International Journal of Fertility and Womens Medicine最新文献_第7页

The evolving role of proteomics in the early detection of breast cancer. 蛋白质组学在乳腺癌早期检测中的作用。

International Journal of Fertility and Womens Medicine Pub Date : 2005-09-01

Timothy M Pawlik, Henry M Kuerer

引用次数: 0

Current status of taxanes as adjuvant therapy for early-stage breast cancer. 紫杉烷类药物作为早期乳腺癌辅助治疗的现状。

International Journal of Fertility and Womens Medicine Pub Date : 2005-09-01

Antonio C Wolff

{"title":"Current status of taxanes as adjuvant therapy for early-stage breast cancer.","authors":"Antonio C Wolff","doi":"","DOIUrl":"","url":null,"abstract":"Several factors explain the significant improvement in outcome among patients diagnosed with breast cancer over the last 20 years. Chief among them are the greater adoption of screening strategies and an improved understanding of the benefit offered by adjuvant systemic therapy in reducing the risk of cancer recurrence and death. Predictive markers of response like the estrogen receptor (ER) and the human epidermal growth factor receptor 2 (HER2) help identify those most likely to derive a survival benefit from adjuvant therapy with anti-estrogens and trastuzumab therapy, respectively. However, despite the lack of robust predictive markers of clinical benefit, adjuvant systemic chemotherapy is an effective tool to improve the survival odds of breast cancer patients, especially those with ER-negative breast cancer. The Oxford Overview confirmed the incremental benefit offered by the use of anthracycline-containing regimens in the adjuvant setting. After being approved in the early 1990's for the treatment of advanced breast cancer, the taxanes gradually established themselves as useful drugs in the adjuvant setting. In this commentary, we review much of the current data that support the use of taxanes in early-stage breast cancer.","PeriodicalId":50324,"journal":{"name":"International Journal of Fertility and Womens Medicine","volume":"50 5 Pt 1","pages":"227-9"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25847099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential role of breast ductoscopy in breast cancer screening. 乳腺导管镜检查在乳腺癌筛查中的潜在作用。

International Journal of Fertility and Womens Medicine Pub Date : 2005-09-01

W Al Sarakbi, Pedro F Escobar, Kefah Mokbel

引用次数: 0

New approaches in breast cancer management: sentinel node biopsy and intraoperative radiotherapy. 乳腺癌治疗的新方法:前哨淋巴结活检和术中放疗。

International Journal of Fertility and Womens Medicine Pub Date : 2005-09-01

Mohammed R S Keshtgar, Dennis W Chicken, Jeffrey S Tobias

{"title":"New approaches in breast cancer management: sentinel node biopsy and intraoperative radiotherapy.","authors":"Mohammed R S Keshtgar, Dennis W Chicken, Jeffrey S Tobias","doi":"","DOIUrl":"","url":null,"abstract":"Breast cancer is presenting earlier, and treatment is becoming less invasive. We review two recent changes in the approach to management. Sentinel lymph node biopsy is a minimally invasive technique to identify the first draining lymph node in direct communication with the primary tumor; it enables \"selective lymphadenectomy.\" Axillary lymph node dissection is reserved as a therapeutic procedure only for proven node positive patients. The concept has been validated, the techniques have been optimized, and randomized controlled trials have confirmed lower morbidity without compromising regional control compared with conventional treatment. The procedure is considered by many as the standard of care for staging the axilla in early breast cancer, although several unanswered questions remain. Adequate training and experience in the technique are vital to ensure high sentinel node identification and low false negative rates. Intraoperative radiotherapy is an attractive concept that enables delivery of single fraction radiotherapy in the operating room immediately after resection of the primary tumor. It is convenient for patients and appears effective in pilot studies. Partial breast irradiation to the index quadrant has been practiced for many years in the form o brachytherapy. Trials are under way comparing intraoperative radiotherapy with conventional external bea irradiation. Intra-operative radiotherapy should not be used outside of clinical trials until the results of the current randomized trials are known.","PeriodicalId":50324,"journal":{"name":"International Journal of Fertility and Womens Medicine","volume":"50 5 Pt 1","pages":"218-26"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25847101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise for breast cancer survival: the effect on cancer risk and cancer-related fatigue (CRF). 乳腺癌生存的运动:对癌症风险和癌症相关疲劳(CRF)的影响。

International Journal of Fertility and Womens Medicine Pub Date : 2005-09-01

Jennifer A Hewitt, Kefah Mokbel, Ken A van Someren, Andrew P Jewell, Rachel Garrod

{"title":"Exercise for breast cancer survival: the effect on cancer risk and cancer-related fatigue (CRF).","authors":"Jennifer A Hewitt, Kefah Mokbel, Ken A van Someren, Andrew P Jewell, Rachel Garrod","doi":"","DOIUrl":"","url":null,"abstract":"To date, all epidemiological research in this area has focused on the relationship between physical activity level and the risk of breast cancer in healthy women, or more recently, those who have recovered from the disease. Most of this research highlights the fact that those women who are physically active are at a reduced risk of the disease. Although physical activity is similar to exercise, it lacks the specificity of a prescribed exercise training program. Consequently, such research can only be viewed as a promising indicator of the beneficial effect that regular exercise may have for breast cancer survivors. Furthermore, due to the nature of such research, there has been a failure to provide specific evidence concerning the most suitable modality, duration, intensity, and frequency of training for risk reduction in breast cancer survivors. Thus, evidence aiding the correct prescription of exercise for this population has been lacking. More promising evidence is provided by randomized controlled trials, which examine the effect of exercise on specific risk factors and provide convincing scientific rationale for the use of exercise among breast cancer survivors. These studies not only provide understanding of the physiological mechanisms by which exercise can be effective at aiding a reduction in breast cancer risk, but also allow conclusions on the correct prescription to be drawn. Additionally, exercise has proven to be effective in combating cancer-related fatigue (CRF), significantly improving both quality of life outcomes (QOL) and physiological capacity in women who have survived breast cancer. In order to promote a wider understanding of the beneficial effect that exercise holds for this population regarding reduction of breast cancer risk and CRF, this review discusses this research, making conclusions regarding the necessary training prescription to elicit such benefits.","PeriodicalId":50324,"journal":{"name":"International Journal of Fertility and Womens Medicine","volume":"50 5 Pt 1","pages":"231-9"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25847102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary: optimal adjuvant endocrine therapy of postmenopausal breast cancer. 评论:绝经后乳腺癌最佳辅助内分泌治疗。

International Journal of Fertility and Womens Medicine Pub Date : 2005-09-01

Giles Cunnick, Kefah Mokbel

引用次数: 0

The obstetric performance of United Kingdom asylum seekers from Somalia: a case-control study and literature review. 来自索马里的联合王国寻求庇护者的产科表现:病例对照研究和文献综述。

International Journal of Fertility and Womens Medicine Pub Date : 2005-07-01

W Yoong, S Kolhe, Mahantesh Karoshi, M Ullah, M Nauta

{"title":"The obstetric performance of United Kingdom asylum seekers from Somalia: a case-control study and literature review.","authors":"W Yoong, S Kolhe, Mahantesh Karoshi, M Ullah, M Nauta","doi":"","DOIUrl":"","url":null,"abstract":"Background: Little published research exists regarding obstetric performance of immigrant women in the United Kingdom. The aim of this study was to evaluate the obstetric performance and fetal outcomes of Somalian women who received prenatal care and requested to deliver at a teaching hospital in North London.Method: This is a case-control study in which consecutive Somalian women were identified as index cases and the subsequent British-born Caucasian women listed in the delivery book served as controls.Results: 69 index and 69 control cases were analyzed. Fifty-five percent of the Somalian women spoke little or no English. Half (50%) had undergone circumcision, the majority being type I WHO classification of female genital circumcision, which did not require significant surgical intervention prior to labor; 13% had cesarean sections, 13% instrumental vaginal deliveries, and 74% had vaginal deliveries. The Somalian women had higher parity (2.35 vs. 1.18) and were more likely to be grand multiparous (9/69 vs. 1/69) compared to controls. Epidural use was less frequent in Somalian women, but otherwise there were no significant differences between the two groups with regard to maternal age, rates of induction of labor, cesarean sections, duration of labor, premature deliveries, instrumental deliveries, and birth weights.Conclusions: The demographic characteristics of the Somalian female population appear to exert minimal effect on obstetric and fetal outcomes. This may be due to the increased vigilance exercised by health professionals as well as to the fact that recent arrivals are from more urban and westernized areas in Somalia.","PeriodicalId":50324,"journal":{"name":"International Journal of Fertility and Womens Medicine","volume":"50 4","pages":"175-9"},"PeriodicalIF":0.0,"publicationDate":"2005-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25793780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychological implications of high-risk pregnancy. 高危妊娠的心理影响。

International Journal of Fertility and Womens Medicine Pub Date : 2005-07-01

Carla-Joy Cumberbatch, Catherine Birndorf, Nehama Dresner

引用次数: 0

Technical description of the B-Lynch brace suture for treatment of massive postpartum hemorrhage and review of published cases. B-Lynch支具缝合治疗产后大出血的技术描述及已发表病例回顾。

International Journal of Fertility and Womens Medicine Pub Date : 2005-07-01

Natalia Price, Christopher B-Lynch

{"title":"Technical description of the B-Lynch brace suture for treatment of massive postpartum hemorrhage and review of published cases.","authors":"Natalia Price, Christopher B-Lynch","doi":"","DOIUrl":"","url":null,"abstract":"Massive uncontrolled hemorrhage after childbirth is a leading cause of the pregnancy-related death and resulting morbidity. Uterine atony is the most common cause (75-90%) of primary postpartum hemorrhage. When simple massage of the uterus and uterotonics such as oxytocins, syntometrine and prostaglandins failed to manage this condition, various surgical solutions have been sought, including uterine artery ligation, more complicated stepwise devascularization of the uterus, internal iliac artery ligation and, ultimately, hysterectomy. All these procedures require above average surgical skill. In contrast, the B-Lynch suturing technique (brace suture) is particularly useful because of its simplicity of application, life saving potential, relative safety and capacity for preserving the uterus and subsequent fertility. The adequacy of haemostasis can be assessed both before and immediately after application of the suture. Only if it fails need other more radical surgical methods be considered. The special advantage of this innovative technique is that it presents an alternative to major surgical procedures for controlling pelvic arterial pulse pressure or hysterectomy. To date, this suturing technique, when applied correctly, has been successful with no problems and no apparent complications. This review provides an update on the B-Lynch brace suturing technique, including choice of suture material, use of the technique in early and late gestation, and comparison with other uterine compression surgical techniques. It also includes a comprehensive review and analysis of all published cases and their postoperative follow-up.","PeriodicalId":50324,"journal":{"name":"International Journal of Fertility and Womens Medicine","volume":"50 4","pages":"148-63"},"PeriodicalIF":0.0,"publicationDate":"2005-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25793778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complete failed fertilization after intracytoplasmic sperm injection--analysis of 10 years' data. 卵胞浆内单精子注射后完全受精失败——10年数据分析。

International Journal of Fertility and Womens Medicine Pub Date : 2005-07-01

Navid Esfandiari, Murid H Javed, Lynda Gotlieb, Robert F Casper

{"title":"Complete failed fertilization after intracytoplasmic sperm injection--analysis of 10 years' data.","authors":"Navid Esfandiari, Murid H Javed, Lynda Gotlieb, Robert F Casper","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To investigate incidence and causes of complete failed fertilization after intracytoplasmic sperm injection (ICSI) in a tertiary care facility.Methods: A total of 1,779 cycles between February 1994 and December 2003 were analyzed. Study parameters were female age, infertility diagnosis, ovarian stimulation protocol, estradiol level on day of hCG administration, number of follicles, number of oocytes retrieved, number of oocytes injected, and semen parameters.Results: Complete failed fertilization occurred in 23 cycles (1.29%) involving a total of 85 oocytes injected. Infertility causes among patients with failed fertilization included unexplained (43.6%), male factor (26%), presence of more than one factor (17.4%), hysterectomy (4.4%), premature ovarian failure (4.3%), and advanced age (4.3%). In 12 cycles (52%), fewer than 5 follicles were present. In three (13%) cycles, no mature (MII) oocyte was available and in 61% (14/23) fewer than 3 MII oocytes were available for ICSI. Immotile sperm was used for ICSI in 5 cycles (21.7%). The source of sperm in 17 (74%) cycles was from ejaculate, in 4 cycles from testicular aspiration (TESA), one from percutaneous epididymal sperm aspiration (PESA) and one from retrograde ejaculation.Conclusions: Our data indicate that major contributing factors to failed fertilization after intracytoplasmic sperm injection are number of MII oocytes retrieved and availability of viable sperm for injection. Although the incidence of complete failed fertilization is not remarkable, it may increase with increasing patient age and a lower number of follicles.","PeriodicalId":50324,"journal":{"name":"International Journal of Fertility and Womens Medicine","volume":"50 4","pages":"187-92"},"PeriodicalIF":0.0,"publicationDate":"2005-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25793781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0