Saudi Journal of Pathology and Microbiology最新文献

筛选

英文中文

Efficacy of Pneumatic Dilation (PD) in Treatment-Naïve Achalasia Patient: A North African Experience Center 气动扩张术 (PD) 对治疗无效的阿卡拉西娅患者的疗效：北非经验中心

Saudi Journal of Pathology and Microbiology Pub Date : 2024-02-01 DOI: 10.36348/sjpm.2024.v09i02.001

M. Kadiri, I. Benelbarhdadi, M. Borahma, F. Ajana

{"title":"Efficacy of Pneumatic Dilation (PD) in Treatment-Naïve Achalasia Patient: A North African Experience Center","authors":"M. Kadiri, I. Benelbarhdadi, M. Borahma, F. Ajana","doi":"10.36348/sjpm.2024.v09i02.001","DOIUrl":"https://doi.org/10.36348/sjpm.2024.v09i02.001","url":null,"abstract":"Background: Pneumatic dilation (PD) is often presented today as a “short term” treatment for achalasia but, in truth, it can last for years. our study aims to determine the short and long-term efficacy of pneumatic dilatation on clinical remission in a treatment-naïve achalasia patient. Materials and Methods: A single center retrospective, descriptive and analytical study conducted between January 2007 and September 2022. Treatment naïve patients with manometric diagnosis of primary achalasia (subtype I and II) were included. We evaluated the clinical outcomes; single vs multiple PD, complications, and estimated duration of effect. Results: 121 patients were included, (mean age 42,2±14,5; 53,8% male), 88,4% (n=104) underwent 2 PD and 11,6% (n=17) underwent 3 PD, 23,1% (n=28) needed repeated PD at one year, The PD procedure was completed without major complications in all patients. Patients with subtype II had a better response to PD than subtype I(p=0,003). In the long-term follow up (median time: 50 months), the mean Eckardt score was 2.2. A subsequent 35 mm dilatation was associated with long-term clinical remission than an initial dilatation with 35 mm.(p=0.003). On univariate analysis, the non-responders more often was male gender, had age< 40 years (p=0.0006), and had high baseline LESP (lower esophageal sphincter pressure>50 mmHg), p=0.004). On multivariate analysis only age<or= 40 years (p=0.02) was associated with poor outcome. Conclusion: PD is an effective, durable and safe treatment for achalasia. A graded-protocol PD starting with a 30 mm dilation applied in the appropriate achalasia subtypes was shown to be a highly effective approach, in both the short- and long-term. Age<40 years, male patients and hight LESP have poorer outcomes following PD.","PeriodicalId":503790,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"107 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139887890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Pneumatic Dilation (PD) in Treatment-Naïve Achalasia Patient: A North African Experience Center 气动扩张术 (PD) 对治疗无效的阿卡拉西娅患者的疗效：北非经验中心

Saudi Journal of Pathology and Microbiology Pub Date : 2024-02-01 DOI: 10.36348/sjpm.2024.v09i02.001

M. Kadiri, I. Benelbarhdadi, M. Borahma, F. Ajana

{"title":"Efficacy of Pneumatic Dilation (PD) in Treatment-Naïve Achalasia Patient: A North African Experience Center","authors":"M. Kadiri, I. Benelbarhdadi, M. Borahma, F. Ajana","doi":"10.36348/sjpm.2024.v09i02.001","DOIUrl":"https://doi.org/10.36348/sjpm.2024.v09i02.001","url":null,"abstract":"Background: Pneumatic dilation (PD) is often presented today as a “short term” treatment for achalasia but, in truth, it can last for years. our study aims to determine the short and long-term efficacy of pneumatic dilatation on clinical remission in a treatment-naïve achalasia patient. Materials and Methods: A single center retrospective, descriptive and analytical study conducted between January 2007 and September 2022. Treatment naïve patients with manometric diagnosis of primary achalasia (subtype I and II) were included. We evaluated the clinical outcomes; single vs multiple PD, complications, and estimated duration of effect. Results: 121 patients were included, (mean age 42,2±14,5; 53,8% male), 88,4% (n=104) underwent 2 PD and 11,6% (n=17) underwent 3 PD, 23,1% (n=28) needed repeated PD at one year, The PD procedure was completed without major complications in all patients. Patients with subtype II had a better response to PD than subtype I(p=0,003). In the long-term follow up (median time: 50 months), the mean Eckardt score was 2.2. A subsequent 35 mm dilatation was associated with long-term clinical remission than an initial dilatation with 35 mm.(p=0.003). On univariate analysis, the non-responders more often was male gender, had age< 40 years (p=0.0006), and had high baseline LESP (lower esophageal sphincter pressure>50 mmHg), p=0.004). On multivariate analysis only age<or= 40 years (p=0.02) was associated with poor outcome. Conclusion: PD is an effective, durable and safe treatment for achalasia. A graded-protocol PD starting with a 30 mm dilation applied in the appropriate achalasia subtypes was shown to be a highly effective approach, in both the short- and long-term. Age<40 years, male patients and hight LESP have poorer outcomes following PD.","PeriodicalId":503790,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"10 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139828180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Paroxysmal Nocturnal Hemoglobinuria (PHN): A Rare Cause of Budd Chiari Syndrome (BCS) 病例报告：阵发性夜间血红蛋白尿（PHN）：巴德-奇亚里氏综合征（BCS）的罕见病因

Saudi Journal of Pathology and Microbiology Pub Date : 2024-01-03 DOI: 10.36348/sjpm.2024.v09i01.001

M. Bouissehak, M. Kadiri, M. Borahma, F. Chabib, C. Berhili, N. Lagdali, I. Benelbardhadi, F. Ajana

引用次数: 0

首页上一页