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Functional probes for the diagnosis and treatment of infectious diseases 用于诊断和治疗传染病的功能探针

Aggregate Pub Date : 2024-06-25 DOI: 10.1002/agt2.620

Zhijin Fan, Yan Liu, Yuyun Ye, Yuhui Liao

引用次数: 0

Microtubule polymerization induced by iridium‐fullerene photosensitizers for cancer immunotherapy via dual‐reactive oxygen species regulation strategy 铱-富勒烯光敏剂通过双重活性氧调节策略诱导微管聚合，用于癌症免疫疗法

Aggregate Pub Date : 2024-06-25 DOI: 10.1002/agt2.623

Xiao‐Xiao Chen, Kun Peng, Xi Chen, Zheng‐Yin Pan, Qing‐Hua Shen, Yu‐Yi Ling, Jian‐Zhang Zhao, Cai‐Ping Tan

{"title":"Microtubule polymerization induced by iridium‐fullerene photosensitizers for cancer immunotherapy via dual‐reactive oxygen species regulation strategy","authors":"Xiao‐Xiao Chen, Kun Peng, Xi Chen, Zheng‐Yin Pan, Qing‐Hua Shen, Yu‐Yi Ling, Jian‐Zhang Zhao, Cai‐Ping Tan","doi":"10.1002/agt2.623","DOIUrl":"https://doi.org/10.1002/agt2.623","url":null,"abstract":"Microtubules (MTs) are key players in cell division, migration, and signaling, and they are regarded as important targets for cancer treatment. In this work, two fullerene (C60)‐functionalized Ir(III) complexes (Ir‐C601 and Ir‐C602) are rationally designed as dual reactive oxygen species (ROS) regulators and MT‐targeted Type I/II photosensitizers. In the dark, Ir‐C601 and Ir‐C602 serve as ROS scavengers to eliminate O2•− and •OH, consequently reducing the dark cytotoxicity and reversing dysfunctional T cells. Due to the efficiently populated C60‐localized intraligand triplet state, Ir‐C601 and Ir‐C602 can be excited by green light (525 nm) to produce O2•− and •OONO− (Type I) and 1O2 (Type II) to overcome tumor hypoxia. Moreover, Ir‐C601 is also able to photooxidize tubulin, consequently interfering with the cellular cytoskeleton structures, inducing immunogenic cell death and inhibiting cell proliferation and migration. Finally, Ir‐C601 exhibits promising photo‐immunotherapeutic effects both in vitro and in vivo. In all, we report here the first MT stabilizing photosensitizer performing through Type I/II photodynamic therapy pathways, which provides insights into the rational design of new photo‐immunotherapeutic agents targeting specific biomolecules.","PeriodicalId":501414,"journal":{"name":"Aggregate","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141551772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sulfato‐β‐cyclodextrin induced multivalent supramolecular directional aggregation of cyanovinylene derivatives for achieving reversible near‐infrared fluorescence 硫酸-β-环糊精诱导氰烯衍生物多价超分子定向聚集，实现可逆近红外荧光

Aggregate Pub Date : 2024-06-24 DOI: 10.1002/agt2.627

Zhixue Liu, Haiqi Chen, Mengdi Tian, Xinyao Sun, Yong‐Xue Li, Jie Wu, Ruotong Wang, Bin Li, Chunju Li, Yu Liu

{"title":"Sulfato‐β‐cyclodextrin induced multivalent supramolecular directional aggregation of cyanovinylene derivatives for achieving reversible near‐infrared fluorescence","authors":"Zhixue Liu, Haiqi Chen, Mengdi Tian, Xinyao Sun, Yong‐Xue Li, Jie Wu, Ruotong Wang, Bin Li, Chunju Li, Yu Liu","doi":"10.1002/agt2.627","DOIUrl":"https://doi.org/10.1002/agt2.627","url":null,"abstract":"Molecular aggregation or supramolecular aggregation‐induced emission is one of the research hotspots in chemistry, biology, and materials. Herein, we report negatively charged sulfato‐β‐cyclodextrin (SCD) induced cyanovinylene derivatives (DPy‐6C) directional aggregation to form regular nanorods (DPy‐6C@SCD) through supramolecular multivalent interactions, not only achieves ultraviolet‐visible absorption redshifted from 453 to 521 nm but also displays near‐infrared (NIR) aggregation‐induced emission with a large spectral redshift of 135 nm. The DPy‐6C monomer presents random nanosheets with weak fluorescence but obtains regular aggregates after assembly with SCD through electrostatic interactions. In the presence of H+, the DPy‐6C@SCD can further aggregate into elliptical nanosheets without fluorescence changes due to the protonation of secondary amines. In contrast, the morphology of DPy‐6C@SCD becomes flexible and sticks together upon the addition of OH− with an emission blue shift of 72 nm and a 90‐fold intensity increase because of disrupting the stacking mode of aggregates, thereby achieving acid‐base regulated reversible fluorescence behaviors that cannot be realized by DPy‐6C monomer. The DPy‐6C@SCD can efficiently select the detection of volatile organic amines both in liquid and gas phases within 5 s at the nanomolar level. Taking advantage of RGB analysis and calculation formula application, the DPy‐6C@SCD has been successfully used to monitor various organic amines on a smartphone, accompanied by naked‐eye visible photoluminescence. Therefore, the present research provides an efficient directional aggregation method through supramolecular multivalent interactions, which not only realizes topological morphology transformation but also achieves reversible NIR luminescent molecular switch and high sensitivity organic amines fluorescent sensing devices.","PeriodicalId":501414,"journal":{"name":"Aggregate","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141513771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scaffold‐free three‐dimensional cartilage regeneration based on cartilaginous organoids bioassembly technology 基于软骨有机体生物组装技术的无支架三维软骨再生技术

Aggregate Pub Date : 2024-06-21 DOI: 10.1002/agt2.619

Yingying Huo, Zheng Ci, Shiqi Wu, Shaoqing Feng, Yuyan Sun, Genke Li, Yu Liu, Yujie Hua, Yixin Zhang, Guangdong Zhou

{"title":"Scaffold‐free three‐dimensional cartilage regeneration based on cartilaginous organoids bioassembly technology","authors":"Yingying Huo, Zheng Ci, Shiqi Wu, Shaoqing Feng, Yuyan Sun, Genke Li, Yu Liu, Yujie Hua, Yixin Zhang, Guangdong Zhou","doi":"10.1002/agt2.619","DOIUrl":"https://doi.org/10.1002/agt2.619","url":null,"abstract":"Cartilage tissue engineering is a promising strategy to repair damaged tissue and reconstruct organ function, but the scaffold‐free cartilage regeneration technology is currently limited in its ability to construct three‐dimensional (3D) shapes, maintain the chondrogenic phenotype, and express cartilage‐specific extracellular matrix (ECM). Recently, cartilaginous organoids (COs), multicellular aggregates with spheroid architecture, have shown great potential in miniaturized cartilage developmental models in vitro. However, high‐efficiency and transferable in vivo organoid‐based 3D cartilage regeneration technology for preclinical research needs further exploration. In this study, we develop novel cartilaginous organoids bioassembly (COBA) strategy to achieve scaffold‐free 3D cartilage regeneration, which displays batch‐to‐batch efficiency, structural integration, and functional reconstruction. For underlying molecule mechanism, cellular adhesion proteins significantly regulate cell aggregation and cytoskeleton reorganization to form cartilaginous spheroids, and the hypoxic microenvironment created by high‐density cell aggregates synergistically activates hypoxia‐inducible factor‐1α‐mediated glycolytic metabolism reprogramming to maintain the chondrogenic phenotype and promote cartilage‐specific ECM deposition. Furthermore, separated COs can integrate into a complete and continuous cartilage tissue through the COBA approach, and thus facilitate raising the nasal dorsa in goats after minimally invasive injection. This study thus demonstrates the promise of COBA technology to achieve scaffold‐free 3D cartilage regeneration for organoid‐based translational applications.","PeriodicalId":501414,"journal":{"name":"Aggregate","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141551771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulating room temperature phosphorescence of carbazole quaternization pyridine in polymer through Hofmeister effect 通过霍夫迈斯特效应调节聚合物中咔唑季铵化吡啶的室温磷光

Aggregate Pub Date : 2024-06-17 DOI: 10.1002/agt2.611

Runying He, Yun Yang, Qian Zhou, Shasha Chang, Yi Cheng, Xiurong Ma, Yonggang Shi, Liyan Zheng, Qiue Cao

引用次数: 0

Mechanism research of type I reactive oxygen species conversion based on molecular and aggregate levels for tumor photodynamic therapy 基于分子和聚集体水平的 I 型活性氧转化机制研究，用于肿瘤光动力疗法

Aggregate Pub Date : 2024-06-17 DOI: 10.1002/agt2.612

Youqin Xu, Yili Xie, Qing Wan, Jianwen Tian, Jing Liang, Jianlong Zhou, Mu Song, Xinke Zhou, Muzhou Teng

{"title":"Mechanism research of type I reactive oxygen species conversion based on molecular and aggregate levels for tumor photodynamic therapy","authors":"Youqin Xu, Yili Xie, Qing Wan, Jianwen Tian, Jing Liang, Jianlong Zhou, Mu Song, Xinke Zhou, Muzhou Teng","doi":"10.1002/agt2.612","DOIUrl":"https://doi.org/10.1002/agt2.612","url":null,"abstract":"Type I photosensitizers (PSs) with the ability to generate reactive oxygen species (ROS) containing superoxide anion and hydroxyl radical have promising application potential for treating hypoxia tumors, but the deep mechanism of type II ROS converts to the type I ROS in the PSs is still unclear, it is urgent to reveal influencing factors about inducing type I ROS generation. Herein, six PSs with aggregation-induced emission properties, which were fabricated with the same electronic acceptor but different electronic donors and “π-bridge”, have been successfully prepared to explore the influencing mechanism of generating superoxide anion and hydroxyl radical from organic PSs. Experimental results discovered two factors containing molecular structure and aggregated environment could decide the ROS efficiency and types of PSs. On the level of designing molecular structure, we discovered that “π-bridge” with a lower energy level of the lowest triplet state could be beneficial for triggering the production of superoxide anion, and electronic donor of triphenylamine was an important factor in producing hydroxyl radical than another donor of dimethylamine. On the level of designing aggregates of PS-based polymeric nanoparticles, bovine serum albumin could improve largely the generation efficiency of superoxide anion. Due to the satisfactory ROS efficiency and better biocompatibility, synthetic PSs showed excellent photodynamic therapy outcomes in vitro/vivo.","PeriodicalId":501414,"journal":{"name":"Aggregate","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141513772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full‐color‐tunable chiral aggregation‐induced emission fluorophores with tailored propeller chirality and their circularly polarized luminescence 具有定制螺旋桨手性的全色可调手性聚集诱导发射荧光团及其圆偏振发光

Aggregate Pub Date : 2024-06-14 DOI: 10.1002/agt2.613

Yifan Li, Junhao Liang, Shiwei Fu, Haoxin Huang, Sheng Liu, Lei Wang, Yi Liu

{"title":"Full‐color‐tunable chiral aggregation‐induced emission fluorophores with tailored propeller chirality and their circularly polarized luminescence","authors":"Yifan Li, Junhao Liang, Shiwei Fu, Haoxin Huang, Sheng Liu, Lei Wang, Yi Liu","doi":"10.1002/agt2.613","DOIUrl":"https://doi.org/10.1002/agt2.613","url":null,"abstract":"The regulation of emission color, emission efficiency, and asymmetry factor is of great significance for the real applications of circularly polarized luminescent (CPL) materials. Herein, we develop a modular synthetic strategy toward full‐color‐tunable CPL materials based on chiral macrocyclic aggregation‐induced emission (AIE) luminogens via delicate molecular engineering. Modular synthesis of chiral AIEgens with different acceptor moieties has afforded a series of bright solid emitters with tunable emission colors. These chiral cyclic AIEgens have retained high solid‐state emission quantum yield and displayed CPL emission from blue to red as nano‐aggregates, in liquid crystal matrix and polymer film. The strong acceptor units in the red‐emitting chiral AIEgens RBTPE‐2CN and SBTPE‐2CN have rendered them twisted intramolecular charge transfer properties and solvatochromic luminescence. And polymer matrix with different polarity further facilitates the tuning of CPL emission color from green to red emission. These results have paved a reliable approach toward constructing full‐spectra solid‐state CPL material.","PeriodicalId":501414,"journal":{"name":"Aggregate","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141340445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0