Eyal Zadicario, Shlomi Rudich, Ghassan Hamarneh, Daniel Cohen-Or
{"title":"Image-based motion detection: using the concept of weighted directional descriptors.","authors":"Eyal Zadicario, Shlomi Rudich, Ghassan Hamarneh, Daniel Cohen-Or","doi":"10.1109/MEMB.2009.935727","DOIUrl":"https://doi.org/10.1109/MEMB.2009.935727","url":null,"abstract":"<p><p>The use of image guidance in medical applications is constantly growing because of its tremendous impact on the future of health care. Although image-based tissue tracking has been thoroughly explored in the academic literature for years, it has not yet matured to become widely accepted by clinicians. Undetected tissue movements in image-based clinical procedures may cause safety and efficacy difficulties. We introduce an image-based approach for detecting tissue movements during clinical procedures. Our method has been validated in more than 600 true clinical cases. The results show that our algorithm agrees with an expert analysis in 98% of the cases, showing zero events of false alarms and zero events of undetected motion. The results show that the approach provides a clinically ready motion detection algorithm. These robust results are achieved by introducing the concept of weighted directional descriptors (WDDs). The technique analyzes the directivity and confidence level of each anatomical feature and uses it to weight local inputs resulting in a robust motion vector. The robustness is further increased by a novel preprocess that screens out features that may be misleading or are repeated in the adjacent search zone. The technique meets the requirements, as defined by our clinicians, and is now integrated in true medical systems. In particular, our approach has been uniquely developed and integrated into a clinical product. ExAblate is the first Food and Drug Administration (FDA)-approved magnetic resonance (MR)-guided noninvasive surgical device using focused ultrasound therapy. It is used in commercial clinics and in leading medical academic research institutions, attesting to the success of our method and its practical clinical value.</p>","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.935727","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29147245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"grand challenges in biomedical engineering [President's Message]","authors":"B. He","doi":"10.1109/MEMB.2009.935728","DOIUrl":"https://doi.org/10.1109/MEMB.2009.935728","url":null,"abstract":"Starting in 2010, the IEEE Engineering in Medicine and Biology Society (EMBS) is launching a new series of forums addressing the grand challenges in biomedical engineering. The forum series will review the significant progress we have made in the past decade and identify the grand challenges facing the scientific community in a specific discipline within the biomedical engineering field in the next ten years.","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.935728","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62476252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Introduction to Molecular Biology, Genomics and Proteomics for Biomedical Engineers (Northrop, R. B. and Connor, A. N.; 2008) [Book Reviews]","authors":"A. Vallés-Lluch","doi":"10.1109/MEMB.2009.935461","DOIUrl":"https://doi.org/10.1109/MEMB.2009.935461","url":null,"abstract":"This book is for engineers and scientists not initially trained in molecular biology to broaden their background and perhaps pique their interest on this multidisciplinary discipline. The book's 11 chapters are supplemented by a good up-to-date bibliography. The book is intended for use in a one-semester classroom course with the purpose of familiarizing biomedical or chemical engineering students, but it should also be considered a valuable reference for academics and scientists stepping in the area of molecular biology.","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.935461","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62475616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Looking Back at EMBC 2009: Student Activities Highlights [Student's Corner]","authors":"C. Linte","doi":"10.1109/MEMB.2010.935915","DOIUrl":"https://doi.org/10.1109/MEMB.2010.935915","url":null,"abstract":"The 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS) was held 2-6 September 2009 at the Hilton Hotel in Minneapolis/St. Paul, Minnesota, the world capital of medical device industry. The meeting gathered more than 2,000 world experts in biomedical engineering, including academics, researchers, industrialists, clinicians, and trainees for five days of science, networking, and social events.","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2010.935915","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62476296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biosignal and Medical Image Processing, Second Edition (Semmlow, J. L.; 2008) [Book Reveiw]","authors":"S. Deutsch","doi":"10.1109/MEMB.2009.935462","DOIUrl":"https://doi.org/10.1109/MEMB.2009.935462","url":null,"abstract":"includes some techniques employed to characterize large protein molecules: the use of microarrays, enzyme-linked-immunosorbent serologic assay (ELISA) tests, and X-ray crystallography. In Chapter 10, GMOs are defined, along with some interesting examples of transgenic plants, transgenic animals, and animal cells, and the explanation of the recombinant DNA technology used to produce them. The different techniques employed in animal reproductive cloning are described. This chapter also provides the definition, classification, and sources of stem cells, with an emphasis on their future potential in regenerative medicine. Chapter 11 offers a summary of the theoretical framework to guide ethical decisions. In this context, the text deals with controversial features in genetic research today: the production of genetically modified food crops, the development and use of chimeras, and finally the use of pluripotent stem cells from human embryos. This book can be useful as supplementary material for students and scientists, and as an excellent resource for academics teaching in the area (its plenty of sketches illustrating the text). It succeeds in motivating anyone interested in molecular biology. Ana Vallés-Lluch Polytechnic University of Valencia, Spain","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.935462","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"62475696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Consciousness platform: the greatest mystery of all time.","authors":"Sid Deutsch","doi":"10.1109/MEMB.2009.935464","DOIUrl":"https://doi.org/10.1109/MEMB.2009.935464","url":null,"abstract":"<p><p>This article is about the model for a very controversial edifice--the many-sided foundation for consciousness. What I refer to is, undoubtedly, the greatest mystery of all time--why do we have an awareness of our own existence? What is the evolutionary advantage of consciousness? Much of the material printed about consciousness has a religious flavor, with references to the human spirit and/or extrasensory perception, but I will have none of that here. In this study, consciousness is tied in with a platform, not a physical platform, of course, but a conceptual platform. This is because we are most comfortable imagining or visualizing an actual platform that has many connections to various parts of the brain, a sort of an old-fashioned telephone switchboard.</p>","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.935464","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28731220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Thermal monitoring: Raman spectrometer system for remote measurement of cellular temperature on a microscopic scale.","authors":"Victor Pikov, Peter H Siegel","doi":"10.1109/MEMB.2009.935468","DOIUrl":"https://doi.org/10.1109/MEMB.2009.935468","url":null,"abstract":"<p><p>A simple setup is demonstrated for remote temperature monitoring of water, water-based media, and cells on a microscopic scale. The technique relies on recording changes in the shape of a stretching band of the hydroxyl group in liquid water at 3,100-3,700 cm(-1). Rather than direct measurements in the near-infrared (IR), a simple Raman spectrometer setup is realized. The measured Raman shifts are observed at near optical wavelengths using an inverted microscope with standard objectives in contrast to costly near-IR elements. This allows for simultaneous visible inspection through the same optical path. An inexpensive 671-nm diode pump laser (< 100 mW), standard dichroic and lowpass filters, and a commercial 600-1,000 nm spectrometer complete the instrument. Temperature changes of 1 degrees C are readily distinguished over a range consistent with cellular processes (25-45 degrees C) using integration times below 10 s. Greatly improved sensitivity was obtained by an automated two-peak fitting procedure. When combined with an optical camera, the instrument can be used to monitor changes in cell behavior as a function of temperature without the need for invasive probing. The instrument is very simple to realize, inexpensive compared with traditional Raman spectrometers and IR microscopes, and applicable to a wide range of problems in microthermometry of biological systems. In a first application of its kind, the instrument was used to successfully determine the temperature rise of a cluster of H1299 derived human lung cells adhered to polystyrene and immersed in phosphate-buffered saline (PBS) under exposure of RF millimeter wave radiation (60 GHz, 1.3, 2.6, and 5.2 mW/mm2).</p>","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.935468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28731688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Angela Hodge, Jie Chen, Pau-Choo Chung, Robert Newcomb, Joseph Chang, Ut-Va Koc, Stephen T C Wong
{"title":"Catch the wave--nanotechnology, the future is now.","authors":"Angela Hodge, Jie Chen, Pau-Choo Chung, Robert Newcomb, Joseph Chang, Ut-Va Koc, Stephen T C Wong","doi":"10.1109/memb.2009.935472","DOIUrl":"https://doi.org/10.1109/memb.2009.935472","url":null,"abstract":"","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/memb.2009.935472","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28758910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robert Brychta, Erica Wohlers, Jon Moon, Kong Chen
{"title":"Energy expenditure: measurement of human metabolism.","authors":"Robert Brychta, Erica Wohlers, Jon Moon, Kong Chen","doi":"10.1109/MEMB.2009.935463","DOIUrl":"https://doi.org/10.1109/MEMB.2009.935463","url":null,"abstract":"<p><p>Obesity is one of the most prevalent chronic diseases globally, especially in the United States. While the United States gained an early lead in unnecessary weight gain, most other countries are quickly closing the gap. The latest U.S. National Health and Nutrition Examination Survey (NHANES, http://www.cdc.gov/nchs/nhanes.htm) documents that about one third of adults in the United States are now overweight [a body-mass index (BMI) between 25 and 30 kg/m2] and another one third (61 million) are considered obese (BMI >30 kg/m2). Being obese is a strong risk factor for cardiovascular diseases, type 2 diabetes, osteoporosis, some cancers, and depression. The economic impact of this condition is staggering: in 2008, more than 147 billion dollars were spent just in the United States for medical costs related to obesity. Time lost from work and spending on weight loss costs even more.</p>","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.935463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28731218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Wireless capsule endoscopy and endoscopic imaging: a survey on various methodologies presented.","authors":"Alexandros Karargyris, Nikolaos Bourbakis","doi":"10.1109/MEMB.2009.935466","DOIUrl":"https://doi.org/10.1109/MEMB.2009.935466","url":null,"abstract":"<p><p>Wireless capsule endoscopy (WCE) is a recently established methodology that offers to medical doctors (gastroenterologists) the capability to examine the interior of the small intestine with a noninvasive procedure. Before the introduction of WCE, it was impossible for a physician to examine tissues of the small intestine without performing a surgical operation. Although WCE has the advantage of investigating the whole digestive system, the viewing and evaluation of each WCE video is a time-consuming process (2-3 h) for MD gastroenterologists. This makes the WCE methodology not widely efficient and acceptable by MDs.</p>","PeriodicalId":50391,"journal":{"name":"IEEE Engineering in Medicine and Biology Magazine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/MEMB.2009.935466","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28731689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}