Journal of Medical and Biological Engineering最新文献

{"title":"Attribute-Enhanced Capsule Network for Pulmonary Nodule Classification","authors":"Yang Xu, Qingshan She, Songkai Sun, Xugang Xi, Shengzhi Du","doi":"10.1007/s40846-024-00846-y","DOIUrl":"https://doi.org/10.1007/s40846-024-00846-y","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Most pulmonary nodule classification methods solely rely on nodule images without considering the corresponding attribute information. Additionally, conventional convolutional structures often fail to capture the relative spatial relationships among different parts of the lung nodule.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>This paper proposes a pulmonary nodule classification method based on attribute privilege and capsule networks. In this approach, eight attribute characteristics of pulmonary nodules are utilized as privileged information during the identification of benign and malignant cases. This additional information empowers the network to distinguish between benign and malignant aspects of pulmonary nodules more accurately. The capsule structure is introduced to help extract and understand the spatial relationships between different parts of the lung nodule images, the Res2net structure is adopted to extract multi-scale information from lung nodules, and an attention mechanism is incorporated into the backbone network to enhance the efficiency of feature extraction. The proposed classification method was thoroughly evaluated through a series of experiments using the LIDC-IDRI dataset.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The mean identification accuracy of pulmonary nodules reaches 91.6%. This outcome demonstrates that the proposed method is capable of identifying benign and malignant pulmonary nodules with high accuracy.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The novel lung nodule recognition method based on attribute privilege and capsule network contributes to achieving better feature extraction and addressing the challenge of small training datasets for pulmonary nodules.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"19 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating Ratio Indices Based on Electroencephalogram Brainwaves in Schizophrenia Detection","authors":"","doi":"10.1007/s40846-024-00851-1","DOIUrl":"https://doi.org/10.1007/s40846-024-00851-1","url":null,"abstract":"<h3>Abstract</h3> <span> <h3>Purpose</h3> <p>Extensive research has been conducted by neurocognitive and psychological scientists to diagnose mental and neurological diseases intelligently. Recently, researchers have shown interest in Electroencephalogram (EEG) analysis, a non-invasive method of recording the brain’s electrical activity from the scalp surface. EEG signals contain different frequency bands, each indicating specific brain activities. Although the relative powers of single EEG waves are not all-inclusive indicators to consistently imitate mental involvement, ratio indices should be considered. These indices calculate the ratio of powers (summations) with more than a single frequency band.</p> </span> <span> <h3>Methods</h3> <p>This study quantifies the EEG signals of healthy control and schizophrenic groups using thirty-seven ratio indices based on EEG brainwaves. These indicators are examined for the first time in schizophrenia. The study evaluates which index is more suitable and efficient for solving a classification problem.</p> </span> <span> <h3>Results</h3> <p>The results show the potential of (delta + theta)/alpha in the schizophrenia classification with an average accuracy of 97.92%. Additionally, the study investigates the effectiveness of different EEG electrodes in the problem of schizophrenia diagnosis while utilizing the above indicators. T5, the left posterior temporal region, yields a maximum average accuracy of 92.92%.</p> </span> <span> <h3>Conclusion</h3> <p>In conclusion, the fusion of EEG frequency ratio indices and machine learning algorithms provides a potential avenue for improving the detection and diagnosis of schizophrenia.</p> </span>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"31 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139759757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Carbon Fiber Reinforced Peek on Stabilization of Sagittal Split Ramus Osteotomy Fixation and Stresses on Temporomandibular Joint: 3d Finite Element Analysis Study","authors":"Musa Erdem, Mehmet Zahit BAŞ","doi":"10.1007/s40846-023-00843-7","DOIUrl":"https://doi.org/10.1007/s40846-023-00843-7","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>This study aimed to compare carbon fiber-reinforced polyetheretherketone (CFR-PEEK) plates and screws with conventional titanium plates and screws for mandibular orthognathic surgery models.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Sagittal split ramus osteotomy (SSRO) was simulated in a 3D finite element model of the mandible. Eight fixation groups with 3 different designs (miniplate, hybrid, and inverted-L) were created using titanium and CFR-PEEK materials. The displacement values in the osteotomy lines, the von Mises stress values on the fixation devices, and the maximum tensile and compressive stress values on the bone in contact with the screws and the temporomandibular joints (TMJ) were compared.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The displacement in the osteotomy line in the models using the CFR-PEEK polymer was higher than in the titanium models. The stress on the miniplate and screws in the CFR-PEEK models was lower than that in the titanium models. The maximum stress on the miniplates was found close to the fracture line in the distal segment. The stress on the TMJ of the CFR-PEEK models was higher than that of the titanium models.</p><p>When the fixation designs were compared regardless of the material, the lowest displacement value (CFR-PEEK: 0.268 mm; Titanium: 0.253 mm), the highest screw stress (CFR-PEEK: 372.9 MPa; Titanium: 1185.5 MPa), and the lowest bone stress (CFR-PEEK: 57.216 MPa; Titanium:64.022 MPa) were observed in the models using the inverted-L technique for fixation.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The results suggest that CFR-PEEK plates and screws reduce stress on the fixation systems and the associated bone while increasing stress on the TMJ.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"7 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139508239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Short Implant, Angled Implant, Distal Extension and Grafting Methods for Atrophic Maxillary Posterior Region: a Finite Element Study","authors":"","doi":"10.1007/s40846-023-00844-6","DOIUrl":"https://doi.org/10.1007/s40846-023-00844-6","url":null,"abstract":"<h3>Abstract</h3> <span> <h3>Purpose</h3> <p>The objective of the study was to determine the most ideal of four different implant-prosthesis treatment combinations that can be used for the posterior maxilla by using the finite element method.</p> </span> <span> <h3>Methods</h3> <p>Among the four models representing the posterior region of the atrophic maxilla, in the first model, a standard implant was installed in the place of tooth 4, while a short implant was inserted in the place of tooth 6 due to increased sinus pneumatization. In the second model, standard implants were placed in tooth 4 and 5 and the implant in tooth 5 was installed with 30° distal inclination so as to tangentially cross the sinus region. In the third model, a graft application was designed for the area with increased sinus pneumatization, and standard implants were inserted in the places of tooth 4 and 6. In the fourth model, two standard implants were placed at teeth 4 and 5 and a distal extension was made in between.</p> </span> <span> <h3>Results</h3> <p>The maximum and minimum principal strain values in cortical bone were obtained as 2594 µε and 5478 µε in Model 4, respectively, and in trabecular bone as 4733 µε and 3761 µε in Model 1. Among the implants and abutments, the highest von Mises stress value of 709 MPa occurred in Model 4.</p> </span> <span> <h3>Conclusions</h3> <p>The third model that features a graft was the most successful model and the fourth model that featured distal extension had the highest likelihood of damage.</p> </span>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"35 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139373886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Pulmonary Function Parameters Non-invasively by Electrical Bioimpedance Tomography","authors":"F. M. Vargas-Luna, M. I. Delgadillo-Cano, J. P. Riu-Costa, S. Kashina, J. M. Balleza-Ordaz","doi":"10.1007/s40846-023-00842-8","DOIUrl":"https://doi.org/10.1007/s40846-023-00842-8","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Electrical Impedance Tomography (EIT) holds promise as a non-invasive method for measuring lung airflow, particularly in patients diagnosed with Chronic Obstructive Pulmonary Disease (COPD). Nonetheless, there are challenges regarding the clinical relevance of EIT. The main purpose of the present research was to identify the primary frequency components of impedance changes recorded by EIT and correlate them with pulmonary function parameters.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>20 COPD patients were analyzed. Each volunteer was connected to a pneumotachometer and an EIT device. They performed three respiratory exercises, and pulmonary function parameters for each volunteer were acquired. The three impedance signals were convolved to simulate the behavior of the thorax as a black box with a single output signal. The convolved impedance signal was analyzed using FFT spectra. Subsequently, it was divided into seven frequency ranges, estimating the area under the curve and quartiles at 25%, 50%, and 75%. Each segment of the FFT spectrum was correlated with each pulmonary function test parameter.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>A significant correlation of over 60% between pulmonary function test parameters and the determinations from the FFT spectrum within seven distinct frequency ranges was observed. However, the determination coefficient (<i>R</i>²) ranged from approximately 10–66% due to data points that did not fit well, particularly in patients with severe pulmonary dysfunction.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>To address the dispersion of data and enhance the correlation between determinations, it is imperative to adjust impedance determinations using anthropometric parameters or employ a mathematical equation that facilitates the characterization of limitations in lung airflow.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"65 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139055541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Surface Modification on the Shortwave Infrared Emission of Rare-Earth-Doped Nanoparticles","authors":"Mohd Yaqub Khan, Jen-Kun Chen, Vivek Jain, Lokesh Agrawal, Cheng-An J. Lin, Min-Hua Chen","doi":"10.1007/s40846-023-00841-9","DOIUrl":"https://doi.org/10.1007/s40846-023-00841-9","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Deep tissue imaging can be achieved using shortwave infrared (SWIR) light, ranging from 900 to 2500 nm in wavelength. SWIR light has several advantages, such as low scattering, reduced photobleaching and autofluorescence, and high sensitivity for biological samples. One of the most efficient materials for SWIR emission is rare-earth-doped nanoparticles (RENP), but they are hydrophobic and incompatible with biological systems. Therefore, we use common surface modifiers, such as polyethylene glycol (PEG) and Tween 20 (Tw), to improve the biocompatibility and dispersibility of RENP in aqueous media. This study aims to evaluate the effects of PEG and Tw as surface modifiers on the stability and SWIR emission intensity of RENP.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Using the thermal decomposition method, we prepared RENP (NaYF₄: Yb, Er) and modified their surface with PEG and Tw. RENP were modified with PEG and Tw using simple phase inversion and sonication-assisted methods, respectively. We characterized the RENP-PEG and RENP-Tw by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier-transform infrared (FTIR) spectroscopy, zeta potential, and thermogravimetric analysis (TGA). We also measured the SWIR emission and spectra of the RENP-PEG and RENP-Tw using a Ninox 640 VIS-SWIR InGaAs camera with a 980 nm NIR laser excitation. To assess the biocompatibility of RENP-Tw, we performed an MTT assay with L929 cells.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The XRD and FTIR analyses confirmed the successful surface modification of RENP and the formation of the hexagonal phase β-NaYF₄. The FTIR spectra showed the characteristic peaks of the functional groups associated with PEG and Tw. The surface modification also changed the zeta potential values of RENP, indicating different surface charges. The stability studies revealed that RENP-Tw remained well-dispersed in aqueous media after 24 h, while RENP-PEG aggregated over time. The RENP-Tw showed bright SWIR emission and a prominent peak at 1385 nm. The biocompatibility assay revealed that RENP-Tw did not cause significant cytotoxicity even at high concentrations (400 μg/mL) for 24 h.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Based on our findings, we propose that Tw is a suitable modifier for rare-earth-doped nanoparticles' performance as a SWIR agent, as it improves their stability properties in aqueous media, biocompatibility, and luminescence emissions.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"77 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139051330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apigenin Release from Chitosan/Gelatin Membranes Promotes Osteogenic Differentiation of Adipose-Derived Mesenchymal Stem Cells","authors":"Azam Bozorgi, Mozafar Khazaei, Maryam Bozorgi, Zahra Jamalpoor","doi":"10.1007/s40846-023-00832-w","DOIUrl":"https://doi.org/10.1007/s40846-023-00832-w","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Apigenin is a widespread phytochemical with beneficial effects on osteoblastic differentiation. However, short half-life and unstable chemical structure restrict apigenin application in bone tissue engineering applications. Here, we investigated the impact of apigenin-loaded chitosan/gelatin (Api. Cs/Gel) membranes on the osteogenic differentiation of human adipose-derived mesenchymal stem cells (hADMSCs).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>Api10. Cs/Gel and Api25. Cs/Gel membranes were fabricated using the solution casting method, followed by characterizing their physicochemical and biological properties. hADMSCs were isolated from healthy donors and characterized using flow cytometry. hADMSCs were seeded onto Api. Cs/Gel membranes and cultured under osteogenic differentiation for 7 and 21 days. The expression of osteogenic markers ALP, RUNX2, OCN, and COL1 was assessed using real-time PCR, and calcium mineralization was analyzed using the quantitative Alizarin red S staining.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The Api. Cs/Gel membranes were successfully fabricated, and characterization data confirmed their structural uniformity, chemical homogeneity, cross-linking, and apigenin incorporation. Membranes exhibited favorable degradation, swelling ratio, and long-term apigenin release. The membranes were non-toxic and supported hADMSCs attachment, viability, and proliferation. The expression of ALP, RUNX2, OCN, and COL1 and cellular mineralization increased on day 21, and significant overexpression was observed in hADMSCs seeded onto Apigenin-loaded membranes.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>Cs/Gel membranes provided an approving matrix for cellular interactions and apigenin inclusion, followed by a sustained release associated with enhanced osteogenic differentiation of hADMSCs and matrix mineralization.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"32 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139051336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Predictive Ability of Prostate Cancer Aggressiveness Using Multi-Modal Radiomic Features and Feature-Level Correlations in Multi-parametric MRI","authors":"Julip Jung, Helen Hong, Sung Il Hwang","doi":"10.1007/s40846-023-00838-4","DOIUrl":"https://doi.org/10.1007/s40846-023-00838-4","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>This study aims to improve the predictive ability of prostate cancer aggressiveness by leveraging complementary information from various feature types extracted from multi-modal images. We propose a prediction model that incorporates Joint Feature Matrix (JFM) features to capture feature-level correlations between T2-weighted magnetic resonance image (T2wMRI) and apparent diffusion coefficient map (ADC).</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>The method involves registering T2wMRI and ADC with ground truth pathology image, enabling identification of prostate cancer regions in T2wMRI and ADC based on pathology image. Uni-modal radiomic features are then extracted from each region of T2wMRI and ADC, while the multi-modal radiomic feature, JFM, is extracted to capture feature-level relationships. Subsequently, a random forest classifier is trained using various combinations of the extracted features to predict aggressiveness of prostate cancer and a feature importance analysis is conducted to identify the most significant features on prediction results.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The experimental results show that incorporating multi-modal radiomic features improves the performance of prediction models. Specifically, using the Concatenated feature enhances specificity by 6.71% and 2.94% compared to the use of T2wMRI and ADC features alone, respectively, indicating improved ability to distinguish the low Gleason score (GS) group by considering both T2wMRI and ADC features. Furthermore, JFM features alone exhibit a higher area under the curve (AUC) compared to Concatenated, Averaged, and Multiplied features. However, the best performance is achieved by combining T2wMRI and ADC features with JFM features, resulting in an AUC improvement of 4.41%, 5.97%, 5.97%, 7.58%, 5.97%, and 2.9% compared to prediction models based on T2wMRI, ADC, Concatenated, Averaged, Multiplied, and JFM features, respectively.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The proposed method effectively captures the joint distribution of features from multiple MRI modalities and demonstrates that consideration of feature-level correlations leads to improved prediction results for prostate cancer aggressiveness.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"1 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138563571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Thrombosis After Coil Embolization of Unruptured Cerebral Aneurysm by Computational Fluid Dynamics Using Porous Media Modeling","authors":"Masanori Tsuji, Fujimaro Ishida, Yoichi Miura, Takenori Sato, Kazuhiro Furukawa, Ryuta Yasuda, Yasuyuki Umeda, Naoki Toma, Hidenori Suzuki","doi":"10.1007/s40846-023-00839-3","DOIUrl":"https://doi.org/10.1007/s40846-023-00839-3","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Preoperative simulations tailored to the therapeutic device are desirable to predict treatment efficacy. We investigated the hemodynamics associated with complete obliteration (CO) of intracranial aneurysms after endovascular treatment by computational fluid dynamics (CFD) using porous media modeling.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>From June 2015 to December 2020, 48 patients with 55 unruptured aneurysms treated with simple coiling or stent-assisted coiling at our institution were included. Patient-specific geometry models were generated from pre-treatment 3 dimension (D) rotational angiography or 3D computed tomography angiography. We simulated the coil and neck-bridging stent with porous media modeling for steady state analysis and calculated residual flow volume (RFV) associated with thrombosis formation after coil embolization. Patients were classified into CO and non-CO groups based on digital subtraction angiography findings after 6 months of treatment, and the groups were statistically evaluated using the Brunner-Munzel test. The area under the receiver operating characteristic (ROC) curve (AUC) was used to evaluate the diagnostic accuracy in predicting CO.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>The aneurysms were classified into 22 CO and 33 non-CO group. There were no significant differences in morphological variables between the two groups. In hemodynamic parameters, RFV was significantly lower in the CO group. The ROC curve analyses showed that RFV with an average flow velocity of more than 0.5 [cm/s] in aneurysm was the most useful to predict CO (AUC, 0.66 [95% CI, 0.51–0.81]; cut-off value, 32.8 mm³; sensitivity, 60.6%; and specificity, 78.9%).</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>These results indicated that CFD could predict aneurysmal CO after coil embolization.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"174 2 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138547932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Biodegradability and Biocompatibility of Pure Zinc Coated with Zinc Phosphate for Cardiovascular Stent Applications","authors":"Guan-Lin Wu, Chin-En Yen, Yi-Syuan Lin, Ming-Long Yeh","doi":"10.1007/s40846-023-00834-8","DOIUrl":"https://doi.org/10.1007/s40846-023-00834-8","url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Purpose</h3><p>Percutaneous coronary intervention is widely used as a primary treatment for cardiovascular diseases. In this regard, it has been revealed from studies that zinc is a potential material for use in stents due to its intrinsic physiological relevance, biocompatibility, biodegradability, and pro-regeneration properties. However, localized corrosion and burst release of zinc ions might cause an early implant failure and a risky environment for vascular remodeling. To resolve these drawbacks effectively, a coating of zinc phosphate on pure zinc was fabricated in this study using a microwave-assisted chemical conversion method.</p><h3 data-test=\"abstract-sub-heading\">Methods</h3><p>In this study, a comprehensive analysis was conducted through materials characterization, electrochemical testing, immersion testing, in vitro testing, and hemocompatibility evaluation to quantify the effect of zinc phosphate coating on zinc cardiovascular stents.</p><h3 data-test=\"abstract-sub-heading\">Results</h3><p>It is revealed that the microstructures of the coatings are mainly composed of zinc phosphate and sodium zinc phosphate. The presence of sodium zinc phosphate could improve corrosion behavior. The assessment of in vitro biocompatibility for the zinc phosphate coatings revealed satisfactory cell viability and a stable and smooth degradation surface for cell adhesion. Furthermore, the zinc phosphate coatings exhibited nonhemolytic properties and inhibitions to the adhesion of platelets.</p><h3 data-test=\"abstract-sub-heading\">Conclusion</h3><p>The zinc phosphate coatings could exhibit a uniform degradation behavior and a positive biological effect on vascular remodeling, and therefore, these coatings could be a promising surface treatment used in stent optimization for zinc.</p>","PeriodicalId":50133,"journal":{"name":"Journal of Medical and Biological Engineering","volume":"15 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138517057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}