International Journal of Medical Robotics and Computer Assisted Surgery最新文献

{"title":"Triphenyl Phosphate Exposure Is Associated With BRG1-Related Cellular and Metabolic Readouts and EREG–EGFR/ERK Signalling in Glioma Cells","authors":"Heng Zhao,&nbsp;Jiwei Wu,&nbsp;Jia Wei,&nbsp;Fangqing Chen","doi":"10.1002/rcs.70242","DOIUrl":"10.1002/rcs.70242","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Triphenyl phosphate (TPP), a ubiquitous organophosphate flame retardant and plasticiser, has emerged as a pervasive environmental contaminant with suspected endocrine-disrupting properties.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this study, we employed an integrated approach combining epigenetic CRISPR-Cas9 knockout screening, spatial transcriptomics, and metabolic flux analysis to explore the response of glioma cells to in vitro exposure to a nominal TPP concentration of 11 μM. Targeted cellular, biochemical, promoter-occupancy and signalling assays were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>TPP exposure was associated with changes in several cellular readouts in glioma cells, including a higher CCK-8 signal, differences in MMP secretion, Rac1 activity and matrix adhesion and differences in glucose, lactate and mitochondrial-respiration readouts. TPP exposure was also associated with increased BRG1 occupancy at the assayed epidermal growth factor receptor (EGFR) promoter region, together with higher EGFR- and epiregulin (EREG)-related readouts. This pattern is consistent with a candidate EREG–EGFR/MAPK–ERK pathway association but does not prove a self-sustaining loop or direct chemical recruitment. Spatial transcriptomic analysis described regional heterogeneity in mitochondrial-gene expression within public glioblastoma tissue.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our findings support a candidate BRG1-associated cellular framework in which nominal TPP exposure is associated with BRG1-related chromatin and EGFR/metabolic readouts in glioma cells.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50311,"journal":{"name":"International Journal of Medical Robotics and Computer Assisted Surgery","volume":"22 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Single-Site Plus One-Port Robotic Distal Pancreatectomy Using the da Vinci SP in Comparison With the Conventional Xi Platforms: A Multicenter Experience","authors":"Yoo Jin Choi,&nbsp;Sung Hyun Kim,&nbsp;Young-Dong Yu,&nbsp;Chang Moo Kang","doi":"10.1002/rcs.70245","DOIUrl":"10.1002/rcs.70245","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Ongoing efforts in minimally invasive surgery aim to reduce access sites. This study evaluated the feasibility of the da Vinci SP platform for single-site plus one-port robotic distal pancreatectomy (SSRDP) by comparing perioperative outcomes with a previously reported Xi-based approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients who underwent SSRDP using the SP or Xi at two tertiary centres from February 2015 to September 2023 were retrospectively reviewed. Each centre exclusively used one platform.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-two patients underwent SSRDP (SP, <i>n</i> = 20; Xi, <i>n</i> = 12). The SP group had higher age, body mass index, and ASA scores. Operative time was shorter in the SP group, whereas blood loss, spleen preservation, conversion, postoperative pancreatic fistula, and overall complications were comparable.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In this early multicenter experience, SSRDP using the SP platform was feasible and achieved acceptable perioperative outcomes comparable to those of Xi-SSRDP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50311,"journal":{"name":"International Journal of Medical Robotics and Computer Assisted Surgery","volume":"22 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Less is More: Robotic Kidney Transplantation in Polycystic Kidney Disease Without Preemptive or Simultaneous Native Nephrectomy","authors":"Haaris Kadri,&nbsp;Ryan Dang,&nbsp;Rossana Maffei,&nbsp;Dor Yoeli,&nbsp;Keith Hansen,&nbsp;Shannon Lyons,&nbsp;Sixto Giusti,&nbsp;Terri Montague,&nbsp;James Cooper,&nbsp;Rashikh Choudhury,&nbsp;Megan Adams,&nbsp;Kendra Conzen,&nbsp;Thomas Bak,&nbsp;Kristin Mekeel,&nbsp;Jesse D. Schold,&nbsp;Trevor Nydam,&nbsp;Peter Kennealey,&nbsp;Thomas Pshak,&nbsp;Phillipe Abreu","doi":"10.1002/rcs.70244","DOIUrl":"10.1002/rcs.70244","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Autosomal dominant polycystic kidney disease (ADPKD) often prompts pre-transplantation or simultaneous native nephrectomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We reviewed adult patients with ADPKD who underwent RKT without native nephrectomy at one transplant centre. Native kidney volume (NKV) and estimated abdominopelvic cavity volume (EACV) were estimated using ellipsoid approximations from cross-sectional imaging, and a Spatial Occupancy Ratio (SOR = combined NKV/EACV) was derived to quantify anatomical crowding.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixteen patients underwent RKT for ADPKD without preemptive native nephrectomy, with a median SOR of 24.7%. Median warm ischaemia and operative times were 37 and 267 minutes, respectively, with an estimated blood loss of 50 mL. Increasing SOR demonstrated a moderate but significant inverse correlation with graft volume (<i>r</i> = −0.52, <i>p</i> = 0.038) and a weak positive correlation with operative time (<i>r</i> = 0.07, <i>p</i> = 0.80).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>RKT without native nephrectomy appears feasible across a broad spectrum of anatomical abdominopelvic occupancy, supporting a selective rather than routine approach to nephrectomy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50311,"journal":{"name":"International Journal of Medical Robotics and Computer Assisted Surgery","volume":"22 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AutoPlan: Autonomous Surgical Planning Framework for Neurosurgery Interventions With Steerable Needles","authors":"Pranali Ingole,&nbsp;Niravkumar Patel","doi":"10.1002/rcs.70239","DOIUrl":"10.1002/rcs.70239","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Accurate path planning for minimally invasive neurosurgery is necessary to navigate complex anatomy that contains critical structures, such as blood vessels, ventricles and white-matter tracts. Planning with nonholonomic kinematics is difficult, and typical planners fail to generate kinematically feasible paths.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>AutoPlan is a deep reinforcement learning (DRL) framework that generates a needle trajectory on a magnetic resonance imaging (MRI) patient dataset. AutoPlan implements kinematic control strategies, variable curvature with fixed insertion (VCFI) and variable insertion with fixed curvature (VIFC), with random and selective start-point initialisation. Path planning was performed on 55 volumes using PPO, SAC, DDPG and RRT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PPO (VIFC, selective start): 90.9% success, path length 45.96 <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>±</mo>\u0000 </mrow>\u0000 <annotation> $pm $</annotation>\u0000 </semantics></math> 14.76 mm, computation time 0.02 <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>±</mo>\u0000 </mrow>\u0000 <annotation> $pm $</annotation>\u0000 </semantics></math> 0.02 s. RRT: 65.5% success, path length 102.07 <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>±</mo>\u0000 </mrow>\u0000 <annotation> $pm $</annotation>\u0000 </semantics></math> 126.15 mm, computation time 9.72 <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <mo>±</mo>\u0000 </mrow>\u0000 <annotation> $pm $</annotation>\u0000 </semantics></math> 20.29 s.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>AutoPlan provides consistent planning while avoiding critical structures, resulting in fast, kinematically safe trajectories.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50311,"journal":{"name":"International Journal of Medical Robotics and Computer Assisted Surgery","volume":"22 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic Beyond Total Mesorectal Excision With Synchronous Perineal Flap Reconstruction: Feasibility and Early Outcomes","authors":"Ahlam H. Alharbi,&nbsp;Muhammad R. Iqbal,&nbsp;Dolly M. Dowsett,&nbsp;Eleanor J. M. Rudge,&nbsp;Hassan I. Shah,&nbsp;Sandeep Kapur,&nbsp;Richard M. Haywood,&nbsp;Anais Rosich-Medina,&nbsp;Irshad A. Shaikh","doi":"10.1002/rcs.70223","DOIUrl":"10.1002/rcs.70223","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Advanced rectal and anal malignancies often require dissections beyond total mesorectal planes for improved oncological outcomes. While minimally invasive techniques facilitate this approach, they result in larger perineal defects, creating reconstructive challenges. Robotic-assisted surgery enhances precision, visualisation, and ergonomics, potentially optimising outcomes. However, data on robotics beyond total mesorectal excision (bTME) remain limited. This study evaluated robotic bTME and synchronous gracilis or PAP (profunda artery perforator) flap reconstruction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective case series reviewed 10 patients with locally advanced or recurrent anorectal cancer who underwent elective robotic bTME with synchronous perineal gracilis or PAP flap reconstruction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Median operative time was 465 minutes. Gracilis flap harvest was concurrent. No major flap-related complications or reoperations. R0 resection was achieved in 80%. At 1-year, local recurrence was 0%, distant metastases 30%, and disease-free survival 70%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Robotics bTME with synchronous gracilis or PAP flap reconstruction is feasible, efficient, and oncologically safe.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50311,"journal":{"name":"International Journal of Medical Robotics and Computer Assisted Surgery","volume":"22 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Configurable Real2Sim Bimanual Teleoperation Framework for Surgical Robotic Tool Design and Evaluation","authors":"Teng Li,&nbsp;Sunny Zhang,&nbsp;Cate Balasubramanian,&nbsp;Thomas Looi,&nbsp;Dale J. Podolsky","doi":"10.1002/rcs.70235","DOIUrl":"10.1002/rcs.70235","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>During surgical robotic tool development, teleoperation can provide a valuable means of evaluating tool performance and informing iterative design improvements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We propose a compact framework for establishing real2sim bimanual teleoperation systems. Using this framework, an Omni-to-Unity system was established to enable bimanual teleoperation of simulated robotic tools using two portable haptic devices. A dVRK-to-Unity system was also implemented to evaluate the framework with a different leader robot. An application scenario was presented to illustrate its use in robotic tool design.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Both systems were integrated with simulated surgical tasks and operated without observed system failures during the reported experiments. The experiments showed the applicability of the framework to different leader robots and simulated robotic tools with different kinematic configurations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The proposed framework provides a compact approach to establishing bimanual real2sim teleoperation systems and facilitates the evaluation of different robotic tool designs through simulated surgical tasks.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50311,"journal":{"name":"International Journal of Medical Robotics and Computer Assisted Surgery","volume":"22 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/rcs.70235","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Robotic Surgery: Engineering Considerations and Future Directions From Surgeons' Perspectives","authors":"Noah Shaikh,&nbsp;Walter Fitschen,&nbsp;Abhinaba Bhattacharjee,&nbsp;Dimitrios Stefanidis,&nbsp;Michael W. Sim,&nbsp;Meghan T. Turner,&nbsp;Sohel Anwar,&nbsp;Muhammad Ashraful Alam","doi":"10.1002/rcs.70238","DOIUrl":"10.1002/rcs.70238","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Since its initial inception, robotic-assisted minimally invasive surgery (RAMIS) is continually being applied to a wider array of procedures. However, there are significant limitations in current surgical subsystems, including a large learning curve, lack of effective haptic feedback, decreased surgical intuition, and decreased dexterity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A narrative review of the literature was conducted to provide an overview of key developments in the field. Relevant articles were identified through searches of PubMed, IEEE, Google Scholar, and EMBASE, along with manual screening of references.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A selection of representative articles covering topics including teleoperation, kinematics, dynamics, and haptic feedback is discussed to highlight major themes and recent advances.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Despite recent advances, limitations to operator experience remain. Numerous strategies and approaches are currently being proposed and explored to further advance surgical subsystems, improving dexterity, haptic feedback, movement time delay, and learning curve.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50311,"journal":{"name":"International Journal of Medical Robotics and Computer Assisted Surgery","volume":"22 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13640045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Exploratory Immune-Associated Prognostic Signature and AREG-Associated Phenotypes in Oral Squamous Cell Carcinoma","authors":"Shiling Dong,&nbsp;Jingjing Cheng,&nbsp;Shuanfeng Xing,&nbsp;Guangwen Yang","doi":"10.1002/rcs.70237","DOIUrl":"10.1002/rcs.70237","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Oral squamous cell carcinoma (OSCC) remains a clinically heterogeneous malignancy with unsatisfactory long-term outcomes, particularly in patients with advanced disease and treatment resistance. Conventional clinicopathologic parameters incompletely capture the biological diversity of OSCC and provide limited guidance for individualised therapeutic stratification.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed an integrated transcriptomic analysis of TCGA-derived OSCC data to construct and evaluate an immune-associated prognostic signature. Associations with survival, clinicopathologic features, immune infiltration, somatic mutation profiles and pathway-level biological programs were assessed. The manuscript-specified ten-gene equation was additionally evaluated without refitting in an independent CPTAC oral-cavity SCC cohort using overall survival, Harrell's C-index and time-dependent ROC analysis. Amphiregulin (AREG) was selected for functional investigation using siRNA-mediated knockdown, proliferation assays, cisplatin sensitivity testing, IC50 estimation and apoptosis analysis in OSCC cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The original TCGA analysis separated survival groups and reported 1-, 3- and 5-year AUCs of 0.701, 0.693 and 0.623. In 42 independent CPTAC patients with 14 deaths, however, the fixed score was not significantly associated with overall survival (HR per SD, 1.181; 95% CI, 0.674–2.069; <i>p</i> = 0.561). The C-index was 0.521, and the 1- and 3-year AUCs were 0.369 and 0.550; 5-year evaluation was unsupported by follow-up. The supplied AREG experiments suggested reduced proliferation and increased cisplatin sensitivity after knockdown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study identifies an exploratory immune-associated score and AREG-associated cellular phenotypes in OSCC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50311,"journal":{"name":"International Journal of Medical Robotics and Computer Assisted Surgery","volume":"22 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Robotic-Assisted Versus Conventional Total Knee Arthroplasty: A Systematic Review and Meta-Analysis","authors":"Abdulazeez Omairi,&nbsp;Ryan Kenny,&nbsp;Oday Al-Dadah","doi":"10.1002/rcs.70228","DOIUrl":"10.1002/rcs.70228","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Robotic-assisted total knee arthroplasty (RTKA) is an emerging alternative to conventional total knee arthroplasty (CTKA) with uncertain effectiveness. This systematic and meta-analysis aims to compare clinical and radiological outcomes between RTKA and CTKA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>52 studies were included (randomised controlled trials and observational cohorts). Outcomes compared were alignment (Hip-Knee-Ankle angle, femoral/tibial component angles), Patient Reported Outcome Measures (PROMs), operative time, length of stay (LOS), blood loss, and complications. Data were pooled using random-effect models, with heterogeneity assessed via <i>I</i>² statistics using R.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>RTKA demonstrated superior accuracy in component alignment, and most PROMs showed minimal differences. Operative time was longer for RTKA, but hospital LOS was shorter. RTKA had lower blood loss. Inflammatory markers and revision rates showed few inconsistent findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>RTKA improves mechanical alignment and reduces outliers, with modest short-term advantages in PROMs and recovery metrics. Long-term clinical benefits necessitate further high-quality studies with standardised outcome measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>This Systematic Review and Meta-Analysis was registered on PROSPERO (ID number: CRD42023410154)</p>\u0000 </section>\u0000 </div>","PeriodicalId":50311,"journal":{"name":"International Journal of Medical Robotics and Computer Assisted Surgery","volume":"22 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149027064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender-Specific Cancer-Related Survival Analysis of Robotic Versus Laparoscopic Low Anterior Resection for Rectal Adenocarcinoma: A Multicenter Study","authors":"Cigdem Benlice,&nbsp;Nur Ramoglu,&nbsp;Ismaıl Ahmet Bilgin,&nbsp;Ayse Gulsah Kaya,&nbsp;Metincan Erkaya,&nbsp;Burak Kutlu,&nbsp;Mehmet Ayhan Kuzu,&nbsp;Bilgi Baca,&nbsp;Ismaıl Hamzaoglu,&nbsp;Tayfun Karahasanoglu","doi":"10.1002/rcs.70234","DOIUrl":"10.1002/rcs.70234","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study compared short- and long-term outcomes of robotic and laparoscopic low anterior resection (LAR) for rectal adenocarcinoma using sex-stratified analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients who underwent elective robotic or laparoscopic LAR for rectal cancer were included. Prospectively maintained database of outcomes was analysed retrospectively. To minimise selection bias, groups were matched.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 409 identified patients, 380 met the eligibility criteria (mean age: 61 years, BMI: 26.2 kg/m²). In a matched cohort of males (<i>n</i> = 172) and females (<i>n</i> = 114), robotic surgery was associated with significantly shorter hospital stay (<i>p</i> &lt; 0.01). Harvested lymph nodes, margins, morbidity and local recurrence were comparable in males (<i>p</i> &gt; 0.05). Robotic surgery in females was associated with fewer harvested lymph nodes (<i>p</i> = 0.01). Five-year disease-specific survival rates did not significantly differ between approaches in either gender.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Robotics and laparoscopic LAR achieved similar oncologic outcomes. The findings should be interpreted as sex-stratified comparisons rather than evidence of differential effect of surgical approach according to sex.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50311,"journal":{"name":"International Journal of Medical Robotics and Computer Assisted Surgery","volume":"22 5","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}