Surgical Endoscopy最新文献

{"title":"Paraesophageal hernia recurrence following repair: making the case for reoperative surgery in a propensity-matched cohort","authors":"Aditya Jog, Alexandra L. Strauss Starling, Isha Kaur, Kenneth Um, Luke J. Keele, Joseph R. Triggs, Maria S. Altieri, Jenny M. Shao","doi":"10.1007/s00464-024-10833-8","DOIUrl":"https://doi.org/10.1007/s00464-024-10833-8","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Paraesophageal hernia repairs (PEHRs) have high rates of radiographic recurrence, with some patients requiring repeat operation. This study characterizes patients who underwent PEHR to identify the factors associated with postoperative symptom improvement and radiographic recurrence. We furthermore use propensity score matching to compare patients undergoing initial and reoperative PEHR to identify the factors predictive of recurrence or need for reoperation.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>After IRB approval, patients who underwent PEHR at a tertiary care center between January 2018 and December 2022 were identified. Patient characteristics, preoperative imaging, operative findings, and postoperative outcomes were recorded. A computational generalization of inverse propensity score weight was then used to construct populations of initial and redo PEHR patients with similar covariate distributions.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 244 patients underwent PEHR (78.7% female, mean age 65.4 ± 12.3 years). Most repairs were performed with crural closure (81.4%) and fundoplication (71.7%) with 14.2% utilizing mesh. Postoperatively, 76.5% of patients had subjective symptom improvement and of 157 patients with postoperative imaging, 52.9% had evidence of radiographic recurrence at a mean follow-up of 10.4 ± 13.6 months. Only 4.9% of patients required a redo operation. Hernia type, crural closure, fundoplication, and mesh usage were not predictors of radiographic recurrence or symptom improvement (<i>P</i> &gt; 0.05). Propensity weight score analysis of 50 redo PEHRs compared to a matched cohort of 194 initial operations revealed lower rates of postoperative symptom improvement (<i>P</i> &lt; 0.05) but no differences in need for revision, complication rates, ED visits, or readmissions.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Most PEHR patients have symptomatic improvement with minimal complications and reoperations despite frequent radiographic recurrence. Hernia type, crural closure, fundoplication, and mesh usage were not significantly associated with recurrence or symptom improvement. Compared to initial PEHR, reoperative PEHRs had lower rates of symptom improvement but similar rates of recurrence, complications, and need for reoperation.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140613996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic sleeve gastrectomy for premenstrual syndrome symptoms in patients with obesity","authors":"Xiangxin Kong, Yuan Zhang, Ke Song, Ming He, Yin Xian, Xing Xie, Junming Cheng, Yixing Ren","doi":"10.1007/s00464-024-10819-6","DOIUrl":"https://doi.org/10.1007/s00464-024-10819-6","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Premenstrual syndrome (PMS) is a pathological condition characterized by a series of abnormal physical, psychological, and behavioral symptoms. We evaluated the effectiveness of laparoscopic sleeve gastrectomy (LSG) in the treatment of patients with obesity and PMS.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>In this case–control study, 131 patients with obesity (BMI ≥ 27.5 kg/cm²) diagnosed with moderate-to-severe PMS from March 2018 to March 2022 were prospectively selected to undergo LSG or not at their own discretion. Participants self-reported their PMS severity using the Premenstrual Syndrome Screening Tool. Among them, 68 patients chose LSG surgery, and 63 control group patients were followed up without surgery. Data were recorded at baseline and at 3 months post-treatment. We used a multivariate analysis to assess the improvement in PMS symptoms and associated factors.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Of the 131 patients with obesity and PMS, the improvement rate of PMS in the LSG group was 57.35% (<i>n</i> = 39), while the improvement rate of PMS in the control group was 25.40% (<i>n</i> = 16). Furthermore, our study revealed that surgery is an independent factor affecting the improvement of patients with PMS. Additionally, there was a correlation between alcohol use, T2DM and obesity-related metabolic diseases, and BMI with PMS. The changes in BMI, testosterone, and estradiol(E2) levels may also contribute to the improvement of patients with obesity and PMS.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>LSG can improve the management of obesity in patients with PMS to some extent. Changes in BMI, testosterone, and E2 may be indicative of improvement in patients with obesity and PMS.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"117 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reasons for conversions in thoracoscopic repairs of neonatal congenital diaphragmatic hernias: a systematic review","authors":"Karina Miura da Costa, Iulia Stratulat, Amulya Kumar Saxena","doi":"10.1007/s00464-024-10831-w","DOIUrl":"https://doi.org/10.1007/s00464-024-10831-w","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>This systematic review focused on reasons for conversions in neonates undergoing thoracoscopic congenital diaphragmatic hernia (CDH) repair.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Systematic search of Medline/Pubmed and Embase was performed for English, Spanish and Portuguese reports, according to PRISMA guidelines.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Of the 153 articles identified (2003–2023), 28 met the inclusion criteria and offered 698 neonates for analysis. Mean birth weight and gestational age were 3109 g and 38.3 weeks, respectively, and neonates were operated at a mean age of 6.12 days. There were 278 males (61.50%; 278/452) and 174 females (38.50%; 174/452). The reasons for the 137 conversions (19.63%) were: (a) defect size (<i>n</i> = 22), (b) need for patch (<i>n</i> = 21); (c) difficulty in reducing organs (<i>n</i> = 14), (d) ventilation issues (<i>n</i> = 10), (e) bleeding, organ injury, cardiovascular instability (<i>n</i> = 3 each), (f) bowel ischemia and defect position (<i>n</i> = 2 each), hepatopulmonary fusion (<i>n</i> = 1), and (g) reason was not specified for <i>n</i> = 56 neonates (40.8%). The repair was primary in 322 neonates (63.1%; 322/510) and patch was used in 188 neonates (36.86%; 188/510). There were 80 recurrences (12.16%; 80/658) and 14 deaths (2.48%; 14/565). Mean LOS and follow-up were 20.17 days and 19.28 months, respectively.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Neonatal thoracoscopic repair for CDH is associated with conversion in 20% of cases. Based on available data, defect size and patch repairs have been identified as the predominant reasons, followed by technical difficulties to reduce the herniated organs and ventilation related issues. However, data specifically relating to conversion is poorly documented in a high number of reports (40%). Accurate data reporting in future will be important to better estimate and quantify reasons for conversions in neonatal thoracoscopy for CDH.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"2014 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the influence of parameters on tissue welding in small bowel end-to-end anastomosis in vitro and in vivo","authors":"Caihui Zhu, Yuyan Na, Xiujun Cheng, Xiaonan Tao, Pengyao Xie, Lei Chen, Hui Zhao, Jian Qiu, Xiaodong Gu, Jianbin Xiang, Kefu Liu","doi":"10.1007/s00464-024-10795-x","DOIUrl":"https://doi.org/10.1007/s00464-024-10795-x","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>The use of high-frequency electric welding technology for intestinal end-to-end anastomosis holds significant promise. Past studies have focused on in vitro, and the safety and efficacy of this technology is uncertain, severely limiting the clinical application of this technology. This study investigates the impact of compression pressure, energy dosage, and duration on anastomotic quality using a homemade anastomosis device in both in vitro and in vivo settings.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Two hundred eighty intestines and 5 experimental pigs were used for in vitro and in vivo experiments, respectively. The in vitro experiments were conducted to study the effects of initial pressure (50–400 kpa), voltage (40–60 V), and time (10–20 s) on burst pressure, breaking strength, thermal damage, and histopathological microstructure of the anastomosis. Optimal parameters were then inlaid into a homemade anastomosis and used for in vivo experiments to study the postoperative porcine survival rate and the pathological structure of the tissues at the anastomosis and the characteristics of the collagen fibers.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The anastomotic strength was highest when the compression pressure was 250 kPa, the voltage was 60 V, and the time was 15 s. The degree of thermal damage to the surrounding tissues was the lowest. The experimental pigs had no adverse reactions after the operation, and the survival rate was 100%. 30 days after the operation, the surgical site healed well, and the tissues at the anastomosis changed from immediate adhesions to permanent connections.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>High-frequency electric welding technology has a certain degree of safety and effectiveness. It has the potential to replace the stapler anastomosis in future and become the next generation of new anastomosis device.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\u0000","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel gastric endoscopic submucosal dissection training model enhances the endoscopic submucosal dissection skills of trainees: a multicenter comparative study","authors":"Tomohiro Mitsui, Hironori Sunakawa, Yusuke Yoda, Masafumi Nishio, Shinpei Kondo, Jun Hamanaka, Chikako Tokoro, Keiichiro Nakajo, Shin Maeda, Tomonori Yano, Kingo Hirasawa","doi":"10.1007/s00464-024-10838-3","DOIUrl":"https://doi.org/10.1007/s00464-024-10838-3","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Endoscopic submucosal dissection (ESD) requires high endoscopic technical skills, and trainees should develop effective training methods. In collaboration with KOTOBUKI Medical, we developed the G-Master, which is a non-animal training model that can simulate various parts of gastric ESD. We aimed to clarify the usefulness of the G-Master for inexperienced ESD trainees.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>We collected data from the first 5 gastric ESD cases conducted by 15 inexperienced ESD trainees at 5 participating centers between 2018 and 2022. The participants were divided into two groups: the G-Master training and non-G-Master training groups. Outcome measurements, such as procedural speed, perforation rate, self-completion rate, and en bloc resection rate, were compared between the two groups retrospectively.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 75 gastric ESD cases were included in this study. The G-Master training group included 25 cases performed by 5 trainees, whereas the non-G-Master training group included 50 cases performed by 10 trainees. The median procedural speed for all cases was significantly faster in the G-Master training group than in the non-G-Master training group. Moreover, the procedural speed was linearly improved from the initial to the last cases in the lower location in the G-Master training group compared with the non-G-Master training group. In addition, although there was no significant difference, the G-Master training group showed lower rates of perforation and a lesser need to transition to expert operators than the non-G-Master training group.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The G-Master could improve the ESD skills of inexperienced ESD trainees.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Risk factors associated with functional esophageal disorders (FED) versus gastroesophageal reflux disease (GERD).","authors":"M. Sachar, M. Wizentier, Emma Risner, Hannah Asmail, Mathew Omara, Shreya Chablaney, Abraham Khan, Rita M. Knotts","doi":"10.1007/s00464-024-10846-3","DOIUrl":"https://doi.org/10.1007/s00464-024-10846-3","url":null,"abstract":"","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"79 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140702416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Equal short-term outcomes of intracorporeal mechanical gastrogastrostomy in laparoscopic pylorus-preserving gastrectomy for cT1N0 gastric cancer in the middle stomach compared with the extracorporeal hand-sewing method","authors":"Hiroki Harada, Kojiro Eto, Manabu Ohashi, Nozomi Kurihara, Motonari Ri, Rie Makuuchi, Satoshi Ida, Masaru Hayami, Koshi Kumagai, Takeshi Sano, Souya Nunobe","doi":"10.1007/s00464-024-10823-w","DOIUrl":"https://doi.org/10.1007/s00464-024-10823-w","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Intracorporeal mechanical gastrogastrostomy (IMG) techniques have recently been developed and their short-term safety was presented in their initial evaluation. However, whether they are comparable to extracorporeal hand-sewing gastrogastrostomy (EHG) remains unclear. The aim of the study is to establish the safety of IMG in totally laparoscopic pylorus-preserving gastrectomy (TLPPG) compared to EHG in laparoscopy-assisted pylorus-preserving gastrectomy (LAPPG).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>We retrospectively analyzed the short-term outcomes of patients with middle-third early gastric cancer who underwent LAPPG or TLPPG between 2005 and 2022. The primary objective of this study was to evaluate the non-inferiority of IMG to EHG in terms of safety, with the primary endpoint being the risk difference in anastomosis-related complications (ARCs). The sample size required to achieve a statistical power of 80% for the non-inferiority test was 971 with a one-sided alpha level of 5% and non-inferiority of 5%.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The analysis included a total of 1,021 patients who underwent LAPPG or TLPPG during the study period. Among them, 488 patients underwent EHG, while 533 underwent IMG. The incidences of ARCs were 11.3% and 11.4% in EHG and IMG, respectively. The observed difference in incidence was 0.0017 (90% confidence interval − 0.0313 to 0.0345), which statistically demonstrated the non-inferiority of IMG to EHG in the incidence of ARCs. Among other complications, the incidence of wound infection in IMG was lower than that in EHG.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>IMG is safe regarding ARCs compared with EHG. These results will encourage surgeons to introduce IMG for patients with early middle gastric cancer.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The outcomes of laparoscopic omentum-preserving gastrectomy compared to open surgery with omentectomy in gastric cancer patients: a propensity score matched study of 249 UICC stage 0–IV gastric cancer patients","authors":"T. Jagric, G. Hladnik, R. Kolaric, I. Arpad, M. Horvat, S. Potrc","doi":"10.1007/s00464-024-10835-6","DOIUrl":"https://doi.org/10.1007/s00464-024-10835-6","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>We performed a propensity score matched study comparing patients’ short- and long-term results after laparoscopic omentum-preserving gastrectomy and open surgery with omentectomy with UICC stages 0–IV.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Between 2015 and 2022, 311 patients with gastric cancer underwent surgery at the University Clinical Centre Maribor. Of these, 249 met the inclusion criteria and 198 were included in the study group after PSM.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Patients in both groups were well-balanced in demographic and pathological characteristics after PSM. There was no significant difference in the 5-year survival between groups (LAP: 62.2% vs. OPN: 54.4%; <i>p</i> = 0.950). The Cox regression model identified UICC stage and age as significant predictors for survival. In both groups, peritoneal dissemination was the most common site of recurrence. The multivariate analysis identified the UICC stage as a significant predictor for peritoneal recurrence, while omental preservation was not associated with a higher risk of peritoneal dissemination. Omentum preservation was not associated with more intestinal obstruction. Patients in the LAP group had significantly shorter hospital stays (LAP: 9(6) vs. OPN: 10(5); <i>p</i> = 0.009), less postoperative morbidity (LAP: 17% vs. OPN: 23.4%; <i>p</i> = 0.009), and significantly more extracted LNs per operation compared to open surgery (LAP: 31 ± 11 LNs vs. OPN: 25 ± 12 LNs; <i>p</i> = 0.002).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Based on our results, we recommend the use of laparoscopic omentum-preserving gastrectomy in patients with early and advanced gastric cancer.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\u0000","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"123 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic liver resection or enucleation for giant hepatic hemangioma: how to choose?","authors":"Haili Zhang, Hongwei Xu, Ningyuan Wen, Bo Li, Kefei Chen, Yonggang Wei","doi":"10.1007/s00464-024-10820-z","DOIUrl":"https://doi.org/10.1007/s00464-024-10820-z","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Laparoscopic treatment has been increasingly adopted for giant hepatic hemangioma (HH), but the role of liver resection or enucleation remains uncertain. The aim of this study is to compare the laparoscopic resection (LR) with laparoscopic enucleation (LE) for HH, and to provide evidence on how to choose the most suitable approach for HH.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>A retrospective analysis of HH patients underwent laparoscopic treatment between March 2015 and August 2022 was performed. Perioperative outcomes were compared based on the surgical approaches, and risk factors for increased blood loss was calculated by logistic regression analysis.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 127 patients in LR group and 287 patients in LE group were enrolled in this study. The median blood loss (300 vs. 200 mL, <i>P</i> &lt; 0.001) was higher in LE group than that in LR group. Independent risk factors for blood loss higher than 400 mL were tumor size ≥ 10 cm, tumor adjacent to major vessels, tumor occupying right liver or caudate lobe, and the portal phase enhancement ratio (PER) ≥ 38.9%, respectively. Subgroup analysis showed that LR was associated with less blood loss (155 vs. 400 mL, <i>P</i> &lt; 0.001) than LE procedure in patients with high PER value. Both LR and LE approaches exhibited similar perioperative outcomes in patients with low PER value.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>Laparoscopic treatment for HH could be feasibly and safely performed by both LE and LR. For patients with PER higher than 38.9%, the LR approach is recommended.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\u0000","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of an intravenous acetaminophen/ibuprofen fixed-dose combination on postoperative opioid consumption and pain after video-assisted thoracic surgery: a double-blind randomized controlled trial","authors":"Ho-Jin Lee, Seungeun Choi, Soohyuk Yoon, Susie Yoon, Jae-Hyon Bahk","doi":"10.1007/s00464-024-10821-y","DOIUrl":"https://doi.org/10.1007/s00464-024-10821-y","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Video-assisted thoracoscopic surgery (VATS) often induces significant postoperative pain, potentially leading to chronic pain and decreased quality of life. This study aimed to evaluate the acetaminophen/ibuprofen combination effectiveness in reducing analgesic requirements and pain intensity in patients undergoing VATS.</p><h3 data-test=\"abstract-sub-heading\">Study design</h3><p>This is a double-blinded randomized controlled trial.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Adult patients scheduled for elective VATS for lung resection were randomized to receive either intravenous acetaminophen and ibuprofen (intervention group) or 100 mL normal saline (control group). Treatments were administered post-anesthesia induction and every 6 h for three cycles. The primary outcome was total analgesic consumption at 24 h postoperatively. Secondary outcomes were cumulative analgesic consumption at 2 and 48 h; analgesic-related side effects at 2, 24, and 48 h; quality of recovery at 24 h and 48 h postoperatively; pain intensity at rest and during coughing; and rescue analgesics use. Chronic postsurgical pain (CPSP) was assessed through telephone interviews 3 months postoperatively.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The study included 96 participants. The intervention group showed significantly lower analgesic consumption at 24 h and 48 h postoperatively (24 h: median difference: − 100 µg equivalent intravenous fentanyl [95% confidence interval (CI) − 200 to − 5 μg], <i>P</i> = 0.037; 48 h: median difference: − 140 μg [95% CI − 320 to − 20 μg], <i>P</i> = 0.035). Compared to the controls, the intervention group exhibited a significantly lower quality of recovery 24 h post-surgery, with no significant difference at 48 h. All pain scores except for coughing at 48 h post-surgery were significantly lower in the intervention group compared to the controls. No significant differences were observed between the groups in postoperative nausea and vomiting occurrence, hospital stay length, and CPSP.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Perioperative administration of acetaminophen/ibuprofen significantly decreased analgesic needs in patients undergoing VATS, providing an effective postoperative pain management strategy, and potentially minimizing the need for stronger analgesics.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"143 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140593633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}