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Molecular Interaction Study between Gentamicin and the Cancer Protein Target (TP53) using in silico Tools 利用硅学工具研究庆大霉素与癌症蛋白靶标（TP53）之间的分子相互作用
UTTAR PRADESH JOURNAL OF ZOOLOGY Pub Date : 2024-02-10 DOI: 10.56557/upjoz/2024/v45i33897
Priyadharshini M., D. Leelavathi, Tanzeem Azeeza S.
{"title":"Molecular Interaction Study between Gentamicin and the Cancer Protein Target (TP53) using in silico Tools","authors":"Priyadharshini M., D. Leelavathi, Tanzeem Azeeza S.","doi":"10.56557/upjoz/2024/v45i33897","DOIUrl":"https://doi.org/10.56557/upjoz/2024/v45i33897","url":null,"abstract":"The most prevalent mutation in hepatocellular carcinoma (HCC), TP53 mutations impacts the course and prognosis of HCC. 3D in silico drug docking techniques were employed to make the possible mutant target tumor protein 53 (TP53) interact with benzene acetic acid (Gentamicin) and non-steroidal anti-inflammatory drugs (NSAIDs). To carry out drug docking techniques, the translated amino acid sequence and three-dimensional chemical compound were obtained from the NCBI database. The use of sophisticated 3D molecular visualization tools was employed in post-docking experiments. The docking study results unequivocally show that gentamicin directly suppresses amino acid mutational sites. TP53 and Gentamicin's electrostatic force is depicted in a three-dimensional manner using notions from molecular dynamics techniques. In the end, it was determined that gentamicin, an Antibiotic medication, helps treat liver cancer. Most chemotherapy medications cause pain. Therefore, Gentamicin shall be used to lessen discomfort while minimizing the symptoms of cancer.","PeriodicalId":503810,"journal":{"name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139786928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fish Assemblage Concerning Physciochemical and Geomorphological Characteristics of Barak River, India 与印度巴拉克河物理化学和地貌特征有关的鱼类组合
UTTAR PRADESH JOURNAL OF ZOOLOGY Pub Date : 2024-02-10 DOI: 10.56557/upjoz/2024/v45i43901
Prabhakar Rai, J. S. Y. Kumar, Arya Sen, Saurav Bhattacharjee
{"title":"Fish Assemblage Concerning Physciochemical and Geomorphological Characteristics of Barak River, India","authors":"Prabhakar Rai, J. S. Y. Kumar, Arya Sen, Saurav Bhattacharjee","doi":"10.56557/upjoz/2024/v45i43901","DOIUrl":"https://doi.org/10.56557/upjoz/2024/v45i43901","url":null,"abstract":"This study investigated the fish population, environmental characteristics, microhabitats, and soil erosion along the Barak River in Manipur and Assam. The survey covered 18 sites spanning from Maram in Senapati district, Manipur, to Badarpur in Karimganj district, Assam. The assessment involved analysing six physciochemical parameters and collecting fish specimens, focusing on human activities affecting different sections of the river. The environmental conditions varied significantly between two distinct geographical regions: the hilly area in Manipur and the plains in Assam. The river exhibited narrowness, shallow depths, rapid flow, and a substrate composed of stones and gravel in the hilly region of Manipur. Conversely, in the plains of Assam, the river was wider, slower flowing, deeper, and featured a substrate consisting of silt and clay. Bank erosion and river meandering were prevalent in the plains, which were densely populated and extensively cultivated. The survey documented a total of 35 fish species from 15 families and 7 orders. Interestingly, the distribution pattern indicated an absence of certain fish species in one region that were present in the other. The highest species diversity was recorded in Namtiram, Tamenglong district, Manipur, for the hilly stretch, and Srikona, Cachar district, Assam, for the plains. Surprisingly, the study noted that physciochemical parameters had minimal influence on fish distribution; instead, it appeared that habitat and other environmental factors played a more significant role in regulating the presence of fish species.","PeriodicalId":503810,"journal":{"name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139846325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fish Assemblage Concerning Physciochemical and Geomorphological Characteristics of Barak River, India 与印度巴拉克河物理化学和地貌特征有关的鱼类组合
UTTAR PRADESH JOURNAL OF ZOOLOGY Pub Date : 2024-02-10 DOI: 10.56557/upjoz/2024/v45i43901
Prabhakar Rai, J. S. Y. Kumar, Arya Sen, Saurav Bhattacharjee
{"title":"Fish Assemblage Concerning Physciochemical and Geomorphological Characteristics of Barak River, India","authors":"Prabhakar Rai, J. S. Y. Kumar, Arya Sen, Saurav Bhattacharjee","doi":"10.56557/upjoz/2024/v45i43901","DOIUrl":"https://doi.org/10.56557/upjoz/2024/v45i43901","url":null,"abstract":"This study investigated the fish population, environmental characteristics, microhabitats, and soil erosion along the Barak River in Manipur and Assam. The survey covered 18 sites spanning from Maram in Senapati district, Manipur, to Badarpur in Karimganj district, Assam. The assessment involved analysing six physciochemical parameters and collecting fish specimens, focusing on human activities affecting different sections of the river. The environmental conditions varied significantly between two distinct geographical regions: the hilly area in Manipur and the plains in Assam. The river exhibited narrowness, shallow depths, rapid flow, and a substrate composed of stones and gravel in the hilly region of Manipur. Conversely, in the plains of Assam, the river was wider, slower flowing, deeper, and featured a substrate consisting of silt and clay. Bank erosion and river meandering were prevalent in the plains, which were densely populated and extensively cultivated. The survey documented a total of 35 fish species from 15 families and 7 orders. Interestingly, the distribution pattern indicated an absence of certain fish species in one region that were present in the other. The highest species diversity was recorded in Namtiram, Tamenglong district, Manipur, for the hilly stretch, and Srikona, Cachar district, Assam, for the plains. Surprisingly, the study noted that physciochemical parameters had minimal influence on fish distribution; instead, it appeared that habitat and other environmental factors played a more significant role in regulating the presence of fish species.","PeriodicalId":503810,"journal":{"name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","volume":"10 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139786495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison between Two Different Feed Formulations to Ensure the Growth of Young Pigeon Squabs 两种不同饲料配方在确保乳鸽幼鸽生长方面的比较
UTTAR PRADESH JOURNAL OF ZOOLOGY Pub Date : 2024-02-10 DOI: 10.56557/upjoz/2024/v45i43900
S. Mahaboobjan, D. V. S. Rajakumari, I. J. Dilda, M. Esakkiammal
{"title":"Comparison between Two Different Feed Formulations to Ensure the Growth of Young Pigeon Squabs","authors":"S. Mahaboobjan, D. V. S. Rajakumari, I. J. Dilda, M. Esakkiammal","doi":"10.56557/upjoz/2024/v45i43900","DOIUrl":"https://doi.org/10.56557/upjoz/2024/v45i43900","url":null,"abstract":"Background: Feed formulation plays a vital role in squabs of racing pigeon’s growth and preparing them for the race from its young age. Some feed formulations which have more protein and fat content has the ability to improve the weight of the eggs and young squabs. \u0000Objective: In this study, two different feed formulations were compared for the parent pigeons for its antenatal and postnatal period to ensure which is suitable and enhance the growth of the eggs and young squabs.  \u0000Methods: Two pairs of racing pigeons Pair A and Pair B have been selected. They fed with two types of feed formulations like one with a basic nutrients and another one with an addition of protein and lipid content. The weight of the eggs and the squabs of these pigeons have been measured. \u0000Results: The average weight of eggs in Pair B (19.16g) is higher than the Average weight of eggs in Pair A (16.75g). At the end of 20thday it was observed that the average weight of the squabs in Pair B (260.41g) is higher than the average weight of squabs in Pair A (229.59g). \u0000Conclusion: The result showed that there is a significant weight difference in the eggs and squabs of pair A and pair B. This difference occurs due to the addition of some nutritious feed ingredients in the feed prepared for the Pair B pigeons.","PeriodicalId":503810,"journal":{"name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","volume":" October","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139787436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Interaction Study between Gentamicin and the Cancer Protein Target (TP53) using in silico Tools 利用硅学工具研究庆大霉素与癌症蛋白靶标（TP53）之间的分子相互作用
UTTAR PRADESH JOURNAL OF ZOOLOGY Pub Date : 2024-02-10 DOI: 10.56557/upjoz/2024/v45i33897
Priyadharshini M., D. Leelavathi, Tanzeem Azeeza S.
{"title":"Molecular Interaction Study between Gentamicin and the Cancer Protein Target (TP53) using in silico Tools","authors":"Priyadharshini M., D. Leelavathi, Tanzeem Azeeza S.","doi":"10.56557/upjoz/2024/v45i33897","DOIUrl":"https://doi.org/10.56557/upjoz/2024/v45i33897","url":null,"abstract":"The most prevalent mutation in hepatocellular carcinoma (HCC), TP53 mutations impacts the course and prognosis of HCC. 3D in silico drug docking techniques were employed to make the possible mutant target tumor protein 53 (TP53) interact with benzene acetic acid (Gentamicin) and non-steroidal anti-inflammatory drugs (NSAIDs). To carry out drug docking techniques, the translated amino acid sequence and three-dimensional chemical compound were obtained from the NCBI database. The use of sophisticated 3D molecular visualization tools was employed in post-docking experiments. The docking study results unequivocally show that gentamicin directly suppresses amino acid mutational sites. TP53 and Gentamicin's electrostatic force is depicted in a three-dimensional manner using notions from molecular dynamics techniques. In the end, it was determined that gentamicin, an Antibiotic medication, helps treat liver cancer. Most chemotherapy medications cause pain. Therefore, Gentamicin shall be used to lessen discomfort while minimizing the symptoms of cancer.","PeriodicalId":503810,"journal":{"name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","volume":"38 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139846773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison between Two Different Feed Formulations to Ensure the Growth of Young Pigeon Squabs 两种不同饲料配方在确保乳鸽幼鸽生长方面的比较
UTTAR PRADESH JOURNAL OF ZOOLOGY Pub Date : 2024-02-10 DOI: 10.56557/upjoz/2024/v45i43900
S. Mahaboobjan, D. V. S. Rajakumari, I. J. Dilda, M. Esakkiammal
{"title":"Comparison between Two Different Feed Formulations to Ensure the Growth of Young Pigeon Squabs","authors":"S. Mahaboobjan, D. V. S. Rajakumari, I. J. Dilda, M. Esakkiammal","doi":"10.56557/upjoz/2024/v45i43900","DOIUrl":"https://doi.org/10.56557/upjoz/2024/v45i43900","url":null,"abstract":"Background: Feed formulation plays a vital role in squabs of racing pigeon’s growth and preparing them for the race from its young age. Some feed formulations which have more protein and fat content has the ability to improve the weight of the eggs and young squabs. \u0000Objective: In this study, two different feed formulations were compared for the parent pigeons for its antenatal and postnatal period to ensure which is suitable and enhance the growth of the eggs and young squabs.  \u0000Methods: Two pairs of racing pigeons Pair A and Pair B have been selected. They fed with two types of feed formulations like one with a basic nutrients and another one with an addition of protein and lipid content. The weight of the eggs and the squabs of these pigeons have been measured. \u0000Results: The average weight of eggs in Pair B (19.16g) is higher than the Average weight of eggs in Pair A (16.75g). At the end of 20thday it was observed that the average weight of the squabs in Pair B (260.41g) is higher than the average weight of squabs in Pair A (229.59g). \u0000Conclusion: The result showed that there is a significant weight difference in the eggs and squabs of pair A and pair B. This difference occurs due to the addition of some nutritious feed ingredients in the feed prepared for the Pair B pigeons.","PeriodicalId":503810,"journal":{"name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","volume":"223 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139847310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proximate Analysis of Oecophylla smaragdina, an Edible Weaver Ant Consumed by Certain Tribes of Assam, India 印度阿萨姆邦某些部落食用的食用蚁 Oecophylla smaragdina 的近似物分析
UTTAR PRADESH JOURNAL OF ZOOLOGY Pub Date : 2024-02-05 DOI: 10.56557/upjoz/2024/v45i33893
Dipika Doloi, D. Basumatari
{"title":"Proximate Analysis of Oecophylla smaragdina, an Edible Weaver Ant Consumed by Certain Tribes of Assam, India","authors":"Dipika Doloi, D. Basumatari","doi":"10.56557/upjoz/2024/v45i33893","DOIUrl":"https://doi.org/10.56557/upjoz/2024/v45i33893","url":null,"abstract":"In the field of entomophagy, the consumption of insects as a sustainable and nutrient-rich food source has gained increasing attention due to its environmental and nutritional benefits. There has been a growing curiosity and interest in the culinary world regarding insects as a source of food. Far from being a passing trend, the exploration of insect-based cuisine has opened up new dimensions in gastronomy. Among the edible insect species, Oecophylla smaragdina, known as the weaver ant, has emerged as a subject of fascination for its unique cultural significance, ecological relevance, and potential as a nutritional powerhouse. It is consumed by certain tribes of Assam during the primary spring festival in Assam. The study was done to determine the proximate analysis of Oecophylla smaragdina using standard methods. From the study, crude protein content was found to be highest amongst the proximate composition. Thus, this study provides valuable insights about the proximate composition of this insect. Moreover, it also adds another layer of importance as it is consumed during the primary spring festival in Assam, adding cultural significance to it.","PeriodicalId":503810,"journal":{"name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","volume":"24 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139803386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Biological Control Strategies for Sustainable Pest Management 生物控制战略在害虫可持续管理方面的进展
UTTAR PRADESH JOURNAL OF ZOOLOGY Pub Date : 2024-02-05 DOI: 10.56557/upjoz/2024/v45i33894
Awanindra Kumar Tiwari
{"title":"Advances in Biological Control Strategies for Sustainable Pest Management","authors":"Awanindra Kumar Tiwari","doi":"10.56557/upjoz/2024/v45i33894","DOIUrl":"https://doi.org/10.56557/upjoz/2024/v45i33894","url":null,"abstract":"Biological control using natural enemies offers environmentally safe and sustainable options for managing insect pests and plant pathogens in agriculture. Recent technological advances have led to promising innovations in mass production, formulation and application of biological control agents (BCAs) including parasitoids, predators, microbial antagonists and semiochemicals. Genomic tools have enabled better understanding of mechanisms of antagonism, host-pathogen interactions and molecular signaling guiding greater efficacy. Nanoparticle based delivery systems, RNA interference (RNAi) technology, synthetic symbionts, endophytes, insect gut microbiome manipulations and transgenic resistance offer tremendous scope for devising novel biological control tactics. Integrated Pest Management (IPM) models using ecologically based approaches and adoption of high-tech tools coupled with predictive algorithms can further harness the biocontrol potential providing effective and durable pest management solutions.","PeriodicalId":503810,"journal":{"name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139806206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proximate Analysis of Oecophylla smaragdina, an Edible Weaver Ant Consumed by Certain Tribes of Assam, India 印度阿萨姆邦某些部落食用的食用蚁 Oecophylla smaragdina 的近似物分析
UTTAR PRADESH JOURNAL OF ZOOLOGY Pub Date : 2024-02-05 DOI: 10.56557/upjoz/2024/v45i33893
Dipika Doloi, D. Basumatari
{"title":"Proximate Analysis of Oecophylla smaragdina, an Edible Weaver Ant Consumed by Certain Tribes of Assam, India","authors":"Dipika Doloi, D. Basumatari","doi":"10.56557/upjoz/2024/v45i33893","DOIUrl":"https://doi.org/10.56557/upjoz/2024/v45i33893","url":null,"abstract":"In the field of entomophagy, the consumption of insects as a sustainable and nutrient-rich food source has gained increasing attention due to its environmental and nutritional benefits. There has been a growing curiosity and interest in the culinary world regarding insects as a source of food. Far from being a passing trend, the exploration of insect-based cuisine has opened up new dimensions in gastronomy. Among the edible insect species, Oecophylla smaragdina, known as the weaver ant, has emerged as a subject of fascination for its unique cultural significance, ecological relevance, and potential as a nutritional powerhouse. It is consumed by certain tribes of Assam during the primary spring festival in Assam. The study was done to determine the proximate analysis of Oecophylla smaragdina using standard methods. From the study, crude protein content was found to be highest amongst the proximate composition. Thus, this study provides valuable insights about the proximate composition of this insect. Moreover, it also adds another layer of importance as it is consumed during the primary spring festival in Assam, adding cultural significance to it.","PeriodicalId":503810,"journal":{"name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","volume":"50 1-2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139863272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in Biological Control Strategies for Sustainable Pest Management 生物控制战略在害虫可持续管理方面的进展
UTTAR PRADESH JOURNAL OF ZOOLOGY Pub Date : 2024-02-05 DOI: 10.56557/upjoz/2024/v45i33894
Awanindra Kumar Tiwari
{"title":"Advances in Biological Control Strategies for Sustainable Pest Management","authors":"Awanindra Kumar Tiwari","doi":"10.56557/upjoz/2024/v45i33894","DOIUrl":"https://doi.org/10.56557/upjoz/2024/v45i33894","url":null,"abstract":"Biological control using natural enemies offers environmentally safe and sustainable options for managing insect pests and plant pathogens in agriculture. Recent technological advances have led to promising innovations in mass production, formulation and application of biological control agents (BCAs) including parasitoids, predators, microbial antagonists and semiochemicals. Genomic tools have enabled better understanding of mechanisms of antagonism, host-pathogen interactions and molecular signaling guiding greater efficacy. Nanoparticle based delivery systems, RNA interference (RNAi) technology, synthetic symbionts, endophytes, insect gut microbiome manipulations and transgenic resistance offer tremendous scope for devising novel biological control tactics. Integrated Pest Management (IPM) models using ecologically based approaches and adoption of high-tech tools coupled with predictive algorithms can further harness the biocontrol potential providing effective and durable pest management solutions.","PeriodicalId":503810,"journal":{"name":"UTTAR PRADESH JOURNAL OF ZOOLOGY","volume":"22 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139866084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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