medRxiv - Neurology最新文献

{"title":"The Autonomous Cognitive Examination: Machine-Learning Based Cognitive Examination","authors":"Calvin W. Howard, Amy Johnson, Sheena Barotono, Katharina Faust, Joseph Peedicail, Marcus Ng","doi":"10.1101/2024.09.05.24313114","DOIUrl":"https://doi.org/10.1101/2024.09.05.24313114","url":null,"abstract":"<strong>INTRODUCTION</strong> The rising prevalence of dementia necessitates a scalable solution to cognitive screening and diagnosis. Digital cognitive assessments offer a solution but lack the extensive validation of older paper-based tests. Creating a digital cognitive assessment which recreates a paper-based assessment could have the strengths of both tests.","PeriodicalId":501367,"journal":{"name":"medRxiv - Neurology","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online monitoring technology for deep phenotyping of cognitive impairment after stroke","authors":"Dragos-Cristian Gruia, Valentina Giunchiglia, Aoife Coghlan, Sophie Brook, Soma Banerjee, Jo Kwan, Peter J. Hellyer, Adam Hampshire, Fatemeh Geranmayeh","doi":"10.1101/2024.09.06.24313173","DOIUrl":"https://doi.org/10.1101/2024.09.06.24313173","url":null,"abstract":"<strong>Background</strong> Despite the high prevalence of disabling post-stroke cognitive sequalae, these impairments are often underdiagnosed and rarely monitored longitudinally. Provision of unsupervised remote online cognitive technology would provide a scalable solution to this problem. However, despite recent advances, such technology is currently lacking, with existing tools either not meeting the scalability challenge or not optimised for specific applications in post-stroke cognitive impairment. To address this gap, we designed and developed a comprehensive online battery highly optimised for detecting cognitive impairments in stroke survivors.","PeriodicalId":501367,"journal":{"name":"medRxiv - Neurology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of Life and Psychiatric Comorbidities Associated with Migraines in Medical Students: A Cross-Sectional Study","authors":"Nusaiba Hassan, Roaa Hassan, Batoul Mohammed, Leina Elomeiri","doi":"10.1101/2024.09.05.24312634","DOIUrl":"https://doi.org/10.1101/2024.09.05.24312634","url":null,"abstract":"<strong>Objectives</strong> This study aims to assess the health-related quality of life (HRQoL) and psychiatric comorbidities among medical students suffering from migraines at the University of Khartoum.","PeriodicalId":501367,"journal":{"name":"medRxiv - Neurology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroligin fragments as blood-based biomarkers for early detection of Alzheimer’s disease","authors":"Milton Guilherme Forestieri Fernandes, Maxime Pinard, Esen Sokullu, Jean-François Gagnon, Frédéric Calon, Benoit Coulombe, Consortium for the early identification of Alzheimer’s disease-Quebec (CIMA-Q), Jonathan Brouillette","doi":"10.1101/2024.09.05.24313143","DOIUrl":"https://doi.org/10.1101/2024.09.05.24313143","url":null,"abstract":"Biomarkers for early detection of Alzheimer’s disease (AD) are essential for improving treatments. Fragments of the synaptic protein neuroligins (NLGNs) are released into the blood due to synaptic degeneration, which occurs in the early stages of AD. Using MS2-targeted mass spectrometry, we assessed the potential of NLGN fragments as blood-based biomarkers for amnestic mild cognitive impairment (aMCI), a prodromal stage of AD. We found higher blood levels of certain NLGN fragments in both aMCI and AD patients compared to healthy subjects and elderly with subjective cognitive disorder (SCD) from the CIMA-Q cohort. Within these same samples, the levels of Tau phosphorylated at various epitopes (pTau181, pTau217, and pTau231) were higher in AD subjects but not in aMCI individuals. Our results suggest that synaptic proteins such as NLGNs could serve as effective biomarkers for detecting the disease in its prodromal stage. This early detection could accelerate diagnosis, prevention, and therapeutic intervention before neurodegeneration leads to irreversible brain damage.","PeriodicalId":501367,"journal":{"name":"medRxiv - Neurology","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired spatial dynamic functional network connectivity and neurophysiological correlates in functional stroke mimics","authors":"E Premi, V Cantoni, A Benussi, A Iraji, VD Calhoun, D Corbo, R Gasparotti, M Tinazzi, B Borroni, M Magoni","doi":"10.1101/2024.09.05.24313161","DOIUrl":"https://doi.org/10.1101/2024.09.05.24313161","url":null,"abstract":"The present study investigated spatial dynamic functional network connectivity (dFNC) in patients with functional hemiparesis (i.e., functional stroke mimics, FSM). The aim of this work was to assess dynamic brain states, which represent distinct dFNC patterns that reoccur in time and across subjects. Resting-state fMRI data were collected from 15 patients with FSM (mean age=42.3±9.4, female=80%) and 52 age-matched healthy controls (HC, mean age=42.1±8.6, female=73%).","PeriodicalId":501367,"journal":{"name":"medRxiv - Neurology","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Rapid Online Cognitive Assessment","authors":"Calvin W. Howard, Amy Johnson, Joseph Peedicail, Marcus Ng","doi":"10.1101/2024.09.05.24313118","DOIUrl":"https://doi.org/10.1101/2024.09.05.24313118","url":null,"abstract":"<strong>INTRODUCTION</strong> Paper-based screening examinations are well-validated but minimally scalable. If a DCA replicate paper-based screening, it would improve scalability while benefiting from their extensive validation.","PeriodicalId":501367,"journal":{"name":"medRxiv - Neurology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and tolerability of intravenous liposomal GM1 in patients with Parkinson disease: A single center open-label clinical phase I trial (NEON trial)","authors":"Stefan Halbherr, Stefanie Lerch, Sebastian Bellwald, Petra Polakova, Bettina Bannert, Marie Roumet, Roch-Philippe Charles, Martin A. Walter, Corrado Bernasconi, Camille Peitsch, Pascal C. Baumgartner, Céline Kaufmann, Heinrich P. Mattle, Alain Kaelin-Lang, Andreas Hartmann, Michael Schuepbach","doi":"10.1101/2024.09.05.24313105","DOIUrl":"https://doi.org/10.1101/2024.09.05.24313105","url":null,"abstract":"<strong>Background:</strong> Parkinson disease (PD) is a chronic progressive neurodegenerative disorder leading to motor and non- motor impairment often resulting in severe loss of quality of life. There are symptomatic treatments without effect on the progression of PD. A disease-modifying treatment that could ideally stop the neurodegenerative process is direly needed. Monosialotetrahexosylganglioside (GM1) is a promising molecule with neuroprotective effects in preclinical models of PD and has yielded encouraging results in patients with PD in a randomized placebo-controlled trial. Talineuren (TLN) is a liposomal formulation of GM1 that has been shown to cross the blood-brain barrier in animals. We assessed the safety and pharmacokinetics of TLN in patients with PD.","PeriodicalId":501367,"journal":{"name":"medRxiv - Neurology","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma biomarkers distinguish Boston Criteria 2.0 cerebral amyloid angiopathy from healthy controls","authors":"Ryan T. Muir, Sophie Stukas, Jennifer G. Cooper, Andrew E. Beaudin, Cheryl R. McCreary, Myrlene Gee, Krista Nelles, Nikita Nukala, Janina Valencia, Kristopher M Kirmess, Sandra E. Black, Michael D. Hill, Richard Camicioli, Cheryl L. Wellington, Eric. E Smith","doi":"10.1101/2024.09.04.24313038","DOIUrl":"https://doi.org/10.1101/2024.09.04.24313038","url":null,"abstract":"<strong>INTRODUCTION</strong> Cerebral Amyloid Angiopathy (CAA) is characterized by the deposition of beta-amyloid (Aβ) in small vessels leading to hemorrhagic stroke and dementia. This study examined whether plasma Aβ_42/40, phosphorylated-tau (p-tau), neurofilament light chain (NfL) and Glial Fibrillary Acidic Protein (GFAP) differ in CAA and their potential to discriminate Boston Criteria 2.0 probable CAA from healthy controls.","PeriodicalId":501367,"journal":{"name":"medRxiv - Neurology","volume":"2013 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated Phonological Error Scoring for Children with Language and Hearing Impairment","authors":"Simon Sundström, Charalambos Themistocleous","doi":"10.1101/2024.09.04.24313011","DOIUrl":"https://doi.org/10.1101/2024.09.04.24313011","url":null,"abstract":"<strong>Purpose</strong> Phonological production impairments are prevalent in children with developmental language disorder (DLD) and hearing impairment (HI). This study aims to quantify and compare phonological errors in Swedish-speaking children using a novel automated assessment tool and provide an automatic machine learning classification algorithm of children with DLD and HI to age-matched controls based on phonological errors.","PeriodicalId":501367,"journal":{"name":"medRxiv - Neurology","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Somatosensory differences between symptomatic and non-symptomatic retired contact sport athletes.","authors":"Brigitte Beck, Dawson J Kidgell, Doug A King, Ashlyn K Frazer, Mark Tommderdahl, Alan J Pearce","doi":"10.1101/2024.09.01.24312914","DOIUrl":"https://doi.org/10.1101/2024.09.01.24312914","url":null,"abstract":"Aim of the study\u0000Interest continues investigating pathophysiology of athlete cohorts with a history involving cumulative career exposure of repeated concussion and non-concussion impacts. One area yet to be explored involves the somatosensory system. Using a novel sensorimotor technique, this study measured the somatosensory system in retired contact sport athletes exposed to repetitive neurotrauma.\u0000Materials and Methods\u0000Retired athletes (n=85, mean age 48.6 +/- 10.6 years, all male) completed a self-report survey on their playing career, number of concussions, and continuing symptoms. Participants completed somatosensory vibrotactile tasks assessing reaction time, amplitude discrimination (sequential, simultaneous), and temporal discrimination (temporal order judgment, duration discrimination). Participants were divided between those reporting persistent symptoms (Symptomatic, n=63) and those without concerns (Nonsymptomatic, n=22).\u0000Results\u0000Symptomatic participants scored higher symptom scores compared to the Nonsymptomatic group (P&lt;0.001). No differences were found between groups for age (P=0.152), number of concussions (P=0.193), total years played (P=0.385), or professional career length (P=0.711). Symptomatic group reaction times were slower to the Nonsymptomatic group (P&lt;0.001). Reaction time variability were greater in the symptomatic group (P=0.002). Differences between groups were found for amplitude discrimination (sequential: P=0.031; simultaneous: P=0.036) and temporal order judgment (P=0.032). Significant correlations were found between total symptom scores and all somatosensory tasks. Correlations showed associations between total exposure years with temporal order judgement and reaction time.\u0000Conclusions.\u0000This novel study showed altered sensorimotor perception in retired athletes with persistent symptoms. Our data adds to the growing pathophysiological evidence in those who experience repetitive neurotrauma during their playing careers.","PeriodicalId":501367,"journal":{"name":"medRxiv - Neurology","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142225078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}