ecancermedicalscience最新文献_第3页

Knowledge, attitudes and practices of cervical cancer screening among female students enrolled in higher education institutions in Cabo Verde 佛得角高等教育机构在校女生对宫颈癌筛查的认识、态度和做法

ecancermedicalscience Pub Date : 2024-03-28 DOI: 10.3332/ecancer.2024.1689

Natalina Sousa Silva Rocha, Bicho M Clara, Lima Mendonça M Luz, Maria do Rosário Oliveira Martins

{"title":"Knowledge, attitudes and practices of cervical cancer screening among female students enrolled in higher education institutions in Cabo Verde","authors":"Natalina Sousa Silva Rocha, Bicho M Clara, Lima Mendonça M Luz, Maria do Rosário Oliveira Martins","doi":"10.3332/ecancer.2024.1689","DOIUrl":"https://doi.org/10.3332/ecancer.2024.1689","url":null,"abstract":"Cervical cancer (CC) is the fourth most common cancer among women in the world and the second in Africa. CC is the third most frequent cancer and the first cause of cancer-related death among women in Cabo Verde, with an estimated incidence of 17 cases per 100,000 women. The mortality rate is around 10.5% and represents one of the largest percentages of all types of cancer diagnosed in women in the country. The high mortality rate can be explained by the absence of a national screening programme and a lack of human and physical resources. This study aims to determine the level of knowledge, attitudes and practices on CC among undergraduate female students in Cabo Verde in 2020. Methods A descriptive cross-sectional study, using a self-administered structured questionnaire, was conducted in six higher education institutions (HEI) in Cabo Verde between November and December 2020. A total of 618 female undergraduate students were recruited using a simple random sampling technique. Descriptive statistical data analysis was used to report the results. Results The response rate was 96.6% (n = 618). Most of the participants, 90.6% (549), were single, with average age of 21.79 years (SD =±4). Although most of the participants had already heard about CC (94.6%), most students showed a low knowledge about this disease (86.2%). Moreover, only 9.1% reported having been screened for CC. Conclusion Most undergraduate female students enrolled in HEI in Cabo Verde have poor knowledge and unfavourable attitudes toward CC. The level of knowledge is quite unsatisfactory. Within this context, the implementation of health policies focused on human papillomavirus education, prevention strategies, and CC screening is crucial.","PeriodicalId":502597,"journal":{"name":"ecancermedicalscience","volume":"37 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140371905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cancer patterns in Arua district, Uganda: a hospital-based retrospective study 乌干达阿鲁阿地区的癌症模式：一项基于医院的回顾性研究

ecancermedicalscience Pub Date : 2024-03-28 DOI: 10.3332/ecancer.2024.1688

Bridget Angucia Sharon, Annet Nakaganda, Geriga Fadhil, Micah June, Ezra Anecho, Gilbert Aniku, Amandua Jacinto, Hesborn Wao, Jackson Orem, Onguru Daniel

{"title":"Cancer patterns in Arua district, Uganda: a hospital-based retrospective study","authors":"Bridget Angucia Sharon, Annet Nakaganda, Geriga Fadhil, Micah June, Ezra Anecho, Gilbert Aniku, Amandua Jacinto, Hesborn Wao, Jackson Orem, Onguru Daniel","doi":"10.3332/ecancer.2024.1688","DOIUrl":"https://doi.org/10.3332/ecancer.2024.1688","url":null,"abstract":"Introduction Cancer is the second leading cause of mortality with over 19 million cases and 10 million deaths worldwide. Available data on cancer patterns in Uganda are through modelling of data from two population-based cancer registries (PBCRs) representing only about 10% of the cancer situation in Uganda. This study sought to determine the common types of cancer among adults and children in Arua District over a 5-year period (2017–2021). Methods Retrospective cohort chart review and ‘catchment population approach’ were employed. All newly diagnosed cancer patients from Arua between 2017 and 2021 were included in this study. Data were collected using Redcap whereas management and analysis were conducted using Stata 17. Cancer patterns were computed as frequencies and percentages and the interest was in finding out the common cancers among adults (above 19 years) and children (0–19 years). Results Over the 5-year study period, a total of 1,118 new cancer cases were registered, with slightly more females (52.1%). The top five common cancers irrespective of sex and age were: liver cancer (13.7%), cervical (11.8%), breast (10.7%), oesophagus (10.5%) and Burkitt’s lymphoma (BL) (6.4%). In this study, 15.3% (n = 171) of the study participants were children. The top five common childhood cancers included BL (42%), leukemia (10.5%), other lymphomas (9.4%), osteosarcoma (4.7%) and nephroblastoma (3%). Conclusion There is a high incidence of liver cancer in Arua district. The high levels of cervical, breast and oesophagus cancer were consistent with what is reported by the two PBCRs in Uganda. However, BL could be due to the presence of a BL treatment centre at Kuluva hospital in Arua. Cancer interventions in Arua should therefore be targeted towards liver, cervix, breast, and oesophagus cancer and furthering research on the reason for the high incidence of liver cancer.","PeriodicalId":502597,"journal":{"name":"ecancermedicalscience","volume":"5 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140372009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochemical outcome in metastatic prostate cancer patients following prostate-directed radiotherapy 前列腺导向放射治疗后转移性前列腺癌患者的生化结果

ecancermedicalscience Pub Date : 2024-03-26 DOI: 10.3332/ecancer.2024.1686

Heba Maged Ayoub, F. M. Elsayed, M. Zamzam, Ihab M.A. Hassanin, Eman Essam Elsemary

{"title":"Biochemical outcome in metastatic prostate cancer patients following prostate-directed radiotherapy","authors":"Heba Maged Ayoub, F. M. Elsayed, M. Zamzam, Ihab M.A. Hassanin, Eman Essam Elsemary","doi":"10.3332/ecancer.2024.1686","DOIUrl":"https://doi.org/10.3332/ecancer.2024.1686","url":null,"abstract":"Background The role of cytoreductive local radiotherapy (RT) in metastatic prostate cancer (mPCa) has recently been established. This study aimed to evaluate the biochemical outcome of local RT in mPCa. Methods This randomised controlled phase III study was conducted at the Clinical Oncology Department, Suez Canal University Hospital. Eligible participants were de-novo or metachronous mPCa patients with Eastern Cooperative Oncology Group performance status of 0–2. Participants were randomised to receive either cytoreductive prostate-directed RT in addition to standard care or standard care alone. The conventional radiation schedule of 70 Gy/35 fractions or the hypofractionated schedule of 55 Gy/20 fractions were delivered. The primary endpoint was biochemical progression-free survival (BPFS), and the secondary endpoint was overall survival (OS). Survival and post-hoc analyses were performed using Cox regression and the Kaplan-Meier method with the log-rank test. Results Between 23 November 2020 and 21 2022, 70 patients were enrolled in this study. Of them, 34 patients were assigned to the prostate RT group, and 29 patients were assigned to the control group. At a median follow-up of 12 months, the median BPFS has not been reached for the prostate RT group compared to 4.067 months for the control group (HR: 0.147, p < 0.001). Subgroup analysis showed that the median BPFS was statistically significantly correlated with low-volume (95% CI, 0.004 to 0.262, p = 0·001) and hormonal-sensitive metastatic disease (95% CI, 0.010 to 0.192, p < 0·001). The median OS was 16.33 months for the prostate-RT group compared to 11.33 months for the control group (HR: 0.313, p = 0.003). Conclusion Prostate-directed RT improved BPFS and OS in mPCa patients, particularly in those with low volume and hormonal-sensitive disease. Trial Registration This trial is registered on (27/4/2023), retrospectively registered with pactr.samrc.ac.za, PACTR202305854600529, URL: https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=25510","PeriodicalId":502597,"journal":{"name":"ecancermedicalscience","volume":"21 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiological and clinical description of patients with oropharyngeal cancer treated in a public oncology referral hospital in Chile 智利一家公立肿瘤转诊医院收治的口咽癌患者的流行病学和临床描述

ecancermedicalscience Pub Date : 2024-03-26 DOI: 10.3332/ecancer.2024.1685

Felipe Carvajal V, Felipe Cardemil, Beatriz P Vásquez, Carolina E Oliva, Tamra A Barría, Maribel A Bruna, Leonor A Moyano, Felipe A Bustos, Paola A Muñoz, Cristóbal F Araya, Jorge E Oyarzún, Eduardo A Villa, Federico A Floriano, Alexis J del Rio, Sebastián Indo, E. Castellón, Héctor R. Contreras

{"title":"Epidemiological and clinical description of patients with oropharyngeal cancer treated in a public oncology referral hospital in Chile","authors":"Felipe Carvajal V, Felipe Cardemil, Beatriz P Vásquez, Carolina E Oliva, Tamra A Barría, Maribel A Bruna, Leonor A Moyano, Felipe A Bustos, Paola A Muñoz, Cristóbal F Araya, Jorge E Oyarzún, Eduardo A Villa, Federico A Floriano, Alexis J del Rio, Sebastián Indo, E. Castellón, Héctor R. Contreras","doi":"10.3332/ecancer.2024.1685","DOIUrl":"https://doi.org/10.3332/ecancer.2024.1685","url":null,"abstract":"Introduction The incidence of squamous carcinoma of the oropharynx (OPSCC) has presented an increase worldwide, a fact that occurs along with a phenomenon of epidemiological transition, whose pathogenesis is linked to human papilloma virus (HPV) in a significant part of the cases. Published evidence at the Latin American level is scarce. The present study aims to evaluate the epidemiological and clinical characteristics of patients with oropharyngeal cancer treated in a public oncology reference centre in Chile. Methodology A cross-sectional study was carried out. Patients with histological confirmation of OPSCC aged 18 years or older, referred to the National Cancer Institute of Chile between 2012 and 2023 were included. The association with HPV was determined by immunohistochemistry for p16. Results 178 patients were analysed, most of them in locoregionally advanced stages involving the palatine tonsil. Seventy-seven percent were male, with a median age of 60 years. Sixty-seven percent of patients were positive for p16, with a progressive increase to 85% in the last 2 years of the study. The p16(+) patients were younger and had fewer classical risk factors. Primary treatment was radiotherapy in 94% of patients. Conclusion The epidemiological profile of patients with OPSCC treated in a Chilean public oncology referral centre reflects the epidemiological transition observed in developed countries. This change justifies the need to adapt health policies and conduct research that considers the characteristics of this new epidemiological profile.","PeriodicalId":502597,"journal":{"name":"ecancermedicalscience","volume":"67 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A hospital-based study of survival in oral cancer patients of Tata Memorial Hospital, Mumbai 孟买塔塔纪念医院口腔癌患者生存情况的医院研究

ecancermedicalscience Pub Date : 2024-02-15 DOI: 10.3332/ecancer.2024.1669

Monika Lokhande, Sivaranjini Kannusamy, Amey Oak, Sandhya Cheulkar, Shalmali Chavan, Varsha Mishra, Pragati Gode, Aijimol S Thakadiyil, Saket Mendhe, Supriya Kadam, Ganesh Balasubramaniam, Pankaj Chaturvedi, Rajesh Dikshit

引用次数: 0

Comprehensive germline profiling of patients with breast cancer: initial experience from a Familial Cancer Clinic 乳腺癌患者的综合种系谱分析：家族性癌症诊所的初步经验

ecancermedicalscience Pub Date : 2024-02-15 DOI: 10.3332/ecancer.2024.1670

Raja Pramanik, Sindhura Chitikela, S. Deo, A. Gogia, A. Batra, Akash Kumar, Ritu Gupta, Deepshi Thakral, V. Ramprasad, Sandeep R. Mathur, DN Sharma, Aparna K Sharma, Ashutosh Mishra, B. Bansal

引用次数: 0

Comprehensive germline profiling of patients with breast cancer: initial experience from a Familial Cancer Clinic 乳腺癌患者的综合种系谱分析：家族性癌症诊所的初步经验

ecancermedicalscience Pub Date : 2024-02-15 DOI: 10.3332/ecancer.2024.1670

Raja Pramanik, Sindhura Chitikela, S. Deo, A. Gogia, A. Batra, Akash Kumar, Ritu Gupta, Deepshi Thakral, V. Ramprasad, Sandeep R. Mathur, DN Sharma, Aparna K Sharma, Ashutosh Mishra, B. Bansal

引用次数: 0

A hospital-based study of survival in oral cancer patients of Tata Memorial Hospital, Mumbai 孟买塔塔纪念医院口腔癌患者生存情况的医院研究

ecancermedicalscience Pub Date : 2024-02-15 DOI: 10.3332/ecancer.2024.1669

Monika Lokhande, Sivaranjini Kannusamy, Amey Oak, Sandhya Cheulkar, Shalmali Chavan, Varsha Mishra, Pragati Gode, Aijimol S Thakadiyil, Saket Mendhe, Supriya Kadam, Ganesh Balasubramaniam, Pankaj Chaturvedi, Rajesh Dikshit

引用次数: 0

Real world study of safety and efficacy of lorlatinib as second line and beyond in ALK-rearranged advanced non-small cell lung cancer patients in India – a multicentre chart review study (ROSELAND) 印度ALK重组晚期非小细胞肺癌患者二线及二线以上使用lorlatinib的安全性和有效性的真实世界研究--多中心病历回顾研究（ROSELAND）

ecancermedicalscience Pub Date : 2024-02-13 DOI: 10.3332/ecancer.2024.1667

B. Biswas, Nikhil S Ghadyalpatil, Shekar Patil, Amol Patel, S. Ganguly, Anvesh Rathore, B. Guleria, Cpalli Firdouse Tarannum, Joydeep Ghosh, Mary Sravani Kondapally, Ravi Thippeswamy, Shashidhara Haragadde Poppa Reddy, Somnath Roy

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Understanding of disease status, prognosis and estimated cost of treatment among cancer patients: experience from a tertiary cancer centre in Nepal 癌症患者对疾病状况、预后和治疗费用估算的了解：尼泊尔一家三级癌症中心的经验

ecancermedicalscience Pub Date : 2024-02-13 DOI: 10.3332/ecancer.2024.1668

S. Baral, S. Silwal, Deep Lamichhane, Abish Adhikari, Nancy Bhattarai

引用次数: 0