Functional probes for the diagnosis and treatment of infectious diseases

Aggregate Pub Date : 2024-06-25 DOI:10.1002/agt2.620
Zhijin Fan, Yan Liu, Yuyun Ye, Yuhui Liao
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Abstract

Infectious diseases present significant challenges to global health, thereby extensively affecting both human society and the economy. In recent years, functional probes have demonstrated remarkable potential as crucial biomedical media for the research and treatment of infectious diseases. Their applications in the realm of infectious diseases include pathogen detection, exploration of biological mechanisms, and development of anti‐infective drugs. This review provides a concise introduction to the severity, classification, and pathogenesis of infectious diseases. Subsequently, we examined the distinctiveness and design strategies of functional probes for diagnosing and treating infectious diseases, shedding light on their design rationale using typical examples. We discuss the current status and challenges associated with the clinical implementation of functional probes. Furthermore, we explored the prospects of using these probes for the diagnosis and treatment of infectious diseases. This review aims to offer novel insights into the design of diagnostic probes for infectious diseases and broaden their applications in disease treatment.

Abstract Image

用于诊断和治疗传染病的功能探针
传染病对全球健康构成重大挑战,从而广泛影响人类社会和经济。近年来,功能探针作为研究和治疗传染病的重要生物医学媒介,已显示出巨大的潜力。它们在传染病领域的应用包括病原体检测、生物机制探索和抗感染药物的开发。本综述简要介绍了传染病的严重程度、分类和发病机制。随后,我们研究了用于诊断和治疗传染病的功能探针的独特性和设计策略,并通过典型实例阐明了其设计原理。我们讨论了与功能探针临床应用相关的现状和挑战。此外,我们还探讨了使用这些探针诊断和治疗传染病的前景。本综述旨在为传染病诊断探针的设计提供新的见解,并拓宽其在疾病治疗中的应用。
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