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Bacteremia Following Alkalihalobacillus clausii (Formerly Bacillus clausii) Administration in Immunosuppressed Adults: A Case Series 免疫抑制成人服用克劳氏碱性卤杆菌（原名克劳氏芽孢杆菌）后出现菌血症：病例系列

Bacteria Pub Date : 2023-12-12 DOI: 10.3390/bacteria2040014

J. P. Díaz-Madriz, Esteban Zavaleta‐Monestel, Carolina Rojas-Chinchilla, Sebastián Arguedas‐Chacón, Bruno Serrano-Arias, Mery Alejandra Ferreto-Meza, Betzy María Romero-Chavarría, Priscila Zumbado-Amerling, A. Vásquez-Mendoza, Karla Sofia Gutiérrez-González, César Rodríguez

{"title":"Bacteremia Following Alkalihalobacillus clausii (Formerly Bacillus clausii) Administration in Immunosuppressed Adults: A Case Series","authors":"J. P. Díaz-Madriz, Esteban Zavaleta‐Monestel, Carolina Rojas-Chinchilla, Sebastián Arguedas‐Chacón, Bruno Serrano-Arias, Mery Alejandra Ferreto-Meza, Betzy María Romero-Chavarría, Priscila Zumbado-Amerling, A. Vásquez-Mendoza, Karla Sofia Gutiérrez-González, César Rodríguez","doi":"10.3390/bacteria2040014","DOIUrl":"https://doi.org/10.3390/bacteria2040014","url":null,"abstract":"(1) Background: Given the widespread use of Alkalihalobacillus clausii (A. clausii) as a probiotic in recent decades and the detection of bacteremia cases in a group of patients, we sought to analyze cases of A. clausii bacteremia following oral probiotic use (2) Methods: A retrospective observational study was conducted at a private hospital in San Jose, Costa Rica. Cases of bacteremia caused by A. clausii confirmed by the microbiology laboratory were analyzed in patients who received oral treatment with this probiotic between January 2020 and January 2022. In addition, an isolate (HCB-AC2) was compared through whole genome sequencing to demonstrate the correlation of bacteremia and A. clausii. Possible vulnerability factors related to the development of this condition were determined. (3) Results: Four cases were identified in this hospital over 2 years. Genomic analysis of isolate HCB-AC2, using two different methods, showed identical results. This indicates that HCB-AC2 is genomically identical to ENTpro and the Enterogermina® reference genome. The median age was 71 years, and all patients had some degree of immunosuppression. All patients met at least three sepsis criteria at the time of bacterial identification. Most patients were treated with vancomycin and levofloxacin. Three of the identified patients died. (4) Conclusion: A. clausii can be used as a probiotic, but caution is advised when used in immunosuppressed and elderly patients. These findings align with those reported in similar case studies.","PeriodicalId":502262,"journal":{"name":"Bacteria","volume":"146 1-3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139183111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Analysis of Klebsiella pneumoniae Culture Identification and Antibiogram: Implications for Antimicrobial Susceptibility Patterns from Sputum Samples in Mardan, Khyber Pakhtunkhwa, Pakistan 肺炎克雷伯菌培养鉴定和抗生素图谱的综合分析：巴基斯坦开伯尔巴图克瓦省马尔丹市痰样本抗菌药敏感性模式的意义

Bacteria Pub Date : 2023-11-15 DOI: 10.3390/bacteria2040012

Ruby Khan, Saima Wali, Bakht Pari

{"title":"Comprehensive Analysis of Klebsiella pneumoniae Culture Identification and Antibiogram: Implications for Antimicrobial Susceptibility Patterns from Sputum Samples in Mardan, Khyber Pakhtunkhwa, Pakistan","authors":"Ruby Khan, Saima Wali, Bakht Pari","doi":"10.3390/bacteria2040012","DOIUrl":"https://doi.org/10.3390/bacteria2040012","url":null,"abstract":"Klebsiella pneumoniae, a Gram-negative pathogen, poses a significant threat as a cause of community- and hospital-acquired infections worldwide. The emergence of multidrug-resistant strains, particularly in nosocomial settings, has further complicated the management of these infections. This study aimed to investigate the culture identification and antibiogram of K. pneumoniae isolated from sputum samples collected in various districts in Mardan, Khyber Pakhtunkhwa, Pakistan. A total of 16 sputum samples were collected from patients at the Mardan Medical Complex. Standard microbiological techniques were employed to identify K. pneumoniae, and the antibiotic susceptibility testing was performed using the Kirby–Bauer disc diffusion method, following CLSI guidelines. Among the confirmed K. pneumoniae isolates, approximately 50% were found to be multidrug-resistant. The results indicated resistance to several antibiotics, including vancomycin (30 g), amikacin (30 g), chloramphenicol (30 g), amoxicillin (30 g), and ticarcillin (75 g), while being susceptible to meropenem (10 g), piperacillin (100 g), and tazobactam (110 g). A bioinformatics analysis was also conducted to gain deeper insights into the resistance patterns and potential clustering of isolates. This comprehensive study provides valuable information on the epidemiological trends and antimicrobial susceptibility profile of K. pneumoniae in the region. The findings of this study highlight the urgent need for antimicrobial stewardship programs to combat the rising challenge of antibiotic resistance. Understanding the resistance landscape of K. pneumoniae can guide healthcare professionals in selecting appropriate antibiotics and improving patient outcomes. These data can contribute to the formulation of local antibiotic policies and assist clinicians in making rational choices for antibiotic therapy.","PeriodicalId":502262,"journal":{"name":"Bacteria","volume":"C-27 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139271103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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