ACS Applied Engineering Materials最新文献

Development of Breathable, Flame-Retardant, Antifouling Fabrics with High-Efficiency Chemical Warfare Agent Decontamination 高效去污化学战剂的透气、阻燃、防污织物的研制

ACS Applied Engineering Materials Pub Date : 2025-12-05 DOI: 10.1021/acsaenm.5c00969

Shiliang Sheng, Pengju Han, Shitao Wang, Yang Xu, Cheng Chen, Xiang Li, Huiying Sang, Manman Zhai, Tengshu Wan, Xiaolong Hao, Rongwu Wang, Jianxin He

{"title":"Development of Breathable, Flame-Retardant, Antifouling Fabrics with High-Efficiency Chemical Warfare Agent Decontamination","authors":"Shiliang Sheng, Pengju Han, Shitao Wang, Yang Xu, Cheng Chen, Xiang Li, Huiying Sang, Manman Zhai, Tengshu Wan, Xiaolong Hao, Rongwu Wang, Jianxin He","doi":"10.1021/acsaenm.5c00969","DOIUrl":"https://doi.org/10.1021/acsaenm.5c00969","url":null,"abstract":"To address the chemical protection requirements in modern complex environments, developing efficient self-decontaminating chemical protective fabrics with comfort, breathability, and multiprotective functionalities holds great significance for national defense security. In this study, a Zr–O bond-mediated in situ growth strategy was proposed to precisely regulate the crystallization of UiO-66-NH2 on polyimide (PI) nanofibers. A Z/PI@UiO-66-NH2 nanofiber composite with a stable chemical structure was fabricated, exhibiting a 98.57% degradation rate for 2-chloroethyl ethyl sulfide (CEES) as well as excellent reusability. The uniform and robust loading of UiO-66-NH2 on the surface of PI nanofibers (loading rate: 52.28%) increased the surface roughness while preserving the original porosity of the fiber membrane, endowing the Z/PI@UiO-66-NH2 nanofiber composite membrane with a water contact angle of 152.8°. This indicates outstanding superhydrophobic and antifouling properties, coupled with a high water vapor permeability of 4897 m–2·d–1. Meanwhile, the extensively loaded MOF crystals imparted excellent flame-retardant performance to the composite, with a limiting oxygen index (LOI) reaching 29.30. Furthermore, the composite maintained a CEES degradation rate of >97% after exposure to acids, alkalis, high temperatures, and oil contamination, demonstrating robust environmental stability. The Z/PI@UiO-66-NH2 nanofiber composite developed in this study provides an approach for the design of self-disinfecting chemical protective fabrics integrating efficient degradation, flame retardancy, and antifouling capabilities.","PeriodicalId":504002,"journal":{"name":"ACS Applied Engineering Materials","volume":"3 12","pages":"4656-4667"},"PeriodicalIF":0.0,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sprayable Ultrablack Photothermal Superhydrophobic Coatings for Anti-Icing Applications 用于防冰应用的可喷涂超黑光热超疏水涂料

ACS Applied Engineering Materials Pub Date : 2025-12-01 DOI: 10.1021/acsaenm.5c00813

Shuang Yang, Qun Wang, Rui Ke, Xudong Zhang, Qiyang Xiong, Yang Li, Songtao Lu, Xinzhi Wang, Xiaohong Wu

{"title":"Sprayable Ultrablack Photothermal Superhydrophobic Coatings for Anti-Icing Applications","authors":"Shuang Yang, Qun Wang, Rui Ke, Xudong Zhang, Qiyang Xiong, Yang Li, Songtao Lu, Xinzhi Wang, Xiaohong Wu","doi":"10.1021/acsaenm.5c00813","DOIUrl":"https://doi.org/10.1021/acsaenm.5c00813","url":null,"abstract":"“Three birds with one stone” strategies for materials that simultaneously optimize ultrablack and photothermal superhydrophobic multifunctional integrity are expected to achieve a proper balance under extreme conditions, such as deep space exploration. Here, based on the combination of nanoscale structural and molecular composition design, the gradient hierarchically sandwich-like three-layered coating structures composed of carbon black resin bottom and porous middle layer and SiO2 top layer are designed through three steps all sprayed room temperature route. The effects of carbon black content and interface composition on adhesion, morphology, hydrophobicity, and light absorption properties of the coating were investigated. Remarkably, the proposed “light-capturing” porous architecture through cation−π interactions salt template route improved the light contact interface of air/adsorbent, and the finite-difference time-domain confirmed the optical/electrical field excitation of multiple higher-order resonances and thus enhanced scattering intensity, resulting in solar-weighted absorptance of 98.60% within the wavelength range of 200–2500 nm. Moreover, the freezing time of the droplets was delayed to 600 s at −20 °C, which is 12 times longer than that of the aluminum blank substrate, and it is 2.2 times superior to the previously reported antifreezing time of 271 s for CNT coatings. The all sprayed salt template method has potential for large-scale preparation of carbon- and inorganic resin-based ultrablack superhydrophobic photothermal coatings with multifunctional integrity by adjusting the architectures of compositional gradients at the nanometer and molecular scale under extreme conditions.","PeriodicalId":504002,"journal":{"name":"ACS Applied Engineering Materials","volume":"3 12","pages":"4492-4506"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147889799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Synergistic Floatation-Sound Absorption: Piezoshell Foam Architectures for Hydroacoustic Attenuation 协同漂浮-吸声：用于水声衰减的压壳泡沫结构

ACS Applied Engineering Materials Pub Date : 2025-11-25 DOI: 10.1021/acsaenm.5c00730

Beibei Huang, Kunhan Chen, Jiawei Du, Zhaohan Yu, Dong Wang, Lu Zhang, Qikuan Cheng, Weibang Xia, Yunming Wang, Huamin Zhou

{"title":"Synergistic Floatation-Sound Absorption: Piezoshell Foam Architectures for Hydroacoustic Attenuation","authors":"Beibei Huang, Kunhan Chen, Jiawei Du, Zhaohan Yu, Dong Wang, Lu Zhang, Qikuan Cheng, Weibang Xia, Yunming Wang, Huamin Zhou","doi":"10.1021/acsaenm.5c00730","DOIUrl":"https://doi.org/10.1021/acsaenm.5c00730","url":null,"abstract":"Large-wavelength low-frequency sound waves are highly penetrative, and existing acoustic load-bearing structures struggle to achieve effective absorption across different media through pore and molecular chain regulation. The development of high-performance underwater acoustic materials is constrained by the limited tunability of traditional microporous structures and the poor pressure stability of viscoelastic polymers. Here, we present a microporous composite structure enhanced by piezoelectric nanoparticle filling for efficient low-frequency sound absorption. This design integrates porous ceramics with microporous piezoelectric polymers to form a multilayer resonant system, wherein embedded nanocomposites facilitate additional sound reflection, resonance, and interfacial collisions. These interactions synergistically promote both acoustic-thermal and acoustic-electric energy dissipation, enabling high-efficiency low-frequency sound absorption within a compact architecture. The optimized structure achieves a noise reduction coefficient of 0.54, with the onset frequency of the sound absorption coefficient exceeding 0.8 as low as 840 Hz. Under hydrostatic pressure ranging from 0.1 to 2 MPa, the attenuation of the average sound absorption coefficient was only 36.62%, significantly lower than the 75.61% observed in conventional polyurethane. In addition, the acoustic–electric conversion property endowed composites with the capability to sense sound waves, while the composite’s lightweight, stress-resistant, and hydrophobic characteristics support mechanical stability and underwater applicability. This work achieves superior broadband absorption and excellent pressure stability, offering a compact, multifunctional solution for advanced acoustic systems.","PeriodicalId":504002,"journal":{"name":"ACS Applied Engineering Materials","volume":"3 12","pages":"4362-4371"},"PeriodicalIF":0.0,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of Polyurethane Based on a Dual-Repair Mechanism of Dynamic Disulfide Bonds and Hydrogen Bonds 基于动态二硫键和氢键双修复机制的聚氨酯设计

ACS Applied Engineering Materials Pub Date : 2025-11-22 DOI: 10.1021/acsaenm.5c00880

Chuanxiu Hu, Y. H. Qu, Wenbo Guo, Xiaodong Liu, Hao Liu, Quan Zhang, Zhiwen Xu, Chao Jiang, Lei Liu, Ruliang Zhang, Yang Yu, Jian Liu

引用次数: 2

Self-Healing Polyurethane Coatings Incorporating Halloysite Nanotubes Loaded with Tannic Acid for Synergistic Corrosion Protection and Enhanced Mechanical Properties 装有单宁酸的含高岭土纳米管的自修复聚氨酯涂料协同防腐和增强机械性能

ACS Applied Engineering Materials Pub Date : 2025-10-27 DOI: 10.1021/acsaenm.5c00719

Kunyan Lin, Weihua Shi, Bin Lu, Chenyi Wang, Shihua Dong, Haibo Wang

{"title":"Self-Healing Polyurethane Coatings Incorporating Halloysite Nanotubes Loaded with Tannic Acid for Synergistic Corrosion Protection and Enhanced Mechanical Properties","authors":"Kunyan Lin, Weihua Shi, Bin Lu, Chenyi Wang, Shihua Dong, Haibo Wang","doi":"10.1021/acsaenm.5c00719","DOIUrl":"https://doi.org/10.1021/acsaenm.5c00719","url":null,"abstract":"Long-term metal protection can be aided by the intelligent release of corrosion inhibitors, which can improve organic coatings’ anticorrosion capabilities. In this study, halloysite nanotubes (HNTs) were vacuum-loaded with tannic acid (TA) and surface-modified via in situ polymerization of polypyrrole (PPy), yielding pH-responsive nanofillers (TA-PPy@HNTs). These nanofillers enabled controlled TA release, forming protective Fe–TA complexes at corrosion sites, while the outer PPy layer imparted photothermal responsiveness, facilitating disulfide bond exchange reactions and enhancing intrinsic self-healing capabilities. Furthermore, the incorporation of polydimethylsiloxane (PDMS) segments improved hydrophobicity and delayed corrosive ion ingress. The optimized PTH-3 coating exhibited excellent corrosion resistance, maintaining an impedance modulus above 108 Ω·cm2 after 90 days in 3.5% NaCl solution. It also demonstrated superior mechanical properties (elongation at break of 447.73% and tensile strength of 30.71 MPa), outstanding cavitation resistance, and efficient sunlight-driven self-healing, restoring over 90% of its mechanical performance after damage. This work provides a promising strategy for designing multifunctional, durable protective coatings for metallic substrates.","PeriodicalId":504002,"journal":{"name":"ACS Applied Engineering Materials","volume":"3 11","pages":"4086-4099"},"PeriodicalIF":0.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Multi-Port Spraying: A Method for Preparation of Ionic Cross-linking Membranes 多孔喷涂：离子交联膜的制备方法

ACS Applied Engineering Materials Pub Date : 2025-10-27 DOI: 10.1021/acsaenm.5c00831

Yuheng Zhou, Gongwei Wang, Lin Zhuang, Li Xiao

{"title":"Multi-Port Spraying: A Method for Preparation of Ionic Cross-linking Membranes","authors":"Yuheng Zhou, Gongwei Wang, Lin Zhuang, Li Xiao","doi":"10.1021/acsaenm.5c00831","DOIUrl":"https://doi.org/10.1021/acsaenm.5c00831","url":null,"abstract":"The properties of ion exchange membranes are largely dependent on their chemical composition and preparation methods. Traditional methods for ionic cross-linking, such as casting or decantation, often result in nonuniform membranes with defects, such as holes, due to precipitation issues. Additionally, regulating the degree of ionic cross-linking is challenging, leading to less research focus compared to covalent cross-linking. In this study, we introduce an ionic cross-linking method for preparing anion exchange membranes (AEMs). Our approach involves spraying quaternary ammonia poly(N-methylpiperidine-co-p-terphenyl) (QAPPT) and Nafion solution from separate ports onto an ultrasonic atomization surface, enabling ionic cross-linking when sprayed onto a heated aluminum foil substrate. This method produces complete and uniform membranes with enhanced properties, including improved swelling degree (SD), water uptake (WU) and tensile strength. Notably, the 5% Nafion ion-cross-linked membrane exhibits ionic selectivity, with hydroxide ion conductivity of 25% faster than carbonate ions at 80 °C. The versatility of this multiport spraying technique allows for the preparation of ionic cross-linking membranes using various anion and cation exchange polymers, offering significant potential for advancing membrane material development.","PeriodicalId":504002,"journal":{"name":"ACS Applied Engineering Materials","volume":"3 11","pages":"4209-4217"},"PeriodicalIF":0.0,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147901036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Enhancing the Proton Conductivity of MOF Materials under Varied Temperature and Humidity 温度和湿度对MOF材料质子电导率的影响

ACS Applied Engineering Materials Pub Date : 2025-10-25 DOI: 10.1021/acsaenm.5c00713

Jiawei Bai, Jie Liu, Jiajun Zhong, Xiaotian Zhang, Wenxuan Yan, Xinran Li, Xiaofeng Zheng, Zhe Liu

{"title":"Enhancing the Proton Conductivity of MOF Materials under Varied Temperature and Humidity","authors":"Jiawei Bai, Jie Liu, Jiajun Zhong, Xiaotian Zhang, Wenxuan Yan, Xinran Li, Xiaofeng Zheng, Zhe Liu","doi":"10.1021/acsaenm.5c00713","DOIUrl":"https://doi.org/10.1021/acsaenm.5c00713","url":null,"abstract":"Exploring approaches to enhance the stability of proton conductivity against environmental temperature and humidity variations is crucial for proton exchange membrane fuel cells (PEMFCs). Incorporating both proton sources and proton hopping sites into the framework of metal–organic frameworks (MOFs) offers a promising route to improve conductivity. In this study, a ligand substitution strategy was employed, adjusting both the rigidity of the ligand skeleton and the relative positions of the proton sources and hopping sites to tailor the MOF properties. Four ligands containing sulfonic groups (proton sources) and amino groups (hopping sites), that is, taurine (Tr), aminomethanesulfonic acid (AMSA), p-aminobenzenesulfonic acid (pASA), and 3-aminobenzenesulfonic acid (mASA), were used to modify MOF-808, yielding MOF-808-X (X = Tr, AMSA, pASA, or mASA). The proton conductivities of MOF-808-X and MOF-808 were investigated under 30%–100% relative humidity (RH) and 303–353 K. All four modified materials exhibited significantly higher proton conductivities than MOF-808. Among them, MOF-808-Tr reached the highest value of 1.95 × 10–1 S·cm–1 at 100% RH and 353 K. In addition, the modified materials showed enhanced stability against environmental changes. For instance, the conductivity change of MOF-808-pASA from 303 K/30% RH to 353 K/100% RH was only one-quarter of that observed for MOF-808. In summary, by integrating proton sources and hopping sites while tuning ligand rigidity and substituent positions, both the conductivity and the environmental stability of MOFs were effectively improved. This work demonstrates a practical structural modification strategy for enhancing the performance stability of proton-conducting MOFs.","PeriodicalId":504002,"journal":{"name":"ACS Applied Engineering Materials","volume":"3 11","pages":"4063-4073"},"PeriodicalIF":0.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147892920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Sodium Phosphate-Based Surfactants as Fluorine-Free Additives for Enhancing Block Resistance in Acrylic Waterborne Coatings 磷酸钠基无氟表面活性剂增强丙烯酸水性涂料抗嵌块性的研究

ACS Applied Engineering Materials Pub Date : 2025-10-23 DOI: 10.1021/acsaenm.5c00492

Jiahui Zhao, Bingrui Li, Stan Brownell, Erica A. Frankel, Ray Drumright, Amy Song, Zhongqi Liu, Yutao Sang, Zhihong Nie

{"title":"Sodium Phosphate-Based Surfactants as Fluorine-Free Additives for Enhancing Block Resistance in Acrylic Waterborne Coatings","authors":"Jiahui Zhao, Bingrui Li, Stan Brownell, Erica A. Frankel, Ray Drumright, Amy Song, Zhongqi Liu, Yutao Sang, Zhihong Nie","doi":"10.1021/acsaenm.5c00492","DOIUrl":"https://doi.org/10.1021/acsaenm.5c00492","url":null,"abstract":"Fluorine-free antiblocking agents (ABAs) significantly reduce environmental impact compared to their fluorine-containing counterparts in waterborne coatings. However, existing fluorine-free ABAs often suffer from insufficient antiblocking performance, limiting their practical applications. In this work, we developed two fluorine-free ABAs, SiO-PO4 and Branch-C20-PO4, and incorporated them into acrylic waterborne coatings. The surface properties and block resistance efficiencies of these coatings were systematically characterized. Notably, SiO-PO4 demonstrated exceptional surface activity and achieved effective block resistance even after a 12-day storage period. X-ray Photoelectron Spectroscopy (XPS) analysis revealed that both ABAs migrated to and adsorbed on the coating surface during film formation, reducing cohesive forces generated by polar components and thereby enhancing block resistance. These results position SiO-PO4 as a promising fluorine-free ABA, demonstrating the potential of tailored phosphate-based surfactants to achieve a balance between environmental sustainability and high-performance functionality in waterborne coatings.","PeriodicalId":504002,"journal":{"name":"ACS Applied Engineering Materials","volume":"3 11","pages":"4131-4140"},"PeriodicalIF":0.0,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147334231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MnCu-MOF-Derived Fan-Deployed Carbon Frameworks: Size-Dependent Broadband Microwave Absorption and Thermal Insulation mncu - mof衍生的风扇部署碳框架：尺寸相关的宽带微波吸收和隔热

ACS Applied Engineering Materials Pub Date : 2025-10-17 DOI: 10.1021/acsaenm.5c00733

Yuhao Liu, Hongbo Liang, Hongli Liu, Yanan Jiao, Xianlin Xiao, Mingwei Li, Wenshuo Cao, Yutong Li, Yuefeng Yan, Xueqian Zhang, Peng Chu, Xiaoxiao Huang

{"title":"MnCu-MOF-Derived Fan-Deployed Carbon Frameworks: Size-Dependent Broadband Microwave Absorption and Thermal Insulation","authors":"Yuhao Liu, Hongbo Liang, Hongli Liu, Yanan Jiao, Xianlin Xiao, Mingwei Li, Wenshuo Cao, Yutong Li, Yuefeng Yan, Xueqian Zhang, Peng Chu, Xiaoxiao Huang","doi":"10.1021/acsaenm.5c00733","DOIUrl":"https://doi.org/10.1021/acsaenm.5c00733","url":null,"abstract":"Developing multifunctional materials that integrate efficient microwave absorption and high-temperature thermal insulation remains a critical challenge for next-generation electromagnetic protection systems, particularly in aerospace and extreme environments. This study presents a fan-structured metallic framework MOF with temperature-triggered transformation: the precursor’s “closed-fan” architecture expands into an open hierarchical structure upon calcination, facilitating multiscale electromagnetic dissipation and tortuous heat conduction pathways. The optimized composite achieves an exceptional effective absorption bandwidth (EAB) of 6.4 GHz at 2.0 mm thickness and remarkable thermal insulation, maintaining a rear surface temperature of ∼360.8 °C after 120 s under 1000 °C heating. Structural characterizations reveal that the fanlike architecture promotes multiple electromagnetic wave reflection/scattering and retards heat transfer, while size-dependent absorption behavior confirms that reduced segment dimensions enhance impedance matching and dielectric loss via increased interface polarization. This work establishes a stimuli-responsive structural transformation paradigm, where hierarchical architecture–chemical composition synergy enables simultaneous optimization of microwave absorption and thermal insulation, offering actionable insights for advanced composites in harsh-environment protection.","PeriodicalId":504002,"journal":{"name":"ACS Applied Engineering Materials","volume":"3 11","pages":"4100-4112"},"PeriodicalIF":0.0,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147900498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ROS-Responsive Hydrogel-Encapsulated MoS ₂ Nanospheres for Photothermal Antibacterial and Wound Healing Promotion Therapy 光热抗菌和促进伤口愈合的MoS - 2纳米微球

ACS Applied Engineering Materials Pub Date : 2025-10-01 DOI: 10.1021/acsaenm.5c00665

Mengzhu Xiao, Yujia Wu, Wanzhen Li, Jun Wang, Weiwei Zhang, Zuchun Zhao, Fei Ge

{"title":"ROS-Responsive Hydrogel-Encapsulated MoS <sub>2</sub> Nanospheres for Photothermal Antibacterial and Wound Healing Promotion Therapy","authors":"Mengzhu Xiao, Yujia Wu, Wanzhen Li, Jun Wang, Weiwei Zhang, Zuchun Zhao, Fei Ge","doi":"10.1021/acsaenm.5c00665","DOIUrl":"https://doi.org/10.1021/acsaenm.5c00665","url":null,"abstract":"The overuse of antibiotics leads to bacterial resistance, which involves complex and diverse mechanisms, among which the activation of drug efflux pumps is a key contributing factor. Excessive accumulation of reactive oxygen species (ROS) in inflamed wound tissues further exacerbates this issue by triggering efflux pump activation. To address bacterial resistance, this study aimed to mitigate ROS accumulation, thereby inhibiting efflux pump expression and enhancing antibacterial efficacy. Researchers synthesized MoS2-based nanocomposites (MoS2/ZnO/Cur designated as MZCs) loaded with ZnO and Cur into cross-linked structures using a hydrothermal method and combined them with photothermal therapy (PTT). To enhance functionality, a ROS-responsive hydrogel was developed by conjugating CGG with a ROS-responsive linker (TPA) and integrating the MZCs, yielding MZC@CGG-TPA. Electron microscopy revealed the internal structure of the hydrogel. Antibacterial assays demonstrated that MZC@CGG-TPA achieved inhibition rates exceeding 95% against multidrug-resistant (MDR) Escherichia coli and Staphylococcus aureus, with biofilm clearance rates surpassing 90%. Photothermal performance testing indicated a photothermal conversion efficiency of 47%. Transcriptomic analysis revealed that MZC@CGG-TPA suppressed the expression of channel protein-related genes, downregulated the key regulator gene marA, and inhibited drug efflux pump activity. This enhanced the retention of antibacterial agents within bacterial cells and improved bactericidal efficacy. Under laser irradiation, the MZC@CGG-TPA hydrogel dressing significantly enhanced anti-infection efficacy and accelerated wound healing in an in vivo wound infection model. These findings present an approach for designing advanced nanosystems to effectively combat MDR bacteria.","PeriodicalId":504002,"journal":{"name":"ACS Applied Engineering Materials","volume":"3 10","pages":"3573-3588"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147914407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1