlled by C1r. Methods : The expression of C1r in ESCC tissues, malignant epithelial cells, and its relationship with survival were analyzed using the Gene Expression Omnibus (GEO) database and tissue microarrays. Single-cell RNA sequencing (scRNA-seq) was used to study the expression of C1r in malignant epithelial cells. C1r knockdown or C1r overexpression in cultured ESCC cells were used to assess the effects of C1r on proliferation, migration, invasion, cell-matrix adhesion, apoptosis, and growth of xenografted tumors in immunocompromised (nude) mice. Western blotting was used to detect the expression of MMP-1 and MMP-10 in C1r knockdown or C1r overexpressing ESCC cells. Results : C1r was highly expressed in ESCC tissues, malignant epithelial cells, and cultured ESCC cell lines. High C1r expression indicated a poor prognosis. Knockdown of C1r significantly suppressed the proliferation, migration, invasion, cell-matrix adhesion, and promoted apoptosis in cultured ESCC cells. Additionally, knockdown of C1r markedly inhibited tumor growth in nude mice. Overexpression of C1r had the opposite effects. C1r induced the expression of MMP-1 and MMP-10. Conclusions : C1r is highly expressed in ESCC and promotes the progression of this tumor type. Our findings suggest that C1r may serve as a novel prognostic biomarker and therapeutic target in ESCC.","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":"16 12","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140753852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Promising Therapeutic Approach in Pancreatic Cancer: Metabolism-Related Genes 胰腺癌的有望治疗方法：代谢相关基因
IF 3.1 4区 生物学
Frontiers in Bioscience-Landmark Pub Date : 2024-04-02 DOI: 10.31083/j.fbl2904137
Soo-Cheon Choe, Woori Kwak, Ehyun Kim, Sohyeon Shin, Miyoung Shin, Hyun Jung Koh, Hyunho Yoon
{"title":"Promising Therapeutic Approach in Pancreatic Cancer: Metabolism-Related Genes","authors":"Soo-Cheon Choe, Woori Kwak, Ehyun Kim, Sohyeon Shin, Miyoung Shin, Hyun Jung Koh, Hyunho Yoon","doi":"10.31083/j.fbl2904137","DOIUrl":"https://doi.org/10.31083/j.fbl2904137","url":null,"abstract":"","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":"13 4","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140754304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interactions between Beta-Amyloid and Pericytes in Alzheimer’s Disease 阿尔茨海默病中β-淀粉样蛋白与周细胞之间的相互作用
IF 3.1 4区 生物学
Frontiers in Bioscience-Landmark Pub Date : 2024-04-02 DOI: 10.31083/j.fbl2904136
You-Yue Li, Dan-Dan Guo, Ruo-Nan Duan, Yi Li
{"title":"Interactions between Beta-Amyloid and Pericytes in Alzheimer’s Disease","authors":"You-Yue Li, Dan-Dan Guo, Ruo-Nan Duan, Yi Li","doi":"10.31083/j.fbl2904136","DOIUrl":"https://doi.org/10.31083/j.fbl2904136","url":null,"abstract":"","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":"252 23","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140751501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FOXA1/UBE2T Inhibits CD8+T Cell Activity by Inducing Mediates Glycolysis in Lung Adenocarcinoma FOXA1/UBE2T 通过诱导介导肺腺癌中的糖酵解抑制 CD8+T 细胞活性
IF 3.1 4区 生物学
Frontiers in Bioscience-Landmark Pub Date : 2024-04-01 DOI: 10.31083/j.fbl2904134
Jiangtao Pu, Dengguo Zhang, Biao Wang, Peiquan Zhu, Wenxing Yang, Kaiqiang Wang, Ze Yang, Qi Song
{"title":"FOXA1/UBE2T Inhibits CD8+T Cell Activity by Inducing Mediates Glycolysis in Lung Adenocarcinoma","authors":"Jiangtao Pu, Dengguo Zhang, Biao Wang, Peiquan Zhu, Wenxing Yang, Kaiqiang Wang, Ze Yang, Qi Song","doi":"10.31083/j.fbl2904134","DOIUrl":"https://doi.org/10.31083/j.fbl2904134","url":null,"abstract":"","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":"530 ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prognostic Cell Death Index for Lung Adenocarcinoma: A Comprehensive Transcriptome-Based Analysis of Twelve Programmed Cell Death Pattern Genes 肺腺癌预后细胞死亡指数：基于十二个程序性细胞死亡模式基因转录组的综合分析
IF 3.1 4区 生物学
Frontiers in Bioscience-Landmark Pub Date : 2024-04-01 DOI: 10.31083/j.fbl2904135
Funan Chen, Jun Ma, Shuqiao Hu, Canxing Wu, Shanshan Chen, Jiehuan Lin
{"title":"Prognostic Cell Death Index for Lung Adenocarcinoma: A Comprehensive Transcriptome-Based Analysis of Twelve Programmed Cell Death Pattern Genes","authors":"Funan Chen, Jun Ma, Shuqiao Hu, Canxing Wu, Shanshan Chen, Jiehuan Lin","doi":"10.31083/j.fbl2904135","DOIUrl":"https://doi.org/10.31083/j.fbl2904135","url":null,"abstract":"","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":"1217 12","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140774492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy, Ferroptosis, Apoptosis and Pyroptosis in Metabolic Dysfunction-Associated Steatotic Liver Disease 代谢功能障碍相关性脂肪肝中的自噬、铁凋亡、细胞凋亡和热凋亡
IF 3.1 4区 生物学
Frontiers in Bioscience-Landmark Pub Date : 2024-01-19 DOI: 10.31083/j.fbl2901030
Shuangshuang Zhao, Yan Guo, Xunzhe Yin
{"title":"Autophagy, Ferroptosis, Apoptosis and Pyroptosis in Metabolic Dysfunction-Associated Steatotic Liver Disease","authors":"Shuangshuang Zhao, Yan Guo, Xunzhe Yin","doi":"10.31083/j.fbl2901030","DOIUrl":"https://doi.org/10.31083/j.fbl2901030","url":null,"abstract":"","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":"8 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139524960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
N6-Methyladenosine Regulator-Mediated Methylation Modification Patterns with Distinct Prognosis, Oxidative Stress, and Tumor Microenvironment in Renal Cell Carcinoma N6-甲基腺苷调节剂介导的甲基化修饰模式与肾细胞癌的不同预后、氧化应激和肿瘤微环境有关
IF 3.1 4区 生物学
Frontiers in Bioscience-Landmark Pub Date : 2024-01-19 DOI: 10.31083/j.fbl2901033
Chunyang Li, Maoshu Zhu, Chuane Gao, Fuhua Lu, Huoshu Chen, Jiancheng Liu, Weimin Zhong
{"title":"N6-Methyladenosine Regulator-Mediated Methylation Modification Patterns with Distinct Prognosis, Oxidative Stress, and Tumor Microenvironment in Renal Cell Carcinoma","authors":"Chunyang Li, Maoshu Zhu, Chuane Gao, Fuhua Lu, Huoshu Chen, Jiancheng Liu, Weimin Zhong","doi":"10.31083/j.fbl2901033","DOIUrl":"https://doi.org/10.31083/j.fbl2901033","url":null,"abstract":"","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":"14 8","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139525495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Centrosomes of Haploid and Diploid Cells Have an Equal Number of Centrioles in the Parasitoid Wasp Anisopteromalus Calandrae 寄生蜂卡兰德拉（Anisopteromalus Calandrae）单倍体和二倍体细胞的中心体具有相同数量的中心粒
IF 3.1 4区 生物学
Frontiers in Bioscience-Landmark Pub Date : 2024-01-19 DOI: 10.31083/j.fbl2901028
Rustem Uzbekov, San-Whouly Mauricette Ouali N'goran, Anastasiia Garanina, Massimo Pancione, Stanislav Yu. Chaika, Christophe Bressac
{"title":"The Centrosomes of Haploid and Diploid Cells Have an Equal Number of Centrioles in the Parasitoid Wasp Anisopteromalus Calandrae","authors":"Rustem Uzbekov, San-Whouly Mauricette Ouali N'goran, Anastasiia Garanina, Massimo Pancione, Stanislav Yu. Chaika, Christophe Bressac","doi":"10.31083/j.fbl2901028","DOIUrl":"https://doi.org/10.31083/j.fbl2901028","url":null,"abstract":"","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":"6 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139525352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
O-glycoprofiling of Serum Apolipoprotein C-III in Colorectal Cancer 大肠癌血清载脂蛋白 C-III 的 O-糖谱分析
IF 3.1 4区 生物学
Frontiers in Bioscience-Landmark Pub Date : 2024-01-19 DOI: 10.31083/j.fbl2901032
Kristína Kianičková, Z. Pakanová, Filip Květoň, Alena Holazová, Paras H. Kundalia, Peter Barath, G. Miljuš, O. Nedić, Jaroslav Katrlík
{"title":"O-glycoprofiling of Serum Apolipoprotein C-III in Colorectal Cancer","authors":"Kristína Kianičková, Z. Pakanová, Filip Květoň, Alena Holazová, Paras H. Kundalia, Peter Barath, G. Miljuš, O. Nedić, Jaroslav Katrlík","doi":"10.31083/j.fbl2901032","DOIUrl":"https://doi.org/10.31083/j.fbl2901032","url":null,"abstract":"","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":"8 11","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139525442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing Humanized Animal Models with Transplantable Human iPSC-Derived Cells 利用可移植的人类 iPSC 衍生细胞开发人源化动物模型
IF 3.1 4区 生物学
Frontiers in Bioscience-Landmark Pub Date : 2024-01-19 DOI: 10.31083/j.fbl2901034
Min Ma, Jian-Yun Ge, Yun-Zhong Nie, Yu-Mei Li, Yun-Wen Zheng
{"title":"Developing Humanized Animal Models with Transplantable Human iPSC-Derived Cells","authors":"Min Ma, Jian-Yun Ge, Yun-Zhong Nie, Yu-Mei Li, Yun-Wen Zheng","doi":"10.31083/j.fbl2901034","DOIUrl":"https://doi.org/10.31083/j.fbl2901034","url":null,"abstract":"","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":"9 2","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139524950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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