Surgical Endoscopy最新文献

{"title":"Patient-reported outcomes during first-line palliative systemic therapy alternated with pressurized intraperitoneal aerosol chemotherapy for unresectable colorectal peritoneal metastases: a single-arm phase II trial (CRC-PIPAC-II)","authors":"Vincent C. J. van de Vlasakker, Paulien Rauwerdink, Koen. P. B. Rovers, Emma C. Wassenaar, Geert-Jan Creemers, Maartje Los, Jacobus . W. A. Burger, Simon W. Nienhuijs, Onno Kranenburg, Marinus J. Wiezer, Robin J. Lurvink, Djamila Boerma, Ignace H. J. T. de Hingh","doi":"10.1007/s00464-024-11185-z","DOIUrl":"https://doi.org/10.1007/s00464-024-11185-z","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>The CRC-PIPAC-II study prospectively assessed bidirectional therapy (BT) consisting of first-line palliative systemic therapy and electrostatic precipitation oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy (ePIPAC-OX) in patients with unresectable colorectal peritoneal metastases (CPM). This study describes the exploration of patient-reported outcomes (PROs).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>In this phase II trial, 20 patients with isolated CPM were treated with up to three cycles of BT, each cycle consisting of two to three courses of systemic therapy, followed by ePIPAC-OX (92 mg/m²). Patients were asked to complete the EuroQoL EQ-5D-5L, EORTC QLQ-C30, and EORTC QLQ-CR29 questionnaires at baseline, during the first cycle of BT, and one and four weeks after each consecutive BT cycle. PRO scores were calculated and compared between baseline and each subsequent time point using linear-mixed modeling (LMM). PROs were categorized into symptom scales and function scales. Symptom scales ranged from 0 to 100, with 100 representing the maximum symptom load. Function scales ranged from 0 to 100, with 100 representing optimal functioning.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Twenty patients underwent a total of 52 cycles of bidirectional therapy. Most PROs (29 of 37, 78%) were not significantly affected during trial treatment. In total, only eight PROs (22%) were significantly affected during trial treatment: Six PROs (index value, global health status, emotional functioning, C30, appetite, and insomnia) showed transient improvement at different time points. Two PROs transiently deteriorated: pain initially improved during the first BT cycle [− 16, <i>p</i> &lt; 0.001] yet worsened temporarily one week after the first two BT cycles (+ 20, <i>p</i> &lt; 0.001; + 17, <i>p</i> = 0.004; respectively). Abdominal pain worsened temporarily one week after the first BT cycle (+ 16, <i>p</i> = 0.004), before improving again four weeks after treatment ended (− 10, <i>p</i> = 0.004). All significant effects on Pros were clinically significant and all deteriorations in PROs were of temporary nature.</p><h3 data-test=\"abstract-sub-heading\">Discussion</h3><p>Patients undergoing BT for unresectable CPM had significant, but reversible alterations in several PROs. Most affected PROs concerned improvements and only two PROs showed deteriorations. Both deteriorated PROs returned to baseline after trial treatment and were of a temporary nature. These outcomes help to design future studies on the role of ePIPAC in the palliative setting.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detailed analysis of learning phases and outcomes in robotic and endoscopic thyroidectomy","authors":"Jia-Fan Yu, Wen-Yu Huang, Jun Wang, Wei Ao, Si-Si Wang, Shao-Jun Cai, Si-Ying Lin, Chi-Peng Zhou, Meng-Yao Li, Xiao-Shan Cao, Xiang-Mao Cao, Zi-Han Tang, Zhi-hong Wang, Surong Hua, Wen-Xin Zhao, Bo Wang","doi":"10.1007/s00464-024-11247-2","DOIUrl":"https://doi.org/10.1007/s00464-024-11247-2","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Thyroid surgery has undergone significant transformation with the introduction of minimally invasive techniques, particularly robotic and endoscopic thyroidectomy. These advancements offer improved precision and faster recovery but also present unique challenges. This study aims to compare the learning curves, operational efficiencies, and patient outcomes of robotic versus endoscopic thyroidectomy.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>A retrospective cohort study was conducted, analyzing 258 robotic (da Vinci) and 214 endoscopic thyroidectomy cases. Key metrics such as operation duration, drainage volume, lymph node dissection outcomes, and hypoparathyroidism incidence were assessed to understand surgical learning curves and efficiency.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Robotic thyroidectomy showed a longer learning curve with initially longer operation times and higher drainage volumes but superior lymph node dissection outcomes. Both techniques were safe, with no permanent hypoparathyroidism or recurrent laryngeal nerve damage reported. The study delineated four distinct stages in the robotic and endoscopic surgery learning curve, each marked by specific improvements in proficiency. Endoscopic thyroidectomy displayed a shorter learning curve, leading to quicker operational efficiency gains.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Robotic and endoscopic thyroidectomies are viable minimally invasive approaches, each with its learning curves and efficiency metrics. Despite initial challenges and a longer learning period for robotic surgery, its benefits in complex dissections may justify specialized training. Structured training programs tailored to each technique are crucial for improving outcomes and efficiency. Future research should focus on optimizing training protocols and increasing accessibility to these technologies, enhancing patient care in thyroid surgery.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison between robotic-assisted and open approaches for large ventral hernia repair—a multicenter analysis of 30 days outcomes using the ACHQC database","authors":"Diego L. Lima, Raquel Nogueira, Jianing Ma, Mohamad Jalloh, Shannon Keisling, Adel Alhaj Saleh, Prashanth Sreeramoju","doi":"10.1007/s00464-024-11249-0","DOIUrl":"https://doi.org/10.1007/s00464-024-11249-0","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction</h3><p>Over the last few decades, there has been an increase in the use of a minimally invasive (MIS) approach for complex hernias involving component separation. A robotic platform provides better visualization and mobilization of tissues for component separation. We aim to assess the outcomes of open and robotic-assisted approaches for large VHR utilizing the ACHQC national database.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>A retrospective review of prospectively collected data from the Abdominal Core Health Quality Collaborative (ACHQC) was performed to include all adult patients who had primary and incisional midline ventral hernias larger than 10 cm and underwent elective open and robotic hernia repairs with mesh from January 2013 to March 2023. Univariate and multivariate analyses were performed comparing Open and Robotic approaches.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The ACHQC database identified 5,516 patients with midline hernias larger than 10 cm who underwent VHR. The open group (OG) had 4,978 patients, and the robotic group (RG) had 538. The RG had a higher median BMI (33.3 kg/m² (IQR 29.8–38.1) vs 32.7 (IQR 28.7–36.6) (<i>p</i> &lt; 0.001). Median hernia width was 15 cm (IQR 12–18) in the OG and 12 cm in the RG (10–14) (<i>p &lt; </i>0.001). Sublay positioning of the mesh was the most common. The fascial closure was higher in the RG (524; 97% versus 4,708; 95%—<i>p</i> = 0.005). Median Length of Stay (LOS) was 5 days (IQR 4–7) in the OG and 2 days (IQR 1–3) in the RG (<i>p &lt; </i>0.001). The readmission rate was higher in the OG (<i>n</i> = 374; 7.5% vs <i>n</i> = 16; 3%; <i>p &lt; </i>0.001). 30-day SSI were higher in the OG (343; 6.9%% vs 14; 2.6%; <i>p &lt; </i>0.001). Logistic regression analysis identified diabetes (OR 1.6; CI 1.1–2.1; <i>p</i> = 0.006) and BMI (OR 1.04, CI 1.02–1.06; <i>p &lt; </i>0.001) as predictors of SSIs, while the robotic approach was protective (OR 0.35, CI 0.17–0.64; <i>p</i> = 0.002). For SSO, logistic regression showed BMI (OR 1.04, CI 1.03–1.06; <i>p &lt; </i>0.001) and smoking (OR 1.8, CI 1.3–2.4; <i>p &lt; </i>0.001) as predictors Robotic approach was associated with lower readmission rates (OR .04, CI 0.2–0.6; <i>p &lt; </i>0.001).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>A robotic approach improves early 30-day outcomes compared to an open technique for large VHR. There was no difference in SSO at 30 days.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"212 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive model for contralateral inguinal hernia repair within three years of primary repair: a nationwide population-based cohort study","authors":"Hung-Yu Lin, Chung-Yen Chen, Jian-Han Chen","doi":"10.1007/s00464-024-11233-8","DOIUrl":"https://doi.org/10.1007/s00464-024-11233-8","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Limited reports have discussed the risk factors for contralateral inguinal hernia (CIH) repair. We generated a risk factor scoring system to predict CIH within 3 years after unilateral inguinal hernia repair.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>We extracted the admission data of patients aged ≥ 18 years who underwent primary unilateral inguinal hernia repair without any other operation from the National Health Insurance Research Database. Patients were randomly divided into 80% and 20% validation cohorts. Multivariate analysis with a logistic regression model was used to generate the scoring system, which was used in the validation group.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Overall, 170,492 adult men were included, with a median follow-up of 87 months. The scoring system ranged from 0–5 points, composited with age (&lt; 45 years, 0 points; 45–65 years, 2 points; 65–80 years, 3 points; &gt; 80 years, 2 points) and two comorbidities (cirrhosis and prostate disease: 1 point each). The areas under receiver operating characteristic (ROC) curves were 0.606 and 0.551 for the derivation and validation groups, respectively. The rates and adjusted odds ratios (OR) of CIH repair in the derivation group were 3.0% at 0–2 points, 5.5% (1.854, <i>p</i> &lt; 0.001) at 3, 6.7% (2.279, <i>p</i> &lt; 0.001) at 4, and 6.9% (2.348, <i>p</i> &lt; 0.001) at 5, with similar results in the validation group [2.3% at 0–2 points, 3.8% (1.668, <i>p</i> &lt; 0.001) at 3, 5.4% (2.386, <i>p</i> &lt; 0.001) at 4, and 6.8% (3.033, <i>p</i> &lt; 0.001) at 5].</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>The CIH scoring system effectively predicted CIH repair within three years of primary unilateral inguinal hernia repair. Surgeons could perform laparoscopic surgery with CIH scores &gt; 2 points which enables easier contralateral exploration and repair during the same surgery, without additional incisions, to minimize the need for future surgeries. However, further prospective validation of this scoring system is required.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the NICE procedure the great equalizer for patients with high BMI undergoing resection for diverticulitis?","authors":"Jacques Bistre-Varon, Ryan Gunter, Roberto Secchi Del Rio, Muhammed Elhadi, Sachika Gandhi, Bryan Robins, Sarah Popeck, Jean-Paul LeFave, Eric M. Haas","doi":"10.1007/s00464-024-11226-7","DOIUrl":"https://doi.org/10.1007/s00464-024-11226-7","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>By 2030, projections indicate that nearly half of USS adults will be obese, with 29 states exceeding a 50% obesity rate. High Body Mass Index (BMI) presents particular challenges in treating diverticulitis, including worsened symptoms and increased risk of surgical complications. The Robotic Natural orifice Intracorporeal Anastomosis with Transrectal Extraction (NICE) procedure has been developed for colorectal surgeries to tackle these challenges. This study evaluates the efficacy of the Robotic NICE procedure in achieving comparable surgical outcomes in patients with both high and normal BMI.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This retrospective cohort study assessed the outcomes of robotic-assisted colectomy utilizing the NICE technique in patients with diverticulitis, dividing them into two groups based on BMI: high BMI (≥ 30 kg/m^2) and non-high BMI (&lt; 30 kg/m^2).</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Among the 194 patients analyzed, the incidence of complicated diverticulitis was significantly higher in the high BMI group (60.5%) compared to the non-high BMI group (39%; <i>p</i> = 0.003).The high BMI group had higher ASA scores, indicating sicker patients. The high BMI group also had a significantly higher rate of unplanned operations within 30 days (7.9% vs. 1.7%, <i>p</i> = 0.034). However, no significant differences were observed in the length of hospital stay, time to first flatus, or ICU admission rates between the two groups. Binary logistic regression highlighted the length of stay as a significant predictor of postoperative complications (Odds Ratio: 1.9686, 95% CI: 1.372–2.825, p &lt; 0.001). Other factors, including age, operative time, and gender, did not significantly predict complications.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The findings suggest that the Robotic NICE procedure can mitigate some of the challenges typically associated with conventional minimally invasive surgery in which abdominal wall incision is made, providing consistent outcomes regardless of BMI. Further research is needed to explore long-term benefits, aiming to establish this approach as a standard for managing diverticulitis in our patient population.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden hernias hurt: a plea for early diagnosis and treatment of occult inguinal hernias","authors":"Harry J. Wong, Cherin Oh, Shirin Towfigh","doi":"10.1007/s00464-024-11253-4","DOIUrl":"https://doi.org/10.1007/s00464-024-11253-4","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction</h3><p>Hidden or occult inguinal hernias are symptomatic hernias that do not present with a bulge. For some surgeons, if a bulge is not present, then no hernia repair is contemplated. We report preoperative findings of patients with occult inguinal hernias and outcomes after repair to assist in early detection and treatment of this special population.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>All patients who underwent inguinal hernia repairs, 2008–2019, were reviewed. Patients were classified as having occult inguinal hernias if they (a) complained of groin pain, (b) did not have bulging on exam, (c) had supportive imaging showing an inguinal hernia, and (d) were confirmed to have inguinal hernias that were repaired intraoperatively. Presentation and outcomes were compared with the non-occult group treated during the same time period.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Of 485 patients who underwent elective inguinal hernia repairs over 10 years, 212 (44%) had occult inguinal hernias. Patients in the occult group were significantly more likely to be female, younger, and with higher BMI compared to the non-occult group. They also had more preoperative pain for a significantly longer time. This was associated with higher incidence of pain medications usage, including opioids, in the occult group. On physical examination, those with occult hernias were twice as likely to have tenderness over the inguinal canal. Most hernia repairs (66%) were laparoscopic and 94% used mesh. Postoperatively, the occult group had 83% resolution of symptoms after hernia repair.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Some surgeons hesitate recommending hernia repair to patients with occult inguinal hernias, as these patients do not fit the traditional definition of a hernia, i.e., a bulge. Our study challenges this perception by showing that discounting groin pain due to occult hernia prolongs patient’s suffering and may risk increased opioid use, especially in females, although 83% cure can be achieved with hernia repair.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\u0000","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142258190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unplanned hospital readmission after cholecystectomy in adults with cerebral palsy","authors":"Lucas Weiser, Matthew Y. C. Lin","doi":"10.1007/s00464-024-11224-9","DOIUrl":"https://doi.org/10.1007/s00464-024-11224-9","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Adults with cerebral palsy (CP) are a largely understudied, growing population with unique health care requirements. We sought to establish a deeper understanding of the surgical risk in adults with CP undergoing a common general surgical procedure: cholecystectomy.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Data were obtained from the State Inpatient Database developed for the Healthcare Cost and Utilization Project. Inclusion criteria included patients ≥ 18 years with CP and a primary ICD-9 procedure code indicating open or laparoscopic cholecystectomy. Demographics, procedure-related factors, and comorbid conditions were analyzed, and unplanned 30 and 90 day readmission rates calculated for each variable. Reasons for readmission based on ICD-9 diagnosis codes were grouped into relevant categories. Univariate analysis identified factors significantly associated with readmission rates.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 802 patients with CP met the inclusion criteria. Unplanned 30 and 90 day readmission rates after laparoscopic cholecystectomy were 11.4% and 18.1%, respectively. Average length of stay (LOS) after laparoscopic cholecystectomy was 7.1 days. After open cholecystectomy, 30 and 90 day readmission rates were 16.9% and 30.3% with an average LOS of 14.6 days. Infection was the most common cause for 30 and 90 day readmission. Factors associated with 30 day readmission included type of cholecystectomy, LOS, discharge to skilled nursing facility, and comorbid diabetes and malnutrition. Factors associated with 90 day readmission included type of cholecystectomy, LOS, discharge to skilled nursing facility, and comorbid heart failure, renal disease, epilepsy, and malnutrition.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Unplanned readmission rates after open and laparoscopic cholecystectomy in adult patients with CP are much higher than previously demonstrated rates in the general population. These patients frequently suffer multiple comorbid conditions that significantly complicate their surgical care. As more and more of these patients live longer into adulthood, further study is warranted to grasp the perioperative risk of simple and complex surgical procedures.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Derivation and validation of a predictive model for subtotal cholecystectomy","authors":"James Lucocq, David Hamilton, Abdelwakeel Bakhiet, Fabiha Tasnim, Jubayer Rahman, John Scollay, Pradeep Patil","doi":"10.1007/s00464-024-11241-8","DOIUrl":"https://doi.org/10.1007/s00464-024-11241-8","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Introduction</h3><p>Rates of subtotal cholecystectomy (STC) are increasing in response to challenging cases of laparoscopic cholecystectomy (LC) to avoid bile duct injury, yet are associated with significant morbidity. The present study identifies risk factors for STC and both derives and validates a risk model for STC.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>LC performed for all biliary pathology across three general surgical units were included (2015–2020). Clinicopathological, intraoperative and post-operative details were reported. Backward stepwise multivariable regression was performed to derive the most parsimonious predictive model for STC. Bootstrapping was performed for internal validation and patients were categorised into risk groups.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>Overall, 2768 patients underwent LC (median age, 53 years; median ASA, 2; median BMI, 29.7 kg/m²), including 99 cases (3.6%) of STC. Post-operatively following STC, there were bile leaks in 29.3%, collections in 19.2% and retained stones in 10.1% of patients. Post-operative intervention was performed in 29.3%, including ERCP (22.2%), laparoscopy (5.0%) and laparotomy (3.0%). The following variables were positive predictors of STC and were included in the final model: age &gt; 60 years, male sex, diabetes mellitus, acute cholecystitis (AC), increased severity of AC (CRP &gt; 90 mg/L), ≥ 3 biliary admissions, pre-operative ERCP with/without stent, pre-operative cholecystostomy and emergency LC (AUC = 0.84). Low, medium and high-risk groups had a STC rate of 0.8%, 3.9% and 24.5%, respectively.</p><h3 data-test=\"abstract-sub-heading\">Discussion</h3><p>The present study determines the morbidity of STC and identifies high-risk features associated with STC. A risk model for STC is derived and internally validated to help surgeons identify high-risk patients and both improve pre-operative decision-making and patient counselling.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cost comparison of GLP-1 receptor agonists and bariatric surgery: what is the break even point?","authors":"Salvatore Docimo, Jay Shah, Gus Warren, Samer Ganam, Joseph Sujka, Christopher DuCoin","doi":"10.1007/s00464-024-11191-1","DOIUrl":"https://doi.org/10.1007/s00464-024-11191-1","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>With the prevalence of obesity rising in the US, medical management is of increasing importance. Two popular options for the treatment of obesity are bariatric surgery (e.g. sleeve gastrectomy and Roux-en-Y gastric bypass) and the increasingly popular GLP-1 Receptor Agonists (GLP-1 s). This study examines the initial and long-term costs of GLP-1 s compared to bariatric surgery.</p><h3 data-test=\"abstract-sub-heading\">Study design</h3><p>We compared average 2023 national retail prices for GLP-1 s to surgical cost estimates from 2015 adjusted for inflation. We then plotted the cumulative medication cost over time against the flat cost of each surgery, thus calculating \"break-even points\" (when medication costs equal surgery costs). The findings revealed a crucial insight, for some GLP-1 s like Saxenda and Wegovy, the high cost of ongoing use surpasses the cost of RYGB in less than a year and sleeve gastrectomy within nine months. Even the most affordable option, Byetta, becomes costlier than surgery after around 1.5 years.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>This highlights the importance of looking beyond the initial financial investment when considering cost-effectiveness. Additionally, while not directly assessed, this study acknowledges that GLP-1 s take time to reach full effectiveness, potentially delaying weight loss while accumulating costs. Concerns also exist about weight regain after discontinuing the medication.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>This study is limited by the real-world variation for individual treatment costs (e.g. insurance), a limited evaluation of long-term costs associated with either treatment modality and their co-morbidities, and the reality of patient preference providing subjective value to either modality. Overall, the study offers insights into the financial trade-offs between GLP-1 s and bariatric surgery.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A calculator for musculoskeletal injuries prediction in surgeons: a machine learning approach","authors":"Luis Sánchez-Guillén, Carlos Lozano-Quijada, Álvaro Soler-Silva, Sergio Hernández-Sánchez, Xavier Barber, José V. Toledo-Marhuenda, Francisco López-Rodríguez-Arias, Emilio J. Poveda-Pagán, César González Mora, Antonio Arroyo","doi":"10.1007/s00464-024-11237-4","DOIUrl":"https://doi.org/10.1007/s00464-024-11237-4","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Background</h3><p>Surgical specialists experience significant musculoskeletal strain as a consequence of their profession, a domain within the healthcare system often recognized for the pronounced impact of such issues. The aim of this study is to calculate the risk of presenting musculoskeletal injuries in surgeons after surgical practice.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Cross-sectional study carried out using an online form (12/2021–03/2022) aimed at members of the Spanish Association of Surgeons. Demographic variables on physical and professional activity were recorded, as well as musculoskeletal pain (MSP) associated with surgical activity. Univariate and multivariate analysis were conducted to identify risk factors associated with the development of MSP based on personalized surgical activity. To achieve this, a risk algorithm was computed and an online machine learning calculator was created to predict them. Physiotherapeutic recommendations were generated to address and alleviate each MSP.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A total of 651 surgeons (112 trainees, 539 specialists). 90.6% reported MSP related to surgical practice, 60% needed any therapeutic measure and 11.7% required a medical leave. In the long term, MSP was most common in the cervical and lumbar regions (52.4, 58.5%, respectively). Statistically significant risk factors (OR CI 95%) were for trunk pain, long interventions without breaks (3.02, 1.65–5.54). Obesity, indicated by BMI, to lumbar pain (4.36, 1.84–12.1), while an inappropriate laparoscopic screen location was associated with cervical and trunk pain (1.95, 1.28–2.98 and 2.16, 1.37–3.44, respectively). A predictive model and an online calculator were developed to assess MSP risk. Furthermore, a need for enhanced ergonomics training was identified by 89.6% of surgeons.</p><h3 data-test=\"abstract-sub-heading\">Conclusions</h3><p>The prevalence of MSP among surgeons is a prevalent but often overlooked health concern. Implementing a risk calculator could enable tailored prevention strategies, addressing modifiable factors like ergonomics.</p>","PeriodicalId":501625,"journal":{"name":"Surgical Endoscopy","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142269298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}