IP Journal of Diagnostic Pathology and Oncology最新文献_第2页

Cutaneous metastasis masquerading an internal malignancy, hilar cholangiocarcinoma – A case report and review of literature 伪装成内部恶性肿瘤的皮肤转移瘤--肝门部胆管癌--病例报告和文献综述

IP Journal of Diagnostic Pathology and Oncology Pub Date : 2024-01-15 DOI: 10.18231/j.jdpo.2024.012

Radhika S, Ilavendiran S, Narendhran Rt, Kavita Vijayakumar, Anand Selva Kumar

{"title":"Cutaneous metastasis masquerading an internal malignancy, hilar cholangiocarcinoma – A case report and review of literature","authors":"Radhika S, Ilavendiran S, Narendhran Rt, Kavita Vijayakumar, Anand Selva Kumar","doi":"10.18231/j.jdpo.2024.012","DOIUrl":"https://doi.org/10.18231/j.jdpo.2024.012","url":null,"abstract":"Cutaneous metastases can be a masquerade of an internal malignancy and is rare accounting for 0.7-0.9% of cancer patients. Cutaneous metastasis of adenocarcinoma histologic subtype indicates widespread disease and poor prognosis. Herein, we report an exceedingly rare case of cutaneous metastasis, possibly of pancreaticobiliary origin and review of literature on cutaneous metastasis. A 48-year-old woman presented with massive ascites since 4 months. Multiple asymptomatic skin nodules were noted. PET- CT showed extensive ill defined skeletal metastasis and low grade metabolically active ill-defined lesions in the bilateral adnexal region – suspicious for metastatic deposits. Upper gastrointestinal tract (GI) endoscopy and colonoscopy did not reveal any specific lesion. Biopsy from the nodule in the left forearm showed cords, a few vague acinar structures and singly lying cells including a few signet ring cells consistent with poorly differentiated adenocarcinoma with few signet ring cell features. On Immunostaining, the neoplastic cells showed diffuse membranous positivity for Cytokeratin (CK), Cytokeratin 7 (CK 7), CK19 , CDX-2 and negative for TTF-1, CK20, PAX 8 and WT-1. This immunohistochemical profile favours an adenocarcinoma possibly of pancreaticobiliary origin. MR Cholangiopancreaticogram showed ill-defined T2 hypointense diffusion restriction at perihilar region involving the confluence, cystic duct and common hepatic ducts – likely neoplastic etiology (Hilar cholangiocarcinoma – Bismuth – Corlette type II). Palliative chemotherapy and radiotherapy was initiated and the patient is on follow-up. This case emphasis that there should be a strong suspicion of cutaneous metastases in case of any skin nodule with non pinchability of skin especially in old age as it could be the initial presentation of an underlying malignancy and it requires a multidisciplinary approach.\u0000 \u0000","PeriodicalId":503065,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malignant mural nodule in ovarian mucinous neoplasms - Needle in a haystack 卵巢黏液性肿瘤中的恶性壁结节--大海捞针

IP Journal of Diagnostic Pathology and Oncology Pub Date : 2024-01-15 DOI: 10.18231/j.jdpo.2024.015

Sivaranjani Selvaraj, U. Amirtham

{"title":"Malignant mural nodule in ovarian mucinous neoplasms - Needle in a haystack","authors":"Sivaranjani Selvaraj, U. Amirtham","doi":"10.18231/j.jdpo.2024.015","DOIUrl":"https://doi.org/10.18231/j.jdpo.2024.015","url":null,"abstract":"Ovarian mucinous tumors with mural nodules are very rare surface epithelial-stromal tumors. The mural nodules are divergent neoplasms that may be benign or malignant. The latter may be in the form of a sarcoma, carcinosarcoma, anaplastic carcinoma, or a variety of other recognized histotypes of carcinoma. They represent the part of the tumor which is undergoing divergent differentiation or collision tumors. Here, we report two such cases to discuss the histo-morphological and immunohistochemical features with prognosis. Case 1 is a 15-year-old female presented with right sided abdominal mass for 4 months. She underwent right salphingo-oophorectomy. On histopathological examination -borderline mucinous neoplasm of ovary with a mural nodule showing rhabdoid differentiation. On immunohistochemistry – malignant mural nodule confirmed to be an anaplastic carcinoma, rhabdoid type. Case 2 is a 16-year-old female presented with abdominal mass associated with pain for the past 1 year. She underwent a left salphingo- oophorectomy with left groin node debulking and abdominal wall deposits excision. On histopathological examination – mucinous carcinoma of ovary with a malignant mural nodule showing morphological features of carcinosarcoma. On immunohistochemistry – malignant mural nodule confirmed to be a sarcoma-like mural nodule, pleomorphic and spindle cell type. A malignant mural nodule can be associated with poor prognosis regardless of the benignity of the associated mucinous tumor. Hence, careful and meticulous examination of this rare lesion within a mucinous cystic tumor supplemented by immunohistochemistry aids in the sometimes, difficult differential diagnosis among these types of mural nodules.","PeriodicalId":503065,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":"24 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging salivary biomarkers for squamous cell carcinoma in the oral cavity: A brief overview 新出现的口腔鳞状细胞癌唾液生物标志物：简要概述

IP Journal of Diagnostic Pathology and Oncology Pub Date : 2024-01-15 DOI: 10.18231/j.jdpo.2024.016

Tejashwini Kotian, Ravi Gupta

引用次数: 0

Correlation of RBC indices and RBC histogram obtained by automated hematology analyser with peripheral smear in the diagnosis of anemia 自动血液分析仪获得的红细胞指数和红细胞直方图与外周涂片在贫血诊断中的相关性

IP Journal of Diagnostic Pathology and Oncology Pub Date : 2024-01-15 DOI: 10.18231/j.jdpo.2024.010

Rose Maria Thomas, Sateesh Chavan S

{"title":"Correlation of RBC indices and RBC histogram obtained by automated hematology analyser with peripheral smear in the diagnosis of anemia","authors":"Rose Maria Thomas, Sateesh Chavan S","doi":"10.18231/j.jdpo.2024.010","DOIUrl":"https://doi.org/10.18231/j.jdpo.2024.010","url":null,"abstract":": The impact of early diagnosis and management of anemia on patient outcome has been tremendous. Although conventional microscopic examination of blood using peripheral smear is unequivocal, the advent of automated hematology analyzer has revolutionized the field of clinical hematology and its practice. This study highlights the efficiency and utility of specific parameters obtained by hematology analyzer and its comparison with peripheral smear in the diagnosis of anemia, also determines the sensitivity of the same.: 501 Ethylenediamine tetra acetic acid blood samples collected at a tertiary care teaching hospital in Karnataka during one and half years from February 2021 to August 2022, were run on the Sysmex 6-part automated hematology analyzer and simultaneous peripheral smears were prepared and stained using Leishman stain based on standard operating procedures. The histogram and peripheral smear findings were noted.: Among the 501 cases, there were 269(53.7%) cases of Normocytic Normochromic Anemia in which 82.9% showed normal curve, 145(28.9%) cases of Microcytic Hypochromic Anemia in which 92.4% showed shift to left, 31(6.2%) cases of Dimorphic Anemia in which 61.3% showed normal curve contrary to the expected double peak, 24(4.8%) cases of Macrocytic Anemia in which 83.3% showed shift to right, 23(4.6%) cases of Pancytopenia in which 39.1% showed normal curve and 9 cases of Normocytic Hypochromic Anemia. : The Automated hematology Analyzer provides highly valuable information with limited sample and is an essential tool in diagnosis, classification and management of anemia.","PeriodicalId":503065,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":"89 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coexisting lactating adenoma and invasive breast carcinoma: A case report and review of literature 泌乳腺瘤与浸润性乳腺癌并存：病例报告与文献综述

IP Journal of Diagnostic Pathology and Oncology Pub Date : 2024-01-15 DOI: 10.18231/j.jdpo.2024.014

Muneerah Saeed, Marya Saeed, Sadaf Abbas, Yousuf Siddiqui, Vishal Teja

引用次数: 0

Isolated tuberculous osteomyelitis of mandibular condyle: A rare presentation unmasked by domestic violence 下颌骨髁突孤立性结核性骨髓炎：家庭暴力掩盖下的罕见病例

IP Journal of Diagnostic Pathology and Oncology Pub Date : 2024-01-15 DOI: 10.18231/j.jdpo.2024.013

Ankita Mehta, Anandita Dalal, Saloni Mahajan, Sunil Arora, Rajeev Sen

引用次数: 0