International Journal of Developmental Biology最新文献_第10页

LIN-35 beyond its classical roles: its function in the stress response. LIN-35超越其经典角色:其在应激反应中的功能。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2021-01-01 DOI: 10.1387/ijdb.200194rn

Alan A González-Rangel, Rosa E Navarro

{"title":"LIN-35 beyond its classical roles: its function in the stress response.","authors":"Alan A González-Rangel, Rosa E Navarro","doi":"10.1387/ijdb.200194rn","DOIUrl":"https://doi.org/10.1387/ijdb.200194rn","url":null,"abstract":"The pocket protein family controls several cellular functions such as cell cycle, differentiation, and apoptosis, among others. However, its role in stress has been poorly explored. The roundworm Caenorhabditis elegans is a simple model organism whose genes are highly conserved during evolution. C. elegans has only one pocket protein, LIN-35; a retinoblastoma protein (pRB)-related protein similar to p130. To control the expression of some of its targets, LIN-35 interacts with E2F-DP (E2 transcription factor/dimerization partner complex) transcription factors and LIN-52, a member of SynMUV (Synthetic Muv) complex. Together, these proteins form the DRM complex, which is also known as the DREAM complex in mammals. In this review, we will focus on the role of LIN-35 and its partners in the stress response. It has been shown that LIN-35 is required to control starvation in L1 and L4 larval stages, and to induce starvation-induced germ apoptosis. Remarkably, during L1 starvation, insulin/IGF-1 receptor signaling (IIS), as well as the pathogenic, toxin, and oxidative stress-responsive genes, are repressed by LIN-35. The lack of lin-35 also triggers a downregulation of oxidative stress genes. Recent works showed that lin-35 and hpl-2 mutant animals showed enhanced resistance to UPRER. Additionally, hpl-2 mutant animals also exhibited upregulation of autophagic genes, suggesting that SynMuv/DRM proteins participate in this process. Finally, lin-35(n745) mutant animals overexpressed hsp-6, a chaperone that participated in the UPRmt. All of these data demonstrate that LIN-35 and its partners play an important role during the stress response.","PeriodicalId":50329,"journal":{"name":"International Journal of Developmental Biology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38477962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cell fusion and fusogens - an interview with Benjamin Podbilewicz. 细胞融合和融合原——采访本杰明·波德比莱维奇。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2021-01-01 DOI: 10.1387/ijdb.200220jc

Jesús Chimal-Monroy, Diana Escalante-Alcalde

引用次数: 0

Lessons from the Organizer - an interview with Edward (Eddy) M. De Robertis. 从组织者那里得到的教训——采访爱德华(艾迪)M.德罗伯蒂斯。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2021-01-01 DOI: 10.1387/ijdb.190298cn

Christof Niehrs

引用次数: 0

Experiences with the marsupial frogs: reminiscences of a developmental biologist. 与有袋类青蛙的经历:一个发育生物学家的回忆。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2021-01-01 DOI: 10.1387/ijdb.190351ed

Eugenia M Del Pino

{"title":"Experiences with the marsupial frogs: reminiscences of a developmental biologist.","authors":"Eugenia M Del Pino","doi":"10.1387/ijdb.190351ed","DOIUrl":"https://doi.org/10.1387/ijdb.190351ed","url":null,"abstract":"This article provides a brief account of the career of Eugenia M. del Pino. Casual events and serendipity played important roles in modeling her career as a developmental biologist. In collaboration with colleagues and students, she analyzed the biology and development of the marsupial frog Gastrotheca riobambae (family: Hemiphractidae) in comparison with Xenopus laevis and tropical frogs. The emphasis was placed on oogenesis and the early stages of development. Topics include the mono- and multi-nucleated modes of oogenesis. She described two modes of gastrulation in frogs, gastrulation modes one and two, according to the timing of notochord elongation. She was able to establish a pioneer laboratory for the comparative analysis of frog development in Ibero America at the Pontifical Catholic University of Ecuador, in Quito. Her contributions to society include her influence in the establishment of the National Academy of Sciences of Ecuador, and efforts toward the conservation of the Galápagos Archipelago. She is part of a pioneer group of professors that placed Biology as an academic discipline in Ecuador. The experiences of her career reveal that we all face difficulties in our jobs. However, nothing is impossible when we follow a passion. Her work reveals that the key to success is to turn obstacles into opportunities.","PeriodicalId":50329,"journal":{"name":"International Journal of Developmental Biology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1387/ijdb.190351ed","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38277755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Latin American Society for Developmental Biology: a successful history. 拉丁美洲发育生物学学会:一个成功的历史。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2021-01-01 DOI: 10.1387/ijdb.200019mz

Pablo Wappner, Mario Zurita

{"title":"The Latin American Society for Developmental Biology: a successful history.","authors":"Pablo Wappner, Mario Zurita","doi":"10.1387/ijdb.200019mz","DOIUrl":"https://doi.org/10.1387/ijdb.200019mz","url":null,"abstract":"The Latin American Society for Developmental Biology (LASDB) is one of the newest societies in this field. However, despite being new, this society already had a highly important impact on the advancement of Developmental Biology across Latin America and globally. From its conception, the society began with the establishment of courses and congresses at the frontiers of knowledge and with the participation of researchers from Latin American countries and other regions, creating an academic and fraternal environment. The first LASDB congress was held in 2003, and recently, in 2019, the LASDB celebrated its tenth meeting, besides the Pan-American congress organized in 2007. Since the creation of this society and throughout its consolidation, the LASDB has been fortunate in receiving the support of highly prominent Developmental Biology societies, with which it has established links and collaboration that have clearly promoted Development Biology not only in Latin America but also in other parts of the world. At this moment, the LASDB looks to the future to continue supporting science in Latin America as it has done up to the present.","PeriodicalId":50329,"journal":{"name":"International Journal of Developmental Biology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1387/ijdb.200019mz","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38277756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inducing your neighbors to become like you: cell recruitment in developmental patterning and growth. 诱导你的邻居变得像你一样:发育模式和生长中的细胞招募。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2021-01-01 DOI: 10.1387/ijdb.200127mn

Luis M Muñoz-Nava, Marycruz Flores-Flores, Marcos Nahmad

引用次数: 3

Developmental Biology in Central America, the northern region of South America and the Caribbean. 中美洲、南美洲北部和加勒比地区的发育生物学。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2021-01-01 DOI: 10.1387/ijdb.200232jg

José E García-Arrarás

引用次数: 0

Unceasingly searching for answers - an interview with Claudio Stern. 不断寻找答案——对克劳迪奥·斯特恩的采访。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2021-01-01 DOI: 10.1387/ijdb.190368cs

Alejandro Sanchez Alvarado

引用次数: 0

Cell signaling molecules in hydra: insights into evolutionarily ancient functions of signaling pathways. 水螅中的细胞信号分子:对信号通路进化上古老功能的洞察。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2020-01-01 DOI: 10.1387/ijdb.190243sg

Surendra Ghaskadbi

{"title":"Cell signaling molecules in hydra: insights into evolutionarily ancient functions of signaling pathways.","authors":"Surendra Ghaskadbi","doi":"10.1387/ijdb.190243sg","DOIUrl":"https://doi.org/10.1387/ijdb.190243sg","url":null,"abstract":"Hydra, a Cnidarian believed to have been evolved about 60 million years ago, has been a favorite model for developmental biologists since Abraham Trembley introduced it in 1744. However, the modern renaissance in research on hydra was initiated by Alfred Gierer when he established a hydra laboratory at the Max Plank Institute in Göttingen in the late 1960s. Several signaling mechanisms that regulate development and pattern formation in vertebrates, including humans, have been found in hydra. These include Wnt, BMP, VEGF, FGF, Notch, and RTK signaling pathways. We have been using hydra to understand the evolution of cell signaling for the past several years. In this article, I will summarize the work on cell signaling pathways in hydra with emphasis on our own work. We have identified and characterized, for the first time, the hydra homologs of the BMP inhibitors Noggin and Gremlin, the vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and several receptor tyrosine kinases (RTKs). Our work, along with that of others, clearly demonstrates that these pathways arose early in evolution to carry out functions that were often quite different from their functions in more complex animals. Apart from providing insights into morphogenesis and pattern formation in adult, budding and regenerating hydra, these findings bring out the utility of hydra as a model system to study evolutionarily ancient, in contrast to recently acquired, functions of various biological molecules.","PeriodicalId":50329,"journal":{"name":"International Journal of Developmental Biology","volume":null,"pages":null},"PeriodicalIF":0.7,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1387/ijdb.190243sg","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38146882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Haltere development in D. melanogaster: implications for the evolution of appendage size, shape and function. 黑腹龙的哈尔特发育:对附属物大小、形状和功能进化的启示。

IF 0.7 4区生物学

International Journal of Developmental Biology Pub Date : 2020-01-01 DOI: 10.1387/ijdb.190133LS

Soumen Khan, C Dilsha, L S Shashidhara

引用次数: 1