IP Journal of Diagnostic Pathology and Oncology最新文献

{"title":"Neo adjuvant chemotherapy in locally advanced oral cancers -A prospective study at a tertiary cancer care hospital","authors":"D. Shunmugam, SS Sundaram, Arumugam Velappar, A. Gandhi, MJ Murali Kannan, Ganesh Babu V, Karthik Manohar","doi":"10.18231/j.jdpo.2024.006","DOIUrl":"https://doi.org/10.18231/j.jdpo.2024.006","url":null,"abstract":"Oral squamous cell carcinoma (OSCC) is the most prevalent type of cancer found in the oral cavity. Approximately 30% of these tumours are detected at an early stage, while the majority are diagnosed as locally advanced tumours. Extensive research has been conducted on neoadjuvant chemotherapy (NACT) in head and neck cancers, aiming to reduce surgical margins, decrease distant metastasis rates, and improve overall outcomes. In this prospective study conducted at the Department of surgical oncology, Tirunelveli Medical College, 60 patients with unresectable locally advanced oral cancers were staged based on the AJCC TNM (8th edition). The period of study was from October 2018 to March 2023. Here the selected patients are examined both clinically and radiologically, measurements of the target lesions are made. These patients are subjected to neoadjuvant chemotherapy (TPF regimen) upto three cycles based on the clinical response after each cycle. reassessment done prior to surgery as done during the prechemotherapy. Adjuvant therapy post-surgery is based on the histopathology. Among the 60 patients enrolled in this study, 33 of 60 (55.0 %) were males and 27 of 60 (45%) were females. Based on age distribution 8.3% of patients were less the 40 years of age, 41.7% were between 51 to 60 years. The common risk factors were tobacco / pan chewing in 66.7% of patients, smoking in 40% of patients and alcoholism in 38.3% of patients. All the 60 patients received TPF regimen as a neo-adjuvant chemotherapy for two or three cycles and the clinical responses were recorded after NACT prior to definitive therapy (surgery vs RT. The mean and median of survival was calculated in 33 patients who had completed treatment by 2021 in view of the follow up period of at least for 24 months were mandatory to analyse the treatment outcome and disease free survival. The overall survival in surgery group was 35.1 months and RT group was 21.8 months. The disease free survival in surgery group was 28 months whereas in RT group was 16 months.Patients who have oral cavity cancers that cannot be surgically amenable up-front may experience a response rate of approximately 25% when treated with an aggressive three-drug regimen (TPF) and these patients may derive benefits from subsequent surgical treatment.","PeriodicalId":503065,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":"19 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical analysis of cdx2 and its correlation with histopathological parameters of gastric enteric and colorectal epithelial malignancies","authors":"Roopashree G, P. Kumar M, Vani D, Nataraju G","doi":"10.18231/j.jdpo.2024.003","DOIUrl":"https://doi.org/10.18231/j.jdpo.2024.003","url":null,"abstract":":Gastrointestinal tract cancers have become the leading causes of death worldwide. In India, the incidence of gastrointestinal carcinomas is increasing due to urbanization, change in food habits and life style. According to National Cancer Registry, gastro-intestinal carcinomas are more common in men than women and more commonly seen in elderly age group. CDX2 is a caudal type Homeo-box gene, encoding a transcription factor that plays an important role in differentiation, proliferation, cell adhesion and migration. CDX2 is often deregulated in cancer and might have oncogenic and tumour suppressor potential.1) To know the expression of CDX2 in gastric, enteric and colo-rectal epithelial. malignancies. 2) To observe and analyse the staining pattern in various grades and stages of tumour.The resected specimens of gastric, enteric and colo-rectal carcinomas were collected from the Department of Pathology, Mysore Medical College and Research Institute, during the year December 2019 to May 2021. Standard protocol for grossing and histopathological techniques were followed by immunohistochemical staining with CDX2 antibody. Expression of CDX2 marker and its staining pattern in various grades and stages of tumour were recorded and compared with patient’s clinicopathological parameters.A total of 67 cases of Gastrointestinal carcinomas were taken for the study. Positive CDX2 expression was seen in 58 out of 67 cases but the intensity of expression varied. There was significant statistical correlation between the CDX2 expression and histopathological grade (p value <0.05).The present study showed consistent expression of CDX2 in gastrointestinal carcinomas. The CDX2 expression decreased with increase in grade of the carcinoma.Therefore, CDX2 can be used as one of the prognostic indicators in intestinal variants gastrointestinal carcinoma.","PeriodicalId":503065,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":"32 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient’s satisfaction and service quality of clinical laboratory: A questionnaire based analysis in accredited tertiary care government hospital","authors":"Swati Raj, Unnati Nath, Natasha Gulati, Madhu Sinha, Abhijit Das","doi":"10.18231/j.jdpo.2024.005","DOIUrl":"https://doi.org/10.18231/j.jdpo.2024.005","url":null,"abstract":"The Phlebotomy is the first phase of interaction of the patient to the laboratory. It is therefore considered as an important step of good clinical laboratory practice and is referred to as \"pre-analytic phase”. Patient’s satisfaction is one of the key quality indicators in the laboratory. : To assess the patient's satisfaction , to investigate, monitor, and analyse the non-conformities in order to remove the root cause by performing corrective and preventive action in order to improve the quality of laboratory services.: A cross-sectional study conducted in a NABH/NABL accredited government super-speciality hospital on 1500 patients over a period of three months. Data were collected in a self administered predesigned, pretested, structured questionaired feedback form in both Hindi and English, further reviewed by Senior Pathologist in a quality assurance meet and CAPA.A statistical analysis performed by using SPSS version 16.0 software and Likert Scale.Overall patient satisfaction with phlebotomy services found to be high, i.e 88%. Highest mean rating of satisfaction was 99.2% for parameter -Whether the seats during phlebotomy was comfortable. The parameter for washroom facility accounted for 75 % dissatisfaction followed by 63.4% overall dissatisfaction noted for ambulatory services. Phlebotomy services needs improvements: 12%.The study enlighten to understand patient preferences through a patient satisfaction questionnaire known as a \"feedback form.\" Knowing how our patients feel about our laboratory services is vital and to identify all problems (non-conformities) found in the analysis and take appropriate CAPA.","PeriodicalId":503065,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroendocrine neoplasms of gastro intestinal tract with special reference to immunohistochemistry markers at a tertiary care hospital","authors":"Misbah Mariyam, K. Alekhya, S. K. A. Saleem, M. Pavani","doi":"10.18231/j.jdpo.2024.002","DOIUrl":"https://doi.org/10.18231/j.jdpo.2024.002","url":null,"abstract":": Neuroendocrine neoplasms (NEN) are rare entity comprising ~2% of all malignancies with the gastro intestinal tract (GIT) and the lung being the most common sites. They are classified as epithelial and non epithelial based on their origin. The epithelial type arise from epithelial neuroendocrine progenitor cells and non-epithelial type are derived from the neural crest. According to the latest WHO classification 2022, NEN are categorized into neuroendocrine tumors (NET), neuroendocrine carcinoma (NEC) and mixed neuroendocrine-non-neuroendocrine neoplasm (MiNEN). The above-mentioned classification is possible with the help of use of immunohistochemistry neuroendocrine markers namely synaptophysin, chromogranin-A and proliferation marker as ki67. Synaptophysin is entirely sensitive, and less specific. Chromogranin A is an excellent marker to follow tumour progression and recurrence but is less useful for the diagnosis as it can be elevated for multiple reasons and is therefore nonspecific but very sensitive.: This study includes 25 cases, with study duration of 2 years including all the cases of neuroendocrine tumours of gastrointestinal tract excluding pancreas. Routine H&E staining was done followed by Immunohistochemical markers consisting of synaptophysin, chromogranin-A and ki67 markers. In our study the affected mean age was 51.8 and there was slight male predominance (1.2:1). The most common site being duodenum followed by stomach, and least affected was oesophagus. Out of total 25 cases of Neuroendocrine neoplasms, 18 cases (72% were diagnosed as NET, which were further categorized into G1 (32%), G2(28%) and G3(12%). Neuroendocrine carcinoma was seen in 04 cases (16%) and 03 cases were of MiNEN.: The GI-NETs are rare but their incidence and prevalence have been increasing. Due to the improvement and advancement in the diagnostic tools and the knowledge about these tumors has helped in diagnosing more of these tumors early and accurately. For accurate grading and pathological diagnosis. It is important to carefully evaluate hot spots for the Ki-67 index, identify areas of the highest mitotic density for mitotic count, and recognize the characteristic histological features of GI-NETS.","PeriodicalId":503065,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":"54 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140506939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of socio-demographic parametrs on anemia in antenatal women in Vijayapur district of North Karnataka- A cross sectional study","authors":"Prakash M Patil, Neelamma G Patil, Naqsh Thakur, Shrey Kumar","doi":"10.18231/j.jdpo.2024.011","DOIUrl":"https://doi.org/10.18231/j.jdpo.2024.011","url":null,"abstract":"Anaemia is one of the leading causes of morbidity and mortality, especially among women having prevalence of approximately 41.8% among pregnant women. In India, Iron deficiency anaemia takes the highest share when it comes to prevalence pan nation. To study the prevalence of anaemia in pregnant women and the factors contributing to it in the population of Vijayapur district. A cross sectional study conducted in a Tertiary care, Centre at Vijayapur, North Karnataka. All the consenting pregnant women between age 20 to 40 years of age and gestational age more than 37 weeks. 57.3% were in the age group of 21-24 years in which 67.4% were non anaemic, 13.9 % were mild anaemic, 17.4% were moderately anaemic, 1.1% were severely anaemic. 27.3% were in the age group of 25-29 years in which 65.8% were non anaemic, 12.1% were mild anaemic, 21.9% were moderately anaemic. Iron deficiency anemia is most prevalent in reproductive age group, low socio-economic status, Iron and Folic acid medication taken in pregnant women which was in concordance with other studies.Conclusion: High prevalence of anaemia is a strong indicator of failure of the healthcare system at national and international level.","PeriodicalId":503065,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":"49 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological, histopathological, and immunohistochemical changes in tissues of adult male Sprague-Dawley rats orally treated with isotretinoin","authors":"Ahmad Khalil, Amneh Alrabie, Tareq Al-Omari, Hasan Abo Siam, Doaa Ghorab","doi":"10.18231/j.jdpo.2024.004","DOIUrl":"https://doi.org/10.18231/j.jdpo.2024.004","url":null,"abstract":"Isotretinoin (ISO) is the most effective drug prescribed by dermatologists for the treatment of acne vulgaris and other clinical skin cases. A significant obstacle to using ISO is concerns regarding its adverse effect profile. Despite the well-established reproductive toxicity in females, information on the effects on human male fertility is scarce, contradictory, and inconclusive. This study aimed to investigate the potential histological and histochemical effects of ISO. Isotretinoin was administered orally for seven successive days to Sprague Dawley male rats in a 5-20 mg/kg/day dose range. Standard histological and immunohistochemical techniques were used to evaluate ISO side effects. High doses of ISO led to infiltration of inflammatory cells in hepatic tissues, atrophy of the kidney glomeruli, and collapse of testicular compartments. Decreased E2F4 production was positively correlated to a reduced rate of spermatogenesis. The findings provide further evidence for ISO's cytotoxic and reprotoxic potencies. These effects are probably partly due to slowing down the expression of an E2F4 transcription factor. The dysregulated gene may play an essential role in spermatogenesis. The diagnostic value of the E2F4 gene needs to be further validated by different proteomics approaches, and its precise role in spermatogenesis needs to be investigated.","PeriodicalId":503065,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":"31 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of hepatitis b and hepatitis d co-infection in blood donors and hospital patients in east district of Sikkim","authors":"Chumila Thinley Bhutia, Deepak Das","doi":"10.18231/j.jdpo.2024.007","DOIUrl":"https://doi.org/10.18231/j.jdpo.2024.007","url":null,"abstract":"Hepatitis Delta virus (HDV) is a small RNA virus responsible for causing both acute and chronic liver disease in persons infected with Hepatitis B. Chronic HDV infection worsens the preexisting HBV-related liver damage. Several reports mention that Hepatitis B and D frequently occur together and is called co-infection. However, no major study has been done on Hepatitis D in this region. Routine screening is not done for detection of Hepatitis D. Therefore there is insufficient data on its incidence or prevalence in this part of India.The present study was conducted to determine the prevalence of Hepatitis B and D coinfection in blood donors and hospital patients in East District of Sikkim.The one year study was carried out in Central Referral Hospital, Tadong and STNM Hospital (Sir Thutop Namgyal Memorial Hospital), Gangtok in the East district of Sikkim. A total of 64 serum samples positive for Hepatitis B were collected, analysed and screened for the presence of anti-HDV IgG antibody using Enzyme Linked Immunosorbent Assay [Human hepatitis D virus (HDV) antibody (IgG) ELISA Kit]. Out of 64 samples positive for HBsAg that were analysed one sample (1.6%) was positive for Hepatitis B and Hepatitis D co-infection.Though the incidence of Hepatitis B & D coinfection is low but routine screening of blood donors for Hepatitis D should be done due to substantial risk of severe chronic liver diseases.","PeriodicalId":503065,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manual versus automated method for reticulocyte count: A comparative study","authors":"Mitali Singh, Vaibhav P Mane","doi":"10.18231/j.jdpo.2024.008","DOIUrl":"https://doi.org/10.18231/j.jdpo.2024.008","url":null,"abstract":"To compare the reliability and degree of acceptability of manual reticulocyte count over automated method in Tertiary Care Hospital: Reticulocytes are precursory to erythrocyte cells released from bone marrow into the blood and their evaluation is helpful in early diagnosis as well as therapeutic monitoring of anemic patients. Reticulocyte count is a rapid and basic hematological test that measures the erythropoietic activity within the bone marrow. An analytical and observational hospital-based study was conducted on all EDTA blood samples received for reticulocyte count by both manual and automated methods. A comparison of both methodologies was done. An evaluation of 230 blood samples was conducted and it showed a strong correlation between both methodologies with a p-value more than 0.05. The study suggests that the manual method for reticulocyte count is as reliable as an automated method. Its cost-effectiveness and reliability are useful in small urban laboratories and also in remote rural areas for early diagnosis as well as treatment of anemia.","PeriodicalId":503065,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":"90 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of expression of immunohistochemical markers high molecular weight cytokeratin (HMWCK) and alpha-methylacyl coa racemose (AMACR) in prostatic needle biopsies and transurethral resection of prostate (TURP) specimen – A one year observational study","authors":"Raghav Kapoor, H. Bannur","doi":"10.18231/j.jdpo.2024.009","DOIUrl":"https://doi.org/10.18231/j.jdpo.2024.009","url":null,"abstract":"In view of increasing incidence of Prostate cancer with age, its early detection and management is of utmost importance. Digital rectal examination, clinical picture and USG findings are non-specific. In prostatic lesions having a suspicious morphology, IHC staining (HMWCK and AMACR) is done to distinguish benign from malignant lesions. Absence of myoepithelial layer (HMWCK negative) along with cytoplasmic granular staining in glands (AMACR positive) is consistent with malignant diagnosis.To evaluate the utility of IHC markers HMWCK and AMACR in resolving morphologically suspicious foci on Prostatic needle core biopsies and TURP specimens.Observational StudyA total of 30 cases of prostatic lesions were studied. The specimens were fixed in 10% formalin and routinely processed. Haematoxylin-Eosin (H&E) and IHC staining (HMWCK and AMACR) was done in all 30 cases.Data collected was analyzed using appropriate statistical test.A total of 30 cases including 19 cases prostatic needle core biopsies and 11 cases of TURP specimens were included in our study. Histopathological diagnosis included 1 case each of Adenosis, Atypical adenomatous hyperplasia and Transitional cell metaplasia; 9 cases of BPH with suspicious foci, 4 cases of LGPIN, 3 cases of HGPIN and 11 cases Prostatic adenocarcinoma. In 5 cases including 3 cases of BPH with suspicious foci and 1 case each of adenosis and AAH, the diagnosis was changed to Prostatic Adenocarcinoma after IHC analysis. We conclude that IHC staining should be done in cases where routine H&E sections have an ambiguous morphology. HMWCK along with AMACR is a good marker combination to differentiate Benign from Malignant lesions.","PeriodicalId":503065,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Ki-67 expression in Phyllodes tumor of breast: An Indian study","authors":"Thingujam Deeparani, Chatura Ramakantha Kasimsetty","doi":"10.18231/j.jdpo.2024.001","DOIUrl":"https://doi.org/10.18231/j.jdpo.2024.001","url":null,"abstract":"Phyllodes tumor (PT) accounts for 0.3-1% of all breast tumors and classified into benign (BP), borderline (BLP) and malignant (MP). However, grading system is somewhat subjective and diagnosis remains challenging. Ancillary techniques may help in classification and prognostication of the tumor.Evaluation of the proliferative activity by Ki-67 index in Indian scenario.50 PTs received from January 2014 to December 2018 were graded using WHO criteria 2019. Ki-67 labelling index (LI) was calculated and graded 1+ (1-35%), 2+ (35-70%), 3+ (70-100%). Relevant statistical analysis was applied. P value of <0.05 was considered significant.70% (35) were BP, 26% (13) BLP and 4% (2) MP. Infiltrative margin, increased stromal cellularity, overgrowth, nuclear atypia and mitotic index were significantly associated with higher grade (P<0.000). The proportion of Ki-67 positive stromal cells in MP (mean76%) was higher than in BLP (mean 56.2%) and BP (mean 23.1%). Increasing Ki-67 index was significantly associated with infiltrative margin, presence of stromal overgrowth, increasing stromal cellularity, nuclear atypia, mitotic index and histological grade (P<0.000). Ki-67 statistically distinguished BP from BLP and MP (P<0.000, P<0.001 respectively), but not between BLP and MP (P<0.329). As a prognostic feature, high Ki-67 index expression did not predict local recurrence and due to fewer recurrent cases, the statistical correlation with any parameter could not be done.Histopathologic characteristics correlated with Ki-67 index. However, it was uncertain whether Ki-67 could provide independent prognostic information beyond histopathological typing. Continued follow-up with greater number of significant episodes may yield more informative correlations.","PeriodicalId":503065,"journal":{"name":"IP Journal of Diagnostic Pathology and Oncology","volume":"32 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}