International Journal of Developmental Biology最新文献_第10页

Early and late stages of Developmental Biology in Argentina. 阿根廷发育生物学的早期和晚期。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2021-01-01 DOI: 10.1387/ijdb.200024ss

Sara S Sánchez, Stella M Honoré

{"title":"Early and late stages of Developmental Biology in Argentina.","authors":"Sara S Sánchez, Stella M Honoré","doi":"10.1387/ijdb.200024ss","DOIUrl":"https://doi.org/10.1387/ijdb.200024ss","url":null,"abstract":"The history of science in Argentina is based on the enormous contribution that the great immigration of the 19th and 20th centuries produced in the country. The scientific and philosophical ideas and the role played especially by Italian scientists who arrived in the country produced a great impact on the different disciplines including Development Biology in emerging universities. The University of Tucumán pioneered the study of experimental biology, making important contributions to reproductive biology and to the early development of amphibians. The contribution of the Italian embryologist Armando Pisanó and the Argentinian Francisco D. Barbieri expanded the field to other universities and research centers located in Córdoba, La Plata, Bahía Blanca and Rosario. Given its strategic position, laboratories located in the city of Buenos Aires reached technological advances faster than others. Indeed, these laboratories saw the evolution from experimental biology to developmental genetics, renewing interest in this area. Currently, Developmental Biology brings together young researchers eager to consolidate regional and global collaboration networks that seek to help solve specific problems such as fertility, epigenetics, stem cells and tissue engineering.","PeriodicalId":50329,"journal":{"name":"International Journal of Developmental Biology","volume":"65 1-2-3","pages":"5-21"},"PeriodicalIF":0.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38477959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LIN-35 beyond its classical roles: its function in the stress response. LIN-35超越其经典角色:其在应激反应中的功能。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2021-01-01 DOI: 10.1387/ijdb.200194rn

Alan A González-Rangel, Rosa E Navarro

{"title":"LIN-35 beyond its classical roles: its function in the stress response.","authors":"Alan A González-Rangel, Rosa E Navarro","doi":"10.1387/ijdb.200194rn","DOIUrl":"https://doi.org/10.1387/ijdb.200194rn","url":null,"abstract":"The pocket protein family controls several cellular functions such as cell cycle, differentiation, and apoptosis, among others. However, its role in stress has been poorly explored. The roundworm Caenorhabditis elegans is a simple model organism whose genes are highly conserved during evolution. C. elegans has only one pocket protein, LIN-35; a retinoblastoma protein (pRB)-related protein similar to p130. To control the expression of some of its targets, LIN-35 interacts with E2F-DP (E2 transcription factor/dimerization partner complex) transcription factors and LIN-52, a member of SynMUV (Synthetic Muv) complex. Together, these proteins form the DRM complex, which is also known as the DREAM complex in mammals. In this review, we will focus on the role of LIN-35 and its partners in the stress response. It has been shown that LIN-35 is required to control starvation in L1 and L4 larval stages, and to induce starvation-induced germ apoptosis. Remarkably, during L1 starvation, insulin/IGF-1 receptor signaling (IIS), as well as the pathogenic, toxin, and oxidative stress-responsive genes, are repressed by LIN-35. The lack of lin-35 also triggers a downregulation of oxidative stress genes. Recent works showed that lin-35 and hpl-2 mutant animals showed enhanced resistance to UPRER. Additionally, hpl-2 mutant animals also exhibited upregulation of autophagic genes, suggesting that SynMuv/DRM proteins participate in this process. Finally, lin-35(n745) mutant animals overexpressed hsp-6, a chaperone that participated in the UPRmt. All of these data demonstrate that LIN-35 and its partners play an important role during the stress response.","PeriodicalId":50329,"journal":{"name":"International Journal of Developmental Biology","volume":"65 4-5-6","pages":"377-382"},"PeriodicalIF":0.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38477962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cell fusion and fusogens - an interview with Benjamin Podbilewicz. 细胞融合和融合原——采访本杰明·波德比莱维奇。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2021-01-01 DOI: 10.1387/ijdb.200220jc

Jesús Chimal-Monroy, Diana Escalante-Alcalde

引用次数: 0

Genomics and epigenomics of axolotl regeneration. 蝾螈再生的基因组学和表观基因组学。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2021-01-01 DOI: 10.1387/ijdb.200276cs

Cynthia Sámano, Rodrigo González-Barrios, Mariana Castro-Azpíroz, Daniela Torres-García, José A Ocampo-Cervantes, Jimena Otero-Negrete, Ernesto Soto-Reyes

{"title":"Genomics and epigenomics of axolotl regeneration.","authors":"Cynthia Sámano, Rodrigo González-Barrios, Mariana Castro-Azpíroz, Daniela Torres-García, José A Ocampo-Cervantes, Jimena Otero-Negrete, Ernesto Soto-Reyes","doi":"10.1387/ijdb.200276cs","DOIUrl":"https://doi.org/10.1387/ijdb.200276cs","url":null,"abstract":"The axolotl (Ambystoma mexicanum) has been a widely studied organism due to its capacity to regenerate most of its cells, tissues and whole-body parts. Since its genome was sequenced, several molecular tools have been developed to study the mechanisms behind this outstanding and extraordinary ability. The complexity of its genome due to its sheer size and the disproportionate expansion of a large number of repetitive elements, may be a key factor at play during tissue remodeling and regeneration mechanisms. Transcriptomic analysis has provided information to identify candidate genes networks and pathways that might define successful or failed tissue regeneration. Nevertheless, the epigenetic machinery that may participate in this phenomenon has largely not been studied. In this review, we outline a broad overview of both genetic and epigenetic molecular processes related to regeneration in axolotl, from the macroscopic to the molecular level. We also explore the epigenetic mechanisms behind regenerative pathways, and its potential importance in future regeneration research. Altogether, understanding the genomics and global regulation in axolotl will be key for elucidating the special biology of this organism and the fantastic phenomenon that is regeneration.","PeriodicalId":50329,"journal":{"name":"International Journal of Developmental Biology","volume":"65 7-8-9","pages":"465-474"},"PeriodicalIF":0.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25409435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Cell signaling molecules in hydra: insights into evolutionarily ancient functions of signaling pathways. 水螅中的细胞信号分子:对信号通路进化上古老功能的洞察。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2020-01-01 DOI: 10.1387/ijdb.190243sg

Surendra Ghaskadbi

{"title":"Cell signaling molecules in hydra: insights into evolutionarily ancient functions of signaling pathways.","authors":"Surendra Ghaskadbi","doi":"10.1387/ijdb.190243sg","DOIUrl":"https://doi.org/10.1387/ijdb.190243sg","url":null,"abstract":"Hydra, a Cnidarian believed to have been evolved about 60 million years ago, has been a favorite model for developmental biologists since Abraham Trembley introduced it in 1744. However, the modern renaissance in research on hydra was initiated by Alfred Gierer when he established a hydra laboratory at the Max Plank Institute in Göttingen in the late 1960s. Several signaling mechanisms that regulate development and pattern formation in vertebrates, including humans, have been found in hydra. These include Wnt, BMP, VEGF, FGF, Notch, and RTK signaling pathways. We have been using hydra to understand the evolution of cell signaling for the past several years. In this article, I will summarize the work on cell signaling pathways in hydra with emphasis on our own work. We have identified and characterized, for the first time, the hydra homologs of the BMP inhibitors Noggin and Gremlin, the vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and several receptor tyrosine kinases (RTKs). Our work, along with that of others, clearly demonstrates that these pathways arose early in evolution to carry out functions that were often quite different from their functions in more complex animals. Apart from providing insights into morphogenesis and pattern formation in adult, budding and regenerating hydra, these findings bring out the utility of hydra as a model system to study evolutionarily ancient, in contrast to recently acquired, functions of various biological molecules.","PeriodicalId":50329,"journal":{"name":"International Journal of Developmental Biology","volume":"64 1-2-3","pages":"141-149"},"PeriodicalIF":0.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1387/ijdb.190243sg","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38146882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Haltere development in D. melanogaster: implications for the evolution of appendage size, shape and function. 黑腹龙的哈尔特发育:对附属物大小、形状和功能进化的启示。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2020-01-01 DOI: 10.1387/ijdb.190133LS

Soumen Khan, C Dilsha, L S Shashidhara

引用次数: 1

Drosophila metamorphosis involves hemocyte mediated macroendocytosis and efferocytosis. 果蝇变态包括血细胞介导的巨吞作用和efferocytosis。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2020-01-01 DOI: 10.1387/ijdb.190215lm

Saikat Ghosh, Sushmit Ghosh, Lolitika Mandal

{"title":"Drosophila metamorphosis involves hemocyte mediated macroendocytosis and efferocytosis.","authors":"Saikat Ghosh, Sushmit Ghosh, Lolitika Mandal","doi":"10.1387/ijdb.190215lm","DOIUrl":"https://doi.org/10.1387/ijdb.190215lm","url":null,"abstract":"Drosophila hemocytes are majorly associated with immune responses, but they also undertake several non-immune functions that are crucial during various stages of development. The activity and behaviour of hemocytes are least documented during the metamorphic phase of fly development. Here we describe the activity, form and behaviour of the most abundant type of hemocyte in Drosophila melanogaster, the \"plasmatocyte,\" throughout pupal development. Our study reveals different forms of plasmatocytes laden with varying degrees of histolyzing debris (muscle and fat) which extend beyond the size of the cell itself, highlighting the phagocytic capacity of these plasmatocytes. Interestingly, the engulfment of apoptotic debris by plasmatocytes is an actin-dependent process, and by the end of metamorphosis, clearance is achieved. The uptake of apoptotic debris consisting of muscles and lipids by the plasmatocytes provides us a model that can be employed to dissect out the relevant components of macroendocytosis and lipid-loaded phagocytosis. This understanding, by itself, is crucial for addressing the emerging role of phagocytes in physiology and pathophysiology.","PeriodicalId":50329,"journal":{"name":"International Journal of Developmental Biology","volume":"64 4-5-6","pages":"319-329"},"PeriodicalIF":0.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1387/ijdb.190215lm","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38147389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Developmental biology of dispersed pollen grains. 分散花粉粒的发育生物学。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2020-01-01 DOI: 10.1387/ijdb.190166ks

Kundaranahalli R Shivanna, Rajesh Tandon

引用次数: 2

The spatiotemporal expression patterns of MSC-associated markers contribute to the identification of progenitor subpopulations in developing limbs. 骨髓间质干细胞相关标记物的时空表达模式有助于确定发育肢体的祖细胞亚群。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2020-01-01 DOI: 10.1387/ijdb.200247jm

Argelia S García-Cervera, Jesús Chimal-Monroy, Jessica C Marín-Llera

{"title":"The spatiotemporal expression patterns of MSC-associated markers contribute to the identification of progenitor subpopulations in developing limbs.","authors":"Argelia S García-Cervera, Jesús Chimal-Monroy, Jessica C Marín-Llera","doi":"10.1387/ijdb.200247jm","DOIUrl":"https://doi.org/10.1387/ijdb.200247jm","url":null,"abstract":"During limb development, skeletal tissues differentiate from their progenitor cells in an orchestrated manner. Mesenchymal stromal cells (MSCs), which are considered to be adult undifferentiated/progenitor cells, have traditionally been identified by the expression of MSC-associated markers (MSC-am) and their differentiation capacities. However, although MSCs have been isolated from bone marrow and a variety of adult tissues, their developmental origin is poorly understood. Remarkably, adult MSCs share similar differentiation characteristics with limb progenitors. Here, we determined the expression patterns of common MSC-am throughout mouse hindlimb development. Our results demonstrate that MSC-am expression is not restricted to undifferentiated cells in vivo. Results from the analysis of MSC-am spatiotemporal expression in the embryonic hindlimb allowed us to propose five subpopulations which represent all limb tissues that potentially correspond to progenitor cells for each lineage. This work contributes to the understanding of MSC-am expression dynamics throughout development and underlines the importance of considering their expression patterns in future MSC studies of the limb.","PeriodicalId":50329,"journal":{"name":"International Journal of Developmental Biology","volume":"64 10-11-12","pages":"499-506"},"PeriodicalIF":0.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38387950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of organ size: a need to focus on growth rate, not size. 器官大小的确定:需要关注生长速度，而不是大小。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2020-01-01 DOI: 10.1387/ijdb.190302cc

Carmen M A Coelho

引用次数: 0