{"title":"Pattern of Testicular Atrophy in Bilateral Orchidectomy Specimens from Patients with Advanced Prostate Cancer","authors":"E. Udoh, I. Essiet, A. Usoro, Joseph Primus","doi":"10.36348/sjpm.2024.v09i07.001","DOIUrl":"https://doi.org/10.36348/sjpm.2024.v09i07.001","url":null,"abstract":"Introduction: One of the palliative treatment modalities for advanced prostate cancer (Pca) is bilateral Orchidectomy. Histopathological analysis of submitted Orchidectomy specimens may display normal to various grades of testicular atrophy. Advancing age may be related to testicular atrophy as well as pre-treatment with luteinizing hormone releasing hormone agonist [LHRH(a)], drugs and chronic illnesses. We retrospectively examined results of Orchidectomy specimens submitted for histopathological analysis. Materials and Methods: Bilateral orchidectomy specimen results of twenty seven (27) patients diagnosed with Pca were retrospectively studied. Their clinical information and ancillary laboratory results were retrieved. Of the 27 patients, two (7.4%) patients had no prior treatments for Pca, while twenty patients (74.1%) and five patients (18.5%) had prior exposure to anti-androgens and LHRH(a) respectively. In the histo-analysis, the specimens were graded from normal to various degrees of atrophy. Data collated were analyzed using Statistical package for social sciences (SPSS) version 20.0 software. Results: The mean age of all patients was 68.52±7.266 years, ranging from 51-87 years. Mean PSA was 59.811+38.84ng/ml, while mean Gleason score was 8.30+8.69. On the whole, 3 patients (11.1%) had normal testes, 16 patients (59.3%) and 8 patients (29.6%) respectively had mild and moderate grades of testicular atrophy. Age correlated positively with the grades of atrophy. Conclusion: Degree of testicular atrophy is widely noted to correlate with age and depends less on pre-treatment in the setting of advanced prostate cancer.","PeriodicalId":503790,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141680013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Premalatha, K, Gangadhara Naik, M.K. Naik, Vinayaka Hegde, B.C. Dhananjaya, Satish, K. M.
{"title":"Exploring Yellow Leaf Disease Patterns in Areca Plantations in Chikkamagaluru District of Karnataka","authors":"Premalatha, K, Gangadhara Naik, M.K. Naik, Vinayaka Hegde, B.C. Dhananjaya, Satish, K. M.","doi":"10.36348/sjpm.2024.v09i03.002","DOIUrl":"https://doi.org/10.36348/sjpm.2024.v09i03.002","url":null,"abstract":"Yellow Leaf Disease (YLD) poses a significant threat to arecanut cultivation, particularly in the South Indian states of Karnataka and Kerala. This study aimed to assess the incidence and intensity of YLD in the Malnad regions of Karnataka during 2021-22. Intensive roving surveys were conducted in major arecanut-growing areas, namely Sringeri, Koppa, and Narasimharajapura taluks of Chikkamagaluru district. The assessment was made through selecting five fields per location and calculating the percent disease incidence and intensity based on observed symptoms following established scoring systems. Results revealed varying levels of disease incidence and intensity across surveyed taluks and villages. In Chikkamagaluru district, Koppa, Narasimharajapura, Sringeri, and Kalasa taluks exhibited incidence ranging from 0 per cent to 100 per cent and intensity from 80 per cent to 100 per cent, while Narasimharajapura and Mudigere taluks showed incidence from 0 per cent to 60 per cent and intensity from 0 per cent to 30 per cent. The study underscores the endemic nature of YLD in these regions, likely influenced by soil and environmental factors, particularly in hilly areas with high rainfall.","PeriodicalId":503790,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"29 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140242144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incidental Finding of “CONGENITAL DUPLICATION OF THE JEJUNUM” in 42 Years Female","authors":"T. S. Sreeja, L. Krishna, P. Deepak","doi":"10.36348/sjpm.2024.v09i02.005","DOIUrl":"https://doi.org/10.36348/sjpm.2024.v09i02.005","url":null,"abstract":"Alimentary Tract Duplications (ATD) are congenital anomalies that can arise at any level from the mouth to the anus [3]. They are rare and often found early in life. A minority of cases may remain undiscovered until adulthood when they may give rise to different symptoms, depending on the location. Diagnosis is difficult due to the rarity of this entity. Surgical correction is the treatment of choice.","PeriodicalId":503790,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"9 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139846355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incidental Finding of “CONGENITAL DUPLICATION OF THE JEJUNUM” in 42 Years Female","authors":"T. S. Sreeja, L. Krishna, P. Deepak","doi":"10.36348/sjpm.2024.v09i02.005","DOIUrl":"https://doi.org/10.36348/sjpm.2024.v09i02.005","url":null,"abstract":"Alimentary Tract Duplications (ATD) are congenital anomalies that can arise at any level from the mouth to the anus [3]. They are rare and often found early in life. A minority of cases may remain undiscovered until adulthood when they may give rise to different symptoms, depending on the location. Diagnosis is difficult due to the rarity of this entity. Surgical correction is the treatment of choice.","PeriodicalId":503790,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"5 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139786633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Abd Kadhum, Murtada Wafi Beden, Ahmad Shandookh Hameed
{"title":"Effect of Piper Cubeba Extract on Biofim Producing Pseudomonas Aeruginosa Isolated from Clinical Samples","authors":"Ali Abd Kadhum, Murtada Wafi Beden, Ahmad Shandookh Hameed","doi":"10.36348/sjpm.2024.v09i02.004","DOIUrl":"https://doi.org/10.36348/sjpm.2024.v09i02.004","url":null,"abstract":"Background: The species of Pseudomonas aeruginosa is a nosocomial bacterium that increases the risk of multidrug-resistant infections, especially in vulnerable patients. The plant Piper cubeba, commonly referred to as cubeb or tailed pepper, it is specifically cultivated for its fruit and essential oil. The plant belongs to the genus Piper. The study aims at assessing the effectiveness of Piper cubeba extract against different P. aeruginosa strains that could produce biofilm and carry blaIMP gene. Method: Isolates from 85 samples (17 sputum, 40 urine and 28 diarrhea samples). Collected from Al Nasiriyah Teaching Hospital during the period of December 2021 to March 2022. Samples were cultivated using routine cultivation methods, catalase test, oxidase reaction, and the Api20E system were performed to identify P. aeruginosa. Results: Out of a total of 17 isolated samples of Pseudomonas aeruginosa, 3 (17.64%) were from sputum, 6(35.29%) from urine, and 8 (47.05%) diarrhea samples. Out of 17 isolates 6 were sensitive in stool isolates 4 isolates were moderate sensitive and 7 isolates were resistance. Conclusion at concentrations of 25, 50, 75, and 100 mg/mL for Piper cubeba, respectively, the greatest MBC of plant extracts was noted. Also, all the isolates were capable of producing a biofilm by using presterilized 96-well polystyrene microtiter plates. Out of 17 isolates, 9 had a potent biofilm ability and the remaining 7 were moderate biofilm producers. Additionally, 7 of the isolates (41.17%) carried the blaIMP gene. Conclusion: Piper cubeba extract has potential as an antimicrobial agent against both sensitive and moderately resistant strains of Pseudomonas aeruginosa. This antimicrobial effect becomes more pronounced with an increase in the concentration of the extract. Additionally, Pseudomonas aeruginosa that produce biofilms tend to consistently produce more Metallo-beta-lactamase (MBL), which can further contribute to antibiotic resistance.","PeriodicalId":503790,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":" 41","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139791167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ali Abd Kadhum, Murtada Wafi Beden, Ahmad Shandookh Hameed
{"title":"Effect of Piper Cubeba Extract on Biofim Producing Pseudomonas Aeruginosa Isolated from Clinical Samples","authors":"Ali Abd Kadhum, Murtada Wafi Beden, Ahmad Shandookh Hameed","doi":"10.36348/sjpm.2024.v09i02.004","DOIUrl":"https://doi.org/10.36348/sjpm.2024.v09i02.004","url":null,"abstract":"Background: The species of Pseudomonas aeruginosa is a nosocomial bacterium that increases the risk of multidrug-resistant infections, especially in vulnerable patients. The plant Piper cubeba, commonly referred to as cubeb or tailed pepper, it is specifically cultivated for its fruit and essential oil. The plant belongs to the genus Piper. The study aims at assessing the effectiveness of Piper cubeba extract against different P. aeruginosa strains that could produce biofilm and carry blaIMP gene. Method: Isolates from 85 samples (17 sputum, 40 urine and 28 diarrhea samples). Collected from Al Nasiriyah Teaching Hospital during the period of December 2021 to March 2022. Samples were cultivated using routine cultivation methods, catalase test, oxidase reaction, and the Api20E system were performed to identify P. aeruginosa. Results: Out of a total of 17 isolated samples of Pseudomonas aeruginosa, 3 (17.64%) were from sputum, 6(35.29%) from urine, and 8 (47.05%) diarrhea samples. Out of 17 isolates 6 were sensitive in stool isolates 4 isolates were moderate sensitive and 7 isolates were resistance. Conclusion at concentrations of 25, 50, 75, and 100 mg/mL for Piper cubeba, respectively, the greatest MBC of plant extracts was noted. Also, all the isolates were capable of producing a biofilm by using presterilized 96-well polystyrene microtiter plates. Out of 17 isolates, 9 had a potent biofilm ability and the remaining 7 were moderate biofilm producers. Additionally, 7 of the isolates (41.17%) carried the blaIMP gene. Conclusion: Piper cubeba extract has potential as an antimicrobial agent against both sensitive and moderately resistant strains of Pseudomonas aeruginosa. This antimicrobial effect becomes more pronounced with an increase in the concentration of the extract. Additionally, Pseudomonas aeruginosa that produce biofilms tend to consistently produce more Metallo-beta-lactamase (MBL), which can further contribute to antibiotic resistance.","PeriodicalId":503790,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"104 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139851233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gastro Intestinal Stromal Tumor -Supra Pubic Region","authors":"Ch. Ratna Kumari, C. Swathi, S. Srikanth","doi":"10.36348/sjpm.2024.v09i02.002","DOIUrl":"https://doi.org/10.36348/sjpm.2024.v09i02.002","url":null,"abstract":"Gastrointestinal stromal tumours (GISTs) are rare mesenchymal neoplasms of the gastrointestinal tract and mesentery. They are usually found in the stomach or small intestine but can occur anywhere along the GIT and rarely have extra GI involvement. They are associated with high rates of malignant transformation. Most GISTs present asymptomatically but also present with bleeding, abdominal pain, and rarely gastric outlet obstruction. There have been many risk stratification classifications systems which are calculated based on tumour size, mitotic rate, location, and perforation. They are best identified by computed tomography (CT) scan and most stain positive for CD117 (C-Kit), CD34, and/or DOG-1. The approaches to treating GISTs are to resect primary low-risk tumours, high-risk tumours and further treated with imatinib therapy and unresectable tumours treated with neoadjuvant imatinib 400 mg daily followed by surgical resection and regular follow up by abdominal CT scan.","PeriodicalId":503790,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139865781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zoulikha Tammouch, M. Salihoun, Fatima Chait, R. E. Mohtarim, S. Derqaoui, Nawal Kabbaj
{"title":"Gastric Burkitt Lymphoma, an Infrequent Cause of Hematemesis","authors":"Zoulikha Tammouch, M. Salihoun, Fatima Chait, R. E. Mohtarim, S. Derqaoui, Nawal Kabbaj","doi":"10.36348/sjpm.2024.v09i02.003","DOIUrl":"https://doi.org/10.36348/sjpm.2024.v09i02.003","url":null,"abstract":"Among gastric malignancies, lymphomas rank as the second most common type, following gastric adenocarcinoma. The majority of gastric lymphomas are either mucosa-associated lymphoid tissue lymphomas or diffuse large B-cell lymphomas. Primary gastric Burkitt lymphoma, is a subtype of non-Hodgkin's lymphoma, represents an exceptionally rare and aggressive malignancy, with only a limited number of reported cases globally. We present the case of a male patient with primary gastric Burkitt lymphoma revealed by digestive hemorrhage. The diagnosis was confirmed by endoscopy and gastric biopsies. The gastric localization of Burkitt's lymphoma is unusual. Our work is a review of the literature on Burkitt's lymphoma in its gastric localization.","PeriodicalId":503790,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"10 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139864919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zoulikha Tammouch, M. Salihoun, Fatima Chait, R. E. Mohtarim, S. Derqaoui, Nawal Kabbaj
{"title":"Gastric Burkitt Lymphoma, an Infrequent Cause of Hematemesis","authors":"Zoulikha Tammouch, M. Salihoun, Fatima Chait, R. E. Mohtarim, S. Derqaoui, Nawal Kabbaj","doi":"10.36348/sjpm.2024.v09i02.003","DOIUrl":"https://doi.org/10.36348/sjpm.2024.v09i02.003","url":null,"abstract":"Among gastric malignancies, lymphomas rank as the second most common type, following gastric adenocarcinoma. The majority of gastric lymphomas are either mucosa-associated lymphoid tissue lymphomas or diffuse large B-cell lymphomas. Primary gastric Burkitt lymphoma, is a subtype of non-Hodgkin's lymphoma, represents an exceptionally rare and aggressive malignancy, with only a limited number of reported cases globally. We present the case of a male patient with primary gastric Burkitt lymphoma revealed by digestive hemorrhage. The diagnosis was confirmed by endoscopy and gastric biopsies. The gastric localization of Burkitt's lymphoma is unusual. Our work is a review of the literature on Burkitt's lymphoma in its gastric localization.","PeriodicalId":503790,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"16 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139804876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gastro Intestinal Stromal Tumor -Supra Pubic Region","authors":"Ch. Ratna Kumari, C. Swathi, S. Srikanth","doi":"10.36348/sjpm.2024.v09i02.002","DOIUrl":"https://doi.org/10.36348/sjpm.2024.v09i02.002","url":null,"abstract":"Gastrointestinal stromal tumours (GISTs) are rare mesenchymal neoplasms of the gastrointestinal tract and mesentery. They are usually found in the stomach or small intestine but can occur anywhere along the GIT and rarely have extra GI involvement. They are associated with high rates of malignant transformation. Most GISTs present asymptomatically but also present with bleeding, abdominal pain, and rarely gastric outlet obstruction. There have been many risk stratification classifications systems which are calculated based on tumour size, mitotic rate, location, and perforation. They are best identified by computed tomography (CT) scan and most stain positive for CD117 (C-Kit), CD34, and/or DOG-1. The approaches to treating GISTs are to resect primary low-risk tumours, high-risk tumours and further treated with imatinib therapy and unresectable tumours treated with neoadjuvant imatinib 400 mg daily followed by surgical resection and regular follow up by abdominal CT scan.","PeriodicalId":503790,"journal":{"name":"Saudi Journal of Pathology and Microbiology","volume":"8 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139806192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}