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Decompositions of the λ-Fold Complete Mixed Graph into Mixed 6-Stars 将 λ 折叠完整混合图分解为混合六星图
AppliedMath Pub Date : 2024-02-05 DOI: 10.3390/appliedmath4010011
Robert Gardner, Kazeem Kosebinu
{"title":"Decompositions of the λ-Fold Complete Mixed Graph into Mixed 6-Stars","authors":"Robert Gardner, Kazeem Kosebinu","doi":"10.3390/appliedmath4010011","DOIUrl":"https://doi.org/10.3390/appliedmath4010011","url":null,"abstract":"Graph and digraph decompositions are a fundamental part of design theory. Probably the best known decompositions are related to decomposing the complete graph into 3-cycles (which correspond to Steiner triple systems), and decomposing the complete digraph into orientations of a 3-cycle (the two possible orientations of a 3-cycle correspond to directed triple systems and Mendelsohn triple systems). Decompositions of the λ-fold complete graph and the λ-fold complete digraph have been explored, giving generalizations of decompositions of complete simple graphs and digraphs. Decompositions of the complete mixed graph (which contains an edge and two distinct arcs between every two vertices) have also been explored in recent years. Since the complete mixed graph has twice as many arcs as edges, an isomorphic decomposition of a complete mixed graph into copies of a sub-mixed graph must involve a sub-mixed graph with twice as many arcs as edges. A partial orientation of a 6-star with two edges and four arcs is an example of such a mixed graph; there are five such mixed stars. In this paper, we give necessary and sufficient conditions for a decomposition of the λ-fold complete mixed graph into each of these five mixed stars for all λ>1.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":"11 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139803707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decompositions of the λ-Fold Complete Mixed Graph into Mixed 6-Stars 将 λ 折叠完整混合图分解为混合六星图
AppliedMath Pub Date : 2024-02-05 DOI: 10.3390/appliedmath4010011
Robert Gardner, Kazeem Kosebinu
{"title":"Decompositions of the λ-Fold Complete Mixed Graph into Mixed 6-Stars","authors":"Robert Gardner, Kazeem Kosebinu","doi":"10.3390/appliedmath4010011","DOIUrl":"https://doi.org/10.3390/appliedmath4010011","url":null,"abstract":"Graph and digraph decompositions are a fundamental part of design theory. Probably the best known decompositions are related to decomposing the complete graph into 3-cycles (which correspond to Steiner triple systems), and decomposing the complete digraph into orientations of a 3-cycle (the two possible orientations of a 3-cycle correspond to directed triple systems and Mendelsohn triple systems). Decompositions of the λ-fold complete graph and the λ-fold complete digraph have been explored, giving generalizations of decompositions of complete simple graphs and digraphs. Decompositions of the complete mixed graph (which contains an edge and two distinct arcs between every two vertices) have also been explored in recent years. Since the complete mixed graph has twice as many arcs as edges, an isomorphic decomposition of a complete mixed graph into copies of a sub-mixed graph must involve a sub-mixed graph with twice as many arcs as edges. A partial orientation of a 6-star with two edges and four arcs is an example of such a mixed graph; there are five such mixed stars. In this paper, we give necessary and sufficient conditions for a decomposition of the λ-fold complete mixed graph into each of these five mixed stars for all λ>1.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139863447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Convection of Physical Quantities of Random Density 随机密度物理量的对流
AppliedMath Pub Date : 2024-02-05 DOI: 10.3390/appliedmath4010012
E. Barletta, S. Dragomir, Francesco Esposito
{"title":"Convection of Physical Quantities of Random Density","authors":"E. Barletta, S. Dragomir, Francesco Esposito","doi":"10.3390/appliedmath4010012","DOIUrl":"https://doi.org/10.3390/appliedmath4010012","url":null,"abstract":"We study the random flow, through a thin cylindrical tube, of a physical quantity of random density, in the presence of random sinks and sources. We model convection in terms of the expectations of the flux and density and solve the initial value problem for the resulting convection equation. We propose a difference scheme for the convection equation, that is both stable and satisfies the Courant–Friedrichs–Lewy test, and estimate the difference between the exact and approximate solutions.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":"193 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139862585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts 放疗前的细胞周期同步:在黑色素瘤异种移植物上使用吉西他滨的数学模型
AppliedMath Pub Date : 2024-02-04 DOI: 10.3390/appliedmath4010010
Frederika Rentzeperis, Benjamin Coleman, Dorothy Wallace
{"title":"Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts","authors":"Frederika Rentzeperis, Benjamin Coleman, Dorothy Wallace","doi":"10.3390/appliedmath4010010","DOIUrl":"https://doi.org/10.3390/appliedmath4010010","url":null,"abstract":"Radiotherapy can differentially affect the phases of the cell cycle, possibly enhancing suppression of tumor growth, if cells are synchronized in a specific phase. A model is designed to replicate experiments that synchronize cells in the S phase using gemcitabine before radiation at various doses, with the goal of quantifying this effect. The model is used to simulate a clinical trial with a cohort of 100 individuals receiving only radiation and another cohort of 100 individuals receiving radiation after cell synchronization. The simulations offered in this study support the statement that, at suitably high levels of radiation, synchronizing melanoma cells with gemcitabine before treatment substantially reduces the final tumor size. The improvement is statistically significant, and the effect size is noticeable, with the near suppression of growth at 8 Gray and 92% synchronization.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139807015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts 放疗前的细胞周期同步:在黑色素瘤异种移植物上使用吉西他滨的数学模型
AppliedMath Pub Date : 2024-02-04 DOI: 10.3390/appliedmath4010010
Frederika Rentzeperis, Benjamin Coleman, Dorothy Wallace
{"title":"Cell-Cycle Synchronization Prior to Radiotherapy: A Mathematical Model of the Use of Gemcitabine on Melanoma Xenografts","authors":"Frederika Rentzeperis, Benjamin Coleman, Dorothy Wallace","doi":"10.3390/appliedmath4010010","DOIUrl":"https://doi.org/10.3390/appliedmath4010010","url":null,"abstract":"Radiotherapy can differentially affect the phases of the cell cycle, possibly enhancing suppression of tumor growth, if cells are synchronized in a specific phase. A model is designed to replicate experiments that synchronize cells in the S phase using gemcitabine before radiation at various doses, with the goal of quantifying this effect. The model is used to simulate a clinical trial with a cohort of 100 individuals receiving only radiation and another cohort of 100 individuals receiving radiation after cell synchronization. The simulations offered in this study support the statement that, at suitably high levels of radiation, synchronizing melanoma cells with gemcitabine before treatment substantially reduces the final tumor size. The improvement is statistically significant, and the effect size is noticeable, with the near suppression of growth at 8 Gray and 92% synchronization.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":"34 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139866796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Model of Hepatitis B Viral Dynamics with Delays 带延迟的乙型肝炎病毒动态模型
AppliedMath Pub Date : 2024-02-01 DOI: 10.3390/appliedmath4010009
B. Chen-Charpentier
{"title":"A Model of Hepatitis B Viral Dynamics with Delays","authors":"B. Chen-Charpentier","doi":"10.3390/appliedmath4010009","DOIUrl":"https://doi.org/10.3390/appliedmath4010009","url":null,"abstract":"Hepatitis B is a liver disease caused by the human hepatitis B virus (HBV). Mathematical models help further the understanding of the processes involved and help make predictions. The basic reproduction number, R0, is an index that predicts whether the disease will be chronic or not. This is the single most-important information that a mathematical model can give. Within-host virus processes involve delays. We study two within-host hepatitis B virus infection models without and with delay. One is a standard one, and the other considering additional processes and with two delays is new. We analyze the basic reproduction number and alternative threshold indices. The values of R0 and the alternative indices change depending on the model. All these indices predict whether the infection will persist or not, but they do not give the same rate of growth of the infection when it is starting. Therefore, the choice of the model is very important in establishing whether the infection is chronic or not and how fast it initially grows. We analyze these indices to see how to decrease their value. We study the effect of adding delays and how the threshold indices depend on how the delays are included. We do this by studying the local asymptotic stability of the disease-free equilibrium or by using an equivalent method. We show that, for some models, the indices do not change by introducing delays, but they change when the delays are introduced differently. Numerical simulations are presented to confirm the results. Finally, some conclusions are presented.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":"321 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139826722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Model of Hepatitis B Viral Dynamics with Delays 带延迟的乙型肝炎病毒动态模型
AppliedMath Pub Date : 2024-02-01 DOI: 10.3390/appliedmath4010009
B. Chen-Charpentier
{"title":"A Model of Hepatitis B Viral Dynamics with Delays","authors":"B. Chen-Charpentier","doi":"10.3390/appliedmath4010009","DOIUrl":"https://doi.org/10.3390/appliedmath4010009","url":null,"abstract":"Hepatitis B is a liver disease caused by the human hepatitis B virus (HBV). Mathematical models help further the understanding of the processes involved and help make predictions. The basic reproduction number, R0, is an index that predicts whether the disease will be chronic or not. This is the single most-important information that a mathematical model can give. Within-host virus processes involve delays. We study two within-host hepatitis B virus infection models without and with delay. One is a standard one, and the other considering additional processes and with two delays is new. We analyze the basic reproduction number and alternative threshold indices. The values of R0 and the alternative indices change depending on the model. All these indices predict whether the infection will persist or not, but they do not give the same rate of growth of the infection when it is starting. Therefore, the choice of the model is very important in establishing whether the infection is chronic or not and how fast it initially grows. We analyze these indices to see how to decrease their value. We study the effect of adding delays and how the threshold indices depend on how the delays are included. We do this by studying the local asymptotic stability of the disease-free equilibrium or by using an equivalent method. We show that, for some models, the indices do not change by introducing delays, but they change when the delays are introduced differently. Numerical simulations are presented to confirm the results. Finally, some conclusions are presented.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":"60 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139886828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Co-Infection Model for Onchocerciasis and Lassa Fever with Optimal Control Analysis 带最优控制分析的盘尾丝虫病和拉沙热双重感染模型
AppliedMath Pub Date : 2024-01-10 DOI: 10.3390/appliedmath4010006
Kabiru Michael Adeyemo, K. Oshinubi, U. M. Adam, Adejimi Adeniji
{"title":"A Co-Infection Model for Onchocerciasis and Lassa Fever with Optimal Control Analysis","authors":"Kabiru Michael Adeyemo, K. Oshinubi, U. M. Adam, Adejimi Adeniji","doi":"10.3390/appliedmath4010006","DOIUrl":"https://doi.org/10.3390/appliedmath4010006","url":null,"abstract":"A co-infection model for onchocerciasis and Lassa fever (OLF) with periodic variational vectors and optimal control is studied and analyzed to assess the impact of controls against incidence infections. The model is qualitatively examined in order to evaluate its asymptotic behavior in relation to the equilibria. Employing a Lyapunov function, we demonstrated that the disease-free equilibrium (DFE) is globally asymptotically stable; that is, the related basic reproduction number is less than unity. When it is bigger than one, we use a suitable nonlinear Lyapunov function to demonstrate the existence of a globally asymptotically stable endemic equilibrium (EE). Furthermore, the necessary conditions for the presence of optimum control and the optimality system for the co-infection model are established using Pontryagin’s maximum principle. The model is quantitatively analyzed by studying how sensitive the basic reproduction number is to the model parameters and the model simulation using Runge–Kutta technique of order 4 is also presented to study the effects of the treatments. We deduced from the quantitative analysis that, if there is an effective treatment and diagnosis of those exposed to and infected with the disease, the spread of the viral disease can be effectively managed. The results presented in this work will be useful for the proper mitigation of the disease.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":"4 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Informational Updates and the Derivative Pricing Kernel 信息更新与衍生品定价内核
AppliedMath Pub Date : 2024-01-03 DOI: 10.3390/appliedmath4010005
Ayan Bhattacharya
{"title":"Informational Updates and the Derivative Pricing Kernel","authors":"Ayan Bhattacharya","doi":"10.3390/appliedmath4010005","DOIUrl":"https://doi.org/10.3390/appliedmath4010005","url":null,"abstract":"It is common in financial markets for market makers to offer prices on derivative instruments even though they are uncertain about the underlying asset’s value. This paper studies the mathematical problem that arises as a result. Derivatives are priced in the risk-neutral framework, so as the market maker acquires more information about the underlying asset, the change of measure for transition to the risk-neutral framework (the pricing kernel) evolves. This evolution takes a precise form when the market maker is Bayesian. It is shown that Bayesian updates can be characterized as additional informational drift in the underlying asset’s stochastic process. With Bayesian updates, the change of measure needed for pricing derivatives is two-fold: the first change is from the prior probability measure to the posterior probability measure, and the second change is from the posterior probability measure to the risk-neutral measure. The relation between the regular pricing kernel and the pricing kernel under this two-fold change of measure is characterized.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":"110 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139388018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamics of the Isotropic Star Differential System from the Mathematical and Physical Point of Views 从数学和物理学角度看各向同性星体差分系统的动力学特性
AppliedMath Pub Date : 2024-01-02 DOI: 10.3390/appliedmath4010004
Joan C. Artés, J. Llibre, N. Vulpe
{"title":"Dynamics of the Isotropic Star Differential System from the Mathematical and Physical Point of Views","authors":"Joan C. Artés, J. Llibre, N. Vulpe","doi":"10.3390/appliedmath4010004","DOIUrl":"https://doi.org/10.3390/appliedmath4010004","url":null,"abstract":"The following differential quadratic polynomial differential system  dxdt=y−x, dydt=2y−yγ−12−γy−5γ−4γ−1x, when the parameter γ∈(1,2] models the structure equations of an isotropic star having a linear barotropic equation of state, being x=m(r)/r where m(r)≥0 is the mass inside the sphere of radius r of the star, y=4πr2ρ where ρ is the density of the star, and t=ln(r/R) where R is the radius of the star. First, we classify all the topologically non-equivalent phase portraits in the Poincaré disc of these quadratic polynomial differential systems for all values of the parameter γ∈R∖{1}. Second, using the information of the different phase portraits obtained we classify the possible limit values of m(r)/r and 4πr2ρ of an isotropic star when r decreases.","PeriodicalId":503400,"journal":{"name":"AppliedMath","volume":"140 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139452898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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