The Pediatric Infectious Disease Journal最新文献

{"title":"KLUYVERA CRYOCRESCENS URINARY TRACT INFECTION IN A NEONATE: A CASE REPORT AND LITERATURE REVIEW.","authors":"Abdullah Zeid Alsuheili,Mohammed Abdullah Alsubaie,Abeer A Alnajjar,Nawaf Al-Dajani","doi":"10.1097/inf.0000000000004507","DOIUrl":"https://doi.org/10.1097/inf.0000000000004507","url":null,"abstract":"This case report details the fourth documented case of urinary tract infection caused by Kluyvera cryocrescens and the first in a neonate. Including a brief literature review on urinary tract infections associated with this organism, the report highlights the importance of considering uncommon pathogens in neonatal infections and the necessity of a thorough diagnostic approach to initiate appropriate antimicrobial treatment.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142260987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nomogram of Predicting Healthcare-Associated Infections in Burned Children.","authors":"Tengfei Long,Xuejiao Hu,Ting Liu,Guanfeng Hu,Jie Fu,Jing Fu","doi":"10.1097/inf.0000000000004514","DOIUrl":"https://doi.org/10.1097/inf.0000000000004514","url":null,"abstract":"BACKGROUNDHealthcare-associated infections (HAIs) are a common clinical concern associated with adverse prognosis and mortality in burned children. This study aimed to construct a predictive nomogram of the risk of HAIs in burned children.METHODSChildren admitted to the burn unit of Wuhan Third Hospital between 2020 and 2022 were included. The univariate and multivariate logistic regression analyses were adopted to ascertain predictors of HAIs. A nomogram was developed to predict the HAI risk of each patient, with receiver operating characteristic curves and calibration curves being generated to assess its predictive ability. Furthermore, decision and impact curves were used to assess the clinical utility.RESULTSOf 1122 burned children, 61 (5.5%) patients experienced HAIs. The multivariate analysis indicated that total burn surface area, length of stay, surgery, central venous catheter use and urinary catheter use were the independent risk factors of HAIs. Using these variables, we developed a predictive nomogram of the occurrence of HAIs in burned children, and the internal validation results demonstrated good discrimination and calibration of the nomogram. The area under the curve values of the nomogram was 0.926 (95% CI, 0.896-0.957). The calibration curve showed high consistency between the actual and predicted HAIs. The decision and impact curve indicated that the nomogram was of good clinical utility and more credible net clinical benefits in predicting HAIs.CONCLUSIONSThe present study constructed a nomogram for predicting the risk of HAIs in burned children. This nomogram may strengthen the effective screening of patients at high risk of HAIs.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous Versus Intermittent Vancomycin Infusions for Coagulase-negative Staphylococcus Bacteremia in Neonates: A Propensity-matched Cohort Study.","authors":"Rémy Gérard,Emilie Pauquet,Barbara Ros,Philippe Lehours,Laurent Renesme","doi":"10.1097/inf.0000000000004538","DOIUrl":"https://doi.org/10.1097/inf.0000000000004538","url":null,"abstract":"BACKGROUNDCoagulase-negative staphylococci (CONS) are a major cause of late-onset neonatal sepsis, particularly in preterm infants, with high morbidity and mortality. While vancomycin is the first-line treatment for these infections, the optimal administration in neonates remains uncertain.OBJECTIVEWe aim to compare the outcomes of neonates with CONS bacteremia treated with adjusted continuous infusion (CIV) versus standard intermittent infusion (IIV) of vancomycin.METHODSThis retrospective study included 110 neonates, with 29 in the CIV group and 47 in the IIV group after propensity score matching. The primary outcome was treatment failure defined by the persistence of a positive blood culture for the same organism after at least 48 hours of vancomycin treatment.RESULTSAfter matching, the CIV group exhibited significantly lower treatment failure rates [5/29 (17%) vs. 26/47 (44%); P = 0.014] and a higher rate of achieving therapeutic vancomycin levels after 24 hours [20/29 (69%) vs. 26/47 (44%); P = 0.002] compared to the IIV group. No significant differences were observed in terms of acute kidney failure between the 2 groups.CONCLUSIONAdjusted continuous vancomycin infusion in neonates with CONS bacteremia is associated with a lower treatment failure rate without an increase in renal toxicity compared to standard intermittent infusion. However, due to the observational design, larger prospective studies are needed to validate these results.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142193753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal Sepsis Due to Multidrug-resistant Bacteria at a Tertiary Teaching Hospital in Ethiopia.","authors":"Mulatu Gashaw, Solomon Ali, M. Berhane, Getnet Tesfaw, Beza Eshetu, N. Workneh, Thomas Seeholzer, G. Froeschl, Arne Kroidl, Andreas Wieser, E. K. Gudina","doi":"10.1097/INF.0000000000004364","DOIUrl":"https://doi.org/10.1097/INF.0000000000004364","url":null,"abstract":"BACKGROUND\u0000The burden of multidrug-resistant bacterial infections in low-income countries is alarming. This study aimed to identify the bacterial etiologies and antibiotic resistance patterns among neonates in Jimma, Ethiopia.\u0000\u0000\u0000METHODS\u0000An observational longitudinal study was conducted among 238 presumptive neonatal sepsis cases tested with blood and/or cerebrospinal fluid culture. The bacterial etiologies were confirmed using matrix-assisted laser desorption ionization-time of flight mass spectrometry. The antibiotic resistance patterns were determined using the automated disc diffusion method (Bio-Rad) and the results were interpreted based on the European Committee on Antimicrobial Susceptibility Testing 2021 breakpoints. Extended-spectrum β-lactamases were detected using a double disc synergy test and confirmed by Mast discs (Mast Diagnostica GmbH).\u0000\u0000\u0000RESULTS\u0000A total of 152 pathogens were identified. Of these, Staphylococcus aureus (18.4%) was the predominant isolate followed by Klebsiella pneumoniae (15.1%) and Escherichia coli (10.5%). All the isolates exhibited a high rate of resistance to first- and second-line antibiotics ranging from 73.3% for gentamicin to 93.3% for ampicillin. Furthermore, 74.4% of the Gram-negative isolates were extended-spectrum β-lactamase producers and 57.1% of S. aureus strains were methicillin resistant. The case fatality rate was 10.1% and 66.7% of the deaths were attributable to infections by multidrug-resistant pathogens.\u0000\u0000\u0000CONCLUSIONS\u0000The study revealed a high rate of infections with multidrug-resistant pathogens. This poses a significant challenge to the current global and national target to reduce neonatal mortality rates. To address these challenges, it is important to employ robust infection prevention practices and continuous antibiotic resistance testing to allow targeted therapy.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"42 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140662557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Warning Signs From the WHO 2009 Dengue Classification in Detecting Severe Dengue in Children.","authors":"M. Karyanti, C. S. Uiterwaal, Sri Rezeki Hadinegoro, I. Widyahening, Siti Rizny F Saldi, J. H. Heesterbeek, Arno W Hoes, Patricia Bruijning-Verhagen","doi":"10.1097/INF.0000000000004326","DOIUrl":"https://doi.org/10.1097/INF.0000000000004326","url":null,"abstract":"BACKGROUND\u0000World Health Organization proposed 7 warning signs to identify the risk of severe dengue in 2009. This study aimed to evaluate the value of these warning signs in detecting severe dengue in children.\u0000\u0000\u0000MATERIAL AND METHODS\u0000A cross-sectional study was conducted utilizing data of children with clinical dengue infection obtained from medical records between January 2009 and December 2018 in Jakarta. Children with confirmed dengue were analyzed and stratified into 3 age groups: infants less than 1 year old, children 1-14 years and adolescents 15-18 years of age. Positive predictive value, negative predictive value (NPV), sensitivity and specificity of each warning sign present or absent on admission in detecting severe dengue were computed.\u0000\u0000\u0000RESULTS\u0000Six hundred ninety-nine children with clinical dengue infection were enrolled, among whom 614 (87.8%) had confirmed dengue infection, either by antigen or antibody serological tests. Severe dengue occurred in 211/614 (34.4%) cases. In infants, important warning signs on admission to detect or exclude severe dengue were liver enlargement (NPV 80.8%) and clinical fluid accumulation (NPV 75%). In children and adolescents, warning sign with highest NPV (in children 76.6% and in adolescents 91.9%) was increase in hematocrit concurrent with a rapid decrease in platelet count. Other warning signs with high NPV values in children were abdominal pain (72%), vomiting (70%), clinical fluid accumulation (69.3%), and in adolescents' abdominal pain (80.7%), vomiting (75.7%), clinical fluid accumulation (82.7%). NPVs increase with more than 1 warning sign in all age groups.\u0000\u0000\u0000CONCLUSION\u0000In infants, liver enlargement or clinical fluid accumulation are important warning signs for severe dengue, when both are absent, severe dengue is unlikely. In older children and adolescents, an increase in hematocrit with the concurrent rapid decrease in platelet count is most discriminative; followed by the absence of abdominal pain, vomiting or fluid accumulation are unlikely severe dengue.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":" 0","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140684430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing Landscape of Antimicrobial Resistance in Neonatal Sepsis: An in silico Analyses of Multidrug Resistance in Klebsiella pneumoniae.","authors":"Santhiya Vijayakumar, Hithesh Kumar, Soumya Basu, Sara Chandy, Anand Anbarasu, Anand Manoharan, Sudha Ramaiah","doi":"10.1097/inf.0000000000004358","DOIUrl":"https://doi.org/10.1097/inf.0000000000004358","url":null,"abstract":"Neonatal sepsis poses a critical healthcare concern, as multidrug-resistant Klebsiella pneumoniae (K. pneumoniae) infections are on the rise. Understanding the antimicrobial susceptibility patterns and underlying resistance mechanism is crucial for effective treatment.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140599129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Course and Outcomes of Infants with Streptococcus bovis/Streptococcus Gallolyticus subspecies pasteurianus Infection: A Systematic Review and Meta-analysis.","authors":"Sandra Lynn Jaya-Bodestyne, Yee Yin Tan, Rehena Sultan, Kee Thai Yeo, Juin Yee Kong","doi":"10.1097/inf.0000000000004361","DOIUrl":"https://doi.org/10.1097/inf.0000000000004361","url":null,"abstract":"Streptococcus gallolyticus subspecies pasteurianus (SGP), a subtype of Streptococcus bovis, is an uncommon but important cause of neonatal sepsis. Although uncommon, SGP infections during infancy have been associated with an increased risk of morbidity and mortality.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140599017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous Immunoglobulin in Diphtheritic Polyneuropathy.","authors":"Tania Van Goethem, Hugo Kerambrun, Yvonnick Boue, A. Chamouine, Sylvain Brisse, Julie Toubiana, Justine Franco","doi":"10.1097/INF.0000000000004367","DOIUrl":"https://doi.org/10.1097/INF.0000000000004367","url":null,"abstract":"","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"15 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140715309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Adenovirus Infection in Hospitalized Children in the United States From 1997 to 2019.","authors":"Balagangadhar R Totapally, Seevitha Totapalli, Prithvi Sendi, Paul A Martinez","doi":"10.1097/inf.0000000000004365","DOIUrl":"https://doi.org/10.1097/inf.0000000000004365","url":null,"abstract":"The study aimed to explore the prevalence, clinical features, resource utilization, temporal trends and outcomes associated with adenoviral infections in hospitalized children.","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140599214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 12-Year-old Boy With a Knee Infection","authors":"Joy Verbakel, Nynke van der Gaast, R. Jaarsma","doi":"10.1097/INF.0000000000004279","DOIUrl":"https://doi.org/10.1097/INF.0000000000004279","url":null,"abstract":"A 12-year-old boy, with no significant past medical history and no known drug allergies, presented to the emergency department with a deep laceration of his left knee after a fall on a ceramic plant pot in May 2013. A 10-cm long, L-shaped laceration heavily contaminated with soil and completely exposing the lateral femoral condyle was noted. He also was found to have a patella tendon avulsion (Fig. 1). The patient was oriented and comfortable with a blood pressure of 115/50 mm Hg, pulse of 68 beats/min and respiratory rate of 18 breaths/min. Blood tests showed the following mildly abnormal values: white cell count of 11.9 × 10 9 /L (normal: 4–11 × 10 9 /L), hemoglobin of 142 g/L (normal: 135–175 g/L), red cell","PeriodicalId":501652,"journal":{"name":"The Pediatric Infectious Disease Journal","volume":"1 1","pages":"483 - 486"},"PeriodicalIF":0.0,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140716688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}