Annals of Medicine & Surgery最新文献_第4页

Protecting our future: Call for RSV vaccine trial in infants 保护我们的未来呼吁在婴儿中开展 RSV 疫苗试验

Annals of Medicine & Surgery Pub Date : 2024-07-17 DOI: 10.1097/ms9.0000000000002385

Rumaisa Riaz, Anusha Sumbal, Afsheen Khan, Md Ariful Haque

引用次数: 0

Chemical burn wounds as a risk factor for gastric cancer: in-silico analyses-experimental research 化学烧伤是胃癌的危险因素：硅内分析-实验研究

Annals of Medicine & Surgery Pub Date : 2024-07-17 DOI: 10.1097/ms9.0000000000002240

M. Zabihi, Mohammad Akhoondian, Mobina Tohidian, Samad Karkhah, Pooyan Ghorbani Vajargah, Seyed Amirhossein Mazhari, B. Farhadi, R. Farzan

{"title":"Chemical burn wounds as a risk factor for gastric cancer: in-silico analyses-experimental research","authors":"M. Zabihi, Mohammad Akhoondian, Mobina Tohidian, Samad Karkhah, Pooyan Ghorbani Vajargah, Seyed Amirhossein Mazhari, B. Farhadi, R. Farzan","doi":"10.1097/ms9.0000000000002240","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002240","url":null,"abstract":"\u0000 \u0000 The present study employs bioinformatics tools to identify shared upregulated genes between chemical burns and gastric cancer.\u0000 \u0000 \u0000 \u0000 GEO retrieved gene sets for this investigation. GSEs with P-value <0.05 and LOG fold change (FC) >1 were valid and upregulated. Gastric cancer and chemical burn common elevated genes were found using Venn diagram online tools. In the second stage, the “string” visualized gastric cancer elevated genes network, and non-coding RNAs were deleted, and “interaction” >1 was examined to choose important gene nodes. Next, they explored the String gene-interaction network for common genes. To determine the most interacting genes, Gephi (V 0.9.7) used “betweenness centrality” > “0” to evaluate the twenty-gene network. TISIDB and drug banks provide gene-related medications.\u0000 \u0000 \u0000 \u0000 In the present study, two genes, including ALOX5AP and SERPINB2, were obtained, with the highest centrality among chemical burns and gastric cancer shared genes. Additionally, the current study presented five drugs, including Urokinase, Tenecteplase, DG031, AM103, and Fiboflapon, which can have predicted effects on gastric cancer following chemical burns.\u0000 \u0000 \u0000 \u0000 According to current in-silicon analyses, ALOX5AP and SERPINB2 are linked genetic keys between gastric chemical burn and cancer. Considering that burn is an environmental factor that leads to the upregulation of the two genes thus, the chemical burn can be related to the incidence of gastric cancer.\u0000","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":"15 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complement protein expression changes in various conditions of breast cancer: in-silico analyses—experimental research 乳腺癌各种情况下补体蛋白表达的变化：硅内分析-实验研究

Annals of Medicine & Surgery Pub Date : 2024-07-17 DOI: 10.1097/ms9.0000000000002216

M. Zabihi, B. Farhadi, Mohammad Akhoondian

{"title":"Complement protein expression changes in various conditions of breast cancer: in-silico analyses—experimental research","authors":"M. Zabihi, B. Farhadi, Mohammad Akhoondian","doi":"10.1097/ms9.0000000000002216","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002216","url":null,"abstract":"\u0000 \u0000 Breast cancer is the most prevalent cancer diagnosed in females worldwide. The known biomarkers are insufficient to understand the actual prognosis of breast cancer, and identifying new biomarkers is desirable and valuable data to improve the patient’s survival. Many inflammatory biomarkers, such as the complement system, can be regarded as prognostic values and as potent inflammatory mediators; complement proteins have a critical role in tumorigenesis. In the current study, the authors aim to investigate complement protein expression changes, particularly complement 3 (C3), complement 7 (C7), complement factor B (CFB), and complement factor D (CFD), in various conditions of breast cancer using in-silico tools.\u0000 \u0000 \u0000 \u0000 The intent data were extracted using webtools, including; Kaplan–Meier plotter, BcGenExMiner, UALCAN, cbioportal, GeneMania, and Enrichr. To select valid data, a P greater than 0.05 was considered.\u0000 \u0000 \u0000 \u0000 The current study clarified that 21 complement genes correlated to survival conditions. Also, down or upregulation of extracted genes and breast cancer statuses were identified. Additionally, expression level difference of complement genes in various breast cancer four stages was detected. Ultimately, co-expression genes with complement genes were extracted and networked.\u0000 \u0000 \u0000 \u0000 Changes in the expression of complement proteins can strongly correlate to breast cancer’s prognosis, status, and survival. Furthermore, considering the vital role of CFD and CFB complement proteins in the alternative pathway in different stages of breast cancer, CFD and CFB can be regarded as reliable prognostic values for diagnosis.\u0000","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":"32 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental diagnosis of bilateral common iliac artery aneurysms: a case report and comprehensive literature review 双侧髂总动脉瘤的偶然诊断：病例报告和文献综述

Annals of Medicine & Surgery Pub Date : 2024-07-17 DOI: 10.1097/ms9.0000000000002382

Shailendra Katwal, Srijana Katwal, Sushmita Bhandari, Pratiksha Paudel, Devendra Bhandari, Shristi Bhandari, Santosh Maharjan

{"title":"Incidental diagnosis of bilateral common iliac artery aneurysms: a case report and comprehensive literature review","authors":"Shailendra Katwal, Srijana Katwal, Sushmita Bhandari, Pratiksha Paudel, Devendra Bhandari, Shristi Bhandari, Santosh Maharjan","doi":"10.1097/ms9.0000000000002382","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002382","url":null,"abstract":"\u0000 \u0000 Aneurysms are dilatations of arteries, with abdominal aortic ectasias (AAE) considered precursors to abdominal aortic aneurysms (AAA). Iliac artery aneurysms (IAAs), often accompanying AAA, present a serious risk, particularly due to rupture. Here, the authors present a case highlighting the importance of recognizing and managing isolated bilateral common iliac artery aneurysms (CIAAs).\u0000 \u0000 \u0000 \u0000 A 66-year-old male presented following a road traffic accident (RTA) with ankle and leg pain. Examination revealed tenderness in the leg, mild right flank tenderness, and a history of mild pelvic pain. Biochemical studies showed deranged glucose and lipid levels. Imaging revealed large CIAAs, prompting surgical intervention. The patient’s fracture was also managed accordingly.\u0000 \u0000 \u0000 \u0000 CIAAs are rare but serious, typically occurring in elderly males with risk factors including advanced age, male sex, smoking, and hypertension, while diabetes and hyperlipidemia may exert protective effects. While often asymptomatic, they can lead to complications such as thrombosis or rupture. Diagnosis relies on imaging, and intervention is recommended for larger or symptomatic aneurysms.\u0000 \u0000 \u0000 \u0000 It’s crucial to consider CIAAs in high-risk individuals and recognize the significance of early detection and intervention to prevent potentially life-threatening complications. Prompt management, either through open surgical repair or endovascular options, is crucial for improving patient outcomes.\u0000","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":"31 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141640030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Penetrating brain injury through the cavernous sinus by chopsticks in Vienamese: a case report 越南人被筷子穿过海绵窦造成的穿透性脑损伤：病例报告

Annals of Medicine & Surgery Pub Date : 2024-07-17 DOI: 10.1097/ms9.0000000000002389

He Van Dong, Anh Quoc Nguyen, Hanh Hong Thi Dong, Hai Trung Vu, A. H. Pham

{"title":"Penetrating brain injury through the cavernous sinus by chopsticks in Vienamese: a case report","authors":"He Van Dong, Anh Quoc Nguyen, Hanh Hong Thi Dong, Hai Trung Vu, A. H. Pham","doi":"10.1097/ms9.0000000000002389","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002389","url":null,"abstract":"\u0000 \u0000 Penetrating brain injuries from chopsticks are exceedingly rare, often documented through case reports. Management strategies are tailored to individual cases, with a focus on mitigating postoperative complications.\u0000 \u0000 \u0000 \u0000 A 33-year-old male presented with a chopstick lodged in his right eye. CT imaging revealed two foreign bodies, prompting collaborative surgical removal by neurosurgery and ophthalmology teams. The procedure involved intricate bone drilling to access critical structures, ensuring a successful outcome with stability at one-month follow-up.\u0000 \u0000 \u0000 \u0000 Common trajectories involve orbital roof penetration, posing risks of frontal lobe injury and intracerebral hematoma. Challenges arise with wooden foreign bodies, necessitating advanced imaging like CT angiography to assess vascular involvement. Surgical intervention offers benefits such as foreign body extraction, neurovascular protection, tissue debridement, hematoma evacuation, and dural repair.\u0000 \u0000 \u0000 \u0000 Although rare, chopstick-related penetrating brain injuries warrant vigilance in neurosurgical practice. Surgical intervention remains the cornerstone of treatment, ensuring optimal patient outcomes.\u0000","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":"19 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geriatric nutritional risk index and quality of life among elderly hemodialysis patients: a cross-sectional study 老年营养风险指数与老年血液透析患者的生活质量：一项横断面研究

Annals of Medicine & Surgery Pub Date : 2024-07-17 DOI: 10.1097/ms9.0000000000002378

Ali Nouri, Roya Mansour-Ghanaei, Mohammad Esmaeilpour-Bandboni, Bahare Gholami Chaboki

{"title":"Geriatric nutritional risk index and quality of life among elderly hemodialysis patients: a cross-sectional study","authors":"Ali Nouri, Roya Mansour-Ghanaei, Mohammad Esmaeilpour-Bandboni, Bahare Gholami Chaboki","doi":"10.1097/ms9.0000000000002378","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002378","url":null,"abstract":"\u0000 \u0000 Nutritional problems are considered one of the main complications of hemodialysis, and the geriatric nutritional risk index (GNRI) is a new instrument for assessing geriatric nutritional status. The present study sought to evaluate the relationship between the GNRI and quality of life (QOL) among elderly hemodialysis patients.\u0000 \u0000 \u0000 \u0000 In the present analytical cross-sectional study, 110 hemodialysis individuals were selected by applying a simple random sampling method, among whom 57 and 53 were males and females, respectively (mean: 70.3±6.93 years). Demographic characteristics, GNRI, and QOL status were determined. The data were analyzed using SPSS 20 software and descriptive statistics, Pearson’s correlation, ANOVA, independent sample t-tests, and multiple linear regression analysis.\u0000 \u0000 \u0000 \u0000 The mean GNRI and mean total QOL were respectively obtained 93.903±11.067 and 20.95 ± 4.89. Among females, a significant direct relationship was observed between GNRI and total QOL (P = 0.010, r = 0.352), autonomy (P = 0.004, r = 0.389), and pleasure (P = 0.015, r = 0.333), while GNRI was not directly and significantly related to QOL in males (P = 0.161, r = 0.188).\u0000 \u0000 \u0000 \u0000 Due to the presence of a significant association between Geriatric GNRI and QOL among elderly hemodialysis patients, particularly among females, highlighting the importance of addressing nutritional status in optimizing well-being.\u0000","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":"24 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141640157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

COVID-19 : vaccination , therapeutics and a review of the science and public health COVID-19：疫苗接种、治疗以及科学和公共卫生回顾

Annals of Medicine & Surgery Pub Date : 2024-07-17 DOI: 10.1097/ms9.0000000000002374

Sanjit Kumar Shah, Kritick Bhandari, Avish Shah, Gopal Chaurasiya

{"title":"COVID-19 : vaccination , therapeutics and a review of the science and public health","authors":"Sanjit Kumar Shah, Kritick Bhandari, Avish Shah, Gopal Chaurasiya","doi":"10.1097/ms9.0000000000002374","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002374","url":null,"abstract":"COVID-19, stemming from the SARS-CoV-2 virus, has initiated a worldwide respiratory pandemic. Remarkable headway has been made in the realm of vaccination, as nearly every nation has initiated COVID-19 vaccine deployment. However, a mere 32.6% of individuals in low-income countries have received only a single vaccine dose. Unprecedented research and development endeavors have yielded over 170 COVID-19 vaccines, several of which are now in practical use. These vaccines have demonstrated remarkable efficacy in averting severe illness, hospitalization, and fatalities from COVID-19, even against emerging variants. Research pursuits persist, concentrating on novel vaccine technologies, oral and nasal vaccines, broader coronavirus protection, and vaccine combinations. In the realm of therapeutics, there have been significant strides in developing oral antiviral medications and monoclonal antibodies. Nonetheless, challenges in COVID-19 vaccination persist, encompassing issues of hesitancy, accessibility, financial barriers, knowledge gaps, and logistical hindrances. Robust monitoring via global agencies and reporting systems remains pivotal. Strategies for enhancing vaccination efficacy are rooted in fostering trust, countering misinformation, and expanding access. As for therapeutics, the approach involves dedicated research, clinical trials, regulatory streamlining, stockpiling, and international collaboration. Telemedicine and public awareness campaigns play integral roles in this effort, with coordination being the linchpin for preserving lives and mitigating the disease’s impact. The global campaign against COVID-19 has witnessed substantial advancements, with an ongoing research focus on developing vaccines and therapeutics that are not only more accessible and affordable but also more effective, particularly for populations in low-income countries and vulnerable communities.","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":"27 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the landscape of bariatric surgery in Africa: Current provisions, challenges and future prospects 探索非洲减肥手术的现状：当前规定、挑战和未来前景

Annals of Medicine & Surgery Pub Date : 2024-07-17 DOI: 10.1097/ms9.0000000000002381

H. Bharadwaj, Muhammad Hamza Shah, Matan Bone, Priyal Dalal, Khabab Abbasher Hussein Mohamed Ahmed

引用次数: 0

Evaluation of occlusal force changes in orthognathic surgery using force sensing sensors in 3 years of follow-up 使用力传感传感器评估正颌外科手术中咬合力变化的 3 年随访结果

Annals of Medicine & Surgery Pub Date : 2024-07-17 DOI: 10.1097/ms9.0000000000002386

Fernando Duarte, João Neves Silva, Carina Ramos, Colin Hopper

{"title":"Evaluation of occlusal force changes in orthognathic surgery using force sensing sensors in 3 years of follow-up","authors":"Fernando Duarte, João Neves Silva, Carina Ramos, Colin Hopper","doi":"10.1097/ms9.0000000000002386","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002386","url":null,"abstract":"\u0000 \u0000 The aimof this study was to test a prototype device called Occlusal Force Diagnostic System in relation to occlusal force adaptation following orthognathic surgery.\u0000 \u0000 \u0000 \u0000 Retrospective study of 10 patients scheduled for a bimaxillary osteotomy involving a combination of maxillary Le Fort I impaction procedure coupled with a sagittal split advancement of the mandible; in a 3 years follow-up period.\u0000 \u0000 \u0000 \u0000 The selection of examiner is not a variable that affects the occlusal force (N) measured by FSS sensors in any of the experimental conditions tested. The sensor position and the surgery recovery time affects the occlusal force irrespective of the examiner selection and/or the surgery recovery time.\u0000 \u0000 \u0000 \u0000 The piezoelectric sensors used in the present study have shown high reliability and validity of measurement. The surgery recovery time impacts the occlusal force (N), with a 50% increase in occlusal force (N) measured after 6 months post-surgery, with the value keeping stable at 36 months. This suggests that the patient is only fully recovered from the functional point-of-view at 6 months, having from that point on an improved and stable masticatory function.\u0000","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":"35 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic effects of herpes oncolytic virus and cyclophosphamide for recurrent malignant glioma: a narrative review 疱疹溶解病毒和环磷酰胺治疗复发性恶性胶质瘤的协同效应：综述

Annals of Medicine & Surgery Pub Date : 2024-07-17 DOI: 10.1097/ms9.0000000000002384

Javed Iqbal, Muhammad Hassan Hafeez, Aamir Amin, Iman Moradi, Anisha Chhabra, Ather Iqbal, Tirath Patel, Muhammad Ashir Shafique, Abdullah Nadeem, Usama Jamil

{"title":"Synergistic effects of herpes oncolytic virus and cyclophosphamide for recurrent malignant glioma: a narrative review","authors":"Javed Iqbal, Muhammad Hassan Hafeez, Aamir Amin, Iman Moradi, Anisha Chhabra, Ather Iqbal, Tirath Patel, Muhammad Ashir Shafique, Abdullah Nadeem, Usama Jamil","doi":"10.1097/ms9.0000000000002384","DOIUrl":"https://doi.org/10.1097/ms9.0000000000002384","url":null,"abstract":"Gliomas, comprising nearly 80% of brain malignancies, present a formidable challenge with glioblastomas being the most aggressive subtype. Despite multidisciplinary care, including surgery and chemoradiotherapy, the prognosis remains grim, emphasizing the need for innovative treatment strategies. The blood-brain barrier complicates drug access, and the diverse histopathology hinders targeted therapies. Oncolytic herpes viruses (oHSVs), particularly HSV1716, G207, and rQNestin34.5v, show promise in glioma treatment by selectively replicating in tumor cells. Preclinical and clinical studies demonstrate the safety and efficacy of oHSVs, with T-Vec being FDA-approved. However, challenges like viral delivery limitations and antiviral responses persist. The combination of oHSVs and combining cyclophosphamide (CPA) addresses these challenges, demonstrating increased transgene expression and viral activity. The immunosuppressive properties of CPA, particularly in metronomic schedules, enhance oHSV efficacy, supporting the development of this combination for recurrent malignant gliomas. CPA with oHSVs enhances viral oncolysis and extends survival. CPA’s immunomodulatory effects, suppressing regulatory T cells, improve oHSV efficiency. While obstacles remain, this synergistic approach offers hope for improved outcomes, necessitating further research and clinical validation.","PeriodicalId":503882,"journal":{"name":"Annals of Medicine & Surgery","volume":"23 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141640086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Annals of Medicine &amp; Surgery最新文献

Annals of Medicine & Surgery最新文献