Annals of the Academy of Medicine, Singapore最新文献_第3页

The alcohol flushing syndrome: A risk factor for cancer. 酒精潮红综合征：癌症的危险因素

IF 2.5

Annals of the Academy of Medicine, Singapore Pub Date : 2024-07-30 DOI: 10.47102/annals-acadmedsg.2024191

Meng Sha, Jia-Qian Sun, Qiang Xia

引用次数: 0

Demographic diversity of participants in clinical trials conducted in Singapore. 新加坡临床试验参与者的人口统计学多样性。

IF 2.5

Annals of the Academy of Medicine, Singapore Pub Date : 2024-07-30 DOI: 10.47102/annals-acadmedsg.2023252

Wen Jun Jerome Bin, Aloysius Chow, Helen Elizabeth Smith, Eng Sing Lee

{"title":"Demographic diversity of participants in clinical trials conducted in Singapore.","authors":"Wen Jun Jerome Bin, Aloysius Chow, Helen Elizabeth Smith, Eng Sing Lee","doi":"10.47102/annals-acadmedsg.2023252","DOIUrl":"https://doi.org/10.47102/annals-acadmedsg.2023252","url":null,"abstract":"Introduction: The under-representativeness of participants in clinical trials limits the generalisability of results. This review evaluates the representative-ness within pharmaceutical randomised controlled trials (RCTs) in Singapore.Method: Four bibliographic databases were searched for papers on pharmaceutical RCTs which included Singapore adults (≥18 years old), published between 2017 and 2022. The demographic characteristics of study participants were compared against the population in the 2020 Singapore census. Recruitment strategies and authors' comments on the generalisa-bility of their findings were reviewed.Results: Thirty-three publications were included (19 Singapore-only studies and 14 multiregional trials which included Singapore). Where data were available, we found that females and Indians were under-represented compared to the census (41.3% versus [vs] 51.1%, P<0.05; 7.3% vs 9.0%, P<0.05). Ethnic diversity varied between individual studies, and almost half (46.2%) of Singapore-only studies achieved census levels. However, more than one-third of the trials provided no data (31.6%) or partial data (5.3%) on ethnicity. Half of the multiregional publications stated the number of participants recruited from Singapore, but only 1 reported any detail beyond Asian participants. Recruitment strategies were mentioned in fewer than half (42.4%), and less than a quarter (24.2%) commented on sample representative-ness or the external validity of the evidence generated.Conclusion: There is room for improvement regarding the recruitment of RCT participants in Singapore, with particular attention to female gender and Indian ethnicity. Demographic data should also be presented in full. RCTs should be designed and reported such that clinicians can ascertain the generalisability to the Singapore population and the potential benefits from the studied interventions in clinical practice.","PeriodicalId":502093,"journal":{"name":"Annals of the Academy of Medicine, Singapore","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in fluid overload-related hospitalisations among patients with diabetes mellitus The impact of chronic kidney disease. 糖尿病患者因体液超负荷而住院的趋势慢性肾病的影响。

IF 2.5

Annals of the Academy of Medicine, Singapore Pub Date : 2024-07-30 DOI: 10.47102/annals-acadmedsg.2024136

Joshua Kuan Tan, Hanis Abdul Kadir, Gek Hsiang Lim, Julian Thumboo, Yong Mong Bee, Cynthia Ciwei Lim

{"title":"Trends in fluid overload-related hospitalisations among patients with diabetes mellitus The impact of chronic kidney disease.","authors":"Joshua Kuan Tan, Hanis Abdul Kadir, Gek Hsiang Lim, Julian Thumboo, Yong Mong Bee, Cynthia Ciwei Lim","doi":"10.47102/annals-acadmedsg.2024136","DOIUrl":"https://doi.org/10.47102/annals-acadmedsg.2024136","url":null,"abstract":"Introduction: Fluid overload is a known complication in patients with diabetes mellitus, particularly those with cardiovascular and/or chronic kidney disease (CKD). This study investigates the impact of fluid overload on healthcare utilisation and its association with diabetes-related complications.Method: Electronic medical records from the SingHealth Diabetes Registry (2013-2022) were analysed. Hospitalisations due to fluid overload were identified using International Classification of Diseases, 10th Revision (ICD-10) discharge codes. Trends were examined using Joinpoint regression, and associations were assessed with generalised estimating equation models.Results: Over a period of 10 years, 259,607 individuals treated at primary care clinics and tertiary hospitals were studied. The incidence of fluid overload-related hospitalisations decreased from 2.99% (n=2778) in 2013 to 2.18% (n=2617) in 2017. However, this incidence increased from 2.42% (n=3091) in 2018 to 3.71% (n=5103) in 2022. The strongest associations for fluid overload-related hospitalisation were found with CKD stages G5 (odds ratio [OR] 6.61, 95% confidence interval [CI] 6.26-6.99), G4 (OR 5.55, 95% CI 5.26-5.86) and G3b (OR 3.18, 95% CI 3.02-3.35), as well as with ischaemic heart disease (OR 3.97, 95% CI 3.84-4.11), acute myocardial infarction (OR 3.07, 95% CI 2.97-3.18) and hypertension (OR 3.90, 95% CI 3.45-4.41). Additionally, the prevalence of stage G5 CKD among patients with fluid overload increased between 2018 and 2022.Conclusion: Our study revealed a significant increase in fluid overload-related hospitalisations and extended lengths of stay, likely driven by severe CKD. This underscores an urgent need for initiatives aimed at slowing CKD progression and reducing fluid overload-related hospitalisations in diabetes patients.","PeriodicalId":502093,"journal":{"name":"Annals of the Academy of Medicine, Singapore","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How close are we from achieving demographic diversity in clinical trials? Insights from Singapore. 我们离实现临床试验中的人口多样性还有多远？来自新加坡的启示。

IF 2.5

Annals of the Academy of Medicine, Singapore Pub Date : 2024-07-30 DOI: 10.47102/annals-acadmedsg.2024226

Yueyang Yi, Thomas Yuen Tung Lam

引用次数: 0

Association between alcohol flushing syndrome and cancer: A systematic review and meta-analysis. 酒精性潮红综合征与癌症的关系：系统回顾和荟萃分析。

IF 2.5

Annals of the Academy of Medicine, Singapore Pub Date : 2024-07-30 DOI: 10.47102/annals-acadmedsg.2023351

Wilson Sim, Jason Timothy Pan, Cheryl Wan Xuan Chua, Khi Yung Fong, Sunny H Wong, Bernett Lee, Hazel H Oon

{"title":"Association between alcohol flushing syndrome and cancer: A systematic review and meta-analysis.","authors":"Wilson Sim, Jason Timothy Pan, Cheryl Wan Xuan Chua, Khi Yung Fong, Sunny H Wong, Bernett Lee, Hazel H Oon","doi":"10.47102/annals-acadmedsg.2023351","DOIUrl":"https://doi.org/10.47102/annals-acadmedsg.2023351","url":null,"abstract":"Introduction: Alcohol flushing syndrome (AFS) is experienced by up to 46% of East Asians. This study aimed to review the risk of cancers in AFS patients, elucidate an exposure-response relationship, and understand risk associated with alcohol intake and cancer.Method: An electronic database search of PubMed, Embase, Scopus and Cochrane Library was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. Observational studies on AFS' effects and all cancers risk were included. Studies including patients with existing malignancy were excluded. Dichotomous variables were pooled using the Mantel-Haenszel method with a random effects model. Sensitivity and subgroup analyses were performed. PROSPERO (CRD42023392916) protocol was followed.Results: A total of 18 articles were included in the final analysis with a total of 387,521 participants. AFS was associated with an increased risk of all cancers (odds ratio [OR] 1.19, 95% confidence interval [CI] 1.06-1.34), esophageal squamous cell carcinoma (OR 1.47, 95% CI 1.05-2.05) and gastric adenocarci-noma (OR 1.40, 95% CI 1.14-1.72). Men with AFS exhibited an increased risk of all cancers (OR 1.34, 95% CI 1.13-1.59). However, this was not observed in women. All cancers risk was associated with AFS in those who consumed drink (i.e. consumed alcohol) more than 200 g of pure ethanol/week (OR 1.68, 95% CI 1.20-2.37) but not those who consumed less than 200 g of pure ethanol/week (OR 1.27, 95% CI 0.90-1.79) or non-drinkers (OR 0.99, 95% CI 0.67-1.47).Conclusion: AFS is associated with an increased risk of all cancers, particularly esophageal squamous cell carcinoma and gastric adenocarcinoma.","PeriodicalId":502093,"journal":{"name":"Annals of the Academy of Medicine, Singapore","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using artificial intelligence as an ethics advisor. 将人工智能用作道德顾问。

IF 2.5

Annals of the Academy of Medicine, Singapore Pub Date : 2024-07-25 DOI: 10.47102/annals-acadmedsg.202471

Kay Choong See

引用次数: 0

Gaps in primary care management of urinary tract infections in Singapore. 新加坡泌尿道感染初级保健管理的差距。

IF 2.5

Annals of the Academy of Medicine, Singapore Pub Date : 2024-07-24 DOI: 10.47102/annals-acadmedsg.2023343

Terence Yi Song Liew, Pey Gein Wong, Justin Wee-Mi Chong, Hwee Ching Chung, Cynthia Kum Wai Cheong, Sky Wei Chee Koh

引用次数: 0

Screen time and social-emotional skills in preschoolers with developmental, behavioural or emotional issues in Singapore. 新加坡有发育、行为或情感问题的学龄前儿童的屏幕时间和社交情感技能。

IF 2.5

Annals of the Academy of Medicine, Singapore Pub Date : 2024-07-24 DOI: 10.47102/annals-acadmedsg.2023384

Jennifer Sh Kiing, Ying Qi Kang, Kalyani Vijaykumar Mulay, Tammy Sh Lim, Shang Chee Chong, Mae Yue Tan, Yiong Huak Chan, Alicia Sy Lim, Ramkumar Aishworiya

{"title":"Screen time and social-emotional skills in preschoolers with developmental, behavioural or emotional issues in Singapore.","authors":"Jennifer Sh Kiing, Ying Qi Kang, Kalyani Vijaykumar Mulay, Tammy Sh Lim, Shang Chee Chong, Mae Yue Tan, Yiong Huak Chan, Alicia Sy Lim, Ramkumar Aishworiya","doi":"10.47102/annals-acadmedsg.2023384","DOIUrl":"https://doi.org/10.47102/annals-acadmedsg.2023384","url":null,"abstract":"Introduction: This study aimed to determine patterns of screen viewing time (SVT) in preschool children with developmental, behavioural or emotional (DBE) issues, and to identify its relationship with social-emotional development.Method: This cross-sectional study involved children aged 0-5 years who were referred to a developmental paediatric clinic for DBE issues. Parents completed a screen time questionnaire, and the Devereux Early Childhood Assessment-Clinical (DECA-C) question-naire which assessed the social-emotional competence of the children. Data were analysed using logistic regression, correlational analyses and tests of comparison.Results: Among 225 children (mean age: 32.4 months), mean daily SVT was 138 minutes. More than half (51.1%) of the children had clinical features of language delay, while 26.6% had features suggestive of autism spectrum disorder. Screen time was first introduced at a mean age of 13.8 months, with 32.4% of children previously experiencing higher SVT. Compared to SVT introduction after 1 year of age, SVT in the first 12 months was primarily to facilitate feeding (P<0.05). Children with higher past SVT had poorer attention, more aggression, and increased behavioural concerns. Children with DBE issues have significantly more screen time than same-aged peers.Conclusion: Children with DBE issues are exposed to SVT at a very young age and have significantly more screen time than their peers. It is crucial to guide parents to reduce SVT in early childhood, particularly around mealtimes.","PeriodicalId":502093,"journal":{"name":"Annals of the Academy of Medicine, Singapore","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Balancing screen time: Insights and impact on preschool children. 平衡屏幕时间：对学龄前儿童的启示和影响。

IF 2.5

Annals of the Academy of Medicine, Singapore Pub Date : 2024-07-24 DOI: 10.47102/annals-acadmedsg.2024172

Daisy Kwai-L Chan

引用次数: 0

The emergence of otter attacks in Singapore: A case series and strategies for management. 新加坡出现水獭袭击事件：一个案例系列和管理策略。

IF 2.5

Annals of the Academy of Medicine, Singapore Pub Date : 2024-07-24 DOI: 10.47102/annals-acadmedsg.2024103

Shaun Kai Kiat Chua, Joel Yeh Siang Chen, Stephanie Sutjipto, Jingwen Ng, Remesh Kunnasegaran

引用次数: 0