medRxiv - Radiology and Imaging最新文献

{"title":"Machine Learning-Based Reconstruction of 2D MRI for Quantitative Morphometry in Epilepsy","authors":"Corey Ratcliffe, Christophe de Bezenac, Kumar Das, Shubhabrata Biswas, Anthony Marson, Simon S. Keller","doi":"10.1101/2024.06.24.24309298","DOIUrl":"https://doi.org/10.1101/2024.06.24.24309298","url":null,"abstract":"Introduction: Structural neuroimaging analyses require 'research quality' images, acquired with costly MRI acquisitions. Isotropic (3D) T1 images are desirable for quantitative analyses, however a routine compromise in the clinical setting is to acquire anisotropic (2D) analogues for qualitative visual inspection. Machine learning-based software have shown promise in addressing some of the limitations of 2D scans in research applications, yet their efficacy in quantitative research is not well understood. To evaluate the applicability of image preprocessing methods, morphometry in idiopathic generalised epilepsy (IGE)--in which, pathology-related abnormalities of the subcortical structures have been reproducibly demonstrated--was investigated first in 3D scans, then in 2D scans, resampled images, and synthesised images. Methods: 2D and 3D T1 MRI were acquired during the same scanning session from 31 individuals (males = 14, mean age = 32.16) undergoing evaluation for IGE at the Walton Centre NHS Foundation Trust, Liverpool, as well as 39 healthy age- and sex-matched controls (males = 16, mean age = 32.13). The DL+DiReCT pipeline was used to provide segmentations of the 2D images, and estimates of regional volume and thickness. The 2D scans were also resampled into isotropic images using NiBabel, and preprocessed into synthetic isotropic images using SynthSR. For the 3D scans, untransformed 2D scans, resampled images, and synthesised images, FreeSurfer 7.2.0 was used to create parcellations of 178 anatomical regions (equivalent to the 178 parcellations provided as part of the DL+DiReCT pipeline), defined by the aseg and Destrieux atlases, and FSL FIRST was used to segment subcortical surface shapes. Spatial correspondence and intraclass correlations between the morphometrics of the five parcellations were first determined, then subcortical surface shape abnormalities associated with IGE were identified by comparing the FSL FIRST outputs of patients with controls. Results: When standardised to the metrics derived from the 3D scans, cortical volume and thickness estimates trended lower for the untransformed 2D, DL+DiReCT, resampled, and SynthSR images, whereas subcortical volume estimates did not differ. Dice coefficients revealed a low spatial similarity between the cortices of the 3D scans and the other images overall, which was higher in the subcortical structures. Intraclass correlation coefficients reiterated this disparity, with estimates of thickness being less similar than those of volume, and DL+DiReCT estimates trending less similar than the other images types. For the people with epilepsy, the 3D scans showed significant surface deflations across various subcortical structures when compared to healthy controls. Analysis of the untransformed 2D scans enabled the detection of a subset of subcortical abnormalities, whereas analyses of the resampled and synthetic images attenuated almost all significance. Conclusions: Generalised image synthe","PeriodicalId":501358,"journal":{"name":"medRxiv - Radiology and Imaging","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RaTEScore: A Metric for Radiology Report Generation","authors":"Weike Zhao, Chaoyi Wu, Xiaoman Zhang, Ya Zhang, Yanfeng Wang, Weidi Xie","doi":"10.1101/2024.06.24.24309405","DOIUrl":"https://doi.org/10.1101/2024.06.24.24309405","url":null,"abstract":"This paper introduces a novel, entity-aware metric, termed as Radiological Report (Text) Evaluation (RaTEScore), to assess the quality of medical reports generated by AI models. RaTEScore emphasizes crucial medical entities such as diagnostic outcomes and anatomical details, and is robust against complex medical synonyms and sensitive to negation expressions. Technically, we developed a comprehensive medical NER dataset, RaTE-NER, and trained an NER model specifically for this purpose. This model enables the decomposition of complex radiological reports into constituent medical entities. The metric itself is derived by comparing the similarity of entity embeddings, obtained from a language model, based on their types and relevance to clinical significance. Our evaluations demonstrate that RaTEScore aligns more closely with human preference than existing metrics, validated both on established public benchmarks and our newly proposed RaTE-Eval benchmark.","PeriodicalId":501358,"journal":{"name":"medRxiv - Radiology and Imaging","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141528929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproducibility of radiomic features of the brain on ultrahigh-resolution MRI at 7 Tesla: a comparison of different segmentation techniques","authors":"Julian Klinger, Doris Leithner, Sungmin Woo, Michael Weber, Hebert Alberto Vargas, Marius E. Mayerhoefer","doi":"10.1101/2024.06.24.24308597","DOIUrl":"https://doi.org/10.1101/2024.06.24.24308597","url":null,"abstract":"Objectives: To determine the impact of segmentation techniques on radiomic features extracted from ultrahigh-field (UHF) MRI of the brain. Materials and Methods: Twenty-one 7T MRI scans of the brain, including a 3D magnetization-prepared two rapid acquisition gradient echo (MP2RAGE) T1-weighted sequence with an isotropic 0.63 mm3 voxel size, were analyzed. Radiomic features (histogram, texture, and shape; total n=101) from six brain regions -cerebral gray and white matter, basal ganglia, ventricles, cerebellum, and brainstem- were extracted from segmentation masks constructed with four different techniques: the iGT (reference standard), based on a custom pipeline that combined automatic segmentation tools and expert reader correction; the deep-learning algorithm Cerebrum-7T; the Freesurfer-v7 software suite; and the Nighres algorithm. Principal components (PCs) were calculated for histogram and texture features. To test the reproducibility of radiomic features, intraclass correlation coefficients (ICC) were used to compare Cerebrum-7, Freesurfer-v7, and Nighres to the iGT, respectively. Results: For histogram PCs, median ICCs for Cerebrum-7T, Freesurfer-v7, and Nighres were 0.99, 0.42, and 0.11 for the gray matter; 0.84, 0.25, and 0.43 for the basal ganglia; 0.89, 0.063, and 0.036 for the white matter; 0.84, 0.21, and 0.33 for the ventricles; 0.94, 0.64, and 0.93 for the cerebellum; and 0.78, 0.21, and 0.53 for the brainstem. For texture PCs, median ICCs for Cerebrum-7T, Freesurfer-v7, and Nighres were 0.95, 0.21, and 0.15 for the gray matter; 0.70, 0.36, and 0.023 for the basal ganglia; 0.91, 0.25, and 0.023 for the white matter; 0.80, 0.75, and 0.59 for the ventricles; 0.95, 0.43, and 0.86 for the cerebellum; and 0.72, 0.39, and 0.46 for the brainstem. For shape features, median ICCs for Cerebrum-7T, FreeSurfer-v7, and Nighres were 0.99, 0.91, and 0.36 for the gray matter; 0.89, 0.90, and 0.13 for the basal ganglia; 0.98, 0.91, and 0.027 for the white matter; 0.91, 0.91, and 0.36 for the ventricles; 0.80, 0.68, and 0.47 for the cerebellum; and 0.79, 0.17, and 0.15 for the brainstem. Conclusions: Radiomic features in UHF MRI of the brain show substantial variability depending on the segmentation algorithm. The deep learning algorithm Cerebrum-7T enabled the highest reproducibility. Dedicated software tools for UHF MRI may be needed to achieve more stable results.","PeriodicalId":501358,"journal":{"name":"medRxiv - Radiology and Imaging","volume":"145 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MVP-VSASL: measuring MicroVascular Pulsatility using Velocity-Selective Arterial Spin Labeling","authors":"Conan Chen, Ryan A Barnes, Katherine J Bangen, Fei Han, Josef Pfeuffer, Eric C Wong, Thomas T Liu, Divya S Bolar","doi":"10.1101/2024.06.21.24309261","DOIUrl":"https://doi.org/10.1101/2024.06.21.24309261","url":null,"abstract":"<strong>Purpose:</strong> By leveraging the small-vessel specificity of velocity-selective arterial spin labeling (VSASL), we present a novel technique for measuring cerebral MicroVascular Pulsatility named MVP-VSASL.\u0000<strong>Theory and Methods:</strong> We present a theoretical model relating the pulsatile, cerebral blood flow-driven VSASL signal to the microvascular pulsatility index (PI), a widely used metric for quantifying cardiac-dependent fluctuations. The model describes the dependence of PI on bolus duration τ (an adjustable VSASL sequence parameter) and provides guidance for selecting a value of τ that maximizes the SNR of the PI measurement. The model predictions were assessed in humans using data acquired with retrospectively cardiac-gated VSASL sequences over a broad range of τ values. In vivo measurements were also used to demonstrate the feasibility of whole-brain voxel-wise PI mapping, assess intrasession repeatability of the PI measurement, and illustrate the potential of this method to explore an association with age.\u0000<strong>Results:</strong> The theoretical model showed excellent agreement to the empirical data in a gray matter region of interest (average R² value of 0.898 ± 0.107 across six subjects). We further showed excellent intrasession repeatability of the pulsatility measurement (ICC = 0.960, p &lt; 0.001) and the potential to characterize associations with age (r = 0.554, p = 0.021).\u0000<strong>Conclusion:</strong> We have introduced a novel, VSASL-based cerebral microvascular pulsatility technique, which may facilitate investigation of cognitive disorders where damage to the microvasculature has been implicated.","PeriodicalId":501358,"journal":{"name":"medRxiv - Radiology and Imaging","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mammographic density assessed using deep learning in women at high risk of developing breast cancer: the effect of weight change on density","authors":"Steven Squires, Michelle Harvie, Anthony Howell, D Gareth Evans, Susan M Astley","doi":"10.1101/2024.06.22.24309234","DOIUrl":"https://doi.org/10.1101/2024.06.22.24309234","url":null,"abstract":"Objectives: High mammographic density (MD) and excess weight are associated with increased risk of breast cancer. Weight loss interventions could reduce risk, but classically defined percentage density measures may not reflect this due to disproportionate loss of breast fat. We investigate an artificial intelligence-based density method, reporting density changes in 46 women enrolled in a weight-loss study in a family history breast cancer clinic, using a volumetric density method as a comparison. Methods: We analysed data from women who had weight recorded and mammograms taken at the start and end of the 12-month weight intervention study. MD was assessed at both time points using a deep learning model, pVAS, trained on expert estimates of percent density, and VolparaTM density software. Results: The Spearman rank correlation between reduction in weight and change in density was 0.17 (-0.13 to 0.43) for pVAS and 0.59 (0.36 to 0.75) for Volpara volumetric percent density. Conclusions: pVAS percent density measurements were not significantly affected by change in weight. Percent density measured with Volpara increased as weight decreased, driven by changes in fat volume. Advances in knowledge: The effect of weight change on pVAS mammographic density predictions has not previously been published.","PeriodicalId":501358,"journal":{"name":"medRxiv - Radiology and Imaging","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review of Hybrid Vision Transformer Architectures for Radiological Image Analysis","authors":"Ji Woong Kim, Aisha Urooj Khan, Imon Banerjee","doi":"10.1101/2024.06.21.24309265","DOIUrl":"https://doi.org/10.1101/2024.06.21.24309265","url":null,"abstract":"Background: Vision Transformer (ViT) and Convolutional Neural Networks (CNNs) each possess distinct strengths in medical imaging: ViT excels in capturing long-range dependencies through self-attention, while CNNs are adept at extracting local features via spatial convolution filters. While ViTs might struggle with capturing detailed local spatial information critical for tasks like anomaly detection in medical imaging, shallow CNNs often fail to effectively abstract global context.\u0000Objective: This study aims to explore and evaluate hybrid architectures that integrate ViT and CNN to lever- age their complementary strengths for enhanced performance in medical vision tasks, such as segmentation, classification, and prediction.\u0000Methods: Following PRISMA guideline, a systematic review was conducted on 28 articles published between 2020 and 2023. These articles proposed hybrid ViT-CNN architectures specifically for medical imaging tasks in radiology. The review focused on analyzing architectural variations, merging strategies between ViT and CNN, innovative applications of ViT, and efficiency metrics including parameters, inference time (GFlops), and performance benchmarks.\u0000Results: The review identified that integrating ViT and CNN can help mitigate the limitations of each architecture, offering comprehensive solutions that combine global context understanding with precise local feature extraction. We benchmarked the articles based on architectural variations, merging strategies, innovative uses of ViT, and efficiency metrics (number of parameters, inference time (GFlops), performance).\u0000Conclusion: By synthesizing current literature, this review defines fundamental concepts of hybrid vision transformers and highlights emerging trends in the field. It provides a clear direction for future research aimed at optimizing the integration of ViT and CNN for effective utilization in medical imaging, contributing to advancements in diagnostic accuracy and image analysis.","PeriodicalId":501358,"journal":{"name":"medRxiv - Radiology and Imaging","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative sodium-MRI detects differential sodium content in benign vs. malignant oncocytic renal tumours","authors":"Ines Horvat-Menih, Jonathan R Birchall, Maria J Zamora-Morales, Alice Bebb, Joshua Kaggie, Frank Riemer, Andrew B Gill, Andrew N Priest, Marta Wylot, Iosif A Mendichovszky, Anne Y Warren, James O Jones, James N Armitage, Thomas J Mitchell, Grant D Stewart, Mary A McLean, Ferdia A Gallagher","doi":"10.1101/2024.06.19.24309026","DOIUrl":"https://doi.org/10.1101/2024.06.19.24309026","url":null,"abstract":"Background: Accurate non-invasive subtyping of localised kidney tumours is an unmet clinical question in uro-oncology. Differentiation of benign renal oncocytomas (RO) from malignant chromophobe renal cell carcinomas (chRCC) is not possible using conventional imaging. Despite the importance of renal function for sodium regulation, little is known about sodium handling in kidney tumours. Purpose: Here we used non-invasive sodium MRI (23Na-MRI) to quantify sodium concentration and relaxation dynamics across a range of different kidney tumour subtypes and have correlated these findings with imaging surrogates for perfusion, hypoxia, and cellularity. Materials and Methods: Between January and April 2023, patients with localised renal masses were prospectively recruited and underwent 23Na and proton (1H) MRI at 3T to acquire 3D maps of B1, total sodium concentration (TSC), proton and sodium relaxation rates (R2*), and diffusion weighted imaging (DWI). Statistical analysis included comparison and correlation of quantified imaging parameters across kidney tumour subtypes. Results: Ten patients were included in the final analysis (mean age ± S.D. = 64 ± 8 years; 7:3 male:female ratio) encompassing seven ROs, two chRCCs, two clear cell RCCs (ccRCC), and one papillary RCC (pRCC). The TSC was significantly higher in the ROs compared to the chRCCs: 162 ± 58 mM vs. 71 ± 2 mM (P &lt; 0.05). The mean TSC in ccRCC was 135 ± 59 mM, and 81 mM in pRCC. The 23Na-derived and 1H-derived R2* values showed a weak correlation (Spearman r = 0.17; P = 0.50). There was a significant inverse correlation between TSC and 1H-R2* (Spearman r = -0.39, P &lt; 0.05), but TSC was independent of the DWI-derived imaging parameters. Conclusion: 23Na-MRI detected markedly different sodium concentrations within benign ROs and malignant chRCCs. In addition, the sodium signal inversely correlated with 1H-R2* as a surrogate for hypoxia. Therefore we have shown the feasibility and potential of 23Na-MRI for future research in renal tumours.","PeriodicalId":501358,"journal":{"name":"medRxiv - Radiology and Imaging","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping Structural Disconnection and Morphometric Similarity Alterations in Multiple Sclerosis","authors":"Mario Tranfa, Maria Petracca, Marcello Moccia, Alessandra Scaravilli, Frederik Barkhof, Vincenzo Brescia Morra, Antonio Carotenuto, Sara Collorone, Andrea Elefante, Fabrizia Falco, Roberta Lanzillo, Luigi Lorenzini, Menno Schoonheim, Ahmed Toosy, Arturo Brunetti, Sirio Cocozza, Mario Quarantelli, Giuseppe Pontillo","doi":"10.1101/2024.06.19.24309154","DOIUrl":"https://doi.org/10.1101/2024.06.19.24309154","url":null,"abstract":"Whilst multiple sclerosis (MS) can be conceptualized as a network disorder, brain network analyses are typically dependent on advanced MRI sequences not commonly acquired in clinical practice. Here, we used conventional MRI to assess cross-sectional and longitudinal modifications of structural disconnection and morphometric similarity networks in people with MS (pwMS), along with their relationship with clinical disability.\u0000In this longitudinal monocentric study, 3T structural MRI scans of pwMS and healthy controls (HC) were retrospectively analysed. Physical and cognitive disabilities were assessed with the expanded disability status scale (EDSS) and the symbol digit modalities test (SDMT), respectively. Demyelinating lesions were automatically segmented on 3D-T1w and FLAIR images and, based on normative tractography data, the corresponding masks were used to compute pairwise structural disconnection between atlas-defined brain regions (100 cortical and 14 subcortical). Using the Morphometric Inverse Divergence (MIND) method, we built matrices of morphometric similarity between cortical regions based on FreeSurfer surface reconstruction. Using network-based statistics (NBS) and its prediction-based extension NBS-predict, we tested whether subject-level connectomes were associated with disease status, progression, clinical disability, and long-term confirmed disability progression (CDP), independently from global lesion burden and atrophy. The coupling between structural disconnection and morphometric similarity was assessed at different scales.\u0000We studied 461 pwMS (age=37.2±10.6 years, F/M=324/137), corresponding to 1235 visits (mean follow-up time=1.9±2.0 years, range=0.1-13.3 years), and 55 HC (age=42.4±15.7 years; F/M=25/30). Long-term clinical follow-up was available for 285 pwMS (mean follow-up time=12.4±2.8 years), 127 of whom (44.6%) exhibited CDP. At baseline, structural disconnection in pwMS was mostly centered around the thalami and cortical sensory and association hubs, while morphometric similarity was extensively disrupted (pFWE&lt;0.01). EDSS was related to fronto-thalamic disconnection (pFWE&lt;0.01) and disrupted morphometric similarity around the left perisylvian cortex (pFWE=0.02), whilst SDMT was associated with cortico-subcortical disconnection in the left hemisphere (pFWE&lt;0.01). Longitudinally, both structural disconnection and morphometric similarity disruption significantly progressed (pFWE=0.04 and pFWE&lt;0.01), correlating with EDSS increase (rho=0.07, p=0.02 and rho=0.11, p&lt;0.001), whilst baseline disconnection predicted long-term CDP with nearly 60% accuracy (p=0.03). On average, structural disconnection and morphometric similarity were positively associated at both the edge (rho=0.18, p&lt;0.001) and node (rho=0.16, p&lt;0.001) levels.\u0000Structural disconnection and morphometric similarity networks, as assessed through conventional MRI, are sensitive to MS-related brain damage and its progression. They explain di","PeriodicalId":501358,"journal":{"name":"medRxiv - Radiology and Imaging","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Modality Synthetic Data Augmentation using GANs: Enhancing Brain MRI and Chest X-ray Classification","authors":"KUNAAL DHAWAN, Siddharth S. Nijhawan","doi":"10.1101/2024.06.09.24308649","DOIUrl":"https://doi.org/10.1101/2024.06.09.24308649","url":null,"abstract":"Brain MRI scans and chest X-ray imaging are pivotal in diagnosing and managing neurological and respiratory diseases, respectively. Given their importance in diagnosis, the datasets to train the artificial intelligence (AI) models for automated diagnosis remain scarce. As an example, annotated chest X-ray datasets, especially those containing rare or abnormal cases like bacterial pneumonia, are scarce. Conventional dataset collection methods are labor-intensive and costly, exacerbating the data scarcity issue. To overcome these challenges, we propose a specialized Generative Adversarial Network (GAN) architecture for generating synthetic chest X-ray data representing healthy lungs and various pneumonia conditions, including viral and bacterial pneumonia. Additionally, we extended our experiments to brain MRI scans by simply swapping the training dataset and demonstrating the power of our GAN approach across different medical imaging contexts. Our method aims to streamline data collection and labeling processes while addressing privacy concerns associated with patient data. We demonstrate the effectiveness of synthetic data in facilitating the development and evaluation of machine learning algorithms, particularly leveraging an EfficientNet v2 model. Through comprehensive experimentation, we evaluate our approach on both real and synthetic datasets, showcasing the potential of synthetic data augmentation in improving disease classification accuracy across diverse pathological conditions. Indeed, the classifier performance when trained with fake + real data on brain MRI classification task shows highest accuracy at 85.9%. Our findings underscore the promising role of synthetic data in advancing automated diagnosis and treatment planning for pneumonia, other respiratory conditions, and brain pathologies.","PeriodicalId":501358,"journal":{"name":"medRxiv - Radiology and Imaging","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of oncogene mutation status in non-small cell lung cancer: A systematic review and meta-analysis with a special focus on artificial-intelligence-based methods","authors":"Almudena Fuster-Matanzo, Alfonso Picó Peris, Fuensanta Bellvís Bataller, Ana Jimenez-Pastor, Glen J. Weiss, Luis Martí-Bonmatí, Antonio Lázaro Sánchez, Giuseppe L. Banna, Alfredo Addeo, Ángel Alberich-Bayarri","doi":"10.1101/2024.05.31.24308261","DOIUrl":"https://doi.org/10.1101/2024.05.31.24308261","url":null,"abstract":"<strong>Background</strong> In non-small cell lung cancer (NSCLC), alternative strategies to determine patient oncogene mutation status are essential to overcome some of the drawbacks associated with current methods. We aimed to review the use of radiomics alone or in combination with clinical data and to evaluate the performance of artificial intelligence (AI)-based models on the prediction of oncogene mutation status.","PeriodicalId":501358,"journal":{"name":"medRxiv - Radiology and Imaging","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141253550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}