Frontiers in Bioscience-Landmark最新文献_第3页

A Cell Specific Effect of MBOAT7 MAFLD-risk Variant on Immune Cells MBOAT7 MAFLD 风险变体对免疫细胞的细胞特异性影响

IF 3.1 4区生物学

Frontiers in Bioscience-Landmark Pub Date : 2024-04-11 DOI: 10.31083/j.fbl2904148

Ziyang Pan, Jawaher Alharthi, A. Bayoumi, Jacob George, M. Eslam

引用次数: 0

UBA2 as a Prognostic Biomarker and Potential Therapeutic Target in Glioma 作为胶质瘤预后生物标志物和潜在治疗靶点的 UBA2

IF 3.1 4区生物学

Frontiers in Bioscience-Landmark Pub Date : 2024-04-09 DOI: 10.31083/j.fbl2904144

Yuhong Ou, Hongtao Luo, Qiuning Zhang, Tianqi Du, Ruifeng Liu, Dandan Wang, Junru Chen, Meng Dong, Yuhang Wang, Zhen Yang, Xiaohu Wang

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The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases 辅酶 A 及其衍生物的代谢在疾病中发挥着至关重要的作用

IF 3.1 4区生物学

Frontiers in Bioscience-Landmark Pub Date : 2024-04-09 DOI: 10.31083/j.fbl2904143

Jumin Xie, Xingyuan Chen, Mei Zheng, Jingzhe Zhu, Hui Mao

{"title":"The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases","authors":"Jumin Xie, Xingyuan Chen, Mei Zheng, Jingzhe Zhu, Hui Mao","doi":"10.31083/j.fbl2904143","DOIUrl":"https://doi.org/10.31083/j.fbl2904143","url":null,"abstract":"Coenzyme A (CoA) functions as a crucial carrier of acyl groups within cells, playing a fundamental role in regulating acyl transfer reactions and participating in cellular metabolic processes. As the principal substrate and cofactor engaged in diverse metabolic reactions, CoA and its derivatives exert central influence over various physiological processes, primarily modulating lipid and ketone metabolism, as well as protein modification. This paper presents a comprehensive review of the molecular mechanisms by which CoA influences the onset and progression of cancer, cardiovascular disease (CVD), neurodegenerative disorders, and other illnesses. The main focal points include the following. (1) In cancer, enzymes such as acetyl-CoA synthetase 2, ATP citrate lyase, and acetyl-CoA carboxylase regulate lipid synthesis and energy metabolism by modulating acetyl-CoA levels. (2) In CVD, the effects of enzymes such as stearoyl-CoA desaturase-1, 3-hydroxy-3-methylglutaryl-CoA (HMGC) synthase 2, and HMGC reductase on the formation and advancement of these diseases are elucidated by their regulation of CoA metabolism across multiple organs. (3) In neurodegenerative disorders, the significance of CoA in maintaining cholesterol homeostasis in the brain and its implications on the development of such disorders are thoroughly discussed. The metabolic processes involving CoA and its derivatives span all physiological aspects within cells, playing a critical role in the onset and progression of various diseases. Elucidating the role of CoA in these conditions yields important insights that can serve as valuable references and guidance for disease diagnosis, treatment, and drug development.","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":"120 11","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140724697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progenitor Cell Function and Cardiovascular Remodelling Induced by SGLT2 Inhibitors SGLT2 抑制剂诱导的祖细胞功能和心血管重塑

IF 3.1 4区生物学

Frontiers in Bioscience-Landmark Pub Date : 2024-04-09 DOI: 10.31083/j.fbl2904145

Theodora M Stougiannou, Konstantinos C. Christodoulou, T. Koufakis, F. Mitropoulos, Dimitrios Mikroulis, Cyril David Mazer, Dimos Karangelis

引用次数: 0

Research Progress of Pericytes in Pulmonary Fibrosis 肺纤维化中的周细胞研究进展

IF 3.1 4区生物学

Frontiers in Bioscience-Landmark Pub Date : 2024-04-08 DOI: 10.31083/j.fbl2904141

Xiaobo He, Yuanhang Fan, Yihuan Lai, Ying Yang, Xiao Xiao Tang, Yichun Wang

引用次数: 0

Deciphering the Enigma of Neuron-Glial Interactions in Neurological Disorders 破解神经系统疾病中神经元与神经胶质细胞相互作用之谜

IF 3.1 4区生物学

Frontiers in Bioscience-Landmark Pub Date : 2024-04-08 DOI: 10.31083/j.fbl2904142

S. R. Ahmad, Md. Zeyaullah, Abdullah M. AlShahrani, Adam Dawria, Haroon Ali, Ali Mohieldin, Abdelrhman AG Altijani, Ufaq Razi, Munzila Mehdi, Sabika Akram, Ejaz Rizvi Hussain

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CD146 Promotes EMT-Mediated Migration and Invasion of NSCLC via PI3K/Akt Signaling Pathway CD146 通过 PI3K/Akt 信号通路促进 EMT 介导的 NSCLC 迁移和侵袭

IF 3.1 4区生物学

Frontiers in Bioscience-Landmark Pub Date : 2024-04-08 DOI: 10.31083/j.fbl2904140

Nan Wei, Xuan Wu, Yi Yu, Huanhuan Zhou, Kai Cui, Xingru Zhao, Xiaoju Zhang

引用次数: 0

Human Placenta-Derived Mesenchymal Stem Cells Improve Neurological Function in Rats with Intrauterine Hypoxic-Ischaemic Encephalopathy by Reducing Apoptosis and Inflammatory Reactions 人胎盘间充质干细胞通过减少细胞凋亡和炎症反应改善宫内缺氧缺血性脑病大鼠的神经功能

IF 3.1 4区生物学

Frontiers in Bioscience-Landmark Pub Date : 2024-04-03 DOI: 10.31083/j.fbl2904139

Yi-Qi Zhao, Yun-Yi Xu, Yan-Mei Zheng, Fei Han, Ying Zhang, Ruo-Lang Pan, Jia-Rong Chen, Yu-Mei Hao, Li-Wei Yang

引用次数: 0

Tumor Cell-Derived Complement Component C1r Acts as a Prognostic Biomarker and Promotes Esophageal Squamous Cell Carcinoma Progression 肿瘤细胞衍生的补体成分 C1r 可作为预后生物标记物并促进食管鳞状细胞癌的进展

IF 3.1 4区生物学

Frontiers in Bioscience-Landmark Pub Date : 2024-04-02 DOI: 10.31083/j.fbl2904138

Maolin Tang, Shisheng Zhao, Ling Ren, Qianqian Li, Li Li, Chaoli Wang, Chunmei Meng, Yuling Chen, Weimin Hu

{"title":"Tumor Cell-Derived Complement Component C1r Acts as a Prognostic Biomarker and Promotes Esophageal Squamous Cell Carcinoma Progression","authors":"Maolin Tang, Shisheng Zhao, Ling Ren, Qianqian Li, Li Li, Chaoli Wang, Chunmei Meng, Yuling Chen, Weimin Hu","doi":"10.31083/j.fbl2904138","DOIUrl":"https://doi.org/10.31083/j.fbl2904138","url":null,"abstract":"Background : Mounting evidence indicates that complement components play a crucial role in cancer progression. Recent findings indicate that certain complement components display a significant rise in expression within esophageal squamous cell carcinoma (ESCC). However, the specific tumorigenic functions of these components remain unclear. This study focuses on investigating the expression pattern of C1r, elucidating a role for C1r in ESCC, as well as exploring underlying mechanisms controlled by C1r. Methods : The expression of C1r in ESCC tissues, malignant epithelial cells, and its relationship with survival were analyzed using the Gene Expression Omnibus (GEO) database and tissue microarrays. Single-cell RNA sequencing (scRNA-seq) was used to study the expression of C1r in malignant epithelial cells. C1r knockdown or C1r overexpression in cultured ESCC cells were used to assess the effects of C1r on proliferation, migration, invasion, cell-matrix adhesion, apoptosis, and growth of xenografted tumors in immunocompromised (nude) mice. Western blotting was used to detect the expression of MMP-1 and MMP-10 in C1r knockdown or C1r overexpressing ESCC cells. Results : C1r was highly expressed in ESCC tissues, malignant epithelial cells, and cultured ESCC cell lines. High C1r expression indicated a poor prognosis. Knockdown of C1r significantly suppressed the proliferation, migration, invasion, cell-matrix adhesion, and promoted apoptosis in cultured ESCC cells. Additionally, knockdown of C1r markedly inhibited tumor growth in nude mice. Overexpression of C1r had the opposite effects. C1r induced the expression of MMP-1 and MMP-10. Conclusions : C1r is highly expressed in ESCC and promotes the progression of this tumor type. Our findings suggest that C1r may serve as a novel prognostic biomarker and therapeutic target in ESCC.","PeriodicalId":50430,"journal":{"name":"Frontiers in Bioscience-Landmark","volume":"16 12","pages":""},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140753852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promising Therapeutic Approach in Pancreatic Cancer: Metabolism-Related Genes 胰腺癌的有望治疗方法：代谢相关基因

IF 3.1 4区生物学

Frontiers in Bioscience-Landmark Pub Date : 2024-04-02 DOI: 10.31083/j.fbl2904137

Soo-Cheon Choe, Woori Kwak, Ehyun Kim, Sohyeon Shin, Miyoung Shin, Hyun Jung Koh, Hyunho Yoon

引用次数: 0